JP7223193B1 - 内臓脂肪低減剤およびその用途 - Google Patents
内臓脂肪低減剤およびその用途 Download PDFInfo
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- JP7223193B1 JP7223193B1 JP2022086038A JP2022086038A JP7223193B1 JP 7223193 B1 JP7223193 B1 JP 7223193B1 JP 2022086038 A JP2022086038 A JP 2022086038A JP 2022086038 A JP2022086038 A JP 2022086038A JP 7223193 B1 JP7223193 B1 JP 7223193B1
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Abstract
Description
本発明の内臓脂肪低減剤は、R-3-ヒドロキシ酪酸および/またはその塩[以下「(R)3HB(塩)」と総称する場合がある]を有効成分とする。
(R)3HB(塩)は、結晶形であってもよく、非晶形であってもよい。これらのうち、固形状組成物または半固形状組成物中における(R)3HB(塩)は結晶形であってもよい。
本発明の内臓脂肪低減剤は、R体である有効成分に加えて、R体の光学異性体であるS体、すなわちS-3-ヒドロキシ酪酸および/またはその塩[(S)3HB(塩)と総称する場合がある]をさらに含んでいてもよい。
本発明の内臓脂肪低減剤は、3HBのオリゴマーをさらに含んでいてもよい。3HBオリゴマーの平均重合度は2以上であればよいが、例えば2~100、好ましくは2~10、さらに好ましくは2~5、より好ましくは2~4.5、最も好ましくは2~4である。3HBのオリゴマーは、3HBの製造過程などにおいて、不可避的に混入したオリゴマーであってもよい。
本発明の内臓脂肪低減剤は、ヒトなどの哺乳類の内臓脂肪を低減するために使用でき、中型または大型の哺乳類(特にヒト)の内臓脂肪を低減するために使用するのが好ましい。また、特に、本発明の内臓脂肪低減剤は、体温を維持したり、内臓や骨を保護する機能を有する皮下脂肪を保持したまま、内臓脂肪を低減できるため、ダイエット目的ではなく、ヒトの生活習慣病を予防または改善するために使用するのが好ましい。
本発明の内臓脂肪低減用組成物は、有効成分として(R)3HB(塩)を含有する。内臓脂肪低減用組成物は、液状組成物(液剤)、固形状組成物(固形剤)、半固形状組成物(半固形剤)のいずれであってもよい。すなわち、本発明の内臓脂肪低減用組成物では、(R)3HB(塩)が前述の内臓脂肪低減剤として液状組成物、固形状組成物または半固形状組成物に配合される。組成物中の有効成分は、好ましい態様も含めて、前記内臓脂肪低減剤として記載されている有効成分と同様である。
本発明の内臓脂肪低減用組成物は、さらに糖類を含んでいてもよい。(R)3HBは、もともとヒトの体内に存在する物質であり、糖質に代わる画期的なエネルギー源として期待されている。そのため、前述のように、ケトジェニックダイエットでは、3HBをエネルギー源として利用することに主眼が置かれているため、体内でエネルギー源として脂肪に容易に変換されて体重の増加につながる糖質の摂取は制限することを目的としている。これに対して、本発明の内臓脂肪低減剤は、ケトジェニックダイエットとは異なり、糖質を低減する必要はないため、糖類と組み合わせてもよく、甘味剤としても機能する糖類と組み合わせることにより、服用性を調整し易い。特に、組成物が飲料などの液状組成物である場合、強い酸味を抑制し、服用性を向上させるために、糖類を含むのが好ましい。また、(R)3HB(塩)は、内臓脂肪低減機能に加えてエネルギー源としても機能するが、本発明の組成物におけるエネルギー源としての機能を強化するために、エネルギー源として糖類を配合してもよい。
本発明の内臓脂肪低減用組成物は、服用性を改善させるために、甘味剤としても機能する前記糖類に加えてまたは前記糖類に代えて、さらに甘味剤(非糖質甘味料)を含んでいてもよい。
本発明の内臓脂肪低減用組成物は、さらに酸味剤(酸味料)を含んでいてもよい。有効成分である(R)3HBは、酸味が極めて強いため、前記糖類および/または甘味剤だけでなく、さらに酸味剤と組み合わせて酸味を調整してもよい。特に、液状組成物の場合は、酸味剤としてアルカリ成分を用いることにより、pHを調整したり、(R)3HBの少なくとも一部を塩の形態に変化させることにより、酸味を調整してもよい。
本発明の内臓脂肪低減用組成物は、エネルギー源として作用させたり、矯味性や機能性を付与するために、さらにアミノ酸を含んでいてもよい。
本発明の内臓脂肪低減用組成物は、服用性を向上させるために、さらに香料を含んでいてもよい。香料は、天然香料であってもよく、合成香料であってもよい。
本発明の内臓脂肪低減用組成物は、さらに油脂類を含んでいてもよい。油脂類は、食用油脂であれば特に限定されず、植物性油脂、動物性油脂、加工油脂のいずれであってもよい。
本発明の内臓脂肪低減用組成物は、さらにプロテインを含んでいてもよい。プロテインとしては、例えば、ホエイプロテイン、カゼインプロテイン、ソイプロテイン(大豆プロテイン)、エンドウ豆プロテイン、小麦プロテイン、エッグプロテイン、ライスプロテインなどが挙げられる。これらのプロテインは、単独でまたは二種以上組み合わせて使用できる。
