DK3644982T3 - 3-hydroxybutyratforbindelser til anvendelse i reduktion af leverfedt - Google Patents
3-hydroxybutyratforbindelser til anvendelse i reduktion af leverfedt Download PDFInfo
- Publication number
- DK3644982T3 DK3644982T3 DK18737388.1T DK18737388T DK3644982T3 DK 3644982 T3 DK3644982 T3 DK 3644982T3 DK 18737388 T DK18737388 T DK 18737388T DK 3644982 T3 DK3644982 T3 DK 3644982T3
- Authority
- DK
- Denmark
- Prior art keywords
- liver fat
- reducing liver
- hydroxybutyrate compounds
- hydroxybutyrate
- compounds
- Prior art date
Links
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical class CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1710229.4A GB201710229D0 (en) | 2017-06-27 | 2017-06-27 | Compounds for new use |
| PCT/GB2018/051752 WO2019002828A1 (en) | 2017-06-27 | 2018-06-22 | 3-HYDROXYBUTYRATE COMPOUNDS FOR USE IN THE REDUCTION OF HEPATIC FAT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3644982T3 true DK3644982T3 (da) | 2023-07-17 |
Family
ID=59523693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18737388.1T DK3644982T3 (da) | 2017-06-27 | 2018-06-22 | 3-hydroxybutyratforbindelser til anvendelse i reduktion af leverfedt |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20200113220A1 (da) |
| EP (2) | EP4215189A1 (da) |
| JP (2) | JP7374000B2 (da) |
| CN (1) | CN110869012B (da) |
| AU (1) | AU2018293398B2 (da) |
| CA (1) | CA3066948A1 (da) |
| DK (1) | DK3644982T3 (da) |
| ES (1) | ES2945964T3 (da) |
| GB (2) | GB201710229D0 (da) |
| PL (1) | PL3644982T3 (da) |
| TW (1) | TWI811222B (da) |
| WO (1) | WO2019002828A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201715654D0 (en) * | 2017-09-27 | 2017-11-08 | Tdeltas Ltd | Method of treatment |
| DK3880641T3 (da) * | 2019-01-17 | 2023-05-30 | Ketolipix Therapeutics Gmbh | Fremgangsmåde til fremstilling af glycerider af hydroxycarboxylsyrer |
| CN109700021A (zh) * | 2019-03-04 | 2019-05-03 | 清华大学 | 3-羟基丁酸及其衍生物在制备预防和治疗肥胖及肥胖相关疾病的产品中的应用 |
| CN110776425B (zh) * | 2019-10-23 | 2021-02-26 | 清华大学 | 一种(r)-3-羟基丁酸及其低聚物的制备方法 |
| IT202100020441A1 (it) * | 2021-07-30 | 2023-01-30 | Unichem Estense S R L | Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici |
| CN113712140A (zh) * | 2021-09-13 | 2021-11-30 | 珠海麦得发生物科技股份有限公司 | 一种含(r)-3羟基丁酸的固体饮料及其制备方法 |
| CN118201608A (zh) * | 2021-11-04 | 2024-06-14 | Vdf未来制剂股份有限公司 | 酮前体及其方法 |
| AU2022411334A1 (en) * | 2021-12-14 | 2024-06-13 | Suntory Holdings Limited | Carbonated beverage, and method for enhancing sense of carbonation of beverage |
| AU2022417093A1 (en) * | 2021-12-14 | 2024-06-13 | Suntory Holdings Limited | Beverage containing 3-hydroxybutyric acid and lower aliphatic alcohol, and method for improving taste |
| JP7223193B1 (ja) | 2022-05-26 | 2023-02-15 | 大阪瓦斯株式会社 | 内臓脂肪低減剤およびその用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| EP2283834B1 (en) * | 1997-03-17 | 2016-07-13 | BTG International Limited | Therapeutic compositions comprising ketone bodies or their precursors |
| CA2314151C (en) * | 1997-12-22 | 2004-10-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| EP1301551A2 (en) * | 2000-07-14 | 2003-04-16 | Metabolix, Inc. | Polyurethanes obtained from hydroxyalkanoates and isocyanates |
