JP2021105034A5 - - Google Patents
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- JP2021105034A5 JP2021105034A5 JP2021063301A JP2021063301A JP2021105034A5 JP 2021105034 A5 JP2021105034 A5 JP 2021105034A5 JP 2021063301 A JP2021063301 A JP 2021063301A JP 2021063301 A JP2021063301 A JP 2021063301A JP 2021105034 A5 JP2021105034 A5 JP 2021105034A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- lam
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 32
- 102000036639 antigens Human genes 0.000 claims 32
- 108091007433 antigens Proteins 0.000 claims 32
- 239000012634 fragment Substances 0.000 claims 24
- 102100031561 Hamartin Human genes 0.000 claims 10
- 238000001514 detection method Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 5
- 201000008827 tuberculosis Diseases 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 208000036981 active tuberculosis Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 201000009671 multidrug-resistant tuberculosis Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023031004A JP2023075196A (ja) | 2016-02-10 | 2023-03-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
| JP2024137825A JP2024174883A (ja) | 2016-02-10 | 2024-08-19 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662293406P | 2016-02-10 | 2016-02-10 | |
| US62/293,406 | 2016-02-10 | ||
| JP2018541386A JP2019506412A (ja) | 2016-02-10 | 2017-02-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗−ＬＡＭおよび抗−ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541386A Division JP2019506412A (ja) | 2016-02-10 | 2017-02-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗−ＬＡＭおよび抗−ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023031004A Division JP2023075196A (ja) | 2016-02-10 | 2023-03-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021105034A JP2021105034A (ja) | 2021-07-26 |
| JP2021105034A5 true JP2021105034A5 (enExample) | 2022-01-11 |
| JP7316685B2 JP7316685B2 (ja) | 2023-07-28 |
Family
ID=59563993
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541386A Pending JP2019506412A (ja) | 2016-02-10 | 2017-02-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗−ＬＡＭおよび抗−ＰＩＭ６／ＬＡＭモノクローナル抗体 |
| JP2021063301A Active JP7316685B2 (ja) | 2016-02-10 | 2021-04-02 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
| JP2023031004A Pending JP2023075196A (ja) | 2016-02-10 | 2023-03-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
| JP2024137825A Pending JP2024174883A (ja) | 2016-02-10 | 2024-08-19 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541386A Pending JP2019506412A (ja) | 2016-02-10 | 2017-02-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗−ＬＡＭおよび抗−ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023031004A Pending JP2023075196A (ja) | 2016-02-10 | 2023-03-01 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
| JP2024137825A Pending JP2024174883A (ja) | 2016-02-10 | 2024-08-19 | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）感染の診断および治療のための新規な抗－ＬＡＭおよび抗－ＰＩＭ６／ＬＡＭモノクローナル抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10729771B2 (enExample) |
| EP (2) | EP4299072A3 (enExample) |
| JP (4) | JP2019506412A (enExample) |
| CN (2) | CN110092830B (enExample) |
| AU (2) | AU2017218415B2 (enExample) |
| CA (1) | CA3013904C (enExample) |
| ES (1) | ES2970828T3 (enExample) |
| RU (1) | RU2732502C2 (enExample) |
| WO (1) | WO2017139153A1 (enExample) |
| ZA (3) | ZA201805990B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2732502C2 (ru) | 2016-02-10 | 2020-09-18 | Ратгерс, Де Стейт Юниверсити Оф Нью Джерси | Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis |
| US10830760B2 (en) | 2017-12-20 | 2020-11-10 | General Electric Company | Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity |
| JP2021521462A (ja) * | 2018-03-29 | 2021-08-26 | ファウンデーション オブ イノベーティブ ニュー ダイアグノスティクス | 抗体または抗体の組み合わせおよび対象の尿試料中のマイコバクテリウム関連抗原の検出のためのその使用 |
| EP3823670A4 (en) * | 2018-07-19 | 2022-04-20 | Rutgers, the State University of New Jersey | METHODS FOR DUAL DETECTION AND DIFFERENTIATION OF INFECTIONS WITH MYCOBACTERIUM TUBERCULOSIS COMPLEX AND NON-TUBERCULOUS MYCOBACTERIA |
| EP3845903A4 (en) | 2018-08-31 | 2021-11-24 | FUJIFILM Corporation | IMMUNOCHROMATOGRAPHY KIT AND METHOD FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS |
| EP4040155B1 (en) | 2019-09-30 | 2024-11-27 | FUJIFILM Corporation | Immunochromatography |
| EP4040151B1 (en) | 2019-09-30 | 2025-08-13 | FUJIFILM Corporation | Immunological test method |
| CN111337665A (zh) * | 2020-01-16 | 2020-06-26 | 卢氏实验室公司 | 一种用于检测肺结核感染的免疫层析试纸条及其制备方法 |
| JP7740995B2 (ja) | 2020-01-31 | 2025-09-17 | 富士フイルム株式会社 | 免疫検査方法 |
| EP4099013A4 (en) | 2020-01-31 | 2023-02-15 | FUJIFILM Corporation | IMMUNOCHROMATOGRAPHY |
| JP7350100B2 (ja) | 2020-01-31 | 2023-09-25 | 富士フイルム株式会社 | イムノクロマトグラフィー |
