JP2023540732A5 - - Google Patents
Info
- Publication number
- JP2023540732A5 JP2023540732A5 JP2023514907A JP2023514907A JP2023540732A5 JP 2023540732 A5 JP2023540732 A5 JP 2023540732A5 JP 2023514907 A JP2023514907 A JP 2023514907A JP 2023514907 A JP2023514907 A JP 2023514907A JP 2023540732 A5 JP2023540732 A5 JP 2023540732A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- cdr2
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20194711 | 2020-09-04 | ||
| EP20194711.6 | 2020-09-04 | ||
| EP20195559.8 | 2020-09-10 | ||
| EP20195559 | 2020-09-10 | ||
| PCT/EP2021/072595 WO2022048883A1 (en) | 2020-09-04 | 2021-08-13 | Anti-ceacam5 antibodies and conjugates and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023540732A JP2023540732A (ja) | 2023-09-26 |
| JP2023540732A5 true JP2023540732A5 (https=) | 2024-08-21 |
| JP7848189B2 JP7848189B2 (ja) | 2026-04-20 |
Family
ID=77543503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023514907A Active JP7848189B2 (ja) | 2020-09-04 | 2021-08-13 | 抗ceacam5抗体及びコンジュゲート並びにそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20250122282A2 (https=) |
| EP (2) | EP4725500A2 (https=) |
| JP (1) | JP7848189B2 (https=) |
| KR (1) | KR20230062600A (https=) |
| CN (1) | CN116113439A (https=) |
| AU (1) | AU2021335257A1 (https=) |
| BR (1) | BR112023001733A2 (https=) |
| CA (1) | CA3190586A1 (https=) |
| CL (2) | CL2023000630A1 (https=) |
| CO (1) | CO2023004252A2 (https=) |
| IL (1) | IL301004A (https=) |
| MX (1) | MX2023002330A (https=) |
| PH (1) | PH12023550266A1 (https=) |
| TW (1) | TW202212362A (https=) |
| WO (1) | WO2022048883A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN116390771A (zh) | 2020-07-13 | 2023-07-04 | 瑞泽恩制药公司 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
| JP2023541637A (ja) * | 2020-09-15 | 2023-10-03 | シンアフィックス ビー.ブイ. | 抗体-エクサテカンコンジュゲート |
| CA3241734A1 (en) * | 2022-01-12 | 2023-07-20 | Amy Han | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
| WO2023172968A1 (en) * | 2022-03-09 | 2023-09-14 | Merck Patent Gmbh | Anti-gd2 antibodies, immunoconjugates and therapeutic uses thereof |
| WO2024091437A1 (en) * | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof |
| EP4619045A1 (en) * | 2022-11-17 | 2025-09-24 | Sanofi | Ceacam5 antibody-drug conjugates and methods of use thereof |
| TW202434306A (zh) * | 2022-11-24 | 2024-09-01 | 瑞士商百濟神州瑞士有限責任公司 | 抗cea抗體藥物軛合物及使用方法 |
| EP4410313A1 (en) | 2023-01-31 | 2024-08-07 | Synaffix B.V. | Homogeneous antibody-conjugates with high payload loading |
| KR20250169306A (ko) | 2023-04-18 | 2025-12-02 | 아스트라제네카 아베 | 절단가능한 링커를 포함하는 접합체 |
| CN121219019A (zh) | 2023-05-05 | 2025-12-26 | 百欧恩泰欧洲股份公司 | 用于增强靶向癌症相关抗原的采用新型连接子-有效载荷系统的抗体药物偶联物 |
| WO2024250925A1 (en) * | 2023-06-05 | 2024-12-12 | Nona Biosciences (Suzhou) Co., Ltd. | Anti-ceacam5 antibodies |
| WO2025100827A1 (ko) * | 2023-11-09 | 2025-05-15 | 주식회사 다안바이오테라퓨틱스 | 항 ceacam5 항체 및 이의 용도 |
| US20250186604A1 (en) * | 2023-12-06 | 2025-06-12 | Adc Therapeutics Sa | Anti-psma antibody conjugates |
| WO2025130991A1 (zh) * | 2023-12-22 | 2025-06-26 | 上海亲合力生物医药科技股份有限公司 | 肿瘤微环境激活的药物偶联物及抗体药物偶联物 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| US12521446B2 (en) | 2024-02-27 | 2026-01-13 | Bristol-Myers Squibb Company | Anti-CEACAM5 antibody drug conjugates |
