JP2020533412A5 - - Google Patents
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- Publication number
- JP2020533412A5 JP2020533412A5 JP2020536496A JP2020536496A JP2020533412A5 JP 2020533412 A5 JP2020533412 A5 JP 2020533412A5 JP 2020536496 A JP2020536496 A JP 2020536496A JP 2020536496 A JP2020536496 A JP 2020536496A JP 2020533412 A5 JP2020533412 A5 JP 2020533412A5
- Authority
- JP
- Japan
- Prior art keywords
- polymorph according
- compound
- polymorph
- approximately
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 26
- 229940126062 Compound A Drugs 0.000 claims description 26
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 26
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 24
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 20
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 18
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 102000009076 src-Family Kinases Human genes 0.000 claims description 11
- 108010087686 src-Family Kinases Proteins 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 8
- -1 2-Me-THF Chemical compound 0.000 claims description 6
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 230000004580 weight loss Effects 0.000 claims description 6
- 238000010583 slow cooling Methods 0.000 claims description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 4
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 4
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims description 4
- 229940011051 isopropyl acetate Drugs 0.000 claims description 4
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims 1
- 230000000877 morphologic effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107781A JP2023157909A (ja) | 2017-09-07 | 2023-06-30 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
| JP2025091579A JP2025131661A (ja) | 2017-09-07 | 2025-06-02 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555390P | 2017-09-07 | 2017-09-07 | |
| US62/555,390 | 2017-09-07 | ||
| PCT/US2018/049829 WO2019051147A1 (en) | 2017-09-07 | 2018-09-07 | SOLID FORMS OF 2- (5- (4- (2-MORPHOLINOETHOXY) PHENYL) PYRIDIN-2-YL) -N-BENZYLACETAMIDE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107781A Division JP2023157909A (ja) | 2017-09-07 | 2023-06-30 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533412A JP2020533412A (ja) | 2020-11-19 |
| JP2020533412A5 true JP2020533412A5 (enExample) | 2021-09-30 |
Family
ID=65517772
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020536496A Pending JP2020533412A (ja) | 2017-09-07 | 2018-09-07 | ２−（５−（４−（２−モルホリノエトキシ）フェニル）ピリジン−２−イル）−ｎ−ベンジルアセトアミドの固体形態 |
| JP2023107781A Pending JP2023157909A (ja) | 2017-09-07 | 2023-06-30 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
| JP2025091579A Pending JP2025131661A (ja) | 2017-09-07 | 2025-06-02 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107781A Pending JP2023157909A (ja) | 2017-09-07 | 2023-06-30 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
| JP2025091579A Pending JP2025131661A (ja) | 2017-09-07 | 2025-06-02 | ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10669236B2 (enExample) |
| EP (1) | EP3679016B1 (enExample) |
| JP (3) | JP2020533412A (enExample) |
| KR (2) | KR20240119192A (enExample) |
| CN (2) | CN111278808B (enExample) |
| AU (2) | AU2018330163B2 (enExample) |
| BR (1) | BR112020004419A2 (enExample) |
| CA (1) | CA3074831A1 (enExample) |
| DK (1) | DK3679016T3 (enExample) |
| FI (1) | FI3679016T3 (enExample) |
| IL (1) | IL272992A (enExample) |
| MX (2) | MX2020002622A (enExample) |
| SG (1) | SG11202001868RA (enExample) |
| TW (1) | TWI815820B (enExample) |
| WO (1) | WO2019051147A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968574B2 (en) * | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| EP4186890A1 (en) | 2021-11-29 | 2023-05-31 | Moehs Ibérica, S.L. | Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin |
