JP2020528431A5 - - Google Patents
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- JP2020528431A5 JP2020528431A5 JP2020503842A JP2020503842A JP2020528431A5 JP 2020528431 A5 JP2020528431 A5 JP 2020528431A5 JP 2020503842 A JP2020503842 A JP 2020503842A JP 2020503842 A JP2020503842 A JP 2020503842A JP 2020528431 A5 JP2020528431 A5 JP 2020528431A5
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- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
- 208000035475 disorder Diseases 0.000 claims description 27
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 14
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims description 14
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 12
- 208000002193 Pain Diseases 0.000 claims description 12
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 12
- 150000003839 salts Chemical group 0.000 claims description 10
- 208000015114 central nervous system disease Diseases 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 6
- -1 NH 2 Inorganic materials 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 6
- 229940127240 opiate Drugs 0.000 claims description 6
- 208000019901 Anxiety disease Diseases 0.000 claims description 5
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 5
- 208000018460 Feeding disease Diseases 0.000 claims description 5
- 208000030990 Impulse-control disease Diseases 0.000 claims description 5
- 206010034158 Pathological gambling Diseases 0.000 claims description 5
- 206010034912 Phobia Diseases 0.000 claims description 5
- 208000028017 Psychotic disease Diseases 0.000 claims description 5
- 206010041250 Social phobia Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 230000003370 grooming effect Effects 0.000 claims description 5
- 230000002969 morbid Effects 0.000 claims description 5
- 208000019906 panic disease Diseases 0.000 claims description 5
- 208000019899 phobic disease Diseases 0.000 claims description 5
- 208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 claims description 4
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 230000000877 morphologic effect Effects 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims description 4
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 3
- 208000007848 Alcoholism Diseases 0.000 claims description 3
- 208000029197 Amphetamine-Related disease Diseases 0.000 claims description 3
- 208000000094 Chronic Pain Diseases 0.000 claims description 3
- 208000022497 Cocaine-Related disease Diseases 0.000 claims description 3
- 208000001640 Fibromyalgia Diseases 0.000 claims description 3
- 206010019233 Headaches Diseases 0.000 claims description 3
- 208000012488 Opiate Overdose Diseases 0.000 claims description 3
- 208000026251 Opioid-Related disease Diseases 0.000 claims description 3
- 208000027520 Somatoform disease Diseases 0.000 claims description 3
- 239000000556 agonist Substances 0.000 claims description 3
- 201000007930 alcohol dependence Diseases 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 201000006145 cocaine dependence Diseases 0.000 claims description 3
- 206010013663 drug dependence Diseases 0.000 claims description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 3
- 206010016256 fatigue Diseases 0.000 claims description 3
- 231100000869 headache Toxicity 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
- 201000001119 neuropathy Diseases 0.000 claims description 3
- 230000007823 neuropathy Effects 0.000 claims description 3
- 201000005040 opiate dependence Diseases 0.000 claims description 3
- 208000027753 pain disease Diseases 0.000 claims description 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 2
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 2
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 claims description 2
- 208000012902 Nervous system disease Diseases 0.000 claims description 2
- 102000048266 Nociceptin Human genes 0.000 claims description 2
- 108090000622 Nociceptin Proteins 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 239000000164 antipsychotic agent Substances 0.000 claims description 2
- 229960002430 atomoxetine Drugs 0.000 claims description 2
