JP2016521760A5 - - Google Patents

Info

Publication number

JP2016521760A5

JP2016521760A5 JP2016520399A JP2016520399A JP2016521760A5 JP 2016521760 A5 JP2016521760 A5 JP 2016521760A5 JP 2016520399 A JP2016520399 A JP 2016520399A JP 2016520399 A JP2016520399 A JP 2016520399A JP 2016521760 A5 JP2016521760 A5 JP 2016521760A5

Authority

JP

Japan

Prior art keywords

chloro

fluoro

phenyl

day

compound

Prior art date

2014-06-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• -1 4-chloro-2-fluorophenyl Chemical group 0.000 claims 21
• 239000003814 drug Substances 0.000 claims 21
• 229940126062 Compound A Drugs 0.000 claims 11
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 11
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 10
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 10
• 229960004117 capecitabine Drugs 0.000 claims 10
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 9
• 229960001756 oxaliplatin Drugs 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 8
• TVTXCJFHQKSQQM-LJQIRTBHSA-N 4-[[(2r,3s,4r,5s)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC=C1NC(=O)[C@H]1[C@H](C=2C(=C(Cl)C=CC=2)F)[C@@](C#N)(C=2C(=CC(Cl)=CC=2)F)[C@H](CC(C)(C)C)N1 TVTXCJFHQKSQQM-LJQIRTBHSA-N 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 6
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 239000004480 active ingredient Substances 0.000 claims 3
• 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
• 239000005711 Benzoic acid Substances 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 235000010233 benzoic acid Nutrition 0.000 claims 2
• 230000003203 everyday effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• ZSTCHQOKNUXHLZ-PIRIXANTSA-L [(1r,2r)-2-azanidylcyclohexyl]azanide;oxalate;pentyl n-[1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate;platinum(4+) Chemical compound [Pt+4].[O-]C(=O)C([O-])=O.[NH-][C@@H]1CCCC[C@H]1[NH-].C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 ZSTCHQOKNUXHLZ-PIRIXANTSA-L 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1