JP2020523282A5 - - Google Patents
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- Publication number
- JP2020523282A5 JP2020523282A5 JP2019552978A JP2019552978A JP2020523282A5 JP 2020523282 A5 JP2020523282 A5 JP 2020523282A5 JP 2019552978 A JP2019552978 A JP 2019552978A JP 2019552978 A JP2019552978 A JP 2019552978A JP 2020523282 A5 JP2020523282 A5 JP 2020523282A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- aryl
- cycloheteroalkenyl
- cycloheteroalkyl
- arylalkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1n[n]cc1*CNc1nc2cc(S)ccc2[s]1 Chemical compound Cc1n[n]cc1*CNc1nc2cc(S)ccc2[s]1 0.000 description 39
- XYEKVCDZBKLYKQ-UHFFFAOYSA-N CC(C)c(cc1)cc2c1[nH]nc2 Chemical compound CC(C)c(cc1)cc2c1[nH]nc2 XYEKVCDZBKLYKQ-UHFFFAOYSA-N 0.000 description 1
- LGMLMQXUCJTHGH-UHFFFAOYSA-N CC(C)c1c[nH]nc1C(F)(F)F Chemical compound CC(C)c1c[nH]nc1C(F)(F)F LGMLMQXUCJTHGH-UHFFFAOYSA-N 0.000 description 1
- ASIFVGBIFBHPJO-KGKSHYRASA-N CCN(CC)CC(c(c1c(cc2)nc(/C(/C(C)=N)=C/N)c3c1CCCC3)c2NN)=C Chemical compound CCN(CC)CC(c(c1c(cc2)nc(/C(/C(C)=N)=C/N)c3c1CCCC3)c2NN)=C ASIFVGBIFBHPJO-KGKSHYRASA-N 0.000 description 1
- RNSHSZQPQQPZMD-UHFFFAOYSA-O CCc1c(C(C(C=C2)[NH3+])C=N)c2nc(C(CC2)=Cc3c2[nH]nc3N(C)CCO)c1CC=C Chemical compound CCc1c(C(C(C=C2)[NH3+])C=N)c2nc(C(CC2)=Cc3c2[nH]nc3N(C)CCO)c1CC=C RNSHSZQPQQPZMD-UHFFFAOYSA-O 0.000 description 1
- KVSVMTWPPWJVEM-UHFFFAOYSA-N CN(C)C(c1n[nH]cc1-c1c(CCCC2)c2c(c2c(cc3)[nH][n]c2)c3c1)=O Chemical compound CN(C)C(c1n[nH]cc1-c1c(CCCC2)c2c(c2c(cc3)[nH][n]c2)c3c1)=O KVSVMTWPPWJVEM-UHFFFAOYSA-N 0.000 description 1
- ARVUNNKSHDGHPF-UHFFFAOYSA-O CN(CCO)c1c[nH]c(cc2)c1c1c2nc(C(C(C2CC2)=N)=C[NH3+])c2c1CCCC2 Chemical compound CN(CCO)c1c[nH]c(cc2)c1c1c2nc(C(C(C2CC2)=N)=C[NH3+])c2c1CCCC2 ARVUNNKSHDGHPF-UHFFFAOYSA-O 0.000 description 1
- GJOOCAXPERKNMN-UHFFFAOYSA-N Cc(c(F)c1)ccc1O Chemical compound Cc(c(F)c1)ccc1O GJOOCAXPERKNMN-UHFFFAOYSA-N 0.000 description 1
- AHAMWENZZWAOED-UHFFFAOYSA-N Cc1c(c(CCC(C2)C(Nc3ccc(C=N)cc3)=O)c2c(C(CCC2)=CC=C2O)n2)c2ccc1NN Chemical compound Cc1c(c(CCC(C2)C(Nc3ccc(C=N)cc3)=O)c2c(C(CCC2)=CC=C2O)n2)c2ccc1NN AHAMWENZZWAOED-UHFFFAOYSA-N 0.000 description 1
- QJDSMZPLJZUCEO-UHFFFAOYSA-O NCC(c(c1c(cc2)nc(-c3c[nH]nc3C(F)(F)F)c3c1CCCC3)c2[NH3+])=N Chemical compound NCC(c(c1c(cc2)nc(-c3c[nH]nc3C(F)(F)F)c3c1CCCC3)c2[NH3+])=N QJDSMZPLJZUCEO-UHFFFAOYSA-O 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022027439A JP7837179B2 (ja) | 2017-03-29 | 2022-02-25 | キナーゼネットワークの阻害剤およびその使用 |
| JP2022150644A JP7668254B2 (ja) | 2017-03-29 | 2022-09-21 | キナーゼネットワークの阻害剤およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762478069P | 2017-03-29 | 2017-03-29 | |
| US62/478,069 | 2017-03-29 | ||
| US201862616643P | 2018-01-12 | 2018-01-12 | |
| US62/616,643 | 2018-01-12 | ||
| PCT/US2018/024991 WO2018183586A1 (en) | 2017-03-29 | 2018-03-29 | Inhibitors of kinase networks and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027439A Division JP7837179B2 (ja) | 2017-03-29 | 2022-02-25 | キナーゼネットワークの阻害剤およびその使用 |
| JP2022150644A Division JP7668254B2 (ja) | 2017-03-29 | 2022-09-21 | キナーゼネットワークの阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523282A JP2020523282A (ja) | 2020-08-06 |
| JP2020523282A5 true JP2020523282A5 (https=) | 2020-09-17 |
| JP7788208B2 JP7788208B2 (ja) | 2025-12-18 |
Family
ID=63677063
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552978A Active JP7788208B2 (ja) | 2017-03-29 | 2018-03-29 | キナーゼネットワークの阻害剤およびその使用 |
| JP2022027439A Active JP7837179B2 (ja) | 2017-03-29 | 2022-02-25 | キナーゼネットワークの阻害剤およびその使用 |
| JP2022150644A Active JP7668254B2 (ja) | 2017-03-29 | 2022-09-21 | キナーゼネットワークの阻害剤およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027439A Active JP7837179B2 (ja) | 2017-03-29 | 2022-02-25 | キナーゼネットワークの阻害剤およびその使用 |
| JP2022150644A Active JP7668254B2 (ja) | 2017-03-29 | 2022-09-21 | キナーゼネットワークの阻害剤およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11040973B2 (https=) |
| EP (2) | EP4233859A1 (https=) |
| JP (3) | JP7788208B2 (https=) |
| CN (1) | CN110662536B (https=) |
| CA (1) | CA3056641A1 (https=) |
