JP2021008427A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2021008427A JP2021008427A JP2019122358A JP2019122358A JP2021008427A JP 2021008427 A JP2021008427 A JP 2021008427A JP 2019122358 A JP2019122358 A JP 2019122358A JP 2019122358 A JP2019122358 A JP 2019122358A JP 2021008427 A JP2021008427 A JP 2021008427A
- Authority
- JP
- Japan
- Prior art keywords
- diffraction peak
- hydroxyapatite particles
- oral composition
- hydroxyapatite
- diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 79
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 79
- 239000002245 particle Substances 0.000 claims abstract description 73
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 claims abstract description 22
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- 238000000034 method Methods 0.000 claims description 12
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- -1 phosphate alkali salt Chemical class 0.000 description 29
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 28
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Abstract
Description
項1.
ヒドロキシアパタイト粒子、乳酸アルミニウム、及びヒドロキシエチルセルロースを含有し、
前記ヒドロキシアパタイト粒子の、CuKα特性X線により測定される粉末X線回折パターンにおける2θ=26°付近の回折ピーク強度に対する2θ=32°付近の回折ピーク強度の比が0.8〜1.5であることを特徴とする、
口腔用組成物。
項2.
前記乳酸アルミニウムの含有量が1〜3質量%である、項1に記載の口腔用組成物。
項3.
前記乳酸アルミニウムの含有量が2質量%である、項2に記載の口腔用組成物。
項4.
前記ヒドロキシアパタイト粒子のCa/Pモル比が1.67未満である、項1〜3のいずれかに記載の口腔用組成物。
項5.
前記ヒドロキシアパタイト粒子のメジアン径が5μm以下である、項1〜4のいずれかに記載の口腔用組成物。
項6.
前記ヒドロキシアパタイト粒子の比表面積が55〜200m2/gである、項1〜5のいずれかに記載の口腔用組成物。
項7.
前記ヒドロキシアパタイト粒子が、CuKα特性X線により測定される粉末X線回折パターンにおける2θ=32°付近の回折ピーク強度に対する2θ=34°付近の回折ピーク強度の比が1以下である、項1〜6のいずれかに記載の口腔用組成物。
項8.
前記ヒドロキシアパタイト粒子が、ヒドロキシアパタイト板状結晶の凝集体である、
項1〜7のいずれかに記載の口腔用組成物。
項9.
知覚過敏予防又は改善用である、項1〜8のいずれかに記載の口腔用組成物。
項10.
乳酸アルミニウムと、ヒドロキシエチルセルロースとを含有する口腔用組成物に、ヒドロキシアパタイト粒子を添加することを特徴とし、
前記ヒドロキシアパタイト粒子の、CuKα特性X線により測定される粉末X線回折パターンにおける2θ=26°付近の回折ピーク強度に対する2θ=32°付近の回折ピーク強度の比が0.8〜1.5である、
口腔用組成物の安定性を向上させる方法。
項11.
前記安定性が、55℃における安定性である、項10に記載の方法。
シュウ酸反応性:5質量%の濃度に調製され、25±1℃に保たれた水酸化カルシウムスラリー50gに、25±1℃に保たれた0.5モル/リットルの濃度のシュウ酸水溶液40gを一気に添加し、添加後pH7.0になるまでの時間(分)。
酸アルカリ塩水溶液と水酸化カルシウムスラリーが全て混合されてから開始する時間、上記態様1〜3において、リン酸アルカリ塩水溶液と水酸化カルシウムスラリーの添加が終了した時点から開始する時間)は、例えば10〜180分間、好ましくは20〜120分間、より好ましくは40〜90分間、さらに好ましくは50〜70分間である。
<製造実施例1>
Ca/Pモル比が0.5になるように、10.7質量%リン酸二水素ナトリウム・2水和物水溶液及び、固形分濃度8.6質量%磨砕処理水酸化カルシウムスラリー(BET比表面積:6.7m2/g シュウ酸反応性:15分30秒 特開第2017−036176号公報)を調製した。リン酸二水素ナトリウム・2水和物水溶液をステンレスビーカーに入れ、撹拌しながら60℃に加温し撹拌停止まで維持した。10%NaOH水溶液を添加してpHを5.5に調整した。そこに水酸化カルシウムスラリーを30分かけて添加した。添加終了後、更に1時間撹拌したあとに、ろ過、水洗、及び80℃にて乾燥させ、ヒドロキシアパタイト粒子(粉末)を得た。
Ca/Pモル比が0.5になるように、10.7質量%リン酸二水素ナトリウム・2水和物水溶液及び、固形分濃度8.6質量%磨砕処理水酸化カルシウムスラリー(BET比表面積:7.9m2/g シュウ酸反応性:12分30秒 特開第2017−036176号公報)を調製した。リン酸二水素ナトリウム・2水和物水溶液をステンレスビーカーに入れ、撹拌しながら60℃に加温し撹拌停止まで維持した。10%NaOH水溶液を添加してpHを6.0に調整した。そこに水酸化カルシウムスラリーを30分かけて添加した。添加終了後、更に1時間撹拌したあとに、ろ過、水洗、及び80℃にて乾燥させ、ヒドロキシアパタイト粒子(粉体)を得た。