| CN115010655A (zh) * | 2022-07-21 | 2022-09-06 | 重庆迈德凯医药有限公司 | 一种替尼布林的纯化方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US7141593B1 (en) * | 1999-06-04 | 2006-11-28 | Abbott Laboratories | Pharmaceutical formulations |
| SK14402003A3 (sk) * | 2001-05-22 | 2004-06-08 | Pfizer Products Inc. | Kryštalické formy azitromycínu |
| US6821502B2 (en) * | 2002-06-12 | 2004-11-23 | Chevron U.S.A. Inc. | Method of making aluminum-containing zeolite with IFR structure |
| US7351833B2 (en) * | 2004-07-23 | 2008-04-01 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| JP5124285B2 (ja) | 2004-12-28 | 2013-01-23 | キネックス ファーマシューティカルズ， エルエルシー | 細胞増殖性障害を処置する組成物および方法 |
| MY152185A (en) * | 2005-06-10 | 2014-08-29 | Novartis Ag | Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation |
| KR20080025763A (ko) * | 2005-09-13 | 2008-03-21 | 시코르, 인크. | 순수한 로쿠로늄 브로마이드 |
| WO2008002676A2 (en) * | 2006-06-29 | 2008-01-03 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| RU2009115860A (ru) * | 2006-09-28 | 2010-11-20 | Мерк Шарп Энд Домэ Корп. (Us) | Фармацевтические композиции ингибиторов hdac и образующих хелатные комплексы соединений металла и хелатные комплексы ингибитора hdac с металлом |
| US7837978B2 (en) * | 2006-10-13 | 2010-11-23 | Chevron U.S.A. Inc. | Process for preparing aluminum-containing molecular sieve SSZ-26 |
| PE20081506A1 (es) * | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| US7935697B2 (en) * | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
| TWI457336B (zh) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
| CA2687647A1 (en) * | 2007-05-22 | 2008-11-27 | Ultimorphix Technologies B.V. | Tenofovir disoproxil hemi-fumaric acid co-crystal |
| WO2015069217A1 (en) * | 2013-11-05 | 2015-05-14 | Baylor College Of Medicine | Src kinase inhibition as treatment for lympangioleiomyomatosis and tuberous sclerosis |
| CN106810490A (zh) * | 2017-02-06 | 2017-06-09 | 重庆泰润制药有限公司 | 一种二芳基化合物的晶型及其制备方法和应用 |
| US10617693B2 (en) | 2017-03-10 | 2020-04-14 | Athenex, Inc. | Methods of treating and/or preventing actinic keratosis |
-
2018
- 2018-09-07 MX MX2020002622A patent/MX2020002622A/es unknown
- 2018-09-07 CA CA3074831A patent/CA3074831A1/en active Pending
- 2018-09-07 KR KR1020247025684A patent/KR20240119192A/ko active Pending
- 2018-09-07 CN CN201880069894.6A patent/CN111278808B/zh active Active
- 2018-09-07 DK DK18854688.1T patent/DK3679016T3/da active
- 2018-09-07 BR BR112020004419-9A patent/BR112020004419A2/pt unknown
- 2018-09-07 TW TW107131540A patent/TWI815820B/zh active
- 2018-09-07 US US16/124,281 patent/US10669236B2/en active Active
- 2018-09-07 JP JP2020536496A patent/JP2020533412A/ja active Pending
- 2018-09-07 WO PCT/US2018/049829 patent/WO2019051147A1/en not_active Ceased
- 2018-09-07 EP EP18854688.1A patent/EP3679016B1/en active Active
- 2018-09-07 AU AU2018330163A patent/AU2018330163B2/en active Active
- 2018-09-07 KR KR1020207010105A patent/KR102691700B1/ko active Active
- 2018-09-07 CN CN202410415705.3A patent/CN118439992A/zh active Pending
- 2018-09-07 SG SG11202001868RA patent/SG11202001868RA/en unknown
- 2018-09-07 FI FIEP18854688.1T patent/FI3679016T3/fi active
-
2020
- 2020-03-01 IL IL272992A patent/IL272992A/en unknown
- 2020-03-06 MX MX2023001805A patent/MX2023001805A/es unknown
- 2020-04-27 US US16/858,854 patent/US11230527B2/en active Active
-
2021
- 2021-12-09 US US17/546,133 patent/US12215083B2/en active Active
-
2023
- 2023-02-21 AU AU2023201010A patent/AU2023201010B2/en active Active
- 2023-06-30 JP JP2023107781A patent/JP2023157909A/ja active Pending
-
2024
- 2024-12-19 US US18/987,655 patent/US20250115555A1/en active Pending
-
2025
- 2025-06-02 JP JP2025091579A patent/JP2025131661A/ja active Pending
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