JP2020536870A - アルファカルボキサミドピロリジン誘導体の調製方法 - Google Patents

アルファカルボキサミドピロリジン誘導体の調製方法 Download PDF

Info

Publication number
JP2020536870A
JP2020536870A JP2020519296A JP2020519296A JP2020536870A JP 2020536870 A JP2020536870 A JP 2020536870A JP 2020519296 A JP2020519296 A JP 2020519296A JP 2020519296 A JP2020519296 A JP 2020519296A JP 2020536870 A JP2020536870 A JP 2020536870A
Authority
JP
Japan
Prior art keywords
formula
compound
boc
tert
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2020519296A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020536870A5 (https=
Inventor
チェン ウェイロング
チェン ウェイロング
コウミング ヴィニー
コウミング ヴィニー
イルダム アーウィン
イルダム アーウィン
エフ．キエスマン ウィリアム
エフ．キエスマン ウィリアム
エー．クウォック ダウ‐ロング
エー．クウォック ダウ‐ロング
エル．マック タメラ
エル．マック タメラ
エム．オパルカ スザンヌ
エム．オパルカ スザンヌ
ビー．ペイシェンス ダニエル
ビー．ペイシェンス ダニエル
ジー．ウォーカー ドナルド
ジー．ウォーカー ドナルド
リアング ウェンリ
リアング ウェンリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of JP2020536870A publication Critical patent/JP2020536870A/ja
Publication of JP2020536870A5 publication Critical patent/JP2020536870A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP2020519296A 2017-10-05 2018-10-05 アルファカルボキサミドピロリジン誘導体の調製方法 Withdrawn JP2020536870A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762568651P 2017-10-05 2017-10-05
US62/568,651 2017-10-05
PCT/US2018/054661 WO2019071162A2 (en) 2017-10-05 2018-10-05 PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES

Publications (2)

Publication Number Publication Date
JP2020536870A true JP2020536870A (ja) 2020-12-17
JP2020536870A5 JP2020536870A5 (https=) 2021-11-25

Family

ID=65995302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020519296A Withdrawn JP2020536870A (ja) 2017-10-05 2018-10-05 アルファカルボキサミドピロリジン誘導体の調製方法

Country Status (12)

Country Link
US (2) US11192856B2 (https=)
EP (1) EP3691634A4 (https=)
JP (1) JP2020536870A (https=)
KR (1) KR20200061381A (https=)
CN (1) CN112153968A (https=)
AU (2) AU2018346763A1 (https=)
CA (1) CA3076823A1 (https=)
IL (1) IL273639B2 (https=)
MA (1) MA50630A (https=)
MX (1) MX2020003811A (https=)
SG (2) SG11202002706XA (https=)
WO (1) WO2019071162A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007290973A (ja) * 2006-04-21 2007-11-08 Univ Nagoya 亜鉛−マグネシウムアート錯体を含む求核試薬及びそれを使用する求核付加体の製造方法
JP2009511519A (ja) * 2005-10-10 2009-03-19 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
JP2013513636A (ja) * 2009-12-15 2013-04-22 エフ．ホフマン−ラ ロシュ アーゲー ピロリジン誘導体
WO2016102967A1 (en) * 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164597A (en) 1962-12-17 1965-01-05 Geigy Chem Corp 5-carboxylic acid-2-phenyl-pyrrolines, corresponding pyrrolidines and functional derivatives thereof
CH674205A5 (https=) * 1988-05-11 1990-05-15 Lonza Ag
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9618349D0 (en) 1996-09-03 1996-10-16 Pharmacia Spa N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity
IT1290910B1 (it) 1997-02-03 1998-12-14 Sigma Tau Ind Farmaceuti 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
TW502019B (en) 1999-03-26 2002-09-11 Cocensys Inc Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
PE20050077A1 (es) 2002-09-20 2005-03-01 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil-eter
MY142651A (en) 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
US7589116B2 (en) 2003-04-03 2009-09-15 Merck & Co. Inc. Biaryl substituted pyrazoles as sodium channel blockers
CA2522476A1 (en) 2003-04-18 2004-11-04 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
EP1524265A1 (en) 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors
WO2005110982A2 (en) 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
WO2005100334A1 (en) 2004-04-14 2005-10-27 Pfizer Products Inc. Dipeptidyl peptidase-iv inhibitors
JP2008540443A (ja) 2005-05-04 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン
WO2006119390A1 (en) 2005-05-04 2006-11-09 Vertex Pharmaceuticals Incorporated Pyridines useful as modulators of ion channels
JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
EA013909B1 (ru) 2005-09-09 2010-08-30 Смитклайн Бичам Корпорейшн Пиридиновые производные и их применение для лечения психотических расстройств
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
DK2477964T5 (en) 2009-09-14 2015-05-26 Convergence Pharmaceuticals A process for the preparation of alpha-carboxamide
WO2011155337A1 (ja) 2010-06-11 2011-12-15 シャープ株式会社 液晶装置
ES2428439T1 (es) * 2010-11-11 2013-11-07 Aarti Healthcare Limited Un procedimiento para la preparación de Ramipril
WO2016160574A2 (en) 2015-03-27 2016-10-06 Scifluor Life Sciences, Inc. Aryl- and heteroaryl-pyrrolidine-2-carboxamide compounds
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
WO2020210486A1 (en) 2019-04-10 2020-10-15 Biogen Inc. Processes for preparing alpha-carboxamide pyrrolidine derivatives
CN114026066A (zh) 2019-04-10 2022-02-08 生物基因麻省公司 制备α-甲酰胺吡咯烷衍生物的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009511519A (ja) * 2005-10-10 2009-03-19 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
JP2007290973A (ja) * 2006-04-21 2007-11-08 Univ Nagoya 亜鉛−マグネシウムアート錯体を含む求核試薬及びそれを使用する求核付加体の製造方法
JP2013513636A (ja) * 2009-12-15 2013-04-22 エフ．ホフマン−ラ ロシュ アーゲー ピロリジン誘導体
WO2016102967A1 (en) * 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAO-SHAN DA; ET AL: "HIGHLY CATALYTIC ASYMMETRIC ADDITION OF DEACTIVATED ALKYL GRIGNARD REAGENTS TO ALDEHYDES", ORGANIC LETTERS, vol. VOL:11, NR:24, JPN5021001659, 2009, pages 5578 - 5581, ISSN: 0004915424 *
JOURNAL OF FLOW CHEMISTRY, vol. 4, JPN5021001657, 2014, pages 40 - 43, ISSN: 0005124050 *
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 17, JPN5021001655, 2013, pages 1192 - 1208, ISSN: 0005124049 *
井上 淳、他: "有機マグネシウム反応剤を用いた新規合成反応の開拓", 有機合成化学協会誌, vol. 61, JPN7022005200, 2003, pages 331 - 342, ISSN: 0005124046 *
佐藤 健太郎: "ターボGrignard試薬の展開", WAKO ORGANIC SQUARE, JPN7022005201, 2013, pages 2 - 5, ISSN: 0005124047 *

