ZA201805990B - Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections - Google Patents
Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infectionsInfo
- Publication number
- ZA201805990B ZA201805990B ZA2018/05990A ZA201805990A ZA201805990B ZA 201805990 B ZA201805990 B ZA 201805990B ZA 2018/05990 A ZA2018/05990 A ZA 2018/05990A ZA 201805990 A ZA201805990 A ZA 201805990A ZA 201805990 B ZA201805990 B ZA 201805990B
- Authority
- ZA
- South Africa
- Prior art keywords
- lam
- pim6
- diagnosis
- treatment
- monoclonal antibodies
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title 1
- 201000008827 tuberculosis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56933—Mycoplasma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/44—Multiple drug resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662293406P | 2016-02-10 | 2016-02-10 | |
| PCT/US2017/016058 WO2017139153A1 (en) | 2016-02-10 | 2017-02-01 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201805990B true ZA201805990B (en) | 2023-01-25 |
Family
ID=59563993
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2018/05990A ZA201805990B (en) | 2016-02-10 | 2018-09-06 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
| ZA2022/09045A ZA202209045B (en) | 2016-02-10 | 2022-08-12 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
| ZA2023/07912A ZA202307912B (en) | 2016-02-10 | 2023-08-15 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2022/09045A ZA202209045B (en) | 2016-02-10 | 2022-08-12 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
| ZA2023/07912A ZA202307912B (en) | 2016-02-10 | 2023-08-15 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10729771B2 (enExample) |
| EP (2) | EP4299072A3 (enExample) |
| JP (4) | JP2019506412A (enExample) |
| CN (2) | CN110092830B (enExample) |
| AU (2) | AU2017218415B2 (enExample) |
| CA (1) | CA3013904C (enExample) |
| ES (1) | ES2970828T3 (enExample) |
| RU (1) | RU2732502C2 (enExample) |
| WO (1) | WO2017139153A1 (enExample) |
| ZA (3) | ZA201805990B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2732502C2 (ru) | 2016-02-10 | 2020-09-18 | Ратгерс, Де Стейт Юниверсити Оф Нью Джерси | Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis |
| US10830760B2 (en) | 2017-12-20 | 2020-11-10 | General Electric Company | Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity |
| JP2021521462A (ja) * | 2018-03-29 | 2021-08-26 | ファウンデーション オブ イノベーティブ ニュー ダイアグノスティクス | 抗体または抗体の組み合わせおよび対象の尿試料中のマイコバクテリウム関連抗原の検出のためのその使用 |
| EP3823670A4 (en) * | 2018-07-19 | 2022-04-20 | Rutgers, the State University of New Jersey | METHODS FOR DUAL DETECTION AND DIFFERENTIATION OF INFECTIONS WITH MYCOBACTERIUM TUBERCULOSIS COMPLEX AND NON-TUBERCULOUS MYCOBACTERIA |
| EP3845903A4 (en) | 2018-08-31 | 2021-11-24 | FUJIFILM Corporation | IMMUNOCHROMATOGRAPHY KIT AND METHOD FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS |
| EP4040155B1 (en) | 2019-09-30 | 2024-11-27 | FUJIFILM Corporation | Immunochromatography |
| EP4040151B1 (en) | 2019-09-30 | 2025-08-13 | FUJIFILM Corporation | Immunological test method |
| CN111337665A (zh) * | 2020-01-16 | 2020-06-26 | 卢氏实验室公司 | 一种用于检测肺结核感染的免疫层析试纸条及其制备方法 |
| JP7740995B2 (ja) | 2020-01-31 | 2025-09-17 | 富士フイルム株式会社 | 免疫検査方法 |
| EP4099013A4 (en) | 2020-01-31 | 2023-02-15 | FUJIFILM Corporation | IMMUNOCHROMATOGRAPHY |
| JP7350100B2 (ja) | 2020-01-31 | 2023-09-25 | 富士フイルム株式会社 | イムノクロマトグラフィー |
| CN111153992A (zh) * | 2020-02-21 | 2020-05-15 | 首都医科大学附属北京胸科医院 | 结核分枝杆菌lam的单克隆抗体及其用途 |
| US20230258633A1 (en) * | 2020-07-07 | 2023-08-17 | The Regents Of The University Of California | Method for antigen detection from direct clinical samples |
| CN116669707B (zh) * | 2020-08-05 | 2025-11-14 | 杜兰教育基金管理委员会 | 体液样品中结核的检测方法 |
| EP4212873A4 (en) | 2020-09-11 | 2024-06-05 | FUJIFILM Corporation | CONCENTRATION DEVICE, METHOD FOR CONCENTRATING A SAMPLE SOLUTION, METHOD FOR TESTING A SAMPLE SOLUTION AND TEST KIT |
| WO2022054524A1 (ja) | 2020-09-11 | 2022-03-17 | 富士フイルム株式会社 | 濃縮デバイス、検体液の濃縮方法、検体液の検査方法、及び、検査キット |
| EP4212876B1 (en) | 2020-09-11 | 2025-05-14 | FUJIFILM Corporation | Liquid specimen concentration method, and liquid specimen inspection method |
| WO2022081716A1 (en) * | 2020-10-13 | 2022-04-21 | Accubit LLC - Biotechnology | Methods of treating iga nephropathy with thiol-containing molecules |