| WO (1) | WO2018183586A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11040973B2 (en) * | 2017-03-29 | 2021-06-22 | Purdue Research Foundation | Inhibitors of kinase networks and uses thereof |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| US20220017908A1 (en) * | 2018-11-20 | 2022-01-20 | Fulcrum Therapeutics, Inc. | Compositions and methods for increasing fetal hemoglobin and treating sickle cell disease |
| SG11202104331YA (en) | 2018-12-11 | 2021-05-28 | Theravance Biopharma R&D Ip Llc | Naphthyridine and quinoline derivatives useful as alk5 inhibitors |
| WO2021061823A1 (en) * | 2019-09-23 | 2021-04-01 | Boragen, Inc. | Chemical compounds |
| CN114728941A (zh) | 2019-11-22 | 2022-07-08 | 施万生物制药研发Ip有限责任公司 | 作为alk5抑制剂的经取代的1,5-萘啶或喹啉 |
| CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
| EP4175637A4 (en) * | 2020-07-02 | 2024-08-07 | Purdue Research Foundation | Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline-containing compounds and uses thereof |
| KR20250004773A (ko) * | 2022-04-20 | 2025-01-08 | 상하이 지멍 바이오파마 아이엔씨 | Rho 관련 단백질 키나아제 억제제 및 이의 제조와 응용 |
| CN117186002A (zh) * | 2022-05-31 | 2023-12-08 | 江苏亚虹医药科技股份有限公司 | 7-氰基-8-羟基喹啉衍生物、其制备方法及其医药用途 |
| EP4532471A2 (en) * | 2022-06-02 | 2025-04-09 | Purdue Research Foundation | 4-(3h-pyrazolo[4,3-f]quinolin-7-yl)-n-(2-(dimethylamino)ethyl)benzamide- or hydroxamic acid compounds, compositions, and methods of use |
| WO2024206164A1 (en) * | 2023-03-24 | 2024-10-03 | Purdue Research Foundation | 3H-PYRAZOLO[4.3:f] QUINOLINE-BASED COMPOUNDS AS STING ANTAGONISTS |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947434A (en) * | 1973-06-06 | 1976-03-30 | Morton-Norwich Products, Inc. | 9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines |
| CA1263378A (en) * | 1985-01-08 | 1989-11-28 | Robert James Alaimo | Imidazo¬4,5-f|quinolines useful as immunomodulating agents |
| CA2134448A1 (en) * | 1992-05-01 | 1993-11-02 | Yoshinori Kyotani | Quinoline derivative or salt thereof and remedy for cardiac diseases containing the same |
| US6228362B1 (en) * | 1992-08-21 | 2001-05-08 | Immunomedics, Inc. | Boron neutron capture therapy using pre-targeting methods |
| US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
| PL215901B1 (pl) * | 1999-04-15 | 2014-02-28 | Bristol Myers Squibb Co | Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek |
| US20050080260A1 (en) * | 2003-04-22 | 2005-04-14 | Mills Randell L. | Preparation of prodrugs for selective drug delivery |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US20060281771A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators |
| CA2598216C (en) * | 2005-06-17 | 2014-04-08 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| WO2007005887A2 (en) * | 2005-07-01 | 2007-01-11 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds, compositions and uses thereof |
| JPWO2011043359A1 (ja) | 2009-10-06 | 2013-03-04 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
| JP2013542243A (ja) | 2010-11-15 | 2013-11-21 | カトリーケ ウニヴェルシテイト ルーヴェン | 新規な抗ウイルス性化合物 |
| US9643965B2 (en) * | 2014-09-17 | 2017-05-09 | Celgene Quantical Research, Inc. | Histone demethylase inhibitors |
| EP3242872B1 (en) | 2015-01-09 | 2019-07-03 | Genentech, Inc. | (piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer |
| US11040973B2 (en) * | 2017-03-29 | 2021-06-22 | Purdue Research Foundation | Inhibitors of kinase networks and uses thereof |
-
2018
- 2018-03-29 US US16/499,133 patent/US11040973B2/en active Active
- 2018-03-29 CN CN201880034786.5A patent/CN110662536B/zh active Active
- 2018-03-29 EP EP23176745.0A patent/EP4233859A1/en active Pending
- 2018-03-29 JP JP2019552978A patent/JP7788208B2/ja active Active
- 2018-03-29 EP EP18776719.9A patent/EP3600287B1/en active Active
- 2018-03-29 WO PCT/US2018/024991 patent/WO2018183586A1/en not_active Ceased
- 2018-03-29 CA CA3056641A patent/CA3056641A1/en active Pending
-
2021
- 2021-04-29 US US17/243,629 patent/US11891391B2/en active Active
-
2022
- 2022-02-25 JP JP2022027439A patent/JP7837179B2/ja active Active
- 2022-09-21 JP JP2022150644A patent/JP7668254B2/ja active Active
-
2023
- 2023-12-21 US US18/392,204 patent/US12384782B2/en active Active
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