JP2020527583A5 - - Google Patents
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- JP2020527583A5 JP2020527583A5 JP2020502652A JP2020502652A JP2020527583A5 JP 2020527583 A5 JP2020527583 A5 JP 2020527583A5 JP 2020502652 A JP2020502652 A JP 2020502652A JP 2020502652 A JP2020502652 A JP 2020502652A JP 2020527583 A5 JP2020527583 A5 JP 2020527583A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treatment
- enantiomer
- bhb
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 15
- 230000004770 neurodegeneration Effects 0.000 claims 10
- 208000015122 neurodegenerative disease Diseases 0.000 claims 8
- 230000002265 prevention Effects 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 7
- 235000015872 dietary supplement Nutrition 0.000 claims 6
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- HIWZHLUXGVVBPK-UHFFFAOYSA-N butane-1,3-diol;3-hydroxybutanoic acid Chemical compound CC(O)CCO.CC(O)CC(O)=O HIWZHLUXGVVBPK-UHFFFAOYSA-N 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims 4
- 206010049565 Muscle fatigue Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 235000020887 ketogenic diet Nutrition 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 230000009467 reduction Effects 0.000 claims 4
- 230000004580 weight loss Effects 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 206010020850 Hyperthyroidism Diseases 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000029578 Muscle disease Diseases 0.000 claims 2
- 208000021642 Muscular disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000036528 appetite Effects 0.000 claims 2
- 235000019789 appetite Nutrition 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 235000021588 free fatty acids Nutrition 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 230000037219 healthy weight Effects 0.000 claims 2
- 201000001421 hyperglycemia Diseases 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 208000011661 metabolic syndrome X Diseases 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- 150000003254 radicals Chemical class 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 230000004584 weight gain Effects 0.000 claims 2
- 235000019786 weight gain Nutrition 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000027626 Neurocognitive disease Diseases 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000007107 neurocognitive deficit Effects 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535754P | 2017-07-21 | 2017-07-21 | |
| US62/535,754 | 2017-07-21 | ||
| PCT/US2018/042948 WO2019018683A1 (en) | 2017-07-21 | 2018-07-19 | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527583A JP2020527583A (ja) | 2020-09-10 |
| JP2020527583A5 true JP2020527583A5 (https=) | 2021-09-09 |
| JP7442095B2 JP7442095B2 (ja) | 2024-03-04 |
Family
ID=65015819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502652A Active JP7442095B2 (ja) | 2017-07-21 | 2018-07-19 | ベータ－ヒドロキシブチレート及びブタンジオールのｓ－エナンチオマー並びにその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11773051B2 (https=) |
| EP (1) | EP3654963A4 (https=) |
| JP (1) | JP7442095B2 (https=) |
| KR (1) | KR102795284B1 (https=) |
| CN (1) | CN111050764A (https=) |
| AU (1) | AU2018304380B2 (https=) |
| BR (1) | BR112020001285A2 (https=) |
| CA (1) | CA3070453A1 (https=) |
| IL (1) | IL272173B2 (https=) |
| MX (1) | MX2020000734A (https=) |
| WO (1) | WO2019018683A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10245243B1 (en) * | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12599579B2 (en) | 2016-04-19 | 2026-04-14 | Axcess Global Sciences, Llc | Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| WO2017213999A1 (en) | 2016-06-07 | 2017-12-14 | The J. David Gladstone Institutes | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
| WO2019018683A1 (en) | 2017-07-21 | 2019-01-24 | Buck Institute For Research On Aging | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| WO2019147503A1 (en) | 2018-01-25 | 2019-08-01 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| JP7448555B2 (ja) * | 2019-02-11 | 2024-03-12 | アクセス・グローバル・サイエンシーズ・エルエルシー | ラセミベータ－ヒドロキシブチレート混合塩－酸組成物および使用方法 |