| EP4263598A4 (en) * | 2020-12-15 | 2025-04-09 | Albert Einstein College of Medicine | High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies |
| CN113480659B (zh) * | 2021-06-30 | 2022-10-21 | 迪比康(上海)生物科技有限公司 | 人源抗结核分枝杆菌复合群lam单克隆抗体及其制备和应用 |
| CN114984870A (zh) * | 2022-03-15 | 2022-09-02 | 齐欣 | 一种重组蛋白质微球及其制备方法和应用 |
| CN117247450B (zh) * | 2023-10-10 | 2025-02-25 | 广州市雷德生物科技有限公司 | 一种lam抗体及其应用 |
| CN118178640B (zh) * | 2024-03-08 | 2025-11-21 | 中国农业大学 | 含有牛分枝杆菌表面多糖的佐剂及其应用 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| EP0729353B2 (en) | 1993-11-19 | 2012-09-12 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
| US6656508B2 (en) | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| US20010007660A1 (en) * | 1997-06-04 | 2001-07-12 | Aharona Glatman-Freedman | Methods of treating and protecting against tuberculosis using a monoclonal antibody selective for mycobacterium tuberculosis |
| US6573238B2 (en) | 1997-11-07 | 2003-06-03 | Chiron Corporation | Method for producing sustained-release formulations |
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| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
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| AP2316A (en) * | 2004-07-20 | 2011-11-04 | Chemogen Inc | Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same. |
| CN101216491B (zh) * | 2008-01-08 | 2012-06-06 | 广州益善生物技术有限公司 | 结核分枝杆菌检测液相芯片及其制备方法 |
| WO2009105150A2 (en) * | 2008-01-28 | 2009-08-27 | Thomas Jefferson University | Method of making hybrid cells that express useful antibodies |
| KR20110057245A (ko) | 2008-09-19 | 2011-05-31 | 메디뮨 엘엘씨 | Ｃｄ105에 대해 지시된 항체 및 그의 용도 |
| WO2011013698A1 (ja) * | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | キャリアペプチドフラグメント及びその利用 |
| EP2668207A4 (en) * | 2011-01-24 | 2015-06-10 | Univ Singapore | MANNOSE-CAPTURED LIPOARABINOMANANE ANTIGEN-BINDING PROTEINS OBTAINED FROM ILLNESSIFYING MYCOBACTERIES |
| PL2821415T3 (pl) | 2012-02-29 | 2021-07-05 | Otsuka Pharmaceutical Co., Ltd. | Przeciwciało przeciwko lipoarabinomannanowi i test immunologiczny do oznaczania zakażenia kwasoopornymi prątkami przy użyciu tego przeciwciała |
| JO3462B1 (ar) * | 2012-08-22 | 2020-07-05 | Regeneron Pharma | أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها |
| RU2732502C2 (ru) | 2016-02-10 | 2020-09-18 | Ратгерс, Де Стейт Юниверсити Оф Нью Джерси | Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis |
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2017
- 2017-02-01 RU RU2018131622A patent/RU2732502C2/ru active
- 2017-02-01 EP EP23208073.9A patent/EP4299072A3/en active Pending
- 2017-02-01 CA CA3013904A patent/CA3013904C/en active Active
- 2017-02-01 AU AU2017218415A patent/AU2017218415B2/en active Active
- 2017-02-01 US US16/076,971 patent/US10729771B2/en active Active
- 2017-02-01 JP JP2018541386A patent/JP2019506412A/ja active Pending
- 2017-02-01 ES ES17750586T patent/ES2970828T3/es active Active
- 2017-02-01 WO PCT/US2017/016058 patent/WO2017139153A1/en not_active Ceased
- 2017-02-01 CN CN201910291444.8A patent/CN110092830B/zh active Active
- 2017-02-01 EP EP17750586.4A patent/EP3414573B1/en active Active
- 2017-02-01 CN CN201780017369.5A patent/CN109073649A/zh active Pending
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2018
- 2018-09-06 ZA ZA2018/05990A patent/ZA201805990B/en unknown
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2020
- 2020-06-24 US US16/910,621 patent/US11273220B2/en active Active
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2021
- 2021-04-02 JP JP2021063301A patent/JP7316685B2/ja active Active
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2022
- 2022-02-17 US US17/651,523 patent/US11707525B2/en active Active
- 2022-08-12 ZA ZA2022/09045A patent/ZA202209045B/en unknown
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2023
- 2023-03-01 JP JP2023031004A patent/JP2023075196A/ja active Pending
- 2023-06-15 US US18/335,489 patent/US12303562B2/en active Active
- 2023-08-15 ZA ZA2023/07912A patent/ZA202307912B/en unknown
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2024
- 2024-08-01 AU AU2024205286A patent/AU2024205286A1/en active Pending
- 2024-08-19 JP JP2024137825A patent/JP2024174883A/ja active Pending
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