Ca/Pモル比が0.5になるように、10.7質量%リン酸二水素ナトリウム・2水和物水溶液及び、固形分濃度8.6質量%磨砕処理水酸化カルシウムスラリー(BET比表面積7.9m2/g シュウ酸反応性:12分30秒 特開第2017−036176号公報)を調製した。リン酸二水素ナトリウム・2水和物水溶液をステンレスビーカーに入れ、撹拌しながら40℃に加温し撹拌停止まで維持した。10%NaOH水溶液を添加してpHを5.5に調整した。そこに水酸化カルシウムスラリーを50分かけて添加した。添加終了後、更に1時間撹拌したあとに、ろ過、水洗、及び80℃にて乾燥させ、ヒドロキシアパタイト粒子(粉体)を得た。
Ca/Pモル比が0.5になるように、10.7質量%リン酸二水素ナトリウム無水物水溶液及び、固形分濃度8.6質量%磨砕処理水酸化カルシウムスラリー(BET比表面積7.9m2/g シュウ酸反応性:12分30秒 特開第2017−036176号公報)を調製した。リン酸二水素ナトリウム無水物水溶液をステンレスビーカーに入れ、撹拌しながら80℃に加温した。pHは4.2のまま調整しなかった。そこに水酸化カルシウムスラリーを30分かけて添加した。添加終了後、更に1時間撹拌したあとに、ろ過、水洗、及び80℃にて乾燥させ、ヒドロキシアパタイト粒子(粉体)を得た。
Ca/Pモル比が0.5になるように、10.7質量%リン酸二水素ナトリウム無水物水溶液及び、固形分濃度8.6質量%磨砕処理水酸化カルシウムスラリー(BET比表面積7.9m2/g シュウ酸反応性:12分30秒 特開第2017−036176号公報)を調製した。リン酸二水素ナトリウム無水物水溶液をステンレスビーカーに入れ、撹拌しながら60℃に加温した。pHは4.2のまま調整しなかった。そこに水酸化カルシウムスラリーを30分かけて添加した。添加終了後、更に1時間撹拌したあとに、ろ過、水洗、及び80℃にて乾燥させ、ヒドロキシアパタイト粒子(粉末)を得た。
表1の配合にて、製剤安定性の検討に供する試験製剤を調製した。各成分は次に記載の物を用いた。乳酸アルミニウム(武蔵野化学研究所製、商品名「乳酸アルミニウム」)、ヒドロキシエチルセルロース(ダイセルファインケム社製、商品名「HECダイセル EE820」)、ヒドロキシアパタイトA(富田製薬社製、商品名「ヒドロキシアパタイト」)。
表1に記載の組成に従って常法にて調製した各例の被検体(口腔用組成物)を、調製直後にスクリューキャップ付きガラス容器(約180mL容)に充填し、55℃、暗所にて3ヶ月放置し、放置後の被検体の状態を目視で確認し、離水があった場合は離水層の高さを計測した
Claims (5)
- ヒドロキシアパタイト粒子、乳酸アルミニウム、及びヒドロキシエチルセルロースを含有し、
前記ヒドロキシアパタイト粒子の、CuKα特性X線により測定される粉末X線回折パターンにおける2θ=26°付近の回折ピーク強度に対する2θ=32°付近の回折ピーク強度の比が0.8〜1.5であることを特徴とする、
口腔用組成物。 - 前記乳酸アルミニウムの含有量が1〜3質量%である、請求項1に記載の口腔用組成物。
- 前記乳酸アルミニウムの含有量が2質量%である、請求項2に記載の口腔用組成物。
- 乳酸アルミニウムと、ヒドロキシエチルセルロースとを含有する口腔用組成物に、ヒドロキシアパタイト粒子を添加することを特徴とし、
前記ヒドロキシアパタイト粒子の、CuKα特性X線により測定される粉末X線回折パターンにおける2θ=26°付近の回折ピーク強度に対する2θ=32°付近の回折ピーク強度の比が0.8〜1.5である、
口腔用組成物の安定性を向上させる方法。 - 前記安定性が、55℃における安定性である、請求項4に記載の方法。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61155314A (ja) * | 1984-12-28 | 1986-07-15 | Lion Corp | 口腔用組成物 |
JPH0920508A (ja) * | 1995-07-06 | 1997-01-21 | Tomita Seiyaku Kk | 歯磨き配合用ヒドロキシアパタイト及びその製造法 |
JP2001122748A (ja) * | 1999-10-25 | 2001-05-08 | Sangi Co Ltd | 口腔用組成物 |
JP2015506971A (ja) * | 2012-02-10 | 2015-03-05 | ペリプロダクツ リミテッド | 多成分系口腔ケア組成物 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS61155314A (ja) * | 1984-12-28 | 1986-07-15 | Lion Corp | 口腔用組成物 |
JPH0920508A (ja) * | 1995-07-06 | 1997-01-21 | Tomita Seiyaku Kk | 歯磨き配合用ヒドロキシアパタイト及びその製造法 |
JP2001122748A (ja) * | 1999-10-25 | 2001-05-08 | Sangi Co Ltd | 口腔用組成物 |
JP2015506971A (ja) * | 2012-02-10 | 2015-03-05 | ペリプロダクツ リミテッド | 多成分系口腔ケア組成物 |
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KIM, MIN SUNG ET AL.: "Synthesis of calcium-deficient hydroxyapatite in the presence of amphiphilic triblock copolymer", MATERIALS LETTERS, vol. 66, JPN6020005990, 2012, pages 33 - 35, ISSN: 0005005653 * |
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