| AU2004245567B2 (en) * | 2003-06-03 | 2011-06-23 | Oxford University Innovation Limited | Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives |
| EP1778213B1 (en) | 2004-07-16 | 2017-04-05 | BTG International Limited | A method for the synthesis of oligomeric compounds |
| CN101489543A (zh) * | 2007-03-14 | 2009-07-22 | 汕头大学 | 提高受试者的学习和/或记忆能力的3-羟基脂肪酸及其衍生物 |
| AU2009204370B2 (en) | 2008-01-04 | 2014-12-04 | Gvmt Of The Usa, As Represented By The Secretary, Department Of Health & Human Services | Ketone bodies and ketone body esters as blood lipid lowering agents |
| CN102164884B (zh) * | 2008-08-21 | 2015-03-11 | 伊希斯创新有限公司 | 羟基丁酸酯及其医学用途 |
| WO2011078204A1 (ja) * | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
| US8865641B2 (en) * | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| PE20151949A1 (es) | 2013-03-19 | 2016-01-05 | Univ South Florida | Composiciones y metodos para producir cetosis elevada y sostenida |
| UA114360C2 (uk) * | 2013-04-22 | 2017-05-25 | Каділа Хелткере Лімітед | Спосіб лікування та/або зменшення інтенсивності неалкогольної жирової хвороби печінки (нжхп) |
| WO2016123229A1 (en) * | 2015-01-29 | 2016-08-04 | Yale University | Compositions and methods for treating nlrp3 inflammasome-related diseases and disorders |
| EA201791982A1 (ru) * | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| WO2017184788A1 (en) * | 2016-04-19 | 2017-10-26 | Keto Patent Group, Inc. | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
-
2017
- 2017-06-27 GB GBGB1710229.4A patent/GB201710229D0/en not_active Ceased
-
2018
- 2018-06-22 EP EP23161905.7A patent/EP4215189A1/en active Pending
- 2018-06-22 TW TW107121496A patent/TWI811222B/zh active
- 2018-06-22 CA CA3066948A patent/CA3066948A1/en active Pending
- 2018-06-22 JP JP2019572783A patent/JP7374000B2/ja active Active
- 2018-06-22 CN CN201880042880.5A patent/CN110869012B/zh active Active
- 2018-06-22 DK DK18737388.1T patent/DK3644982T3/da active
- 2018-06-22 ES ES18737388T patent/ES2945964T3/es active Active
- 2018-06-22 PL PL18737388.1T patent/PL3644982T3/pl unknown
- 2018-06-22 AU AU2018293398A patent/AU2018293398B2/en active Active
- 2018-06-22 US US16/626,293 patent/US20200113220A1/en active Pending
- 2018-06-22 EP EP18737388.1A patent/EP3644982B1/en active Active
- 2018-06-22 GB GB1810300.2A patent/GB2567273B/en active Active
- 2018-06-22 WO PCT/GB2018/051752 patent/WO2019002828A1/en unknown
-
2023
- 2023-06-30 JP JP2023107837A patent/JP2023120442A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB2567273B (en) | 2020-10-07 |
| CN110869012A (zh) | 2020-03-06 |
| CN110869012B (zh) | 2024-06-11 |
| ES2945964T3 (es) | 2023-07-11 |
| CA3066948A1 (en) | 2019-01-03 |
| TWI811222B (zh) | 2023-08-11 |
| PL3644982T3 (pl) | 2023-08-14 |
| JP7374000B2 (ja) | 2023-11-06 |
| AU2018293398A1 (en) | 2020-01-16 |
| US20200113220A1 (en) | 2020-04-16 |
| EP4215189A1 (en) | 2023-07-26 |
| TW201904568A (zh) | 2019-02-01 |
| AU2018293398B2 (en) | 2023-11-23 |
| EP3644982A1 (en) | 2020-05-06 |
| GB201710229D0 (en) | 2017-08-09 |
| JP2023120442A (ja) | 2023-08-29 |
| JP2020527547A (ja) | 2020-09-10 |
| KR20200019745A (ko) | 2020-02-24 |
| GB201810300D0 (en) | 2018-08-08 |
| GB2567273A (en) | 2019-04-10 |
| EP3644982B1 (en) | 2023-04-12 |
| WO2019002828A1 (en) | 2019-01-03 |
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