JP2020531511A - 眼球用医薬組成物 - Google Patents
眼球用医薬組成物 Download PDFInfo
- Publication number
- JP2020531511A JP2020531511A JP2020511176A JP2020511176A JP2020531511A JP 2020531511 A JP2020531511 A JP 2020531511A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020531511 A JP2020531511 A JP 2020531511A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- active agent
- pharmaceutically acceptable
- formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *Nc1nc(O*)nc(Nc2ccccc2)n1 Chemical compound *Nc1nc(O*)nc(Nc2ccccc2)n1 0.000 description 2
- LONBLURXLSDGME-UHFFFAOYSA-N CCN(CC)/C(/N=C(\N)/OC(C(F)(F)F)C(F)(F)F)=N/C(C)Nc1ccccc1 Chemical compound CCN(CC)/C(/N=C(\N)/OC(C(F)(F)F)C(F)(F)F)=N/C(C)Nc1ccccc1 LONBLURXLSDGME-UHFFFAOYSA-N 0.000 description 1
- IQWQRKAECXHZKW-UHFFFAOYSA-N CNc1nc(Nc2ccccc2)nc(OC(C(F)(F)F)C(F)(F)F)n1 Chemical compound CNc1nc(Nc2ccccc2)nc(OC(C(F)(F)F)C(F)(F)F)n1 IQWQRKAECXHZKW-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549872P | 2017-08-24 | 2017-08-24 | |
| US62/549,872 | 2017-08-24 | ||
| PCT/US2018/048025 WO2019040919A1 (en) | 2017-08-24 | 2018-08-24 | OCULAR PHARMACEUTICAL COMPOSITIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020531511A true JP2020531511A (ja) | 2020-11-05 |
| JP2020531511A5 JP2020531511A5 (enExample) | 2021-09-30 |
Family
ID=65439930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511176A Pending JP2020531511A (ja) | 2017-08-24 | 2018-08-24 | 眼球用医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11839616B2 (enExample) |
| EP (1) | EP3672598A4 (enExample) |
| JP (1) | JP2020531511A (enExample) |
| KR (1) | KR20200044873A (enExample) |
| CN (1) | CN111629730A (enExample) |
| AU (1) | AU2018321926B2 (enExample) |
| CA (1) | CA3073718A1 (enExample) |
| WO (1) | WO2019040919A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023541261A (ja) * | 2020-09-10 | 2023-09-29 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Pdeiv媒介性の疾患又は状態を処置する方法 |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| US12065412B2 (en) | 2015-12-24 | 2024-08-20 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11957413B2 (en) * | 2019-08-06 | 2024-04-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Solitary wave-based trans-lid tonometer |
| EP4069195A1 (en) * | 2019-12-05 | 2022-10-12 | Vanda Pharmaceuticals Inc. | Ophthalmic pharmaceutical compositions |
| WO2025179141A1 (en) * | 2024-02-22 | 2025-08-28 | Vanda Pharmaceuticals, Inc. | Treatment of dry eye disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPS62126178A (ja) | 1985-11-26 | 1987-06-08 | Mitsubishi Petrochem Co Ltd | 新規トリアジン誘導体及びこれを含む除草剤 |
| US5236952A (en) | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| AU5433594A (en) | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
| US6403598B1 (en) * | 1998-01-30 | 2002-06-11 | R-Tech Ueno, Ltd. | Ophthalmic composition |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| IL137655A0 (en) | 1998-03-31 | 2001-10-31 | Warner Lambert Co | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
| JP4794793B2 (ja) | 1999-12-28 | 2011-10-19 | ファーマコペイア, インコーポレイテッド | N−ヘテロ環TNF−α発現阻害剤 |
| IL160984A0 (en) | 2001-09-21 | 2004-08-31 | Reddy Us Therapeutics Inc | Triazine derivatives and pharmaceutical compositions containing the same |
| US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| HK1080074A1 (zh) | 2002-10-01 | 2006-04-21 | Johnson & Johnson Pharmaceutical Research & Development, Inc. | 作为酪氨酸蛋白激酶抑制剂的4,6-二氨基取代-2-[氧基或氨氧基]-[1,3,5]三嗪 |
| JP2006528640A (ja) | 2003-07-22 | 2006-12-21 | ニューロジェン・コーポレーション | 置換ピリジン−2−イルアミン類縁体 |
| ES2631362T3 (es) | 2004-01-30 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Moduladores de transportadores de casete de unión a ATP |
| US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| WO2007095812A1 (en) | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| KR101352709B1 (ko) | 2007-05-22 | 2014-01-16 | 아스테라스 세이야쿠 가부시키가이샤 | 1위 치환 테트라히드로이소퀴놀린 화합물 |
| US20090105240A1 (en) | 2007-10-17 | 2009-04-23 | Tomas Mustelin | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same |
