CN110869012B - 用于减少肝脏脂肪的3-羟基丁酸化合物 - Google Patents

用于减少肝脏脂肪的3-羟基丁酸化合物 Download PDF

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Publication number
CN110869012B
CN110869012B CN201880042880.5A CN201880042880A CN110869012B CN 110869012 B CN110869012 B CN 110869012B CN 201880042880 A CN201880042880 A CN 201880042880A CN 110869012 B CN110869012 B CN 110869012B
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liver
subject
fat
compound
fatty liver
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CN110869012A (zh
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K·克拉克
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Tederta Co ltd
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Tederta Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
CN201880042880.5A 2017-06-27 2018-06-22 用于减少肝脏脂肪的3-羟基丁酸化合物 Active CN110869012B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1710229.4A GB201710229D0 (en) 2017-06-27 2017-06-27 Compounds for new use
GB1710229.4 2017-06-27
PCT/GB2018/051752 WO2019002828A1 (en) 2017-06-27 2018-06-22 3-HYDROXYBUTYRATE COMPOUNDS FOR USE IN THE REDUCTION OF HEPATIC FAT

Publications (2)

Publication Number Publication Date
CN110869012A CN110869012A (zh) 2020-03-06
CN110869012B true CN110869012B (zh) 2024-06-11

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CN201880042880.5A Active CN110869012B (zh) 2017-06-27 2018-06-22 用于减少肝脏脂肪的3-羟基丁酸化合物

Country Status (13)

Country Link
US (1) US12439944B2 (enExample)
EP (2) EP3644982B1 (enExample)
JP (2) JP7374000B2 (enExample)
KR (1) KR102680437B1 (enExample)
CN (1) CN110869012B (enExample)
AU (1) AU2018293398B2 (enExample)
CA (1) CA3066948A1 (enExample)
DK (1) DK3644982T3 (enExample)
ES (1) ES2945964T3 (enExample)
GB (2) GB201710229D0 (enExample)
PL (1) PL3644982T3 (enExample)
TW (1) TWI811222B (enExample)
WO (1) WO2019002828A1 (enExample)

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GB2577723A (en) 2018-10-04 2020-04-08 Tdeltas Ltd Compounds for new use
JP7235873B2 (ja) * 2019-01-17 2023-03-08 アイオーアイ オレオ ゲーエムベーハー ヒドロキシカルボン酸のグリセリドの製造方法
CN109700021A (zh) * 2019-03-04 2019-05-03 清华大学 3-羟基丁酸及其衍生物在制备预防和治疗肥胖及肥胖相关疾病的产品中的应用
CN110776425B (zh) * 2019-10-23 2021-02-26 清华大学 一种(r)-3-羟基丁酸及其低聚物的制备方法
JP7638693B2 (ja) * 2020-12-15 2025-03-04 大阪瓦斯株式会社 ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体
EP4256966A4 (en) * 2021-06-01 2024-12-11 Osaka Gas Co., Ltd. 3-hydroxybutyric-acid-containing oil and fat composition
US20240342121A1 (en) * 2021-07-09 2024-10-17 Georgia State University Research Foundation, Inc. The use of beta-hydroxybutyrates for the treatment or prevention of aneurysms and dissections
IT202100020441A1 (it) * 2021-07-30 2023-01-30 Unichem Estense S R L Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici
CN113712140A (zh) * 2021-09-13 2021-11-30 珠海麦得发生物科技股份有限公司 一种含(r)-3羟基丁酸的固体饮料及其制备方法
CA3236459A1 (en) * 2021-11-04 2024-05-11 Gleb ANDRYIANAU Ketone precursors and methods therefor
IL312317B2 (en) * 2021-11-12 2025-04-01 Arxada Ag Polyol-derived compounds
AU2022417093A1 (en) * 2021-12-14 2024-06-13 Suntory Holdings Limited Beverage containing 3-hydroxybutyric acid and lower aliphatic alcohol, and method for improving taste
WO2023112818A1 (ja) * 2021-12-14 2023-06-22 サントリーホールディングス株式会社 炭酸飲料及び炭酸飲料の炭酸感を増強する方法
JP7223193B1 (ja) 2022-05-26 2023-02-15 大阪瓦斯株式会社 内臓脂肪低減剤およびその用途
CN116966173A (zh) * 2023-06-15 2023-10-31 浙江大学 3-羟基苯乙酸在制备改善非酒精性脂肪肝药物中的应用
CN118903420A (zh) * 2024-07-02 2024-11-08 南方医科大学 Irf4抑制剂在治疗非酒精性脂肪性肝炎的应用

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Publication number Publication date
KR102680437B1 (ko) 2024-07-01
CA3066948A1 (en) 2019-01-03
GB2567273B (en) 2020-10-07
JP2020527547A (ja) 2020-09-10
GB201810300D0 (en) 2018-08-08
TWI811222B (zh) 2023-08-11
CN110869012A (zh) 2020-03-06
GB2567273A (en) 2019-04-10
JP7632979B2 (ja) 2025-02-19
EP3644982B1 (en) 2023-04-12
EP3644982A1 (en) 2020-05-06
US20200113220A1 (en) 2020-04-16
WO2019002828A1 (en) 2019-01-03
GB201710229D0 (en) 2017-08-09
AU2018293398A1 (en) 2020-01-16
EP4215189A1 (en) 2023-07-26
ES2945964T3 (es) 2023-07-11
DK3644982T3 (da) 2023-07-17
JP2023120442A (ja) 2023-08-29
KR20200019745A (ko) 2020-02-24
PL3644982T3 (pl) 2023-08-14
AU2018293398B2 (en) 2023-11-23
JP7374000B2 (ja) 2023-11-06
TW201904568A (zh) 2019-02-01
US12439944B2 (en) 2025-10-14

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