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 claims description 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 2
- 229960001736 buprenorphine Drugs 0.000 claims description 2
- 229960004606 clomipramine Drugs 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229960002866 duloxetine Drugs 0.000 claims description 2
- 229960001797 methadone Drugs 0.000 claims description 2
- 239000004005 microsphere Substances 0.000 claims description 2
- 229960000600 milnacipran Drugs 0.000 claims description 2
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 2
- 229960004127 naloxone Drugs 0.000 claims description 2
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 2
- 229960003086 naltrexone Drugs 0.000 claims description 2
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 claims description 2
- 229960005017 olanzapine Drugs 0.000 claims description 2
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 2
- 239000004031 partial agonist Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 229960004431 quetiapine Drugs 0.000 claims description 2
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims description 2
- 229960001534 risperidone Drugs 0.000 claims description 2
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims description 2
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 2
- 229960004425 sibutramine Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 21
- 0 Fc1ccc(*CCCN2C[C@]3c(cccc4*C(C5)=I)c4N5[C@@]3CC2)cc1 Chemical compound Fc1ccc(*CCCN2C[C@]3c(cccc4*C(C5)=I)c4N5[C@@]3CC2)cc1 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000004199 lung function Effects 0.000 description 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- 206010061619 Deformity Diseases 0.000 description 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 229940125425 inverse agonist Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229960002296 paroxetine Drugs 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537287P | 2017-07-26 | 2017-07-26 | |
| US62/537,287 | 2017-07-26 | ||
| US201862639244P | 2018-03-06 | 2018-03-06 | |
| US62/639,244 | 2018-03-06 | ||
| US201862682546P | 2018-06-08 | 2018-06-08 | |
| US62/682,546 | 2018-06-08 | ||
| PCT/US2018/043100 WO2019023062A1 (en) | 2017-07-26 | 2018-07-20 | ORGANIC COMPOUNDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528431A JP2020528431A (ja) | 2020-09-24 |
| JP2020528431A5 true JP2020528431A5 (cg-RX-API-DMAC7.html) | 2021-08-26 |
| JP7223742B2 JP7223742B2 (ja) | 2023-02-16 |
Family
ID=65040269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503842A Active JP7223742B2 (ja) | 2017-07-26 | 2018-07-20 | 有機化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11376249B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3658145A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7223742B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102899502B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111093665A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2018307479B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112020001666A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3071119A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL272249B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2020000968A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019023062A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150080404A1 (en) | 2012-04-14 | 2015-03-19 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| CN113786407B (zh) | 2016-01-26 | 2024-05-24 | 细胞内治疗公司 | 有机化合物 |
| EP3407889B1 (en) | 2016-03-25 | 2021-05-19 | Intra-Cellular Therapies, Inc. | Organic compounds and their use in treating or preventing central nervous system disorders |
| EP3525763B1 (en) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| MX395214B (es) | 2017-03-24 | 2025-03-25 | Intra Cellular Therapies Inc | Composiciones novedosas y metodos |
| US11427587B2 (en) | 2017-07-26 | 2022-08-30 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN111107847A (zh) | 2017-09-26 | 2020-05-05 | 细胞内治疗公司 | 新的盐和晶体 |
| MX2020009668A (es) | 2018-03-16 | 2021-01-08 | Intra Cellular Therapies Inc | Métodos novedosos. |
