JP2020536506A5 - - Google Patents

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Publication number
JP2020536506A5
JP2020536506A5 JP2020515126A JP2020515126A JP2020536506A5 JP 2020536506 A5 JP2020536506 A5 JP 2020536506A5 JP 2020515126 A JP2020515126 A JP 2020515126A JP 2020515126 A JP2020515126 A JP 2020515126A JP 2020536506 A5 JP2020536506 A5 JP 2020536506A5
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JP
Japan
Prior art keywords
ribonucleotide
sequence
rna
rna molecule
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020515126A
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English (en)
Japanese (ja)
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JP2020536506A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/AU2018/051015 external-priority patent/WO2019051563A1/en
Publication of JP2020536506A publication Critical patent/JP2020536506A/ja
Publication of JP2020536506A5 publication Critical patent/JP2020536506A5/ja
Priority to JP2023146180A priority Critical patent/JP2023164536A/ja
Pending legal-status Critical Current

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JP2020515126A 2017-09-15 2018-09-17 Ｒｎａ分子 Pending JP2020536506A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023146180A JP2023164536A (ja) 2017-09-15 2023-09-08 Ｒｎａ分子

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AU2017903773 2017-09-15
AU2017903773A AU2017903773A0 (en) 2017-09-15 RNA molecules
AU2018902840A AU2018902840A0 (en) 2018-08-03 RNA molecules
AU2018902840 2018-08-03
AU2018902896 2018-08-08
AU2018902896A AU2018902896A0 (en) 2018-08-08 RNA molecules
PCT/AU2018/051015 WO2019051563A1 (en) 2017-09-15 2018-09-17 Rna molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023146180A Division JP2023164536A (ja) 2017-09-15 2023-09-08 Ｒｎａ分子

Publications (2)

Publication Number Publication Date
JP2020536506A JP2020536506A (ja) 2020-12-17
JP2020536506A5 true JP2020536506A5 (https=) 2021-11-04

Family

ID=65722312

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020515126A Pending JP2020536506A (ja) 2017-09-15 2018-09-17 Ｒｎａ分子
JP2023146180A Pending JP2023164536A (ja) 2017-09-15 2023-09-08 Ｒｎａ分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023146180A Pending JP2023164536A (ja) 2017-09-15 2023-09-08 Ｒｎａ分子

Country Status (14)

