JP2020526549A5 - - Google Patents
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- Publication number
- JP2020526549A5 JP2020526549A5 JP2020501256A JP2020501256A JP2020526549A5 JP 2020526549 A5 JP2020526549 A5 JP 2020526549A5 JP 2020501256 A JP2020501256 A JP 2020501256A JP 2020501256 A JP2020501256 A JP 2020501256A JP 2020526549 A5 JP2020526549 A5 JP 2020526549A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- triazole
- pyrrolo
- phenyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023061174A JP2023085449A (ja) | 2017-07-14 | 2023-04-05 | 二環式ケトン化合物及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532767P | 2017-07-14 | 2017-07-14 | |
| US62/532,767 | 2017-07-14 | ||
| PCT/EP2018/068998 WO2019012063A1 (en) | 2017-07-14 | 2018-07-12 | BICYCLIC KETONIC COMPOUNDS AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061174A Division JP2023085449A (ja) | 2017-07-14 | 2023-04-05 | 二環式ケトン化合物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020526549A JP2020526549A (ja) | 2020-08-31 |
| JP2020526549A5 true JP2020526549A5 (it) | 2021-08-19 |
| JP7258843B2 JP7258843B2 (ja) | 2023-04-17 |
Family
ID=62916677
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501256A Active JP7258843B2 (ja) | 2017-07-14 | 2018-07-12 | 二環式ケトン化合物及びその使用方法 |
| JP2023061174A Pending JP2023085449A (ja) | 2017-07-14 | 2023-04-05 | 二環式ケトン化合物及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023061174A Pending JP2023085449A (ja) | 2017-07-14 | 2023-04-05 | 二環式ケトン化合物及びその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11098058B2 (it) |
| EP (1) | EP3652178B1 (it) |
| JP (2) | JP7258843B2 (it) |
| KR (2) | KR102664604B1 (it) |
| CN (1) | CN110914271A (it) |
| AR (1) | AR112274A1 (it) |
| AU (3) | AU2018300043B2 (it) |
| BR (1) | BR112020000771A2 (it) |
| CA (2) | CA3185865A1 (it) |
| CL (1) | CL2020000101A1 (it) |
| CO (1) | CO2020000134A2 (it) |
| CR (1) | CR20200002A (it) |
| DK (1) | DK3652178T3 (it) |
| ES (1) | ES2973661T3 (it) |
| FI (1) | FI3652178T3 (it) |
| HR (1) | HRP20240354T1 (it) |
| IL (2) | IL271981B (it) |
| LT (1) | LT3652178T (it) |
| MA (1) | MA49560B1 (it) |
| PH (1) | PH12020500105A1 (it) |
| PL (1) | PL3652178T3 (it) |
| PT (1) | PT3652178T (it) |
| RS (1) | RS65308B1 (it) |
| SG (1) | SG11202000333UA (it) |
| SI (1) | SI3652178T1 (it) |
| TW (1) | TWI805595B (it) |
| UA (1) | UA125448C2 (it) |
| WO (1) | WO2019012063A1 (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548484A1 (en) | 2016-12-02 | 2019-10-09 | H. Hoffnabb-La Roche Ag | Bicyclic amide compounds and methods of use thereof |
| IL271981B (en) | 2017-07-14 | 2022-09-01 | Hoffmann La Roche | Bicyclic ketone compounds and methods of using them |
| PE20211247A1 (es) | 2017-10-31 | 2021-07-13 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos |
| WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
| EP4144722A4 (en) * | 2020-04-27 | 2024-05-22 | Autotac Inc. | COMPOUND AS UBR-BOX DOMAIN LIGAND |
| WO2022212809A1 (en) | 2021-04-02 | 2022-10-06 | Genentech, Inc. | Processes for making bicyclic ketone compounds |
| WO2023039795A1 (zh) * | 2021-09-16 | 2023-03-23 | 维泰瑞隆（北京）生物科技有限公司 | Rip1激酶抑制剂及其用途 |
| TW202406906A (zh) * | 2022-05-19 | 2024-02-16 | 美商默沙東有限責任公司 | Ripk1抑制劑及使用方法 |
Family Cites Families (52)
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| DE1620508A1 (de) | 1965-07-23 | 1969-09-18 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3948903A (en) | 1972-12-15 | 1976-04-06 | Parke, Davis & Company | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8610530D0 (en) | 1986-04-30 | 1986-06-04 | Fbc Ltd | Herbicides |