| EP2231624A4 (en) | 2007-12-21 | 2011-07-06 | Progenics Pharm Inc | TRIAZINE AND CORRESPONDING COMPOUNDS WITH ANTIVIRAL EFFECT, COMPOSITIONS AND METHOD THEREFOR |
| JP5618837B2 (ja) | 2008-03-05 | 2014-11-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | インスリン分泌刺激剤としてのキノキサリノン誘導体、それらを得る方法および糖尿病を治療するためのそれらの使用 |
| CN102227430A (zh) | 2008-10-23 | 2011-10-26 | 沃泰克斯药物股份有限公司 | 囊性纤维化跨膜传导调节因子的调节剂 |
| WO2010073011A2 (en) | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| FR2958645B1 (fr) | 2010-04-09 | 2012-08-31 | Commissariat Energie Atomique | Hemi-anticorps a auto-assemblage |
| CA2797118C (en) | 2010-04-22 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
| WO2012092471A2 (en) | 2010-12-29 | 2012-07-05 | Development Center For Biotechnology | Novel tubulin inhibitors and methods of using the same |
| KR20150095925A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | Cftr 억제제로서의 트리시클릭 화합물 |
| WO2015018823A1 (en) * | 2013-08-08 | 2015-02-12 | Galapagos Nv | Thieno[2,3-c]pyrans as cftr modulators |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| JP6716687B2 (ja) | 2015-09-11 | 2020-07-01 | イオン−トフ テクノロジーズ ゲーエムベーハー | 二次イオン質量分析計及び二次イオン質量分析方法 |
| US10035962B2 (en) * | 2015-12-21 | 2018-07-31 | Exxonmobil Research And Engineering Company | Trim dewaxing of distillate fuel |
| AU2016377782B2 (en) | 2015-12-24 | 2021-07-29 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| CN108699040B (zh) | 2015-12-24 | 2021-08-10 | 加利福尼亚大学董事会 | Cftr调节剂及其使用方法 |
| JP6938510B2 (ja) | 2015-12-24 | 2021-09-22 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Cftr制御因子及びこの使用方法 |
| KR20180128390A (ko) | 2015-12-24 | 2018-12-03 | 레스피버트 리미티드 | 인돌리논 화합물과 섬유성 질환의 치료에서 이의 용도 |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
-
2018
- 2018-08-24 US US16/641,621 patent/US11839616B2/en active Active
- 2018-08-24 CA CA3073718A patent/CA3073718A1/en active Pending
- 2018-08-24 JP JP2020511176A patent/JP2020531511A/ja active Pending
- 2018-08-24 WO PCT/US2018/048025 patent/WO2019040919A1/en not_active Ceased
- 2018-08-24 EP EP18849250.8A patent/EP3672598A4/en active Pending
- 2018-08-24 CN CN201880069116.7A patent/CN111629730A/zh active Pending
- 2018-08-24 KR KR1020207008360A patent/KR20200044873A/ko not_active Ceased
- 2018-08-24 AU AU2018321926A patent/AU2018321926B2/en active Active
-
2023
- 2023-10-30 US US18/497,962 patent/US20240156828A1/en not_active Abandoned
-
2025
- 2025-08-11 US US19/296,874 patent/US20250367207A1/en active Pending
Non-Patent Citations (6)
| Title |
|---|
| "点眼薬", 慶應義塾大学病院ホームページ, JPN6023012383, May 2017 (2017-05-01), ISSN: 0005027640 * |
| AMER. J. VET. RES., vol. 71, no. 6, JPN6023012381, 2010, pages 671 - 676, ISSN: 0005027638 * |
| INVEST. OPHTHAL. VIS. SCI., vol. 50, no. 5, JPN6022025178, 2009, pages 2132 - 2138, ISSN: 0005027637 * |
| J. MED. CHEM., vol. 60, JPN6022025177, January 2017 (2017-01-01), pages 1210 - 1218, ISSN: 0005027636 * |
| OCUL. SURF., vol. 14, no. 2, JPN6023012384, 2016, pages 264 - 316, ISSN: 0005027641 * |
| 比較眼科雑誌, vol. 32, JPN6023012382, 2013, pages 3 - 13, ISSN: 0005027639 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12065412B2 (en) | 2015-12-24 | 2024-08-20 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| JP2023541261A (ja) * | 2020-09-10 | 2023-09-29 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Pdeiv媒介性の疾患又は状態を処置する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240156828A1 (en) | 2024-05-16 |
| US20250367207A1 (en) | 2025-12-04 |
| US20210154201A1 (en) | 2021-05-27 |
| EP3672598A1 (en) | 2020-07-01 |
| AU2018321926A1 (en) | 2020-03-12 |
| EP3672598A4 (en) | 2021-04-28 |
| CA3073718A1 (en) | 2019-02-28 |
| WO2019040919A1 (en) | 2019-02-28 |
| US11839616B2 (en) | 2023-12-12 |
| RU2020111560A (ru) | 2021-09-24 |
| KR20200044873A (ko) | 2020-04-29 |
| RU2020111560A3 (enExample) | 2021-10-29 |
| CN111629730A (zh) | 2020-09-04 |
| AU2018321926B2 (en) | 2023-09-21 |
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