JP2020527170A5 - - Google Patents
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- Publication number
- JP2020527170A5 JP2020527170A5 JP2020522788A JP2020522788A JP2020527170A5 JP 2020527170 A5 JP2020527170 A5 JP 2020527170A5 JP 2020522788 A JP2020522788 A JP 2020522788A JP 2020522788 A JP2020522788 A JP 2020522788A JP 2020527170 A5 JP2020527170 A5 JP 2020527170A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous
- corresponds
- solvent
- alkoxylated
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002904 solvent Substances 0.000 claims 47
- 239000000203 mixture Substances 0.000 claims 28
- 239000000693 micelle Substances 0.000 claims 16
- 238000002156 mixing Methods 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000000243 solution Substances 0.000 claims 10
- 239000007864 aqueous solution Substances 0.000 claims 8
- 239000000155 melt Substances 0.000 claims 8
- 238000002844 melting Methods 0.000 claims 7
- 230000008018 melting Effects 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 229930003827 cannabinoid Natural products 0.000 claims 4
- 239000003557 cannabinoid Substances 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 claims 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 238000000354 decomposition reaction Methods 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 230000003647 oxidation Effects 0.000 claims 3
- 238000007254 oxidation reaction Methods 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims 2
- 241001367053 Autographa gamma Species 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 235000010389 delta-tocopherol Nutrition 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229920005862 polyol Polymers 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 229930003802 tocotrienol Natural products 0.000 claims 2
- 239000011731 tocotrienol Substances 0.000 claims 2
- 229940068778 tocotrienols Drugs 0.000 claims 2
- 235000019148 tocotrienols Nutrition 0.000 claims 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims 2
- 239000002446 δ-tocopherol Substances 0.000 claims 2
- CYQFCXCEBYINGO-DLBZAZTESA-N Dronabinol Natural products C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@H]21 CYQFCXCEBYINGO-DLBZAZTESA-N 0.000 claims 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 1
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims 1
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 1
- 229950011318 cannabidiol Drugs 0.000 claims 1
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims 1
- 229960004242 dronabinol Drugs 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- 0 *C(*)(C(*)(*)c1c2*)C(*)(*)Oc1c(*)c(*)c2I* Chemical compound *C(*)(C(*)(*)c1c2*)C(*)(*)Oc1c(*)c(*)c2I* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17180380.2A EP3424493A1 (en) | 2017-07-07 | 2017-07-07 | Stable cannabinoid compositions |
| EP17180380.2 | 2017-07-07 | ||
| PCT/EP2018/068452 WO2019008179A1 (en) | 2017-07-07 | 2018-07-06 | STABLE CANNABINOID COMPOSITIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527170A JP2020527170A (ja) | 2020-09-03 |
| JP2020527170A5 true JP2020527170A5 (https=) | 2021-07-26 |
| JP7186222B2 JP7186222B2 (ja) | 2022-12-08 |
Family
ID=59315425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020522788A Active JP7186222B2 (ja) | 2017-07-07 | 2018-07-06 | 安定なカンナビノイド組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11752126B2 (https=) |
| EP (2) | EP3424493A1 (https=) |
| JP (1) | JP7186222B2 (https=) |
| KR (1) | KR102680507B1 (https=) |
| CN (2) | CN115120558A (https=) |
| AU (1) | AU2018296679B2 (https=) |
| CA (1) | CA3076750A1 (https=) |
| EA (1) | EA202090177A1 (https=) |
| IL (1) | IL271892B2 (https=) |
| WO (1) | WO2019008179A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112915121A (zh) * | 2019-12-06 | 2021-06-08 | 汉义生物科技（北京）有限公司 | 一种大麻素纳米胶束制剂及其制备方法 |
| EP4466002A1 (de) | 2022-01-20 | 2024-11-27 | Solmic Biotech GmbH | Topisch anwendbare zusammensetzung enthaltend solubilisate lipophiler wirkstoffe |
| DE202022000150U1 (de) | 2022-01-20 | 2022-07-07 | Solmic Bio Tech Gmbh | Maske für medizinische oder kosmetische Zwecke mit mizellierten Extrakten |
| EP4275694A1 (de) | 2022-05-13 | 2023-11-15 | Solmic Biotech GmbH | Verwendung von solubilisaten in erzeugnissen zur topischen anwendung |
| CN117986017B (zh) * | 2023-11-27 | 2025-11-21 | 陕西师范大学 | 一种（Sm2-aYa）Ba4CuBiO10纳米粉体及用其改善单畴SmBCO超导块材性能的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2270426T3 (es) | 1994-03-18 | 2007-04-01 | Supernus Pharmaceuticals, Inc. | Sistema de suministros de farmacos emulsionados. |
| MXPA01011981A (es) * | 1999-05-24 | 2003-09-04 | Sonus Pharma Inc | Vehiculo de emulsion para farmacos poco solubles. |
| US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| ES2283756T3 (es) * | 2002-03-01 | 2007-11-01 | Novagali Pharma Sa | Sistemas autoemulsionantes de administracion de farmaco para taxoides. |
| US20080045559A1 (en) * | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| US20100235972A1 (en) | 2005-07-28 | 2010-09-23 | Guasch Michael N | Fuel repellent compositions, fabrics and articles |
| US7402325B2 (en) * | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| TWI392507B (zh) * | 2006-10-20 | 2013-04-11 | Solvay Pharm Bv | 包埋的膠束奈米顆粒 |
| WO2008046905A1 (en) * | 2006-10-20 | 2008-04-24 | Solvay Pharmaceuticals B.V. | Micellar nanoparticles of chemical substances |
| PL2352497T3 (pl) * | 2008-10-31 | 2017-08-31 | University Of Mississippi | Proces przygotowania estrów aminokwasowych delta-9-thc |
| US20120088829A1 (en) * | 2010-09-29 | 2012-04-12 | MyCell Holdings Limited | Formulations of Ubiquinol and Resveratrol Esters |
| US8808734B2 (en) | 2011-07-11 | 2014-08-19 | Full Spectrum Laboratories Limited | Cannabinoid formulations |
| WO2014165672A1 (en) * | 2013-04-06 | 2014-10-09 | Igdrasol, Inc. | Nanoparticle therapeutic agents, their formulations, and methods of their use |
| US9861611B2 (en) * | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
| US20170119660A1 (en) * | 2015-10-29 | 2017-05-04 | Solubest Ltd | Pharmaceutical compositions for transmucosal delivery |
-
2017
- 2017-07-07 EP EP17180380.2A patent/EP3424493A1/en not_active Withdrawn
-
2018
- 2018-07-06 KR KR1020207003610A patent/KR102680507B1/ko active Active
- 2018-07-06 EP EP18738297.3A patent/EP3675825A1/en active Pending
- 2018-07-06 CA CA3076750A patent/CA3076750A1/en active Pending
- 2018-07-06 US US16/628,865 patent/US11752126B2/en active Active
- 2018-07-06 WO PCT/EP2018/068452 patent/WO2019008179A1/en not_active Ceased
- 2018-07-06 JP JP2020522788A patent/JP7186222B2/ja active Active
- 2018-07-06 EA EA202090177A patent/EA202090177A1/ru unknown
- 2018-07-06 CN CN202210164448.1A patent/CN115120558A/zh active Pending
- 2018-07-06 CN CN201880057928.XA patent/CN111246844A/zh active Pending
- 2018-07-06 AU AU2018296679A patent/AU2018296679B2/en active Active
-
2020
- 2020-01-07 IL IL271892A patent/IL271892B2/en unknown
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