| CN111153992A (zh) * | 2020-02-21 | 2020-05-15 | 首都医科大学附属北京胸科医院 | 结核分枝杆菌lam的单克隆抗体及其用途 |
| US20230258633A1 (en) * | 2020-07-07 | 2023-08-17 | The Regents Of The University Of California | Method for antigen detection from direct clinical samples |
| CN116669707B (zh) * | 2020-08-05 | 2025-11-14 | 杜兰教育基金管理委员会 | 体液样品中结核的检测方法 |
| EP4212873A4 (en) | 2020-09-11 | 2024-06-05 | FUJIFILM Corporation | CONCENTRATION DEVICE, METHOD FOR CONCENTRATING A SAMPLE SOLUTION, METHOD FOR TESTING A SAMPLE SOLUTION AND TEST KIT |
| WO2022054524A1 (ja) | 2020-09-11 | 2022-03-17 | 富士フイルム株式会社 | 濃縮デバイス、検体液の濃縮方法、検体液の検査方法、及び、検査キット |
| EP4212876B1 (en) | 2020-09-11 | 2025-05-14 | FUJIFILM Corporation | Liquid specimen concentration method, and liquid specimen inspection method |
| WO2022081716A1 (en) * | 2020-10-13 | 2022-04-21 | Accubit LLC - Biotechnology | Methods of treating iga nephropathy with thiol-containing molecules |
| EP4263598A4 (en) * | 2020-12-15 | 2025-04-09 | Albert Einstein College of Medicine | High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies |
| CN113480659B (zh) * | 2021-06-30 | 2022-10-21 | 迪比康(上海)生物科技有限公司 | 人源抗结核分枝杆菌复合群lam单克隆抗体及其制备和应用 |
| CN114984870A (zh) * | 2022-03-15 | 2022-09-02 | 齐欣 | 一种重组蛋白质微球及其制备方法和应用 |
| CN117247450B (zh) * | 2023-10-10 | 2025-02-25 | 广州市雷德生物科技有限公司 | 一种lam抗体及其应用 |
| CN118178640B (zh) * | 2024-03-08 | 2025-11-21 | 中国农业大学 | 含有牛分枝杆菌表面多糖的佐剂及其应用 |
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| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| EP0729353B2 (en) | 1993-11-19 | 2012-09-12 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
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| US20010007660A1 (en) * | 1997-06-04 | 2001-07-12 | Aharona Glatman-Freedman | Methods of treating and protecting against tuberculosis using a monoclonal antibody selective for mycobacterium tuberculosis |
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| CN101216491B (zh) * | 2008-01-08 | 2012-06-06 | 广州益善生物技术有限公司 | 结核分枝杆菌检测液相芯片及其制备方法 |
| WO2009105150A2 (en) * | 2008-01-28 | 2009-08-27 | Thomas Jefferson University | Method of making hybrid cells that express useful antibodies |
| KR20110057245A (ko) | 2008-09-19 | 2011-05-31 | 메디뮨 엘엘씨 | Ｃｄ105에 대해 지시된 항체 및 그의 용도 |
| WO2011013698A1 (ja) * | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | キャリアペプチドフラグメント及びその利用 |
| EP2668207A4 (en) * | 2011-01-24 | 2015-06-10 | Univ Singapore | MANNOSE-CAPTURED LIPOARABINOMANANE ANTIGEN-BINDING PROTEINS OBTAINED FROM ILLNESSIFYING MYCOBACTERIES |
| PL2821415T3 (pl) | 2012-02-29 | 2021-07-05 | Otsuka Pharmaceutical Co., Ltd. | Przeciwciało przeciwko lipoarabinomannanowi i test immunologiczny do oznaczania zakażenia kwasoopornymi prątkami przy użyciu tego przeciwciała |
| JO3462B1 (ar) * | 2012-08-22 | 2020-07-05 | Regeneron Pharma | أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها |
| RU2732502C2 (ru) | 2016-02-10 | 2020-09-18 | Ратгерс, Де Стейт Юниверсити Оф Нью Джерси | Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis |
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2017
- 2017-02-01 RU RU2018131622A patent/RU2732502C2/ru active
- 2017-02-01 EP EP23208073.9A patent/EP4299072A3/en active Pending
- 2017-02-01 CA CA3013904A patent/CA3013904C/en active Active
- 2017-02-01 AU AU2017218415A patent/AU2017218415B2/en active Active
- 2017-02-01 US US16/076,971 patent/US10729771B2/en active Active
- 2017-02-01 JP JP2018541386A patent/JP2019506412A/ja active Pending
- 2017-02-01 ES ES17750586T patent/ES2970828T3/es active Active
- 2017-02-01 WO PCT/US2017/016058 patent/WO2017139153A1/en not_active Ceased
- 2017-02-01 CN CN201910291444.8A patent/CN110092830B/zh active Active
- 2017-02-01 EP EP17750586.4A patent/EP3414573B1/en active Active
- 2017-02-01 CN CN201780017369.5A patent/CN109073649A/zh active Pending
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2018
- 2018-09-06 ZA ZA2018/05990A patent/ZA201805990B/en unknown
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2020
- 2020-06-24 US US16/910,621 patent/US11273220B2/en active Active
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2021
- 2021-04-02 JP JP2021063301A patent/JP7316685B2/ja active Active
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2022
- 2022-02-17 US US17/651,523 patent/US11707525B2/en active Active
- 2022-08-12 ZA ZA2022/09045A patent/ZA202209045B/en unknown
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2023
- 2023-03-01 JP JP2023031004A patent/JP2023075196A/ja active Pending
- 2023-06-15 US US18/335,489 patent/US12303562B2/en active Active
- 2023-08-15 ZA ZA2023/07912A patent/ZA202307912B/en unknown
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2024
- 2024-08-01 AU AU2024205286A patent/AU2024205286A1/en active Pending
- 2024-08-19 JP JP2024137825A patent/JP2024174883A/ja active Pending