JP2020524675A5 - - Google Patents
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- JP2020524675A5 JP2020524675A5 JP2019569931A JP2019569931A JP2020524675A5 JP 2020524675 A5 JP2020524675 A5 JP 2020524675A5 JP 2019569931 A JP2019569931 A JP 2019569931A JP 2019569931 A JP2019569931 A JP 2019569931A JP 2020524675 A5 JP2020524675 A5 JP 2020524675A5
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- JP
- Japan
- Prior art keywords
- moiety
- adc
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- conjugation
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- Prior art date
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- LIXLFMBECHROQQ-FBLRIXIVSA-N CC(C)N(C)Cc1nc([C@@](C[C@@H](c2c(c(C(c(c3ccc4)c4OC)=O)c4C3=O)O)O[C@@H]3O[C@@H](C)[C@H]5O[C@H](COCC6)N6[C@H]5C3)(Cc2c4O)O)c[s]1 Chemical compound CC(C)N(C)Cc1nc([C@@](C[C@@H](c2c(c(C(c(c3ccc4)c4OC)=O)c4C3=O)O)O[C@@H]3O[C@@H](C)[C@H]5O[C@H](COCC6)N6[C@H]5C3)(Cc2c4O)O)c[s]1 LIXLFMBECHROQQ-FBLRIXIVSA-N 0.000 description 1
- 0 CC[C@](C)[C@@]([C@@](CC(N(CCC1)[C@@]1C([C@@](C)C(N[C@](C*)Cc1ccccc1)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)C(C)C)=O)=O Chemical compound CC[C@](C)[C@@]([C@@](CC(N(CCC1)[C@@]1C([C@@](C)C(N[C@](C*)Cc1ccccc1)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)C(C)C)=O)=O 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023131993A JP2023138866A (ja) | 2017-06-20 | 2023-08-14 | Ｃｄ３８抗体薬物コンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522516P | 2017-06-20 | 2017-06-20 | |
| US62/522,516 | 2017-06-20 | ||
| US201762553438P | 2017-09-01 | 2017-09-01 | |
| US62/553,438 | 2017-09-01 | ||
| PCT/IB2018/054564 WO2018235024A1 (en) | 2017-06-20 | 2018-06-20 | Cd38 antibody drug conjugate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131993A Division JP2023138866A (ja) | 2017-06-20 | 2023-08-14 | Ｃｄ３８抗体薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524675A JP2020524675A (ja) | 2020-08-20 |
| JP2020524675A5 true JP2020524675A5 (https=) | 2021-07-29 |
| JP7359700B2 JP7359700B2 (ja) | 2023-10-11 |
Family
ID=63036271
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019569931A Active JP7359700B2 (ja) | 2017-06-20 | 2018-06-20 | Ｃｄ３８抗体薬物コンジュゲート |
| JP2023131993A Pending JP2023138866A (ja) | 2017-06-20 | 2023-08-14 | Ｃｄ３８抗体薬物コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131993A Pending JP2023138866A (ja) | 2017-06-20 | 2023-08-14 | Ｃｄ３８抗体薬物コンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11191845B2 (https=) |
| EP (2) | EP3641831B1 (https=) |
| JP (2) | JP7359700B2 (https=) |
| KR (1) | KR102771835B1 (https=) |
| CN (1) | CN110997009B (https=) |
| AU (1) | AU2018288463A1 (https=) |
| CA (1) | CA3067311A1 (https=) |
| ES (1) | ES2996334T3 (https=) |
| WO (1) | WO2018235024A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3103114A1 (en) | 2018-06-20 | 2019-12-26 | Sorrento Therapeutics, Inc. | Variant antibody that binds cd38 |
| EP3636284A1 (en) * | 2018-10-11 | 2020-04-15 | NBE Therapeutics AG | Binding protein-toxin conjugates comprising anthracyclines, and use thereof in immune-oncological applications |
| CA3134612A1 (en) * | 2019-03-29 | 2020-10-08 | Sorrento Therapeutics, Inc. | Engineered variant antibodies that bind cd38 |
| GB201908886D0 (en) * | 2019-06-20 | 2019-08-07 | Almac Discovery Ltd | Anthracycline derivatives |
