JP2020531511A5 - - Google Patents
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- JP2020531511A5 JP2020531511A5 JP2020511176A JP2020511176A JP2020531511A5 JP 2020531511 A5 JP2020531511 A5 JP 2020531511A5 JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020531511 A5 JP2020531511 A5 JP 2020531511A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- patient
- eye
- micrograms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 239000003889 eye drop Substances 0.000 claims 14
- 229940126062 Compound A Drugs 0.000 claims 8
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 8
- 229940012356 eye drops Drugs 0.000 claims 8
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 6
- 230000004489 tear production Effects 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 4
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549872P | 2017-08-24 | 2017-08-24 | |
| US62/549,872 | 2017-08-24 | ||
| PCT/US2018/048025 WO2019040919A1 (en) | 2017-08-24 | 2018-08-24 | OCULAR PHARMACEUTICAL COMPOSITIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020531511A JP2020531511A (ja) | 2020-11-05 |
| JP2020531511A5 true JP2020531511A5 (enExample) | 2021-09-30 |
Family
ID=65439930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511176A Pending JP2020531511A (ja) | 2017-08-24 | 2018-08-24 | 眼球用医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11839616B2 (enExample) |
| EP (1) | EP3672598A4 (enExample) |
| JP (1) | JP2020531511A (enExample) |
| KR (1) | KR20200044873A (enExample) |
| CN (1) | CN111629730A (enExample) |
| AU (1) | AU2018321926B2 (enExample) |
| CA (1) | CA3073718A1 (enExample) |
| WO (1) | WO2019040919A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6938510B2 (ja) | 2015-12-24 | 2021-09-22 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｃｆｔｒ制御因子及びこの使用方法 |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| US11957413B2 (en) * | 2019-08-06 | 2024-04-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Solitary wave-based trans-lid tonometer |
| EP4069195A1 (en) * | 2019-12-05 | 2022-10-12 | Vanda Pharmaceuticals Inc. | Ophthalmic pharmaceutical compositions |
| JP2023541261A (ja) * | 2020-09-10 | 2023-09-29 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Ｐｄｅｉｖ媒介性の疾患又は状態を処置する方法 |
| WO2025179141A1 (en) * | 2024-02-22 | 2025-08-28 | Vanda Pharmaceuticals, Inc. | Treatment of dry eye disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPS62126178A (ja) | 1985-11-26 | 1987-06-08 | Mitsubishi Petrochem Co Ltd | 新規トリアジン誘導体及びこれを含む除草剤 |
| US5236952A (en) | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| AU5433594A (en) | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
| US6403598B1 (en) * | 1998-01-30 | 2002-06-11 | R-Tech Ueno, Ltd. | Ophthalmic composition |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| IL137655A0 (en) | 1998-03-31 | 2001-10-31 | Warner Lambert Co | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
| JP4794793B2 (ja) | 1999-12-28 | 2011-10-19 | ファーマコペイア， インコーポレイテッド | Ｎ−ヘテロ環ＴＮＦ−α発現阻害剤 |
| IL160984A0 (en) | 2001-09-21 | 2004-08-31 | Reddy Us Therapeutics Inc | Triazine derivatives and pharmaceutical compositions containing the same |
| US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| HK1080074A1 (zh) | 2002-10-01 | 2006-04-21 | Johnson & Johnson Pharmaceutical Research & Development, Inc. | 作为酪氨酸蛋白激酶抑制剂的4，6-二氨基取代-2-[氧基或氨氧基]-[1，3，5]三嗪 |
| JP2006528640A (ja) | 2003-07-22 | 2006-12-21 | ニューロジェン・コーポレーション | 置換ピリジン−２−イルアミン類縁体 |
| ES2631362T3 (es) | 2004-01-30 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Moduladores de transportadores de casete de unión a ATP |
| US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| WO2007095812A1 (en) | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| KR101352709B1 (ko) | 2007-05-22 | 2014-01-16 | 아스테라스 세이야쿠 가부시키가이샤 | 1위 치환 테트라히드로이소퀴놀린 화합물 |
| US20090105240A1 (en) | 2007-10-17 | 2009-04-23 | Tomas Mustelin | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same |
| EP2231624A4 (en) | 2007-12-21 | 2011-07-06 | Progenics Pharm Inc | TRIAZINE AND CORRESPONDING COMPOUNDS WITH ANTIVIRAL EFFECT, COMPOSITIONS AND METHOD THEREFOR |
| JP5618837B2 (ja) | 2008-03-05 | 2014-11-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | インスリン分泌刺激剤としてのキノキサリノン誘導体、それらを得る方法および糖尿病を治療するためのそれらの使用 |
| CN102227430A (zh) | 2008-10-23 | 2011-10-26 | 沃泰克斯药物股份有限公司 | 囊性纤维化跨膜传导调节因子的调节剂 |
| WO2010073011A2 (en) | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| FR2958645B1 (fr) | 2010-04-09 | 2012-08-31 | Commissariat Energie Atomique | Hemi-anticorps a auto-assemblage |
| CA2797118C (en) | 2010-04-22 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
| WO2012092471A2 (en) | 2010-12-29 | 2012-07-05 | Development Center For Biotechnology | Novel tubulin inhibitors and methods of using the same |
| KR20150095925A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | Cftr 억제제로서의 트리시클릭 화합물 |
| WO2015018823A1 (en) * | 2013-08-08 | 2015-02-12 | Galapagos Nv | Thieno[2,3-c]pyrans as cftr modulators |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| JP6716687B2 (ja) | 2015-09-11 | 2020-07-01 | イオン−トフ テクノロジーズ ゲーエムベーハー | 二次イオン質量分析計及び二次イオン質量分析方法 |
| US10035962B2 (en) * | 2015-12-21 | 2018-07-31 | Exxonmobil Research And Engineering Company | Trim dewaxing of distillate fuel |
| AU2016377782B2 (en) | 2015-12-24 | 2021-07-29 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| CN108699040B (zh) | 2015-12-24 | 2021-08-10 | 加利福尼亚大学董事会 | Cftr调节剂及其使用方法 |
| JP6938510B2 (ja) | 2015-12-24 | 2021-09-22 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｃｆｔｒ制御因子及びこの使用方法 |
| KR20180128390A (ko) | 2015-12-24 | 2018-12-03 | 레스피버트 리미티드 | 인돌리논 화합물과 섬유성 질환의 치료에서 이의 용도 |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
-
2018
- 2018-08-24 US US16/641,621 patent/US11839616B2/en active Active
- 2018-08-24 CA CA3073718A patent/CA3073718A1/en active Pending
- 2018-08-24 JP JP2020511176A patent/JP2020531511A/ja active Pending
- 2018-08-24 WO PCT/US2018/048025 patent/WO2019040919A1/en not_active Ceased
- 2018-08-24 EP EP18849250.8A patent/EP3672598A4/en active Pending
- 2018-08-24 CN CN201880069116.7A patent/CN111629730A/zh active Pending
- 2018-08-24 KR KR1020207008360A patent/KR20200044873A/ko not_active Ceased
- 2018-08-24 AU AU2018321926A patent/AU2018321926B2/en active Active
-
2023
- 2023-10-30 US US18/497,962 patent/US20240156828A1/en not_active Abandoned
-
2025
- 2025-08-11 US US19/296,874 patent/US20250367207A1/en active Pending
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