JP2020522568A5 - - Google Patents

Info

Publication number

JP2020522568A5

JP2020522568A5 JP2020516788A JP2020516788A JP2020522568A5 JP 2020522568 A5 JP2020522568 A5 JP 2020522568A5 JP 2020516788 A JP2020516788 A JP 2020516788A JP 2020516788 A JP2020516788 A JP 2020516788A JP 2020522568 A5 JP2020522568 A5 JP 2020522568A5

Authority

JP

Japan

Prior art keywords

capecitabine

day

pharmaceutical composition

administration

day cycle

Prior art date

2018-06-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 81
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims description 81
• 229960004117 capecitabine Drugs 0.000 claims description 81
• 238000000034 method Methods 0.000 claims description 42
• 206010006187 Breast cancer Diseases 0.000 claims description 24
• 206010028980 Neoplasm Diseases 0.000 claims description 21
• 201000011510 cancer Diseases 0.000 claims description 21
• 208000026310 Breast neoplasm Diseases 0.000 claims description 18
• MODVSQKJJIBWPZ-VLLPJHQWSA-N tesetaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3CC[C@@]2(C)[C@H]2[C@@H](C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C(=CC=CN=4)F)C[C@]1(O)C3(C)C)O[C@H](O2)CN(C)C)C(=O)C1=CC=CC=C1 MODVSQKJJIBWPZ-VLLPJHQWSA-N 0.000 claims description 17
• 229950009016 tesetaxel Drugs 0.000 claims description 17
• 229940123237 Taxane Drugs 0.000 claims description 9
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 9
• 206010055113 Breast cancer metastatic Diseases 0.000 claims description 6
• 108091008039 hormone receptors Proteins 0.000 claims description 6
• 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims description 3
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 3
• 229930012538 Paclitaxel Natural products 0.000 claims description 3
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 3
• 238000009098 adjuvant therapy Methods 0.000 claims description 3
• 229960003668 docetaxel Drugs 0.000 claims description 3
• 238000009261 endocrine therapy Methods 0.000 claims description 3
• 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 claims description 3
• 108010038795 estrogen receptors Proteins 0.000 claims description 3
• 238000009099 neoadjuvant therapy Methods 0.000 claims description 3
• 229960001592 paclitaxel Drugs 0.000 claims description 3
• 108090000468 progesterone receptors Proteins 0.000 claims description 3
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 3
• 231100000402 unacceptable toxicity Toxicity 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 34
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 102000015694 estrogen receptors Human genes 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 102000003998 progesterone receptors Human genes 0.000 claims 2
• 102100038595 Estrogen receptor Human genes 0.000 description 1
• 102100025803 Progesterone receptor Human genes 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1