| WO2021115497A2 (zh) * | 2020-12-08 | 2021-06-17 | 和铂医药(上海)有限责任公司 | 蛋白-药物偶联物和定点偶联方法 |
| US20240181073A1 (en) | 2021-03-03 | 2024-06-06 | Sorrento Therapeutics, Inc. | Antibody-Drug Conjugates Comprising an Anti-BCMA Antibody |
| CN113181373B (zh) * | 2021-05-10 | 2024-03-01 | 深圳安特生物医药科技有限公司 | 一种抗体药物偶联制剂及其制备方法和应用 |
| JP2024546152A (ja) * | 2021-12-16 | 2024-12-17 | 上海宝済薬業股▲ふん▼有限公司 | 免疫グロブリン分解酵素による切断に対抗するＦｃ変異体 |
| EP4489790A1 (en) | 2022-03-10 | 2025-01-15 | Vivasor, Inc. | Antibody-drug conjugates and uses thereof |
| EP4522223A1 (en) * | 2022-05-10 | 2025-03-19 | Vivasor, Inc. | Antibody-drug conjugates comprising an anti-folr1 antibody |
| CN116621927B (zh) * | 2023-01-09 | 2024-03-26 | 联宁（苏州）生物制药有限公司 | 带有伊喜替康和C-lock定点偶联基团的抗体偶联中间体、偶联方法及抗体偶联药物 |
| CN121969397A (zh) | 2023-04-05 | 2026-05-01 | 维硕公司 | 抗体偶联药物及其用途 |
| CN121969398A (zh) | 2023-04-05 | 2026-05-01 | 维硕公司 | 抗体偶联药物及其用途 |
| WO2024211235A1 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024235130A1 (zh) * | 2023-05-12 | 2024-11-21 | 四川科伦博泰生物医药股份有限公司 | 多环化合物及其制备方法和用途 |
| CN117659041A (zh) * | 2023-12-08 | 2024-03-08 | 联宁（苏州）生物制药有限公司 | 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140066259A (ko) | 2004-02-06 | 2014-05-30 | 모르포시스 아게 | 항-ｃｄ３８ 인간 항체 및 그의 용도 |
| JP2008521828A (ja) | 2004-11-29 | 2008-06-26 | シアトル ジェネティックス， インコーポレイテッド | 操作された抗体およびイムノコンジュゲート |
| EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| SG189817A1 (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
| SMT202000031T1 (it) | 2010-06-09 | 2020-03-13 | Genmab As | Anticorpi contro cd38 umano |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| CN104640572B (zh) * | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| RU2639287C2 (ru) * | 2012-06-27 | 2017-12-20 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения |
| CN104411337A (zh) * | 2012-07-09 | 2015-03-11 | 基因泰克公司 | 包含抗cd79b抗体的免疫偶联物 |
| BR112015027313A2 (pt) * | 2013-04-29 | 2017-09-26 | Teva Pharmaceuticals Australia Pty Ltd | anticorpos anti-cd38 e fusões ao interferon alfa-2b atenuado |
| JP2017506640A (ja) * | 2014-02-14 | 2017-03-09 | セントローズ， エルエルシー | 細胞外標的化薬物共役体 |
| EP3250238B1 (en) | 2015-01-28 | 2022-06-01 | Sorrento Therapeutics, Inc. | Antibody drug conjugates |
| US20170224835A1 (en) | 2015-02-06 | 2017-08-10 | Sorrento Therapeutics, Inc. | Antibody Drug Conjugates |
| US9951144B2 (en) * | 2015-04-08 | 2018-04-24 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD38 |
-
2018
- 2018-06-20 EP EP18746292.4A patent/EP3641831B1/en active Active
- 2018-06-20 JP JP2019569931A patent/JP7359700B2/ja active Active
- 2018-06-20 US US16/013,828 patent/US11191845B2/en active Active
- 2018-06-20 CN CN201880051692.9A patent/CN110997009B/zh active Active
- 2018-06-20 AU AU2018288463A patent/AU2018288463A1/en not_active Abandoned
- 2018-06-20 CA CA3067311A patent/CA3067311A1/en active Pending
- 2018-06-20 KR KR1020207001730A patent/KR102771835B1/ko active Active
- 2018-06-20 WO PCT/IB2018/054564 patent/WO2018235024A1/en not_active Ceased
- 2018-06-20 ES ES18746292T patent/ES2996334T3/es active Active
- 2018-06-20 EP EP24208209.7A patent/EP4509143A3/en active Pending
-
2021
- 2021-11-03 US US17/518,375 patent/US20220118105A1/en active Pending
-
2023
- 2023-08-14 JP JP2023131993A patent/JP2023138866A/ja active Pending
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