JP2021050208A5 - - Google Patents
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- JP2021050208A5 JP2021050208A5 JP2020195185A JP2020195185A JP2021050208A5 JP 2021050208 A5 JP2021050208 A5 JP 2021050208A5 JP 2020195185 A JP2020195185 A JP 2020195185A JP 2020195185 A JP2020195185 A JP 2020195185A JP 2021050208 A5 JP2021050208 A5 JP 2021050208A5
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- 238000000034 method Methods 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- MJSHDCCLFGOEIK-UHFFFAOYSA-N benzyl (2,5-dioxopyrrolidin-1-yl) carbonate Chemical compound O=C1CCC(=O)N1OC(=O)OCC1=CC=CC=C1 MJSHDCCLFGOEIK-UHFFFAOYSA-N 0.000 claims 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
- -1 lithium aluminum hydride Chemical compound 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 claims 2
- 239000007821 HATU Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- USZLCYNVCCDPLQ-UHFFFAOYSA-N hydron;n-methoxymethanamine;chloride Chemical compound Cl.CNOC USZLCYNVCCDPLQ-UHFFFAOYSA-N 0.000 claims 1
- 239000012280 lithium aluminium hydride Substances 0.000 claims 1
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 claims 1
- 229910000103 lithium hydride Inorganic materials 0.000 claims 1
- LWLPYZUDBNFNAH-UHFFFAOYSA-M magnesium;butane;bromide Chemical compound [Mg+2].[Br-].CCC[CH2-] LWLPYZUDBNFNAH-UHFFFAOYSA-M 0.000 claims 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 claims 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 claims 1
- LVKCSZQWLOVUGB-UHFFFAOYSA-M magnesium;propane;bromide Chemical compound [Mg+2].[Br-].C[CH-]C LVKCSZQWLOVUGB-UHFFFAOYSA-M 0.000 claims 1
- UGVPKMAWLOMPRS-UHFFFAOYSA-M magnesium;propane;bromide Chemical compound [Mg+2].[Br-].CC[CH2-] UGVPKMAWLOMPRS-UHFFFAOYSA-M 0.000 claims 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 claims 1
- 0 CC(C)(CC(*)C(O)=O)C(F)F Chemical compound CC(C)(CC(*)C(O)=O)C(F)F 0.000 description 1
- CXJPNNLKKCQPQG-UHFFFAOYSA-N CCCC(C)(C(C(OCC)=O)C([O](CC)C(C)OC(C(C(C)(C)C(F)(F)F)C(OCC)=O)=O)=O)C(F)F Chemical compound CCCC(C)(C(C(OCC)=O)C([O](CC)C(C)OC(C(C(C)(C)C(F)(F)F)C(OCC)=O)=O)=O)C(F)F CXJPNNLKKCQPQG-UHFFFAOYSA-N 0.000 description 1
- ISCDNFWOBLCVJQ-UHFFFAOYSA-N CCCC(C)(CC=O)C(F)F Chemical compound CCCC(C)(CC=O)C(F)F ISCDNFWOBLCVJQ-UHFFFAOYSA-N 0.000 description 1
- NEDLTEQUFXVARN-UHFFFAOYSA-N CCOC(C(C(OCC)=O)=C(C)C(F)F)=O Chemical compound CCOC(C(C(OCC)=O)=C(C)C(F)F)=O NEDLTEQUFXVARN-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024032219A JP2024073492A (ja) | 2015-10-23 | 2024-03-04 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
| JP2025139729A JP2025176049A (ja) | 2015-10-23 | 2025-08-25 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245553P | 2015-10-23 | 2015-10-23 | |
| US62/245,553 | 2015-10-23 | ||
| US201662336219P | 2016-05-13 | 2016-05-13 | |
| US62/336,219 | 2016-05-13 | ||
| JP2018521294A JP6800968B2 (ja) | 2015-10-23 | 2016-10-21 | セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521294A Division JP6800968B2 (ja) | 2015-10-23 | 2016-10-21 | セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024032219A Division JP2024073492A (ja) | 2015-10-23 | 2024-03-04 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021050208A JP2021050208A (ja) | 2021-04-01 |
