CN113347974A - 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 - Google Patents

2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 Download PDF

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CN113347974A
CN113347974A CN201980090422.3A CN201980090422A CN113347974A CN 113347974 A CN113347974 A CN 113347974A CN 201980090422 A CN201980090422 A CN 201980090422A CN 113347974 A CN113347974 A CN 113347974A
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formulation
compound
inhibitors
inhibitor
amount
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Chinese (zh)
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罗威娜·费尔南德斯·乔德里
威拉德·福斯
许哲雄
阿莫勒·蒙吉卡尔
樸兪
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Celgene Corp
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Celgene Corp
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    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980090422.3A 2018-12-31 2019-12-30 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 Pending CN113347974A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862787034P 2018-12-31 2018-12-31
US62/787,034 2018-12-31
PCT/US2019/068924 WO2020142422A1 (en) 2018-12-31 2019-12-30 Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5yl) methyl)-2,2-difluoroacetamide

Publications (1)

Publication Number Publication Date
CN113347974A true CN113347974A (zh) 2021-09-03

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CN201980090422.3A Pending CN113347974A (zh) 2018-12-31 2019-12-30 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法

Country Status (13)

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US (1) US20200206212A1 (https=)
EP (1) EP3906030A4 (https=)
JP (1) JP2022515670A (https=)
KR (1) KR20210110616A (https=)
CN (1) CN113347974A (https=)
AU (1) AU2019418587A1 (https=)
BR (1) BR112021012578A2 (https=)
CA (1) CA3125189A1 (https=)
EA (1) EA202191833A1 (https=)
IL (1) IL284509A (https=)
MX (1) MX2021007800A (https=)
SG (1) SG11202106598QA (https=)
WO (1) WO2020142422A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601777B (zh) 2016-01-08 2021-08-03 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂
JP2022554346A (ja) 2019-11-05 2022-12-28 セルジーン コーポレーション ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドとの併用療法
MX2022006133A (es) 2019-12-06 2022-06-17 Celgene Corp Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
US20240294489A1 (en) * 2020-08-03 2024-09-05 Captor Therapeutics S.A. Low molecular weight protein degraders and their applications
EP4572804A2 (en) * 2022-08-17 2025-06-25 The Regents of the University of California Inhalable compositions of cdk9 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170348298A1 (en) * 2016-06-06 2017-12-07 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CN108601777A (zh) * 2016-01-08 2018-09-28 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499514B2 (en) * 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601777A (zh) * 2016-01-08 2018-09-28 细胞基因公司 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂
US20170348298A1 (en) * 2016-06-06 2017-12-07 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

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EA202191833A1 (ru) 2021-10-11
US20200206212A1 (en) 2020-07-02
CA3125189A1 (en) 2020-07-09
EP3906030A4 (en) 2022-09-07
MX2021007800A (es) 2021-10-26
JP2022515670A (ja) 2022-02-21
KR20210110616A (ko) 2021-09-08
AU2019418587A1 (en) 2021-07-22
BR112021012578A2 (pt) 2021-09-08
WO2020142422A1 (en) 2020-07-09
IL284509A (en) 2021-08-31
SG11202106598QA (en) 2021-07-29
EP3906030A1 (en) 2021-11-10

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Application publication date: 20210903