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| JPH07509250A (ja) | 1992-07-27 | 1995-10-12 | アメリカ合衆国 | 血液脳バリヤーへのリポソームの標的化 |
| US6080772A (en) | 1995-06-07 | 2000-06-27 | Sugen, Inc. | Thiazole compounds and methods of modulating signal transduction |
| CA2293400A1 (en) | 1997-06-13 | 1998-12-17 | Gerald Mcmahon | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction |
| JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
| US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
| AU2001286930A1 (en) | 2000-08-30 | 2002-03-13 | The Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
| US7034036B2 (en) | 2000-10-30 | 2006-04-25 | Pain Therapeutics, Inc. | Inhibitors of ABC drug transporters at the blood-brain barrier |
| DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US20030162695A1 (en) | 2002-02-27 | 2003-08-28 | Schatzberg Alan F. | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
| CA2494700C (en) | 2002-08-26 | 2011-06-28 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| KR101186210B1 (ko) | 2002-12-03 | 2012-10-08 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 혈뇌장벽을 통과하는 물질 수송용 인공 저밀도 지단백질 운반체 |
| JP2006526015A (ja) | 2003-05-02 | 2006-11-16 | エラン ファーマシューティカルズ，インコーポレイテッド | 炎症疾患治療のためのブラジキニンｂ１受容体アンタゴニストとしての４−ブロモ−５−（２−クロロ−ベンゾイルアミノ）−１ｈ−ピラゾール−３−カルボン酸アミド誘導体および関連化合物 |
| EP1663239A4 (en) | 2003-09-10 | 2008-07-23 | Cedars Sinai Medical Center | KALIUM CHANNEL-MEDIATED FEEDING OF MEDICINES BY THE BLOOD BRAIN BARRIER |
| WO2006114706A1 (en) | 2005-04-26 | 2006-11-02 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
| EP2083009A1 (de) | 2008-01-22 | 2009-07-29 | Grünenthal GmbH | Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln |
| US8299077B2 (en) | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| CN101824036A (zh) | 2009-03-05 | 2010-09-08 | 上海恒瑞医药有限公司 | 四氢咪唑并[1，5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用 |
| AR077463A1 (es) | 2009-07-09 | 2011-08-31 | Irm Llc | Derivados de imidazo[1, 2 - a]pirazina y su uso en medicamentos para el tratamiento de enfermedades parasitarias |
| WO2013067260A1 (en) | 2011-11-03 | 2013-05-10 | Genentech, Inc. | Bicyclic piperazine compounds |
| KR20150023445A (ko) | 2012-05-22 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | 치환된 다이피리딜아민 및 이의 용도 |
| TWI498325B (zh) | 2013-01-18 | 2015-09-01 | Hoffmann La Roche | ３－取代吡唑及其用途 |
| TWI637951B (zh) * | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
| JP6523251B2 (ja) | 2013-05-01 | 2019-05-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃ−結合ヘテロシクロアルキル置換ピリミジン類及びそれらの用途 |
| AU2014261894C1 (en) | 2013-05-01 | 2019-07-11 | F. Hoffmann-La Roche Ag | Biheteroaryl compounds and uses thereof |
| KR102306951B1 (ko) | 2013-07-10 | 2021-10-01 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 융합된 피페리딘 아미드 |
| MX2016008110A (es) | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
| PE20161223A1 (es) | 2014-03-26 | 2016-11-12 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa) |
| EP3182974A1 (en) | 2014-08-21 | 2017-06-28 | GlaxoSmithKline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
| WO2016128908A1 (en) * | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| WO2016142310A1 (en) | 2015-03-09 | 2016-09-15 | F. Hoffmann-La Roche Ag | Tricyclic dlk inhibitors and uses thereof |
