AU2017217663B2 - Tetrahydroisoquinoline derivatives - Google Patents

Tetrahydroisoquinoline derivatives Download PDF

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Publication number
AU2017217663B2
AU2017217663B2 AU2017217663A AU2017217663A AU2017217663B2 AU 2017217663 B2 AU2017217663 B2 AU 2017217663B2 AU 2017217663 A AU2017217663 A AU 2017217663A AU 2017217663 A AU2017217663 A AU 2017217663A AU 2017217663 B2 AU2017217663 B2 AU 2017217663B2
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AU
Australia
Prior art keywords
alkyl
compound
group
halogen
salt
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Ceased
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AU2017217663A
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AU2017217663A1 (en
Inventor
Luke Ashcraft
Scott Emile Collibee
Marc GARARD
Takashi Kamikubo
Hiroshi Kiyohara
Pu-Ping Lu
Fady Malik
Yuji Matsushima
Kayoko Mihara
Masanori Miura
Bradley Paul Morgan
Munemichi OHE
Tomoyuki Saito
Ippei Sato
Yasuhiro Shiina
Hiroaki Tanaka
Jeffrey Michael Warrington
Susumu Yamaki
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Cytokinetics Inc
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Cytokinetics Inc
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Assigned to CYTOKINETICS, INCORPORATED reassignment CYTOKINETICS, INCORPORATED Request for Assignment Assignors: ASTELLAS PHARMA INC., CYTOKINETICS, INCORPORATED
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2017217663A 2016-02-12 2017-02-10 Tetrahydroisoquinoline derivatives Ceased AU2017217663B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662285039P 2016-02-12 2016-02-12
US62/285,039 2016-02-12
PCT/US2017/017295 WO2017139526A1 (en) 2016-02-12 2017-02-10 Tetrahydroisoquinoline derivatives

Publications (2)

Publication Number Publication Date
AU2017217663A1 AU2017217663A1 (en) 2018-10-04
AU2017217663B2 true AU2017217663B2 (en) 2021-06-17

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AU2017217663A Ceased AU2017217663B2 (en) 2016-02-12 2017-02-10 Tetrahydroisoquinoline derivatives

Country Status (34)

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US (5) US9914741B2 (https=)
EP (2) EP4032877A1 (https=)
JP (2) JP6832943B2 (https=)
KR (1) KR20180120701A (https=)
CN (2) CN109069498B (https=)
AR (1) AR107592A1 (https=)
AU (1) AU2017217663B2 (https=)
BR (1) BR112018016475A2 (https=)
CA (1) CA3012839A1 (https=)
CL (1) CL2018002287A1 (https=)
CO (1) CO2018007920A2 (https=)
CY (1) CY1125222T1 (https=)
DK (1) DK3413892T3 (https=)
ES (1) ES2913423T3 (https=)
HR (1) HRP20220655T1 (https=)
HU (1) HUE058820T2 (https=)
IL (1) IL261055B (https=)
LT (1) LT3413892T (https=)
MA (1) MA44018B1 (https=)
MD (1) MD3413892T2 (https=)
MX (1) MX379159B (https=)
NZ (1) NZ746311A (https=)
PH (1) PH12018501694B1 (https=)
PL (1) PL3413892T3 (https=)
PT (1) PT3413892T (https=)
RS (1) RS63240B1 (https=)
RU (1) RU2743424C2 (https=)
SG (1) SG11201806416XA (https=)
SI (1) SI3413892T1 (https=)
SM (1) SMT202200201T1 (https=)
TW (2) TWI773118B (https=)
UA (1) UA124879C2 (https=)
WO (1) WO2017139526A1 (https=)
ZA (1) ZA201804947B (https=)

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WO2025080100A1 (ko) * 2023-10-11 2025-04-17 한국화학연구원 신규한 디-아미드 화합물, 이의 제조방법, 이를 유효성분으로 포함하는 암 또는 자가면역질환의 예방 또는 치료용 약학적 조성물
CN117379425A (zh) * 2023-11-14 2024-01-12 广州日聚商贸发展有限公司 喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用

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HRP20220655T1 (hr) 2022-06-24
PH12018501694A1 (en) 2019-01-28
US20170233402A1 (en) 2017-08-17
PH12018501694B1 (en) 2023-08-30
CN109069498B (zh) 2021-08-17
CO2018007920A2 (es) 2018-12-14
UA124879C2 (uk) 2021-12-08
US10689393B2 (en) 2020-06-23
AU2017217663A1 (en) 2018-10-04
CN113666938A (zh) 2021-11-19
RU2743424C2 (ru) 2021-02-18
US20230125280A1 (en) 2023-04-27
JP2021073270A (ja) 2021-05-13
US20200270266A1 (en) 2020-08-27
EP3413892A1 (en) 2018-12-19
EP3413892A4 (en) 2019-08-14
ZA201804947B (en) 2024-05-30
WO2017139526A8 (en) 2018-08-16
IL261055B (en) 2021-03-25
AR107592A1 (es) 2018-05-16
IL261055A (en) 2018-10-31
JP7137650B2 (ja) 2022-09-14
WO2017139526A1 (en) 2017-08-17
JP6832943B2 (ja) 2021-02-24
CN109069498A (zh) 2018-12-21
CY1125222T1 (el) 2025-03-28
SG11201806416XA (en) 2018-08-30
TW202138373A (zh) 2021-10-16
US9914741B2 (en) 2018-03-13
TW201741316A (zh) 2017-12-01
ES2913423T3 (es) 2022-06-02
US11479561B2 (en) 2022-10-25
DK3413892T3 (da) 2022-05-23
MX2018009759A (es) 2018-11-29
KR20180120701A (ko) 2018-11-06
SI3413892T1 (sl) 2022-06-30
CL2018002287A1 (es) 2019-01-04
MD3413892T2 (ro) 2022-06-30
JP2019509267A (ja) 2019-04-04
US20190194220A1 (en) 2019-06-27
RS63240B1 (sr) 2022-06-30
HUE058820T2 (hu) 2022-09-28
MX379159B (es) 2025-03-10
RU2018130002A3 (https=) 2020-03-24
CA3012839A1 (en) 2017-08-17
SMT202200201T1 (it) 2022-07-21
US10259821B2 (en) 2019-04-16
TWI719138B (zh) 2021-02-21
LT3413892T (lt) 2022-06-10
EP3413892B1 (en) 2022-04-20
PT3413892T (pt) 2022-05-30
US20180148458A1 (en) 2018-05-31
MA44018B1 (fr) 2022-05-31
TWI773118B (zh) 2022-08-01
BR112018016475A2 (en) 2018-12-26
MA44018A (fr) 2018-12-19
NZ746311A (en) 2022-08-26
EP4032877A1 (en) 2022-07-27
PL3413892T3 (pl) 2022-06-13
RU2018130002A (ru) 2020-03-12

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