JP2020526501A5 - - Google Patents
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- JP2020526501A5 JP2020526501A5 JP2019572475A JP2019572475A JP2020526501A5 JP 2020526501 A5 JP2020526501 A5 JP 2020526501A5 JP 2019572475 A JP2019572475 A JP 2019572475A JP 2019572475 A JP2019572475 A JP 2019572475A JP 2020526501 A5 JP2020526501 A5 JP 2020526501A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- methyl
- difluoroacetamide
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229940125904 compound 1 Drugs 0.000 claims description 41
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 34
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 34
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- PWBHUSLMHZLGRN-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide Chemical compound ClC1=CC=C(C=C1)C(C(=O)NCC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)(F)F PWBHUSLMHZLGRN-UHFFFAOYSA-N 0.000 description 3
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- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 1
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- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
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Images
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023080568A JP2023113681A (ja) | 2017-06-30 | 2023-05-16 | ２－（４－クロロフェニル）－ｎ－｛［２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル］メチル｝－２，２－ジフルオロアセトアミドの組成物及び使用法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527744P | 2017-06-30 | 2017-06-30 | |
| US62/527,744 | 2017-06-30 | ||
| US201862653436P | 2018-04-05 | 2018-04-05 | |
| US62/653,436 | 2018-04-05 | ||
| US201862673064P | 2018-05-17 | 2018-05-17 | |
| US62/673,064 | 2018-05-17 | ||
| PCT/US2018/040286 WO2019006299A1 (en) | 2017-06-30 | 2018-06-29 | COMPOSITIONS AND METHODS FOR THE USE OF 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-YL) -1-OXOISOINDOLIN-5-YL) METHYL) -2,2-DIFLUOROACETAMIDE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023080568A Division JP2023113681A (ja) | 2017-06-30 | 2023-05-16 | ２－（４－クロロフェニル）－ｎ－｛［２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル］メチル｝－２，２－ジフルオロアセトアミドの組成物及び使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020526501A JP2020526501A (ja) | 2020-08-31 |
| JP2020526501A5 true JP2020526501A5 (https=) | 2021-08-26 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572475A Pending JP2020526501A (ja) | 2017-06-30 | 2018-06-29 | ２−（４−クロロフェニル）−ｎ−｛［２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン−５−イル］メチル｝−２，２−ジフルオロアセトアミドの組成物及び使用法 |
| JP2023080568A Pending JP2023113681A (ja) | 2017-06-30 | 2023-05-16 | ２－（４－クロロフェニル）－ｎ－｛［２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル］メチル｝－２，２－ジフルオロアセトアミドの組成物及び使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023080568A Pending JP2023113681A (ja) | 2017-06-30 | 2023-05-16 | ２－（４－クロロフェニル）－ｎ－｛［２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル］メチル｝－２，２－ジフルオロアセトアミドの組成物及び使用法 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20190030018A1 (https=) |
| EP (2) | EP4201399A3 (https=) |
| JP (2) | JP2020526501A (https=) |
| KR (1) | KR20200020899A (https=) |
| CN (1) | CN111032043A (https=) |
| AU (1) | AU2018294327A1 (https=) |
| BR (1) | BR112019028101A2 (https=) |
| CA (1) | CA3068591A1 (https=) |
| CL (1) | CL2019003857A1 (https=) |
| DK (1) | DK3644999T3 (https=) |
| ES (1) | ES2939739T3 (https=) |
| FI (1) | FI3644999T3 (https=) |
| HR (1) | HRP20230210T1 (https=) |
| HU (1) | HUE061356T2 (https=) |
| IL (1) | IL271726A (https=) |
| LT (1) | LT3644999T (https=) |
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| TW202423434A (zh) * | 2022-10-07 | 2024-06-16 | 瑞士商歐庫利斯營運股份有限公司 | mTOR抑制劑的點眼劑微懸液 |
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-
2018
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- 2018-06-29 BR BR112019028101-0A patent/BR112019028101A2/pt not_active Application Discontinuation
- 2018-06-29 PT PT188237192T patent/PT3644999T/pt unknown
- 2018-06-29 MX MX2019015886A patent/MX2019015886A/es unknown
- 2018-06-29 SM SM20230068T patent/SMT202300068T1/it unknown
- 2018-06-29 SG SG11201913008TA patent/SG11201913008TA/en unknown
- 2018-06-29 EP EP18823719.2A patent/EP3644999B1/en active Active
- 2018-06-29 JP JP2019572475A patent/JP2020526501A/ja active Pending
- 2018-06-29 ES ES18823719T patent/ES2939739T3/es active Active
- 2018-06-29 HU HUE18823719A patent/HUE061356T2/hu unknown
- 2018-06-29 CN CN201880056213.2A patent/CN111032043A/zh active Pending
- 2018-06-29 PL PL18823719.2T patent/PL3644999T3/pl unknown
- 2018-06-29 US US16/024,581 patent/US20190030018A1/en not_active Abandoned
- 2018-06-29 DK DK18823719.2T patent/DK3644999T3/da active
- 2018-06-29 KR KR1020207002231A patent/KR20200020899A/ko not_active Withdrawn
- 2018-06-29 HR HRP20230210TT patent/HRP20230210T1/hr unknown
- 2018-06-29 SI SI201830859T patent/SI3644999T1/sl unknown
- 2018-06-29 AU AU2018294327A patent/AU2018294327A1/en not_active Abandoned
- 2018-06-29 RS RS20230153A patent/RS64029B1/sr unknown
- 2018-06-29 WO PCT/US2018/040286 patent/WO2019006299A1/en not_active Ceased
- 2018-06-29 LT LTEPPCT/US2018/040286T patent/LT3644999T/lt unknown
- 2018-06-29 CA CA3068591A patent/CA3068591A1/en active Pending
- 2018-06-29 FI FIEP18823719.2T patent/FI3644999T3/fi active
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2019
- 2019-12-20 MX MX2022001410A patent/MX2022001410A/es unknown
- 2019-12-23 ZA ZA2019/08605A patent/ZA201908605B/en unknown
- 2019-12-26 IL IL271726A patent/IL271726A/en unknown
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2023
- 2023-05-16 JP JP2023080568A patent/JP2023113681A/ja active Pending
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