Country Link
US (1) US12428641B2 (https=)
EP (1) EP3673066A4 (https=)
JP (2) JP2020536506A (https=)
KR (2) KR20250035034A (https=)
CN (2) CN111344407B (https=)
AU (2) AU2018333285C1 (https=)
BR (1) BR112020005103A2 (https=)
CA (1) CA3075746A1 (https=)
IL (2) IL273245B2 (https=)
MX (1) MX2020002872A (https=)
PH (1) PH12020500527A1 (https=)
SG (1) SG11202002264RA (https=)
WO (1) WO2019051563A1 (https=)
ZA (1) ZA202001649B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4007813A4 (en) * 2019-08-02 2023-08-30 Commonwealth Scientific and Industrial Research Organisation Rna molecules for modulating flowering in plants
WO2022011452A1 (en) * 2020-07-15 2022-01-20 University Of Manitoba Use of paperclip rna structure to inhibit target gene expression
US20240084267A1 (en) * 2021-01-12 2024-03-14 Duke University Compositions and methods for the genetic manipulation of the influenza virus
EP4095248A1 (en) * 2021-05-25 2022-11-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Circrnas for gene silencing
CN113564186B (zh) * 2021-07-16 2023-07-25 山西大学 苹果黄蚜Tre基因及其核酸干扰剂制备方法与应用
CN115011609B (zh) * 2022-06-06 2024-03-19 江苏大学 BnaFANCM基因、应用及获得油菜雄性不育突变体的方法
CN118932072B (zh) * 2024-08-01 2025-06-24 延安大学 ApABCG4在调控豌豆蚜耐旱性及生物防治中的应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766072A (en) 1985-07-17 1988-08-23 Promega Corporation Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence
DE3850683T2 (de) 1987-02-09 1994-10-27 Lubrizol Genetics Inc Hybrides RNS-Virus.
US5780269A (en) 1989-02-24 1998-07-14 The University Of Medicine And Denistry Of New Jersey Hybrid molecules
US5436141A (en) 1989-02-24 1995-07-25 University Of Medicine And Dentistry Of New Jersey Method for synthesizing stable single-stranded CDNA in eukaryotes by means of a bacterial retron and products
DE59010432D1 (de) 1989-03-16 1996-09-05 Boehringer Ingelheim Int Genetische Einheiten zur Inhibierung der Funktion von RNA
US5583198A (en) 1989-12-22 1996-12-10 Commonwealth Scientific And Industrial Research Organization Amino acids, peptides or derivatives thereof coupled to fats
US5665710A (en) 1990-04-30 1997-09-09 Georgetown University Method of making liposomal oligodeoxynucleotide compositions
DE4027616A1 (de) 1990-08-31 1992-03-05 Boehringer Mannheim Gmbh Verfahren zur bestimmung von polymerase-aktivitaet
GB9105383D0 (en) 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
JP3220180B2 (ja) 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム
US5354854A (en) 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
FR2685346B1 (fr) 1991-12-18 1994-02-11 Cis Bio International Procede de preparation d'arn double-brin, et ses applications.
US6451603B1 (en) 1992-06-29 2002-09-17 Gene Shears Pty. Limited Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens
WO1994003607A1 (en) 1992-07-30 1994-02-17 Keygene N.V. Dna constructs, cells and plants derived therefrom
WO1994007367A1 (en) 1992-09-29 1994-04-14 Apollon, Inc. Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids
US6872872B1 (en) 1992-11-17 2005-03-29 E. I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
JP2001505401A (ja) 1993-09-20 2001-04-24 シー． リード，ジョン ｂｃ１−２遺伝子発現の調節
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
AUPM747694A0 (en) 1994-08-16 1994-09-08 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids and peptides
US6146886A (en) 1994-08-19 2000-11-14 Ribozyme Pharmaceuticals, Inc. RNA polymerase III-based expression of therapeutic RNAs
US5756122A (en) 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
CA2227989A1 (en) 1995-08-01 1997-02-13 Karen Ophelia Hamilton Liposomal oligonucleotide compositions
FR2741066B1 (fr) 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
CA2279673A1 (en) 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acids for therapeutic and diagnostic uses
AUPN741696A0 (en) 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
IT1283876B1 (it) 1996-01-12 1998-05-07 Univ Roma Molecole chimeriche ribozima-snrna ad attivita' catalitica per rna a localizzazione nucleare
US5989864A (en) 1996-10-29 1999-11-23 Smithkline Beecham Corporation DNA encoding spo-rel polypeptides
AU725002B2 (en) 1996-06-21 2000-10-05 Plant Genetic Systems N.V. Gene expression in plants
US5942395A (en) 1997-05-09 1999-08-24 Universite De Montreal Hybrid ribozymes and methods of use
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN1202246C (zh) 1998-04-08 2005-05-18 联邦科学和工业研究组织 获得修饰表型的方法和措施
US6135942A (en) 1998-11-30 2000-10-24 Leptin; Maria Nucleic acids proteins of a D. melanogaster insulin-like gene and uses thereof