| WO2019183341A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3801527B1 (en) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
| US10695345B2 (en) | 2018-08-31 | 2020-06-30 | Intra-Cellular Therapies, Inc. | Pharmaceutical capsule compositions comprising lumateperone mono-tosylate |
| EP3843738A4 (en) * | 2018-08-31 | 2022-06-01 | Intra-Cellular Therapies, Inc. | NEW METHODS |
| JP7520012B2 (ja) * | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| CN113423568A (zh) | 2018-12-17 | 2021-09-21 | 细胞内治疗公司 | 有机化合物 |
| US12297200B2 (en) | 2018-12-17 | 2025-05-13 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| US12331052B2 (en) | 2018-12-21 | 2025-06-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3897643B1 (en) | 2018-12-21 | 2023-11-15 | Intra-Cellular Therapies, Inc. | A pyridopyrroloquinoxaline compound and its medical use |
| AU2020212019B2 (en) * | 2019-01-23 | 2025-04-17 | Intra-Cellular Therapies, Inc. | Methods of treating addiction |
| US20220184072A1 (en) * | 2019-04-04 | 2022-06-16 | Intra-Cellular Therapies, Inc. | Methods of treating neuropathic pain |
| CN114072150A (zh) | 2019-07-07 | 2022-02-18 | 细胞内治疗公司 | 新方法 |
| US12478623B2 (en) | 2019-09-25 | 2025-11-25 | Intra-Cellular Therapies, Inc. | Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor |
| JP7261942B2 (ja) | 2019-12-11 | 2023-04-20 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2022132182A1 (en) * | 2020-12-18 | 2022-06-23 | Hung, Shu-Mei | Feed pipe height adjustment mechanism for livestock feeding systems |
| EP4419523A4 (en) * | 2021-10-19 | 2025-09-17 | Intra Cellular Therapies Inc | NEW PROCESSES |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| AU2023418793A1 (en) * | 2022-12-30 | 2025-06-12 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor |
| WO2025257090A1 (en) | 2024-06-10 | 2025-12-18 | Interquim, S.A. | Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2490813A (en) | 1944-11-29 | 1949-12-13 | Standard Oil Co | Continuous process for making aryl amines |
| US3299078A (en) | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
| US3813392A (en) | 1969-06-09 | 1974-05-28 | J Sellstedt | Pyrrolo(1,2,3-alpha epsilon)quinoxalin-2(3h)-ones and related compounds |
| US3914421A (en) | 1972-06-19 | 1975-10-21 | Endo Lab | Pyridopyrrolobenzheterocycles for combatting depression |
| US4115577A (en) | 1972-06-19 | 1978-09-19 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
| US4238607A (en) | 1972-06-19 | 1980-12-09 | Endo Laboratories Inc. | Pyridopyrrolo benzheterocycles |
| US4183936A (en) | 1972-06-19 | 1980-01-15 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
| US4001263A (en) | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
| IE41352B1 (en) | 1974-04-01 | 1979-12-19 | Pfizer | 5-aryl-1,2,3,4-tetrahydro- -carbolines |
| US4219550A (en) | 1978-11-09 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Cis- and trans- octahydropyridopyrrolobenzheterocycles |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4522944A (en) | 1982-12-23 | 1985-06-11 | Erba Farmitalia | Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, compositions and use |
| CH656884A5 (de) | 1983-08-26 | 1986-07-31 | Sandoz Ag | Polyolester, deren herstellung und verwendung. |
| ES2058068T3 (es) | 1986-03-19 | 1994-11-01 | Kumiai Chemical Industry Co | Derivados de 5h-1,3,4-tiadiazol-(3,2-a)-pirimidin-5-ona y compuestos fungicidas con contenido en dichos derivados. |
| JP2641443B2 (ja) | 1986-04-07 | 1997-08-13 | クミアイ化学工業株式会社 | ５Ｈ−１，３，４−チアジアゾロ〔３，２−ａ〕ピリミジン−５−オン誘導体及びこれを有効成分とする農園芸用殺菌剤 |
| HU208484B (en) | 1988-08-17 | 1993-11-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia |
| US5114976A (en) | 1989-01-06 | 1992-05-19 | Norden Michael J | Method for treating certain psychiatric disorders and certain psychiatric symptoms |
| US5538739A (en) | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| JP2848060B2 (ja) | 1991-10-24 | 1999-01-20 | 株式会社日立製作所 | プログラマブルコントローラおよびシーケンス制御方法 |
| IT1271352B (it) | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| SK282231B6 (sk) | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| US5648539A (en) | 1996-02-29 | 1997-07-15 | Xerox Corporation | Low temperature arylamine processes |