Also Published As

Publication number Publication date
AU2023204011A1 (en) 2023-07-13
WO2019071162A2 (en) 2019-04-11
IL273639B1 (en) 2023-03-01
IL273639A (en) 2020-05-31
CA3076823A1 (en) 2019-04-11
US11192856B2 (en) 2021-12-07
EP3691634A2 (en) 2020-08-12
SG11202002706XA (en) 2020-04-29
MA50630A (fr) 2021-03-31
CN112153968A (zh) 2020-12-29
MX2020003811A (es) 2021-01-15
IL273639B2 (en) 2023-07-01
EP3691634A4 (en) 2021-03-31
US20200270206A1 (en) 2020-08-27
SG10202112966SA (en) 2021-12-30
WO2019071162A3 (en) 2020-03-26
AU2018346763A1 (en) 2020-04-16
KR20200061381A (ko) 2020-06-02
US20220356154A1 (en) 2022-11-10

Similar Documents

Publication Publication Date Title
JP2022166243A (ja) オメカムティブメカルビルの合成
JP2018523633A (ja) ブリバラセタムを製造する方法
WO2006002004A1 (en) Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
EP3237379B1 (en) Process for preparing alpha-carboxamide pyrrolidine derivatives
JP2010513499A (ja) （１ｒ，２ｓ，５ｓ）−ｎ−［（１ｓ）−３−アミノ−１−（シクロブチルメチル）−２，３−ジオキソプロピル］−３−［（２ｓ）−２−［［［（１，１−ジメチルエチル）アミノ］カルボニル］−アミノ］−３，３−ジメチル−１−オキソブチル］−６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサン−２−カルボキサミドを調製するための方法
JP2020536870A (ja) アルファカルボキサミドピロリジン誘導体の調製方法
JPH11513984A (ja) 成長ホルモン分泌促進剤の製造方法
JP2019529378A (ja) インドールカルボキサミド化合物の製造方法
AU2020297336A1 (en) Processes and intermediates for the preparation of 2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethenone
Avenoza et al. Asymmetric synthesis of meso-and (2R, 4R)-2, 4-diaminoglutaric acids
JP2025527633A (ja) Ｇｌｙｔ－１阻害剤の調製のための拡張可能な方法
CN104151313B (zh) 一种纯化他达拉非中间体的方法
CN110964013B (zh) 利格列汀及其中间体的制备方法
US20220177482A1 (en) Process for the preparation of n-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide
HK40044058A (en) Process for preparing alpha-carboxamide pyrolidine derivatives
US20050096466A1 (en) Process for the preparation of tetrazol-derived compounds as growth hormone secretagogues
RU2190597C2 (ru) Способ получения антагонистов nmda (n-метил-d-аспартата)
CN120882716A (zh) 吡咯并三嗪化合物的制备方法
JP2024520479A (ja) ベンゾオキサゼピンオキサゾリジノン化合物の調製のための方法
CN118084734A (zh) 一种o-[2-[[叔丁氧羰基]氨基]乙基]-n-[芴甲氧羰基]-l-酪氨酸的制备方法
JP2023528035A (ja) ヒドロキシル化シクロペンチルピリミジン化合物を製造するための方法
JPH0114907B2 (https=)
HK1245792B (en) Process for preparing alpha-carboxamide pyrrolidine derivatives

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211004

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20211004

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20211004

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220915

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230508

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230808

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20230823