CN102827146B - 一种氟喹诺酮醛缩异烟腙及其制备方法和应用 - Google Patents
一种氟喹诺酮醛缩异烟腙及其制备方法和应用 Download PDFInfo
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- CN102827146B CN102827146B CN201210249727.4A CN201210249727A CN102827146B CN 102827146 B CN102827146 B CN 102827146B CN 201210249727 A CN201210249727 A CN 201210249727A CN 102827146 B CN102827146 B CN 102827146B
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- formula
- fluoroquinolone
- vanizide
- hydrogen atom
- ethyl
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
供试样品 | VERO cells细胞毒性(IC50) | 供试样品 | VERO cells细胞毒性(IC50) |
实施例1 | >100 | 实施例7 | >100 |
实施例2 | >100 | 实施例8 | >100 |
实施例3 | >100 | 实施例9 | >100 |
实施例4 | >100 | 实施例10 | >100 |
实施例5 | >100 | 实施例11 | >100 |
实施例6 | >100 | 实施例12 | >100 |
实施例13 | >100 | 异烟肼 | >100 |
左氧氟沙星 | 75 |
Claims (9)
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CN201210249727.4A CN102827146B (zh) | 2012-07-18 | 2012-07-18 | 一种氟喹诺酮醛缩异烟腙及其制备方法和应用 |
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CN201210249727.4A CN102827146B (zh) | 2012-07-18 | 2012-07-18 | 一种氟喹诺酮醛缩异烟腙及其制备方法和应用 |
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CN102827146A CN102827146A (zh) | 2012-12-19 |
CN102827146B true CN102827146B (zh) | 2014-01-22 |
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CN201210249727.4A Expired - Fee Related CN102827146B (zh) | 2012-07-18 | 2012-07-18 | 一种氟喹诺酮醛缩异烟腙及其制备方法和应用 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013072703A1 (en) * | 2011-11-18 | 2013-05-23 | Redx Pharma Limited | Antibacterial drug derivatives |
CN103709138B (zh) * | 2013-12-23 | 2015-09-09 | 河南大学 | 5-(氟喹诺酮c3-叉甲基)-3-吡咯酰胺衍生物、制备方法及应用 |
CN106854214B (zh) * | 2016-12-26 | 2018-11-23 | 郑州工业应用技术学院 | 氧氟沙星醛缩4-芳基氨基硫脲类衍生物及其制备方法和应用 |
CN106699779B (zh) * | 2016-12-26 | 2018-11-09 | 郑州工业应用技术学院 | 芦氟沙星醛缩4-芳基氨基硫脲类衍生物及其制备方法和应用 |
CN106854213B (zh) * | 2016-12-26 | 2018-11-23 | 郑州工业应用技术学院 | 左氧氟沙星醛缩4-芳基氨基硫脲类衍生物及其制备方法和应用 |
CN113788828B (zh) * | 2021-10-26 | 2023-06-30 | 黄河水利职业技术学院 | 异白叶藤碱类似物、从诺氟沙星到异白叶藤碱类似物的制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101643471A (zh) * | 2009-08-24 | 2010-02-10 | 河南大学 | 以噁二唑为连接链的c3/c3氟喹诺酮二聚体衍生物及其制备方法和应用 |
CN102443011A (zh) * | 2011-09-28 | 2012-05-09 | 河南大学 | 左旋氟喹诺酮c3双唑甲硫醚季铵盐、制备方法及其应用 |
CN102516168A (zh) * | 2011-12-13 | 2012-06-27 | 河南大学 | 一种环丙氟喹诺酮c3/c7双腙西弗碱、制备方法及其应用 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101643471A (zh) * | 2009-08-24 | 2010-02-10 | 河南大学 | 以噁二唑为连接链的c3/c3氟喹诺酮二聚体衍生物及其制备方法和应用 |
CN102443011A (zh) * | 2011-09-28 | 2012-05-09 | 河南大学 | 左旋氟喹诺酮c3双唑甲硫醚季铵盐、制备方法及其应用 |
CN102516168A (zh) * | 2011-12-13 | 2012-06-27 | 河南大学 | 一种环丙氟喹诺酮c3/c7双腙西弗碱、制备方法及其应用 |
Non-Patent Citations (2)
Title |
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"Studies on Prodrugs. 7. Synthesis and Antimicrobial Activity of 3-Formylquinolone Derivatives";Hirosato Kondo, et al.;《J. MED. CHEM.》;19881231;第31卷;第221-225页 * |
Hirosato Kondo, et al.."Studies on Prodrugs. 7. Synthesis and Antimicrobial Activity of 3-Formylquinolone Derivatives".《J. MED. CHEM.》.1988,第31卷第221-225页. |
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