| US5648542A (en) | 1996-02-29 | 1997-07-15 | Xerox Corporation | Arylamine processes |
| US5654482A (en) | 1996-02-29 | 1997-08-05 | Xerox Corporation | Triarylamine processes |
| US5847166A (en) | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| US5723671A (en) | 1997-01-30 | 1998-03-03 | Xerox Corporation | Arylamine processes |
| US5723669A (en) | 1997-01-30 | 1998-03-03 | Xerox Corporation | Arylamine processes |
| TWI242011B (en) | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
| US6323366B1 (en) | 1997-07-29 | 2001-11-27 | Massachusetts Institute Of Technology | Arylamine synthesis |
| GB2328686B (en) | 1997-08-25 | 2001-09-26 | Sankio Chemical Co Ltd | Method for producing arylamine |
| WO1999018057A1 (en) | 1997-10-06 | 1999-04-15 | Massachusetts Institute Of Technology | Preparation of diaryl ether by condensation reactions |
| US6235936B1 (en) | 1998-02-26 | 2001-05-22 | Massachusetts Institute Of Technology | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates |
| WO1999043643A2 (en) | 1998-02-26 | 1999-09-02 | Massachusetts Institute Of Technology | Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes |
| US5902901A (en) | 1998-05-07 | 1999-05-11 | Xerox Corporation | Arylamine processes |
| ES2257864T3 (es) | 1998-07-10 | 2006-08-01 | Massachusetts Institute Of Technology | Ligandos para metales y procesos mejorados catalizados por metales basados en los mismos. |
| US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US6395916B1 (en) | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US20010008942A1 (en) | 1998-12-08 | 2001-07-19 | Buchwald Stephen L. | Synthesis of aryl ethers |
| CA2354472C (en) | 1998-12-17 | 2009-02-24 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| US6407092B1 (en) | 1999-04-23 | 2002-06-18 | Pharmacia & Upjohn Company | Tetracyclic azepinoindole compounds |
| AR023574A1 (es) | 1999-04-23 | 2002-09-04 | Pharmacia & Upjohn Co Llc | Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios |
| US7071186B2 (en) | 1999-06-15 | 2006-07-04 | Bristol-Myers Squibb Pharma Co. | Substituted heterocycle fused gamma-carbolines |
| US6713471B1 (en) | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
| AU5737900A (en) * | 1999-06-15 | 2001-01-02 | Du Pont Pharmaceuticals Company | Substituted heterocycle fused gamma-carbolines |
| US6541639B2 (en) | 2000-07-26 | 2003-04-01 | Bristol-Myers Squibb Pharma Company | Efficient ligand-mediated Ullmann coupling of anilines and azoles |
| EE200300296A (et) | 2000-12-20 | 2003-12-15 | Bristol-Myers Squibb Company | Asendatud püridoindoolid kui serotoniini agonistid ja antagonistid ning nende kasutamine |
| US6849619B2 (en) | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| CN1854128B (zh) | 2001-04-24 | 2012-05-16 | 麻省理工学院 | 铜-催化的碳-杂原子键和碳-碳键的形成 |
| EP1414819B1 (en) | 2001-08-08 | 2005-10-12 | Pharmacia & Upjohn Company LLC | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES |
| EP1314554A1 (fr) | 2001-11-23 | 2003-05-28 | Kba-Giori S.A. | Dispositif de décollage d'éléments de sécurité |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| CN1684670A (zh) | 2002-07-29 | 2005-10-19 | 阿尔扎公司 | 用于控制释放帕潘立酮的方法和剂型 |
| JP2005534700A (ja) | 2002-08-02 | 2005-11-17 | マサチューセッツ インスティテュート オブ テクノロジー | 銅触媒による炭素−ヘテロ原子および炭素−炭素結合の形成 |
| US7223870B2 (en) | 2002-11-01 | 2007-05-29 | Pfizer Inc. | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
| WO2004041281A1 (en) | 2002-11-01 | 2004-05-21 | Oregon Health And Science University | Treatment of hyperkinetic movement disorder with donepezil |
| WO2004056324A2 (en) | 2002-12-19 | 2004-07-08 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
| EP1654226B1 (en) | 2003-07-21 | 2008-10-22 | SmithKline Beecham Corporation | (2s,4s)-4-fluoro-1- 4-fluoro-beta-(4-fluorophenyl)-l-phenylalanyl -2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt and anhydrous crystalline forms thereof |
| JP2005259113A (ja) | 2004-02-12 | 2005-09-22 | Ricoh Co Ltd | プロセス編集装置、プロセス管理装置、プロセス編集プログラム、プロセス管理プログラム、記録媒体、プロセス編集方法及びプロセス管理方法 |
| CA2564018A1 (en) | 2004-03-05 | 2005-10-13 | Pharma C S.A. | 8-phenoxy-.gamma. carboline derivatives |