| TW202602918A (zh) | 2024-04-12 | 2026-01-16 | 大陸商四川科倫博泰生物醫藥股份有限公司 | Ceacam5結合蛋白及其用途 |
| WO2025242091A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技(成都)有限公司 | 针对ceacam5的抗体及其用途 |
| WO2025242099A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技(成都)有限公司 | 针对cdh17的抗体偶联药物及其用途 |
| WO2025242098A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技(成都)有限公司 | 针对ceacam5的抗体偶联药物及其用途 |
| WO2025242845A1 (en) | 2024-05-22 | 2025-11-27 | Merck Patent Gmbh | Colorectal cancer treatment |
| WO2026012312A1 (en) | 2024-07-09 | 2026-01-15 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Anti-ceacam5 antibody-drug conjugate and method for preparation and use thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US244A (en) | 1837-06-30 | Edward flint | ||
| US5204A (en) | 1847-07-24 | james cantelo | ||
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| DE69535243T2 (de) | 1994-07-13 | 2007-05-10 | Chugai Seiyaku K.K. | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| ES2233974T3 (es) | 1995-09-11 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Anticuerpo contra la cadena alfa del receptor de la interleucina 5 humana. |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| JP2001522241A (ja) | 1997-04-10 | 2001-11-13 | ロイヤル ネザーランズ アカデミー オブ アーツ アンド サイエンシズ | 診断方法および試薬 |
| GB0308731D0 (en) | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
| WO2004094613A2 (en) | 2003-04-22 | 2004-11-04 | Ibc Pharmaceuticals | Polyvalent protein complex |
| MX2009000709A (es) | 2006-07-18 | 2009-02-04 | Sanofi Aventis | Anticuerpo antagonista contra epha2 para el tratamiento de cancer. |
| MX338397B (es) | 2007-08-29 | 2016-04-15 | Sanofi Aventis | Anticuerpos anti - cxcr5 humanizados, derivados de los mismos y su uso. |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP2478110B1 (en) * | 2009-09-16 | 2016-01-06 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
| DK3199552T3 (da) * | 2012-11-20 | 2020-03-30 | Sanofi Sa | Anti-ceacam5-antistoffer og anvendelser heraf |
-
2021
- 2021-08-13 AU AU2021335257A patent/AU2021335257A1/en active Pending
- 2021-08-13 BR BR112023001733A patent/BR112023001733A2/pt unknown
- 2021-08-13 EP EP26161788.0A patent/EP4725500A2/en active Pending
- 2021-08-13 CA CA3190586A patent/CA3190586A1/en active Pending
- 2021-08-13 CN CN202180054670.XA patent/CN116113439A/zh active Pending
- 2021-08-13 US US18/043,715 patent/US20250122282A2/en active Pending
- 2021-08-13 PH PH1/2023/550266A patent/PH12023550266A1/en unknown
- 2021-08-13 KR KR1020237011156A patent/KR20230062600A/ko active Pending
- 2021-08-13 MX MX2023002330A patent/MX2023002330A/es unknown
- 2021-08-13 WO PCT/EP2021/072595 patent/WO2022048883A1/en not_active Ceased
- 2021-08-13 IL IL301004A patent/IL301004A/en unknown
- 2021-08-13 EP EP21762680.3A patent/EP4208481B1/en active Active
- 2021-08-13 JP JP2023514907A patent/JP7848189B2/ja active Active
- 2021-08-19 TW TW110130639A patent/TW202212362A/zh unknown
-
2023
- 2023-03-03 CL CL2023000630A patent/CL2023000630A1/es unknown
- 2023-03-31 CO CONC2023/0004252A patent/CO2023004252A2/es unknown
-
2025
- 2025-09-03 CL CL2025002681A patent/CL2025002681A1/es unknown
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