JP2021073270A5 - - Google Patents
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- Publication number
- JP2021073270A5 JP2021073270A5 JP2021014223A JP2021014223A JP2021073270A5 JP 2021073270 A5 JP2021073270 A5 JP 2021073270A5 JP 2021014223 A JP2021014223 A JP 2021014223A JP 2021014223 A JP2021014223 A JP 2021014223A JP 2021073270 A5 JP2021073270 A5 JP 2021073270A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- treating
- crystalline form
- form according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 208000010428 Muscle Weakness Diseases 0.000 claims 9
- 206010028372 Muscular weakness Diseases 0.000 claims 9
- 239000013078 crystal Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 206010006895 Cachexia Diseases 0.000 claims 4
- 206010049565 Muscle fatigue Diseases 0.000 claims 4
- 206010066218 Stress Urinary Incontinence Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 230000004064 dysfunction Effects 0.000 claims 4
- 210000003205 muscle Anatomy 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 238000001228 spectrum Methods 0.000 claims 4
- 208000020431 spinal cord injury Diseases 0.000 claims 4
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000034347 Faecal incontinence Diseases 0.000 claims 2
- 208000036119 Frailty Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 208000021642 Muscular disease Diseases 0.000 claims 2
- 201000009623 Myopathy Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 2
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
- 206010046543 Urinary incontinence Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 206010003549 asthenia Diseases 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- 201000010235 heart cancer Diseases 0.000 claims 2
- 208000024348 heart neoplasm Diseases 0.000 claims 2
- 230000003387 muscular Effects 0.000 claims 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000001076 sarcopenia Diseases 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SXDWQYMMHKECBL-UHFFFAOYSA-N 4,4-dimethyl-3-oxospiro[2H-isoquinoline-1,3'-oxetane]-6-carbonitrile Chemical compound CC1(C(NC2(COC2)C2=CC=C(C=C12)C#N)=O)C SXDWQYMMHKECBL-UHFFFAOYSA-N 0.000 claims 1
- LJFXOWSKSMYONP-UHFFFAOYSA-N N#CC1=CC=C(C2(COC2)NC=C2)C2=C1 Chemical compound N#CC1=CC=C(C2(COC2)NC=C2)C2=C1 LJFXOWSKSMYONP-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662285039P | 2016-02-12 | 2016-02-12 | |
| US62/285,039 | 2016-02-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541693A Division JP6832943B2 (ja) | 2016-02-12 | 2017-02-10 | テトラヒドロイソキノリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021073270A JP2021073270A (ja) | 2021-05-13 |
| JP2021073270A5 true JP2021073270A5 (https=) | 2021-06-24 |
| JP7137650B2 JP7137650B2 (ja) | 2022-09-14 |
Family
ID=59561239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541693A Expired - Fee Related JP6832943B2 (ja) | 2016-02-12 | 2017-02-10 | テトラヒドロイソキノリン誘導体 |
| JP2021014223A Active JP7137650B2 (ja) | 2016-02-12 | 2021-02-01 | テトラヒドロイソキノリン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541693A Expired - Fee Related JP6832943B2 (ja) | 2016-02-12 | 2017-02-10 | テトラヒドロイソキノリン誘導体 |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US9914741B2 (https=) |
| EP (2) | EP4032877A1 (https=) |
| JP (2) | JP6832943B2 (https=) |
| KR (1) | KR20180120701A (https=) |
| CN (2) | CN109069498B (https=) |
| AR (1) | AR107592A1 (https=) |
| AU (1) | AU2017217663B2 (https=) |
| BR (1) | BR112018016475A2 (https=) |
| CA (1) | CA3012839A1 (https=) |
| CL (1) | CL2018002287A1 (https=) |
| CO (1) | CO2018007920A2 (https=) |