本発明の内臓脂肪低減用組成物は、さらに3HBのオリゴマーをさらに含んでいてもよい。3HBオリゴマーの平均重合度は2以上であればよいが、例えば2~100、好ましくは2~10、さらに好ましくは2~5、より好ましくは2~4.5、最も好ましくは2~4である。3HBのオリゴマーは、組成物の製造過程などにおいて、不可避的に混入したオリゴマーであってもよい。3HBオリゴマーの割合は、有効成分100質量部に対して10質量部以下であってもよく、好ましくは5質量部以下、さらに好ましくは3質量部以下、最も好ましくは1質量部以下である。
本発明の内臓脂肪低減用組成物は、さらに他の成分を含んでいてもよい。他の成分としては、健康食品(機能性食品)分野や医薬品分野で利用される慣用の添加剤などが挙げられる。
本発明の内臓脂肪低減用組成物が液状組成物である場合、水をさらに含むのが好ましい。水の割合は、有効成分100質量部に対して、例えば100~10000質量部、好ましくは500~8000質量部、さらに好ましくは1000~5000質量部、より好ましくは2000~4000質量部である。
本発明の内臓脂肪低減用組成物は、ヒトなどの哺乳類の内臓脂肪を低減するための組成物であってもよく、中型または大型の哺乳類(特にヒト)の内臓脂肪を低減するための組成物であるのが好ましい。また、特に、本発明の内臓脂肪低減剤は、体温を維持したり、内臓や骨を保護する機能を有する皮下脂肪を保持したまま、内臓脂肪を低減できるため、ダイエット目的ではなく、ヒトの生活習慣病を予防または改善するための組成物であるのが特に好ましい。
本発明の内臓脂肪低減用組成物は、形態に応じて慣用の製造方法で製造できる。本発明の内臓脂肪低減用組成物が液状組成物である場合、(R)3HB(塩)が酸の形態であると、酸味が強すぎるため、(R)3HBとアルカリ成分とを混合して内臓脂肪低減用液状組成物を製造するのが好ましい。この製造方法では、原料としてアルカリ成分を用いることにより、液状組成物のpHを上昇させたり、(R)3HBを塩の形態に変化させることにより、酸味を抑制できる。アルカリ成分としては、食品や医薬品で汎用されているアルカリ成分であれば特に限定されないが、アルカリ金属化合物、アルカリ土類金属化合物、塩基性アミノ酸などが汎用され、酸味剤またはpH調整剤としてのアルカリ金属化合物またはアルカリ土類金属化合物が好ましく、酸味剤としてのアルカリ金属化合物が特に好ましい。
((R)3HB)
結晶性(R)3HB:大阪ガスケミカル(株)製「OKETOA(登録商標)」
(糖類)
エリスリトール
(アミノ酸)
アラニン
(酸味料)
クエン酸
クエン酸ナトリウム
(香料)
香料
(甘味料)
スクラロース
アセスルファムK。
ランダム化プラセボ対照二重盲検並行群間比較にて12週間、毎朝、3HBを3g含むドリンク剤(飲料)を摂取する試験を行った。中途脱落者を除外した43名(被験食品群に21名、プラセボ群に22名)について解析を行った。試験者は、日本人男女、20歳以上、健常者、BMI値が23kg/m2以上30kg/m2未満であった。この臨床試験については、UMIN臨床試験登録システム(UMIN-CTR)に登録した(UMIN登録番号:UMIN000045322)。
表2に示す実施例1のドリンク剤(被験食品群)および参考例1のドリンク剤(プラセボ群)を調製し、経口摂取した前後の生理的な変化について調査した。試験中の体調不良等に関する情報を表3に示す。
Claims (14)
- 経口摂取してヒトの内臓脂肪を低減する低減剤であって、
R-3-ヒドロキシ酪酸および/またはその塩を有効成分とし、かつ
1日当たりの服用量が、有効成分換算で、体重1kgに対して0.01~0.5gである内臓脂肪低減剤。 - 前記R-3-ヒドロキシ酪酸および/またはその塩の割合が、80質量%以上である請求項1記載の内臓脂肪低減剤。
- 前記有効成分が、R-3-ヒドロキシ酪酸とR-3-ヒドロキシ酪酸の塩との混合物である請求項1または2記載の内臓脂肪低減剤。
- 経口摂取してヒトの内臓脂肪を低減する組成物であって、
R-3-ヒドロキシ酪酸および/またはその塩を有効成分として含有し、かつ
1日当たりの服用量が、有効成分換算で、体重1kgに対して0.01~0.5gである内臓脂肪低減用組成物。 - 前記有効成分がR-3-ヒドロキシ酪酸を含み、かつ液状組成物である請求項4記載の組成物。
- 前記有効成分がR-3-ヒドロキシ酪酸の塩を含み、かつ固形状または半固形状組成物である請求項4記載の組成物。
- さらに糖類を含む請求項4~6のいずれか一項に記載の組成物。
- さらに酸味剤を含む請求項4~6のいずれか一項に記載の組成物。
- 油脂類を含まない請求項4~6のいずれか一項に記載の組成物。
- ヒトが経口摂取するための機能性食品組成物または医薬組成物である請求項4~6のいずれか一項に記載の組成物。
- 運動および食事制限することなく、内臓脂肪を低減するための組成物である請求項4~6のいずれか一項に記載の組成物。
- 皮下脂肪の低減を抑制し、かつ内臓脂肪を低減するための組成物である請求項4~6のいずれか一項に記載の組成物。
- 生活習慣病を予防または改善するための組成物である請求項4~6のいずれか一項に記載の組成物。
- R-3-ヒドロキシ酪酸とアルカリ成分とを混合して、有効成分換算で、体重1kgに対して1日当たり0.01~0.5gの服用量で経口摂取してヒトの内臓脂肪を低減する液状組成物を製造する方法。
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