JP2020532578A5 - - Google Patents
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- JP2020532578A5 JP2020532578A5 JP2020527860A JP2020527860A JP2020532578A5 JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5
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- JP
- Japan
- Prior art keywords
- group
- compound
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- pharmaceutically acceptable
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- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O Chemical compound CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O 0.000 description 3
- ULMKNGVHAZDIEL-OLNZRHPYSA-O C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl Chemical compound C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl ULMKNGVHAZDIEL-OLNZRHPYSA-O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537758P | 2017-07-27 | 2017-07-27 | |
| US62/537,758 | 2017-07-27 | ||
| PCT/US2018/044183 WO2019023635A1 (en) | 2017-07-27 | 2018-07-27 | SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532578A JP2020532578A (ja) | 2020-11-12 |
| JP2020532578A5 true JP2020532578A5 (enExample) | 2021-09-16 |
| JP7274478B2 JP7274478B2 (ja) | 2023-05-16 |
Family
ID=65040330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527860A Active JP7274478B2 (ja) | 2017-07-27 | 2018-07-27 | 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10689376B2 (enExample) |
| EP (1) | EP3658138B1 (enExample) |
| JP (1) | JP7274478B2 (enExample) |
| CN (1) | CN111615388B (enExample) |
| WO (1) | WO2019023635A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3807264A1 (en) | 2018-06-12 | 2021-04-21 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (sting) |
| EP3829561A4 (en) | 2018-08-01 | 2021-12-29 | Stingray Therapeutics, Inc. | Substituted-3h-imidazo[4,5-c]pyridine and 1h pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (enpp1) and stimulator for interferon genes (sting) modulators as cancer immunotherapeutics |
| MA54879A (fr) * | 2019-02-01 | 2021-12-08 | Univ Leland Stanford Junior | Inhibiteurs d'enpp1 et méthodes de modulation de réponse immunitaire |
| CN113795267A (zh) | 2019-03-12 | 2021-12-14 | 艾库斯生物科学有限公司 | 致癌基因驱动的癌症的治疗 |
| BR112021018947A2 (pt) | 2019-03-28 | 2022-02-08 | Lupin Ltd | Compostos macrocíclicos como agonistas de sting |
| CN113874397A (zh) | 2019-03-29 | 2021-12-31 | 艾库斯生物科学有限公司 | 利用鉴定的腺苷指纹治疗癌症 |
| AU2020291796B2 (en) | 2019-06-12 | 2024-01-18 | Ryvu Therapeutics S.A. | Next-generation modulators of stimulator of interferon genes (STING) |
| GEP20247627B (en) | 2019-07-22 | 2024-05-27 | Lupin Ltd | Macrocyclic compounds as sting agonists and methods and uses thereof |
| US20230002387A1 (en) | 2019-09-16 | 2023-01-05 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| KR102915463B1 (ko) * | 2019-12-11 | 2026-01-19 | 리부 세라퓨틱스 에스.에이. | 인터페론 유전자 자극제(sting)의 조절제인 헤테로사이클릭 화합물 |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| US20230159469A1 (en) | 2020-05-08 | 2023-05-25 | Txinno Bioscience Inc. | Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| KR102720206B1 (ko) | 2020-12-29 | 2024-10-21 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| WO2022146022A1 (ko) | 2020-12-29 | 2022-07-07 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| US20240116882A1 (en) | 2021-01-29 | 2024-04-11 | Txinno Bioscience Inc. | Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
| AU2023213905A1 (en) * | 2022-01-28 | 2024-07-11 | Insilico Medicine Ip Limited | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof |
| US20230346771A1 (en) | 2022-04-29 | 2023-11-02 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| WO2026006739A1 (en) * | 2024-06-28 | 2026-01-02 | Riboscience Llc | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081253A (en) | 1989-12-21 | 1992-01-14 | American Home Products Corporation | Imidazo(4,5-c)pyridines as antiosteoporotic agents |
| EP1020451B1 (en) | 1997-03-25 | 2005-06-15 | Kowa Co., Ltd. | Anilide compounds and drugs containing the same |
| US9643933B2 (en) * | 2013-04-23 | 2017-05-09 | The General Hospital Corporation | Compounds useful as antibiotic tolerance inhibitors |
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2018
- 2018-07-27 EP EP18837593.5A patent/EP3658138B1/en active Active
- 2018-07-27 WO PCT/US2018/044183 patent/WO2019023635A1/en not_active Ceased
- 2018-07-27 US US16/047,915 patent/US10689376B2/en active Active
- 2018-07-27 JP JP2020527860A patent/JP7274478B2/ja active Active
- 2018-07-27 CN CN201880063421.5A patent/CN111615388B/zh active Active