| CY (1) | CY1125222T1 (https=) |
| DK (1) | DK3413892T3 (https=) |
| ES (1) | ES2913423T3 (https=) |
| HR (1) | HRP20220655T1 (https=) |
| HU (1) | HUE058820T2 (https=) |
| IL (1) | IL261055B (https=) |
| LT (1) | LT3413892T (https=) |
| MA (1) | MA44018B1 (https=) |
| MD (1) | MD3413892T2 (https=) |
| MX (1) | MX379159B (https=) |
| NZ (1) | NZ746311A (https=) |
| PH (1) | PH12018501694B1 (https=) |
| PL (1) | PL3413892T3 (https=) |
| PT (1) | PT3413892T (https=) |
| RS (1) | RS63240B1 (https=) |
| RU (1) | RU2743424C2 (https=) |
| SG (1) | SG11201806416XA (https=) |
| SI (1) | SI3413892T1 (https=) |
| SM (1) | SMT202200201T1 (https=) |
| TW (2) | TWI773118B (https=) |
| UA (1) | UA124879C2 (https=) |
| WO (1) | WO2017139526A1 (https=) |
| ZA (1) | ZA201804947B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018016475A2 (en) * | 2016-02-12 | 2018-12-26 | Cytokinetics, Incorporated | tetrahydroisoquinoline derivatives |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| WO2022099011A1 (en) * | 2020-11-06 | 2022-05-12 | Cytokinetics, Inc. | Bicyclic 1,4-diazepanones and therapeutic uses thereof |
| WO2025080100A1 (ko) * | 2023-10-11 | 2025-04-17 | 한국화학연구원 | 신규한 디-아미드 화합물, 이의 제조방법, 이를 유효성분으로 포함하는 암 또는 자가면역질환의 예방 또는 치료용 약학적 조성물 |
| CN117379425A (zh) * | 2023-11-14 | 2024-01-12 | 广州日聚商贸发展有限公司 | 喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3301857A (en) | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
| SE368009B (https=) | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| US6492520B1 (en) * | 1996-08-06 | 2002-12-10 | Pfizer Inc | Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives |
| KR100567649B1 (ko) | 1996-09-25 | 2006-04-05 | 아스트라제네카 유케이 리미티드 | 혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체 |
| US6410254B1 (en) | 1999-05-18 | 2002-06-25 | Cytokinetics | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
| US6743599B1 (en) | 1999-05-18 | 2004-06-01 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
| US7202051B1 (en) | 1999-05-18 | 2007-04-10 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
| US6958333B1 (en) * | 1999-07-26 | 2005-10-25 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
| JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
| GB0321538D0 (en) | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
| JP4361566B2 (ja) * | 2004-04-28 | 2009-11-11 | 武田薬品工業株式会社 | 縮合キノリン誘導体およびその使用 |
| WO2007075783A2 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Substituted isoquinoline-1,3(2h,4h)-diones, 1-thioxo-1,4-dihydro-2h-isoquinoline-3-ones and 1,4-dihydro-3(2h)-isoquinolones and use thereof as kinase inhibitor |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| ES2558517T3 (es) | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
| NZ577980A (en) * | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| RU2443698C2 (ru) | 2007-01-05 | 2012-02-27 | Дайити Санкио Компани, Лимитед | Конденсированное замещенное производное аминопирролидина |
| US8163909B2 (en) | 2007-05-25 | 2012-04-24 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| JP5451646B2 (ja) * | 2008-02-27 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| CN101518971B (zh) * | 2008-02-29 | 2012-07-18 | E.I.内穆尔杜邦公司 | 聚酯叠层膜和使用该叠层膜的太阳能电池板 |
| NZ592008A (en) * | 2008-10-02 | 2011-12-22 | Taisho Pharmaceutical Co Ltd | 7-piperidinoalkyl-3,4-dihydroquinolone derivative |
| CN102256493A (zh) | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| WO2010131145A1 (en) | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| CN103476757A (zh) * | 2011-02-18 | 2013-12-25 | 阿勒根公司 | 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物 |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| SG10201701101YA (en) | 2012-04-02 | 2017-04-27 | Cytokinetics Inc | Methods for improving diaphragm function |
