JP2020524675A5 - - Google Patents

Info

Publication number

JP2020524675A5

JP2020524675A5 JP2019569931A JP2019569931A JP2020524675A5 JP 2020524675 A5 JP2020524675 A5 JP 2020524675A5 JP 2019569931 A JP2019569931 A JP 2019569931A JP 2019569931 A JP2019569931 A JP 2019569931A JP 2020524675 A5 JP2020524675 A5 JP 2020524675A5

Authority

JP

Japan

Prior art keywords

moiety

adc

linker

conjugation

composition according

Prior art date

2018-06-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000005647 linker group Chemical group 0.000 claims description 20
• 239000000611 antibody drug conjugate Substances 0.000 claims description 19
• 229940049595 antibody-drug conjugate Drugs 0.000 claims description 19
• 230000021615 conjugation Effects 0.000 claims description 15
• 239000000203 mixture Substances 0.000 claims description 15
• 239000003053 toxin Substances 0.000 claims description 12
• 231100000765 toxin Toxicity 0.000 claims description 12
• 229940079593 drug Drugs 0.000 claims description 10
• 239000003814 drug Substances 0.000 claims description 10
• 208000034578 Multiple myelomas Diseases 0.000 claims description 5
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 5
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
• 229940122429 Tubulin inhibitor Drugs 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000000034 method Methods 0.000 description 5
• 239000003744 tubulin modulator Substances 0.000 description 2
• LIXLFMBECHROQQ-FBLRIXIVSA-N CC(C)N(C)Cc1nc([C@@](C[C@@H](c2c(c(C(c(c3ccc4)c4OC)=O)c4C3=O)O)O[C@@H]3O[C@@H](C)[C@H]5O[C@H](COCC6)N6[C@H]5C3)(Cc2c4O)O)c[s]1 Chemical compound CC(C)N(C)Cc1nc([C@@](C[C@@H](c2c(c(C(c(c3ccc4)c4OC)=O)c4C3=O)O)O[C@@H]3O[C@@H](C)[C@H]5O[C@H](COCC6)N6[C@H]5C3)(Cc2c4O)O)c[s]1 LIXLFMBECHROQQ-FBLRIXIVSA-N 0.000 description 1
• 0 CC[C@](C)[C@@]([C@@](CC(N(CCC1)[C@@]1C([C@@](C)C(N[C@](C*)Cc1ccccc1)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)C(C)C)=O)=O Chemical compound CC[C@](C)[C@@]([C@@](CC(N(CCC1)[C@@]1C([C@@](C)C(N[C@](C*)Cc1ccccc1)=O)OC)=O)OC)N(C)C([C@](C(C)C)NC([C@](C(C)C)N(C)C(C)C)=O)=O 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1