JP2020527547A5 - - Google Patents
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- JP2020527547A5 JP2020527547A5 JP2019572783A JP2019572783A JP2020527547A5 JP 2020527547 A5 JP2020527547 A5 JP 2020527547A5 JP 2019572783 A JP2019572783 A JP 2019572783A JP 2019572783 A JP2019572783 A JP 2019572783A JP 2020527547 A5 JP2020527547 A5 JP 2020527547A5
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- JP
- Japan
- Prior art keywords
- compound according
- liver
- formula
- subject
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107837A JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1710229.4 | 2017-06-27 | ||
| GBGB1710229.4A GB201710229D0 (en) | 2017-06-27 | 2017-06-27 | Compounds for new use |
| PCT/GB2018/051752 WO2019002828A1 (en) | 2017-06-27 | 2018-06-22 | 3-HYDROXYBUTYRATE COMPOUNDS FOR USE IN THE REDUCTION OF HEPATIC FAT |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107837A Division JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527547A JP2020527547A (ja) | 2020-09-10 |
| JP2020527547A5 true JP2020527547A5 (enExample) | 2021-07-29 |
| JP7374000B2 JP7374000B2 (ja) | 2023-11-06 |
Family
ID=59523693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572783A Active JP7374000B2 (ja) | 2017-06-27 | 2018-06-22 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
| JP2023107837A Active JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107837A Active JP7632979B2 (ja) | 2017-06-27 | 2023-06-30 | 肝臓脂肪を減らすことにおいて使用するための３－ヒドロキシ酪酸化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12439944B2 (enExample) |
| EP (2) | EP4215189A1 (enExample) |
| JP (2) | JP7374000B2 (enExample) |
| KR (1) | KR102680437B1 (enExample) |
| CN (1) | CN110869012B (enExample) |
| AU (1) | AU2018293398B2 (enExample) |
| CA (1) | CA3066948A1 (enExample) |
| DK (1) | DK3644982T3 (enExample) |
| ES (1) | ES2945964T3 (enExample) |
| GB (2) | GB201710229D0 (enExample) |
| PL (1) | PL3644982T3 (enExample) |
| TW (1) | TWI811222B (enExample) |
| WO (1) | WO2019002828A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710229D0 (en) | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
| GB201715654D0 (en) * | 2017-09-27 | 2017-11-08 | Tdeltas Ltd | Method of treatment |
| GB2577723A (en) | 2018-10-04 | 2020-04-08 | Tdeltas Ltd | Compounds for new use |
| US12258609B2 (en) | 2019-01-17 | 2025-03-25 | Ketolipix Therapeutics Gmbh | Method for producing glycerides of hydroxycarboxylic acids |
| CN109700021A (zh) * | 2019-03-04 | 2019-05-03 | 清华大学 | 3-羟基丁酸及其衍生物在制备预防和治疗肥胖及肥胖相关疾病的产品中的应用 |
| CN110776425B (zh) * | 2019-10-23 | 2021-02-26 | 清华大学 | 一种(r)-3-羟基丁酸及其低聚物的制备方法 |
| JP7638693B2 (ja) * | 2020-12-15 | 2025-03-04 | 大阪瓦斯株式会社 | ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体 |
| WO2022254764A1 (ja) * | 2021-06-01 | 2022-12-08 | 大阪瓦斯株式会社 | ３－ヒドロキシ酪酸含有油脂組成物 |
| WO2023283654A1 (en) * | 2021-07-09 | 2023-01-12 | Georgia State University Research Foundation, Inc. | The use of beta-hydroxybutyrates for the treatment or prevention of aneurysms and dissections |
| IT202100020441A1 (it) * | 2021-07-30 | 2023-01-30 | Unichem Estense S R L | Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici |
| CN113712140A (zh) * | 2021-09-13 | 2021-11-30 | 珠海麦得发生物科技股份有限公司 | 一种含(r)-3羟基丁酸的固体饮料及其制备方法 |
| AU2022381752B2 (en) * | 2021-11-04 | 2026-01-08 | Vdf Futureceuticals, Inc | Ketone precursors and methods therefor |
| AU2022387742A1 (en) * | 2021-11-12 | 2024-06-27 | Arxada Ag | Polyol-derived compounds |
| CN118382365A (zh) * | 2021-12-14 | 2024-07-23 | 三得利控股株式会社 | 含有3羟基丁酸及低级脂肪族醇的饮料及呈味改善方法 |
| CN118541034A (zh) * | 2021-12-14 | 2024-08-23 | 三得利控股株式会社 | 碳酸饮料及增强碳酸饮料的碳酸感的方法 |
| JP7223193B1 (ja) | 2022-05-26 | 2023-02-15 | 大阪瓦斯株式会社 | 内臓脂肪低減剤およびその用途 |
| CN116966173A (zh) * | 2023-06-15 | 2023-10-31 | 浙江大学 | 3-羟基苯乙酸在制备改善非酒精性脂肪肝药物中的应用 |