| US20050222209A1 (en) | 2004-04-01 | 2005-10-06 | Zeldis Jerome B | Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease |
| US7592454B2 (en) | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
| EP1793671B1 (en) | 2004-09-20 | 2011-04-27 | Mount Sinai School of Medicine | Use of memantine (namenda) to treat autism, compulsivity, and impulsivity |
| MX2007002459A (es) | 2004-09-21 | 2007-05-04 | Pfizer Prod Inc | N-metilhidroxietilamina util en el tratamiento de afecciones del snc. |
| US7614727B2 (en) | 2004-09-30 | 2009-11-10 | Fujifilm Corporation | Liquid ejection head, manufacturing method thereof, and image forming apparatus |
| WO2006063709A1 (en) | 2004-12-15 | 2006-06-22 | F.Hoffmann-La Roche Ag | Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer’s disease |
| EP1848433A2 (en) | 2005-01-25 | 2007-10-31 | Celgene Corporation | Methods and compositions using 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1-3-dione |
| WO2007025103A2 (en) | 2005-08-23 | 2007-03-01 | Intra-Cellular Therapies, Inc. | Organic compounds for treating reduced dopamine receptor signalling activity |
| EP1973876A2 (en) | 2006-01-13 | 2008-10-01 | Wyeth | Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors |
| KR101981840B1 (ko) | 2007-03-12 | 2019-05-23 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| MX2010001218A (es) | 2007-08-01 | 2010-04-07 | Medivation Neurology Inc | Metodos y composiciones para tratamiento contra esquizofrenia mediante uso de terapia combinada de agentes antipsicoticos. |
| CN101983058A (zh) | 2008-02-05 | 2011-03-02 | 克莱拉有限公司 | 缓解抑郁症或改善认知的组合物和方法 |
| WO2009114181A2 (en) | 2008-03-12 | 2009-09-17 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines solid |
| AU2009251816B2 (en) | 2008-05-27 | 2015-12-10 | Intra-Cellular Therapies, Inc. | Methods and compositions for sleep disorders and other disorders |
| US8309772B2 (en) | 2008-07-31 | 2012-11-13 | Celanese International Corporation | Tunable catalyst gas phase hydrogenation of carboxylic acids |
| WO2011133224A1 (en) | 2010-04-22 | 2011-10-27 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US20150080404A1 (en) | 2012-04-14 | 2015-03-19 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| PL2968320T3 (pl) | 2013-03-15 | 2021-05-17 | Intra-Cellular Therapies, Inc. | Związki organiczne |
| US9956227B2 (en) | 2013-12-03 | 2018-05-01 | Intra-Cellular Therapies, Inc. | Method for the treatment of residual symptoms of schizophrenia |
| AU2015240526A1 (en) | 2014-04-04 | 2016-11-24 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP2017509686A (ja) | 2014-04-04 | 2017-04-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| WO2015191554A1 (en) | 2014-06-09 | 2015-12-17 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
| CN113786407B (zh) * | 2016-01-26 | 2024-05-24 | 细胞内治疗公司 | 有机化合物 |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
| US11427587B2 (en) | 2017-07-26 | 2022-08-30 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2019183341A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3801527B1 (en) * | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
-
2018
- 2018-07-20 EP EP18838429.1A patent/EP3658145A4/en active Pending
- 2018-07-20 MX MX2020000968A patent/MX2020000968A/es unknown
- 2018-07-20 JP JP2020503842A patent/JP7223742B2/ja active Active
- 2018-07-20 US US16/634,055 patent/US11376249B2/en active Active
- 2018-07-20 CN CN201880057546.7A patent/CN111093665A/zh active Pending
- 2018-07-20 KR KR1020207005454A patent/KR102899502B1/ko active Active
- 2018-07-20 AU AU2018307479A patent/AU2018307479B2/en active Active
- 2018-07-20 CA CA3071119A patent/CA3071119A1/en active Pending
- 2018-07-20 BR BR112020001666-7A patent/BR112020001666A2/pt not_active Application Discontinuation
- 2018-07-20 WO PCT/US2018/043100 patent/WO2019023062A1/en not_active Ceased
- 2018-07-20 IL IL272249A patent/IL272249B2/en unknown
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2022
- 2022-06-03 US US17/832,282 patent/US20220296591A1/en active Pending
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2024
- 2024-09-17 AU AU2024219805A patent/AU2024219805A1/en active Pending
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