| CN111840294A (zh) | 2012-04-11 | 2020-10-30 | 赛特凯恩蒂克公司 | 改善对骨骼肌疲劳的抵抗力的方法 |
| AR091699A1 (es) * | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
| HUE057533T2 (hu) | 2014-04-29 | 2022-05-28 | Cytokinetics Inc | Eljárások vitálkapacitás csökkenésének gátlására |
| JP6573618B2 (ja) | 2014-09-09 | 2019-09-11 | アステラス製薬株式会社 | 尿失禁予防用及び／又は治療用新規医薬組成物 |
| BR112018016475A2 (en) * | 2016-02-12 | 2018-12-26 | Cytokinetics, Incorporated | tetrahydroisoquinoline derivatives |
-
2017
- 2017-02-10 BR BR112018016475-5A patent/BR112018016475A2/en not_active IP Right Cessation
- 2017-02-10 US US15/429,738 patent/US9914741B2/en active Active
- 2017-02-10 MX MX2018009759A patent/MX379159B/es unknown
- 2017-02-10 DK DK17750801.7T patent/DK3413892T3/da active
- 2017-02-10 JP JP2018541693A patent/JP6832943B2/ja not_active Expired - Fee Related
- 2017-02-10 NZ NZ746311A patent/NZ746311A/en not_active IP Right Cessation
- 2017-02-10 EP EP22160176.8A patent/EP4032877A1/en not_active Withdrawn
- 2017-02-10 KR KR1020187026486A patent/KR20180120701A/ko not_active Withdrawn
- 2017-02-10 PL PL17750801T patent/PL3413892T3/pl unknown
- 2017-02-10 UA UAA201809258A patent/UA124879C2/uk unknown
- 2017-02-10 LT LTEPPCT/US2017/017295T patent/LT3413892T/lt unknown
- 2017-02-10 HU HUE17750801A patent/HUE058820T2/hu unknown
- 2017-02-10 SI SI201731142T patent/SI3413892T1/sl unknown
- 2017-02-10 ES ES17750801T patent/ES2913423T3/es active Active
- 2017-02-10 EP EP17750801.7A patent/EP3413892B1/en active Active
- 2017-02-10 TW TW110103986A patent/TWI773118B/zh not_active IP Right Cessation
- 2017-02-10 HR HRP20220655TT patent/HRP20220655T1/hr unknown
- 2017-02-10 MA MA44018A patent/MA44018B1/fr unknown
- 2017-02-10 PT PT177508017T patent/PT3413892T/pt unknown
- 2017-02-10 SG SG11201806416XA patent/SG11201806416XA/en unknown
- 2017-02-10 CN CN201780010949.1A patent/CN109069498B/zh not_active Expired - Fee Related
- 2017-02-10 CN CN202110837700.6A patent/CN113666938A/zh active Pending
- 2017-02-10 SM SM20220201T patent/SMT202200201T1/it unknown
- 2017-02-10 CA CA3012839A patent/CA3012839A1/en active Pending
- 2017-02-10 AR ARP170100336A patent/AR107592A1/es unknown
- 2017-02-10 AU AU2017217663A patent/AU2017217663B2/en not_active Ceased
- 2017-02-10 TW TW106104493A patent/TWI719138B/zh not_active IP Right Cessation
- 2017-02-10 WO PCT/US2017/017295 patent/WO2017139526A1/en not_active Ceased
- 2017-02-10 PH PH1/2018/501694A patent/PH12018501694B1/en unknown
- 2017-02-10 RS RS20220483A patent/RS63240B1/sr unknown
- 2017-02-10 MD MDE20181214T patent/MD3413892T2/ro unknown
- 2017-02-10 RU RU2018130002A patent/RU2743424C2/ru active
-
2018
- 2018-01-17 US US15/873,571 patent/US10259821B2/en active Active
- 2018-07-23 ZA ZA2018/04947A patent/ZA201804947B/en unknown
- 2018-07-30 CO CONC2018/0007920A patent/CO2018007920A2/es unknown
- 2018-08-08 IL IL261055A patent/IL261055B/en active IP Right Grant
- 2018-08-10 CL CL2018002287A patent/CL2018002287A1/es unknown
-
2019
- 2019-03-04 US US16/291,481 patent/US10689393B2/en active Active
-
2020
- 2020-05-11 US US16/871,532 patent/US11479561B2/en active Active
-
2021
- 2021-02-01 JP JP2021014223A patent/JP7137650B2/ja active Active
-
2022
- 2022-06-03 CY CY20221100392T patent/CY1125222T1/el unknown
- 2022-09-13 US US17/944,060 patent/US20230125280A1/en not_active Abandoned
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