JP2022515670A5 - - Google Patents

Info

Publication number
JP2022515670A5
JP2022515670A5 JP2021538284A JP2021538284A JP2022515670A5 JP 2022515670 A5 JP2022515670 A5 JP 2022515670A5 JP 2021538284 A JP2021538284 A JP 2021538284A JP 2021538284 A JP2021538284 A JP 2021538284A JP 2022515670 A5 JP2022515670 A5 JP 2022515670A5
Authority
JP
Japan
Prior art keywords
formulation
approximately
leukemia
stereoisomers
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021538284A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022515670A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/068924 external-priority patent/WO2020142422A1/en
Publication of JP2022515670A publication Critical patent/JP2022515670A/ja
Publication of JP2022515670A5 publication Critical patent/JP2022515670A5/ja
Pending legal-status Critical Current

Links

JP2021538284A 2018-12-31 2019-12-30 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドの組成物及び使用方法 Pending JP2022515670A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862787034P 2018-12-31 2018-12-31
US62/787,034 2018-12-31
PCT/US2019/068924 WO2020142422A1 (en) 2018-12-31 2019-12-30 Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5yl) methyl)-2,2-difluoroacetamide

Publications (2)

Publication Number Publication Date
JP2022515670A JP2022515670A (ja) 2022-02-21
JP2022515670A5 true JP2022515670A5 (https=) 2023-02-22

Family

ID=71121614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021538284A Pending JP2022515670A (ja) 2018-12-31 2019-12-30 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドの組成物及び使用方法

Country Status (13)

Country Link
US (1) US20200206212A1 (https=)
EP (1) EP3906030A4 (https=)
JP (1) JP2022515670A (https=)
KR (1) KR20210110616A (https=)
CN (1) CN113347974A (https=)
AU (1) AU2019418587A1 (https=)
BR (1) BR112021012578A2 (https=)
CA (1) CA3125189A1 (https=)
EA (1) EA202191833A1 (https=)
IL (1) IL284509A (https=)
MX (1) MX2021007800A (https=)
SG (1) SG11202106598QA (https=)
WO (1) WO2020142422A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601777B (zh) 2016-01-08 2021-08-03 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂
JP2022554346A (ja) 2019-11-05 2022-12-28 セルジーン コーポレーション 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドとの併用療法
MX2022006133A (es) 2019-12-06 2022-06-17 Celgene Corp Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
US20240294489A1 (en) * 2020-08-03 2024-09-05 Captor Therapeutics S.A. Low molecular weight protein degraders and their applications
EP4572804A2 (en) * 2022-08-17 2025-06-25 The Regents of the University of California Inhalable compositions of cdk9 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499514B2 (en) * 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
CN108601777B (zh) * 2016-01-08 2021-08-03 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂
US10245258B2 (en) * 2016-06-06 2019-04-02 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Similar Documents

Publication Publication Date Title
JP2022515670A5 (https=)
US20230212201A1 (en) Stat3 degraders and uses thereof
JP2020526501A5 (https=)
KR20240167633A (ko) 종양 치료용 약학 조성물
RU2708247C2 (ru) Соединение для лечения рака
KR20220148847A (ko) 다브라페닙, erk 억제제, 및 shp2 억제제를 포함하는 삼중 약학적 조합물
JP2023504230A (ja) Prmt5阻害剤の組合せ医薬
CN108366992A (zh) 蛋白水解靶向嵌合体化合物及其制备和应用方法
KR102282794B1 (ko) 인돌리논 화합물의 용도
WO2015154725A1 (zh) 喹唑啉衍生物及其制备方法和在医药上的应用
JP2018512403A (ja) 置換2,3−ジヒドロイミダゾ[1,2−c]キナゾリン類の使用
JPWO2021060453A5 (https=)
Zhong et al. Recent advances in small molecule inhibitors of VEGFR and EGFR signaling pathways
CN119403808A (zh) 用于医学治疗的细胞周期蛋白依赖性激酶2抑制剂
KR20200102948A (ko) Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
CA3233554A1 (en) Combination therapy using a ptpn11 inhibitor and a kras g12c inhibitor
JP5344910B2 (ja) 薬剤耐性癌の処置方法
TW201636350A (zh) 作為激酶調節劑之三唑並嗒
WO2014177915A1 (en) Cancer combination therapy using imidazo[4,5-c]quinoline derivatives
CA3213359A1 (en) Alk-5 inhibitors and uses thereof
CN113490497A (zh) 包括flt3抑制剂和低甲基化剂的用于治疗急性髓系白血病的药物组合物
CN116261455A (zh) 一种药物组合物及其在治疗癌症中的用途
EP4615869A1 (en) Combination therapy comprising bispecific antibodies comprising an nrp1 binding domain
KR20250166103A (ko) 종양 치료용 약제학적 조성물
HK40107305A (zh) Mcl-1抑制剂与抗癌剂的组合