| JP2021050208A5 true JP2021050208A5 (https=) | 2021-05-13 |
| JP7449843B2 JP7449843B2 (ja) | 2024-03-14 |
Family
ID=58557891
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521294A Active JP6800968B2 (ja) | 2015-10-23 | 2016-10-21 | セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
| JP2020195185A Active JP7449843B2 (ja) | 2015-10-23 | 2020-11-25 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
| JP2024032219A Withdrawn JP2024073492A (ja) | 2015-10-23 | 2024-03-04 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
| JP2025139729A Pending JP2025176049A (ja) | 2015-10-23 | 2025-08-25 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521294A Active JP6800968B2 (ja) | 2015-10-23 | 2016-10-21 | セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024032219A Withdrawn JP2024073492A (ja) | 2015-10-23 | 2024-03-04 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
| JP2025139729A Pending JP2025176049A (ja) | 2015-10-23 | 2025-08-25 | セストリン－ｇａｔｏｒ２相互作用のモジュレーターおよびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US10100066B2 (https=) |
| EP (2) | EP3364958B1 (https=) |
| JP (4) | JP6800968B2 (https=) |
| KR (2) | KR102708250B1 (https=) |
| CN (2) | CN108289866B (https=) |
| AU (4) | AU2016342027B2 (https=) |
| BR (1) | BR122021005850B1 (https=) |
| CA (2) | CA3001703C (https=) |
| CO (1) | CO2018005315A2 (https=) |
| DK (1) | DK3364958T3 (https=) |
| ES (1) | ES2941969T3 (https=) |
| FI (1) | FI3364958T3 (https=) |
| HR (1) | HRP20230331T1 (https=) |
| HU (1) | HUE061437T2 (https=) |
| IL (1) | IL258779B (https=) |
| LT (1) | LT3364958T (https=) |
| MX (2) | MX389001B (https=) |
| PL (1) | PL3364958T3 (https=) |
| PT (1) | PT3364958T (https=) |
| RS (1) | RS64114B1 (https=) |
| SG (1) | SG11201803099SA (https=) |
| SI (1) | SI3364958T1 (https=) |
| WO (1) | WO2017070518A1 (https=) |
Families Citing this family (15)
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| US20160145344A1 (en) * | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
| AU2016342027B2 (en) | 2015-10-23 | 2021-05-13 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| PL3615019T3 (pl) * | 2017-04-26 | 2026-01-19 | Navitor Pharmaceuticals, Inc. | Modulator interakcji sestryna-gator2 do zastosowania w leczeniu depresji opornej na leczenie |
| EP3870158A4 (en) * | 2018-10-24 | 2022-08-10 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| CN111689993B (zh) * | 2019-03-11 | 2023-04-14 | 凯特立斯（深圳）科技有限公司 | 一种新的含硼类佐米药物关键中间体手性α-氨基硼酸酯的制备方法 |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| US11723890B2 (en) * | 2019-11-01 | 2023-08-15 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mTORC1 modulator |
| CN112699498B (zh) * | 2021-03-23 | 2021-05-25 | 中国空气动力研究与发展中心计算空气动力研究所 | 基于归一化物理量间断特征的喷流模拟激波快速判别方法 |
| EP4234014A1 (en) * | 2022-02-28 | 2023-08-30 | Insusense ApS | Amino acid based carbamates and/or ureas for the treatment of sortilin dependent diseases |
| KR102777583B1 (ko) * | 2024-05-24 | 2025-03-07 | 충남대학교산학협력단 | 세스트린2를 포함하는 전립선 질환 예방 또는 치료용 조성물 |
| WO2026085331A1 (en) | 2024-10-16 | 2026-04-23 | Navitor Pharmaceuticals, Inc. | Mefluleucin for use in the treatment of suicidal ideations associated with depression |
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