| ES3033482T3 (en) * | 2019-02-11 | 2025-08-04 | Axcess Global Sciences Llc | S-beta-hydroxybutyrate compounds and compositions enriched with s-enantiomer |
| JP7706372B2 (ja) * | 2019-02-11 | 2025-07-11 | アクセス・グローバル・サイエンシーズ・エルエルシー | 非ラセミ体のベータ－ヒドロキシブチレート化合物およびｒ－エナンチオマー富化組成物ならびに使用方法 |
| CN109806251A (zh) * | 2019-03-04 | 2019-05-28 | 清华大学 | 3-羟基丁酸及其衍生物在制备抗动脉粥样硬化的产品中的应用 |
| CA3129569A1 (en) | 2019-03-14 | 2020-09-17 | Thomas Weimbs | Methods and compositions for supporting renal health |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| EP4146337B1 (de) * | 2020-07-13 | 2024-04-17 | KetoLipix Therapeutics GmbH | Verfahren zur herstellung von polyglycerinestern von mit oxobutanol veresterten polycarbonsäuren |
| EP4146339B1 (de) * | 2020-07-13 | 2024-04-10 | KetoLipix Therapeutics GmbH | Oxobutanol-ester von polymeren carbonsäuren und deren herstellung |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| CN112341542B (zh) * | 2021-01-08 | 2021-05-14 | 清华大学 | 一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用 |
| US20220249497A1 (en) * | 2021-02-05 | 2022-08-11 | Health Via Modern Nutrition, Inc. | Compositions and methods for improving relaxation, sleep, cognition, and/or physical performance |
| WO2023283654A1 (en) * | 2021-07-09 | 2023-01-12 | Georgia State University Research Foundation, Inc. | The use of beta-hydroxybutyrates for the treatment or prevention of aneurysms and dissections |
| US20250282707A1 (en) * | 2022-04-29 | 2025-09-11 | Buck Institute For Research On Aging | Novel ketone ester compounds |
| EP4566598A1 (en) * | 2023-12-04 | 2025-06-11 | ZoSaLa Pharma, Inc | Compositions providing sglt2i and bhb activity and methods of use to treat human disease |
| WO2025166164A1 (en) | 2024-02-02 | 2025-08-07 | Selah Therapeutics Limited | DL- AND L-β-HYDROXYBUTYRATE AND METHODS OF USE THEREOF |
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| JPS42663Y1 (https=) | 1966-03-07 | 1967-01-17 | ||
| US4263216A (en) | 1978-10-20 | 1981-04-21 | The Procter & Gamble Company | Diglyceride manufacture |
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| BE1001209A3 (fr) | 1987-11-19 | 1989-08-22 | Solvay | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
| EP0556387B1 (en) | 1988-04-27 | 1995-08-09 | Daicel Chemical Industries, Ltd. | Process for preparing optically active 1,3-butanediol |
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| WO2017213999A1 (en) | 2016-06-07 | 2017-12-14 | The J. David Gladstone Institutes | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
| WO2019018683A1 (en) | 2017-07-21 | 2019-01-24 | Buck Institute For Research On Aging | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
| WO2019147503A1 (en) * | 2018-01-25 | 2019-08-01 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
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| WO2021211609A1 (en) | 2020-04-16 | 2021-10-21 | Buck Institute For Research On Aging | Treatment of viral pathologies with exogenous ketones |
-
2018
- 2018-07-19 WO PCT/US2018/042948 patent/WO2019018683A1/en not_active Ceased
- 2018-07-19 IL IL272173A patent/IL272173B2/en unknown
- 2018-07-19 CA CA3070453A patent/CA3070453A1/en active Pending
- 2018-07-19 CN CN201880056204.3A patent/CN111050764A/zh active Pending
- 2018-07-19 MX MX2020000734A patent/MX2020000734A/es unknown
- 2018-07-19 EP EP18835222.3A patent/EP3654963A4/en active Pending
- 2018-07-19 AU AU2018304380A patent/AU2018304380B2/en active Active
- 2018-07-19 BR BR112020001285-8A patent/BR112020001285A2/pt not_active Application Discontinuation
- 2018-07-19 KR KR1020207004340A patent/KR102795284B1/ko active Active
- 2018-07-19 US US16/631,374 patent/US11773051B2/en active Active
- 2018-07-19 JP JP2020502652A patent/JP7442095B2/ja active Active
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