| CN118903420A (zh) * | 2024-07-02 | 2024-11-08 | 南方医科大学 | Irf4抑制剂在治疗非酒精性脂肪性肝炎的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| AU6513298A (en) | 1997-03-17 | 1998-10-12 | British Technology Group Limited | Therapeutic compositions |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| ATE345359T1 (de) * | 1997-12-22 | 2006-12-15 | Metabolix Inc | Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten |
| US6753384B2 (en) * | 2000-07-14 | 2004-06-22 | Metabolix, Inc. | Polyurethanes obtained from hydroxyalkanoates and isocyanates |
| AU2004245567B2 (en) | 2003-06-03 | 2011-06-23 | Oxford University Innovation Limited | Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives |
| SE0400355D0 (sv) * | 2004-02-17 | 2004-02-17 | Synbiotics Ab | New synbiotec use |
| EP1778213B1 (en) | 2004-07-16 | 2017-04-05 | BTG International Limited | A method for the synthesis of oligomeric compounds |
| US7485743B2 (en) | 2004-07-20 | 2009-02-03 | Btg International Limited | Oligomeric ketone compounds |
| WO2008110034A1 (en) * | 2007-03-14 | 2008-09-18 | Shantou University | 3-hydroxy fatty acid and its derivatives for improving of learning and/or memory of subjects |
| ES2730879T3 (es) | 2008-01-04 | 2019-11-13 | Univ Oxford Innovation Ltd | Cuerpos de cetona y ésteres de cuerpos de cetona como agentes reductores de lípidos de la sangre |
| ES2655367T3 (es) * | 2008-08-21 | 2018-02-19 | Oxford University Innovation Limited | Bebida que comprende éster de hidroxibutirato y uso médico de la misma |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| WO2011078204A1 (ja) | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
| US8865641B2 (en) * | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| CN105246870A (zh) | 2013-03-14 | 2016-01-13 | 伊希斯创新有限公司 | (r)-3-羟基丁酸(r)-3-羟基丁酯的制备方法 |
| PE20151949A1 (es) | 2013-03-19 | 2016-01-05 | Univ South Florida | Composiciones y metodos para producir cetosis elevada y sostenida |
| EP2988736A1 (en) | 2013-04-22 | 2016-03-02 | Cadila Healthcare Limited | A novel composition for nonalcoholic fatty liver disease (nafld) |
| US11814664B2 (en) * | 2013-05-24 | 2023-11-14 | Genomatica, Inc. | Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| GB201314127D0 (en) | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| US20150283163A1 (en) | 2014-04-04 | 2015-10-08 | Organic Medical Ventures, L.L.C. | Muscle treatment composition and method making same |
| WO2016123229A1 (en) * | 2015-01-29 | 2016-08-04 | Yale University | Compositions and methods for treating nlrp3 inflammasome-related diseases and disorders |
| MX386778B (es) * | 2015-03-09 | 2025-03-19 | Intekrin Therapeutics Inc | Métodos para el tratamiento de enfermedad de hígado graso no alcohólico y/o lipodistrofia. |
| SG11201809211QA (en) * | 2016-04-19 | 2018-11-29 | Keto Patent Group Inc | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| GB201710229D0 (en) | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
-
2017
- 2017-06-27 GB GBGB1710229.4A patent/GB201710229D0/en not_active Ceased
-
2018
- 2018-06-22 DK DK18737388.1T patent/DK3644982T3/da active
- 2018-06-22 ES ES18737388T patent/ES2945964T3/es active Active
- 2018-06-22 EP EP23161905.7A patent/EP4215189A1/en active Pending
- 2018-06-22 WO PCT/GB2018/051752 patent/WO2019002828A1/en not_active Ceased
- 2018-06-22 CA CA3066948A patent/CA3066948A1/en active Pending
- 2018-06-22 AU AU2018293398A patent/AU2018293398B2/en active Active
- 2018-06-22 KR KR1020207002473A patent/KR102680437B1/ko active Active
- 2018-06-22 US US16/626,293 patent/US12439944B2/en active Active
- 2018-06-22 PL PL18737388.1T patent/PL3644982T3/pl unknown
- 2018-06-22 GB GB1810300.2A patent/GB2567273B/en active Active
- 2018-06-22 CN CN201880042880.5A patent/CN110869012B/zh active Active
- 2018-06-22 EP EP18737388.1A patent/EP3644982B1/en active Active
- 2018-06-22 TW TW107121496A patent/TWI811222B/zh active
- 2018-06-22 JP JP2019572783A patent/JP7374000B2/ja active Active
-
2023
- 2023-06-30 JP JP2023107837A patent/JP7632979B2/ja active Active
-
2025
- 2025-09-18 US US19/332,258 patent/US20260007157A1/en active Pending
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