SI3644999T1 - Sestavki in postopki uporabe 2-(4-klorofenil)-N-((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-5-il) metil)-2,2-difluoroacetamida - Google Patents
Sestavki in postopki uporabe 2-(4-klorofenil)-N-((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-5-il) metil)-2,2-difluoroacetamidaInfo
- Publication number
- SI3644999T1 SI3644999T1 SI201830859T SI201830859T SI3644999T1 SI 3644999 T1 SI3644999 T1 SI 3644999T1 SI 201830859 T SI201830859 T SI 201830859T SI 201830859 T SI201830859 T SI 201830859T SI 3644999 T1 SI3644999 T1 SI 3644999T1
- Authority
- SI
- Slovenia
- Prior art keywords
- difluoroacetamide
- dioxopiperidin
- oxoisoindolin
- chlorophenyl
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762527744P | 2017-06-30 | 2017-06-30 | |
US201862653436P | 2018-04-05 | 2018-04-05 | |
US201862673064P | 2018-05-17 | 2018-05-17 | |
PCT/US2018/040286 WO2019006299A1 (en) | 2017-06-30 | 2018-06-29 | COMPOSITIONS AND METHODS FOR THE USE OF 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-YL) -1-OXOISOINDOLIN-5-YL) METHYL) -2,2-DIFLUOROACETAMIDE |
EP18823719.2A EP3644999B1 (en) | 2017-06-30 | 2018-06-29 | Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3644999T1 true SI3644999T1 (sl) | 2023-04-28 |
Family
ID=64741897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201830859T SI3644999T1 (sl) | 2017-06-30 | 2018-06-29 | Sestavki in postopki uporabe 2-(4-klorofenil)-N-((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-5-il) metil)-2,2-difluoroacetamida |
Country Status (24)
Country | Link |
---|---|
US (1) | US20190030018A1 (sl) |
EP (2) | EP3644999B1 (sl) |
JP (2) | JP2020526501A (sl) |
KR (1) | KR20200020899A (sl) |
CN (1) | CN111032043A (sl) |
AU (1) | AU2018294327A1 (sl) |
BR (1) | BR112019028101A2 (sl) |
CA (1) | CA3068591A1 (sl) |
CL (1) | CL2019003857A1 (sl) |
DK (1) | DK3644999T3 (sl) |
ES (1) | ES2939739T3 (sl) |
FI (1) | FI3644999T3 (sl) |
HR (1) | HRP20230210T1 (sl) |
HU (1) | HUE061356T2 (sl) |
IL (1) | IL271726A (sl) |
LT (1) | LT3644999T (sl) |
MX (2) | MX2019015886A (sl) |
PL (1) | PL3644999T3 (sl) |
PT (1) | PT3644999T (sl) |
RS (1) | RS64029B1 (sl) |
SG (1) | SG11201913008TA (sl) |
SI (1) | SI3644999T1 (sl) |
WO (1) | WO2019006299A1 (sl) |
ZA (1) | ZA201908605B (sl) |
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CA3125753A1 (en) * | 2019-01-09 | 2020-07-16 | Celgene Corporation | Antiproliferative compounds and second active agents for use in treating multiple myeloma |
US20220378773A1 (en) * | 2019-10-28 | 2022-12-01 | Celgene Corporation | Methods for treating leukemia and use of a leukemic stem cell signature to predict clinical sensitivity to therapies |
JP2023500482A (ja) * | 2019-10-28 | 2023-01-06 | セルジーン コーポレーション | 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドに対する臨床的感受性を予測するためのバイオマーカーの使用 |
AU2020382214B2 (en) * | 2019-11-13 | 2023-07-06 | Taiho Pharmaceutical Co., Ltd. | Novel salt of terphenyl compound |
IL296557A (en) * | 2020-03-16 | 2022-11-01 | Celgene Corp | Combined treatment for acute myeloid leukemia |
US20240050428A1 (en) * | 2020-10-07 | 2024-02-15 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
EP4277901A1 (en) | 2021-01-13 | 2023-11-22 | Monte Rosa Therapeutics, Inc. | Isoindolinone compounds |
CN113125602A (zh) * | 2021-04-16 | 2021-07-16 | 山东铂源药业有限公司 | 一种哌柏西利中残留溶剂的检测方法 |