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
JP2002538812A (ja) 1999-03-16 2002-11-19 エクセリクシス，インク 昆虫ｐ５３ガン抑制遺伝子及びタンパク質
US6703491B1 (en) 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
ES2316363T3 (es) 1999-04-20 2009-04-16 Bayer Bioscience N.V. Metodos para administracion de rna inhibidor a las plantas y aplicaciones de los mismos.
CA2373628A1 (en) 1999-06-14 2000-12-21 Michael A. Costa Animal models and methods for analysis of lipid metabolism and screening of pharmaceutical and pesticidal agents that modulate lipid metabolism
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
AU7487300A (en) 1999-09-16 2001-04-17 Genoptera, Llc Lethal insectidice targets
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2047001A (en) 1999-11-24 2001-06-04 Dna Plant Technology Corporation Methods of inhibiting plant parasitic nematodes and insect pests by expression of nematode and insect specific double-stranded rna in plants
WO2001038359A2 (en) 1999-11-29 2001-05-31 Genoptera, Llc Drosophila nicotinic acetylcholine receptor
AU2625501A (en) 1999-12-30 2001-07-16 Rutgers, The State University Of New Jersey Compositions and methods for gene silencing
EP1354035B1 (en) 2001-01-26 2016-08-24 Commonwealth Scientific and Industrial Research Organisation Methods and means for producing efficient silencing construct using recombinational cloning
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
US20090247606A1 (en) 2001-08-28 2009-10-01 Sirna Therapeutics, Inc. RNA Interference Mediated Inhibition of Adenosine A1 Receptor (ADORA1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
CA2478910C (en) 2002-03-14 2012-08-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for monitoring and modulating gene silencing
CA2478904A1 (en) 2002-03-14 2003-09-18 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing rna and uses thereof
US20040053876A1 (en) 2002-03-26 2004-03-18 The Regents Of The University Of Michigan siRNAs and uses therof
ITRM20020253A1 (it) 2002-05-08 2003-11-10 Univ Roma Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche.
US7501503B2 (en) 2002-12-31 2009-03-10 Mcgill University Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase
PT1633767T (pt) 2003-06-02 2019-02-27 Univ Massachusetts Métodos e composições para controlar a eficácia do silenciamento de arn
WO2005026356A1 (en) 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
PL1687435T3 (pl) 2003-11-17 2012-02-29 Bayer Cropscience Nv Odporność na owady z użyciem hamowania ekspresji genów
ES2556272T3 (es) * 2004-11-18 2016-01-14 The Board Of Trustees Of The University Of Illinois Constructos de ARNsi multicistrónico para inhibir tumores
US20080280848A1 (en) 2005-10-28 2008-11-13 Volker Patzel Structures of Active Guide Rna Molecules and Method of Selection
CA2650861A1 (en) 2006-05-03 2007-11-15 Commonwealth Scientific And Industrial Research Organisation Improved gene silencing methods
AU2008211580B2 (en) 2007-01-29 2013-08-29 University Of The Witwatersrand Johannesburg Use of double stranded RNA hairpin duplexes in gene silencing
JP5296328B2 (ja) 2007-05-09 2013-09-25 独立行政法人理化学研究所 １本鎖環状ｒｎａおよびその製造方法
US8841437B2 (en) 2008-06-20 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Precursor miRNA loop-modulated target regulation
AU2008286701B2 (en) 2007-08-14 2015-02-12 Commonwealth Scientific And Industrial Research Organisation Improved gene silencing methods
GB0810912D0 (en) 2008-06-13 2008-07-23 Inst Animal Health Ltd Vector
ES2343618B1 (es) 2009-02-03 2011-06-20 Consejo Superior De Investigaciones Cientificas (Csic) Polinucleotido que comprende secuencias de gliadinas de trigo y su uso para silenciamiento mediante rnai.
WO2011109380A1 (en) 2010-03-01 2011-09-09 The Children's Hospital Of Philadelphia Nucleic acids for targeting multiple regions of the hcv genome
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
US20130245102A1 (en) 2010-10-12 2013-09-19 Research Foundation Of The City University Of New York Novel dna templates for small rna production in mammalian cells
CN103403189B (zh) * 2011-06-08 2015-11-25 辛辛那提大学 用于稳定的多价RNA纳米颗粒中的pRNA多价连接域
US9212363B2 (en) 2012-05-11 2015-12-15 City Of Hope RNAI molecules with non-watson crick pairing based on artificial mutation consensus sequences to counter escape mutations
KR20150103280A (ko) * 2013-01-08 2015-09-09 베니텍 바이오파마 리미티드 연령-관련 황반 변성 치료
WO2016100333A1 (en) * 2014-12-15 2016-06-23 Syngenta Participations Ag Pesticidal microrna carriers and use thereof
GB201509578D0 (en) * 2015-06-03 2015-07-15 Univ Singapore Vectors

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