| WO2017004500A1 (en) | 2015-07-02 | 2017-01-05 | Genentech, Inc. | Bicyclic lactams and methods of use thereof |
| WO2017096301A1 (en) | 2015-12-04 | 2017-06-08 | Denali Therapeutics Inc. | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (ripk 1) |
| US10961258B2 (en) | 2015-12-21 | 2021-03-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| WO2017136727A2 (en) | 2016-02-05 | 2017-08-10 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP3548484A1 (en) | 2016-12-02 | 2019-10-09 | H. Hoffnabb-La Roche Ag | Bicyclic amide compounds and methods of use thereof |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| WO2018128908A1 (en) | 2017-01-05 | 2018-07-12 | Microsoft Technology Licensing, Llc | Redirecting audio output |
| IL271981B (en) | 2017-07-14 | 2022-09-01 | Hoffmann La Roche | Bicyclic ketone compounds and methods of using them |
| RU2020114670A (ru) | 2017-10-11 | 2021-11-12 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения для применения в качестве ингибиторов rip1 киназы |
| PE20211247A1 (es) | 2017-10-31 | 2021-07-13 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos |
-
2018
- 2018-07-12 IL IL271981A patent/IL271981B/en unknown
- 2018-07-12 AU AU2018300043A patent/AU2018300043B2/en active Active
- 2018-07-12 RS RS20240314A patent/RS65308B1/sr unknown
- 2018-07-12 KR KR1020207004030A patent/KR102664604B1/ko active IP Right Grant
- 2018-07-12 LT LTEPPCT/EP2018/068998T patent/LT3652178T/lt unknown
- 2018-07-12 WO PCT/EP2018/068998 patent/WO2019012063A1/en active Application Filing
- 2018-07-12 EP EP18740815.8A patent/EP3652178B1/en active Active
- 2018-07-12 MA MA49560A patent/MA49560B1/fr unknown
- 2018-07-12 CR CR20200002A patent/CR20200002A/es unknown
- 2018-07-12 BR BR112020000771-4A patent/BR112020000771A2/pt unknown
- 2018-07-12 PL PL18740815.8T patent/PL3652178T3/pl unknown
- 2018-07-12 HR HRP20240354TT patent/HRP20240354T1/hr unknown
- 2018-07-12 AR ARP180101941 patent/AR112274A1/es unknown
- 2018-07-12 FI FIEP18740815.8T patent/FI3652178T3/fi active
- 2018-07-12 JP JP2020501256A patent/JP7258843B2/ja active Active
- 2018-07-12 US US16/034,207 patent/US11098058B2/en active Active
- 2018-07-12 CN CN201880046714.2A patent/CN110914271A/zh active Pending
- 2018-07-12 CA CA3185865A patent/CA3185865A1/en active Pending
- 2018-07-12 UA UAA202000831A patent/UA125448C2/uk unknown
- 2018-07-12 KR KR1020247014915A patent/KR20240065201A/ko active Search and Examination
- 2018-07-12 TW TW107124048A patent/TWI805595B/zh active
- 2018-07-12 CA CA3067944A patent/CA3067944C/en active Active
- 2018-07-12 DK DK18740815.8T patent/DK3652178T3/da active
- 2018-07-12 SG SG11202000333UA patent/SG11202000333UA/en unknown
- 2018-07-12 SI SI201831080T patent/SI3652178T1/sl unknown
- 2018-07-12 PT PT187408158T patent/PT3652178T/pt unknown
- 2018-07-12 ES ES18740815T patent/ES2973661T3/es active Active
- 2018-07-12 IL IL294961A patent/IL294961A/en unknown
-
2020
- 2020-01-08 CO CONC2020/0000134A patent/CO2020000134A2/es unknown
- 2020-01-13 CL CL2020000101A patent/CL2020000101A1/es unknown
- 2020-01-14 PH PH12020500105A patent/PH12020500105A1/en unknown
-
2021
- 2021-01-12 US US17/147,449 patent/US11834461B2/en active Active
- 2021-06-26 AU AU2021204369A patent/AU2021204369A1/en not_active Abandoned
-
2023
- 2023-04-05 JP JP2023061174A patent/JP2023085449A/ja active Pending
- 2023-05-25 AU AU2023203292A patent/AU2023203292A1/en active Pending
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