WO2024015855A1 (en) * | 2022-07-13 | 2024-01-18 | Monte Rosa Therapeutics, Inc. | COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS |
WO2024074699A1 (en) * | 2022-10-07 | 2024-04-11 | Oculis Operations Sarl | Eye drop microsuspensions of mtor inhibitors |
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2018
- 2018-06-29 LT LTEPPCT/US2018/040286T patent/LT3644999T/lt unknown
- 2018-06-29 CA CA3068591A patent/CA3068591A1/en active Pending
- 2018-06-29 US US16/024,581 patent/US20190030018A1/en not_active Abandoned
- 2018-06-29 CN CN201880056213.2A patent/CN111032043A/zh active Pending
- 2018-06-29 BR BR112019028101-0A patent/BR112019028101A2/pt not_active Application Discontinuation
- 2018-06-29 PT PT188237192T patent/PT3644999T/pt unknown
- 2018-06-29 JP JP2019572475A patent/JP2020526501A/ja active Pending
- 2018-06-29 KR KR1020207002231A patent/KR20200020899A/ko not_active Application Discontinuation
- 2018-06-29 PL PL18823719.2T patent/PL3644999T3/pl unknown
- 2018-06-29 WO PCT/US2018/040286 patent/WO2019006299A1/en active Application Filing
- 2018-06-29 EP EP18823719.2A patent/EP3644999B1/en active Active
- 2018-06-29 HU HUE18823719A patent/HUE061356T2/hu unknown
- 2018-06-29 HR HRP20230210TT patent/HRP20230210T1/hr unknown
- 2018-06-29 FI FIEP18823719.2T patent/FI3644999T3/fi active
- 2018-06-29 SI SI201830859T patent/SI3644999T1/sl unknown
- 2018-06-29 MX MX2019015886A patent/MX2019015886A/es unknown
- 2018-06-29 DK DK18823719.2T patent/DK3644999T3/da active
- 2018-06-29 SG SG11201913008TA patent/SG11201913008TA/en unknown
- 2018-06-29 EP EP22212562.7A patent/EP4201399A3/en active Pending
- 2018-06-29 ES ES18823719T patent/ES2939739T3/es active Active
- 2018-06-29 RS RS20230153A patent/RS64029B1/sr unknown
- 2018-06-29 AU AU2018294327A patent/AU2018294327A1/en active Pending
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2019
- 2019-12-20 MX MX2022001410A patent/MX2022001410A/es unknown
- 2019-12-23 ZA ZA2019/08605A patent/ZA201908605B/en unknown
- 2019-12-26 CL CL2019003857A patent/CL2019003857A1/es unknown
- 2019-12-26 IL IL271726A patent/IL271726A/en unknown
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2023
- 2023-05-16 JP JP2023080568A patent/JP2023113681A/ja active Pending
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MX2019015886A (es) | 2020-09-10 |
IL271726A (en) | 2020-02-27 |
EP3644999B1 (en) | 2022-12-14 |
CN111032043A (zh) | 2020-04-17 |
EP4201399A2 (en) | 2023-06-28 |
PL3644999T3 (pl) | 2023-05-08 |
EP3644999A4 (en) | 2021-08-04 |
HRP20230210T1 (hr) | 2023-04-14 |
SG11201913008TA (en) | 2020-01-30 |
EP4201399A3 (en) | 2023-08-09 |
WO2019006299A1 (en) | 2019-01-03 |
CL2019003857A1 (es) | 2020-07-03 |
PT3644999T (pt) | 2023-03-10 |
BR112019028101A2 (pt) | 2020-07-28 |
HUE061356T2 (hu) | 2023-06-28 |
KR20200020899A (ko) | 2020-02-26 |
US20190030018A1 (en) | 2019-01-31 |
RS64029B1 (sr) | 2023-03-31 |
EP3644999A1 (en) | 2020-05-06 |
AU2018294327A1 (en) | 2020-01-23 |
JP2023113681A (ja) | 2023-08-16 |
DK3644999T3 (da) | 2023-03-06 |
ZA201908605B (en) | 2023-04-26 |
JP2020526501A (ja) | 2020-08-31 |
MX2022001410A (es) | 2022-06-09 |
LT3644999T (lt) | 2023-03-10 |
CA3068591A1 (en) | 2019-01-03 |
FI3644999T3 (fi) | 2023-03-19 |
ES2939739T3 (es) | 2023-04-26 |
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