JP2020519230A5 - - Google Patents
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- Publication number
- JP2020519230A5 JP2020519230A5 JP2018564966A JP2018564966A JP2020519230A5 JP 2020519230 A5 JP2020519230 A5 JP 2020519230A5 JP 2018564966 A JP2018564966 A JP 2018564966A JP 2018564966 A JP2018564966 A JP 2018564966A JP 2020519230 A5 JP2020519230 A5 JP 2020519230A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- protein according
- sequence
- peptide
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 21
- 102000037865 fusion proteins Human genes 0.000 claims 21
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims 11
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 230000003834 intracellular effect Effects 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 230000003248 secreting effect Effects 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 244000309459 oncolytic virus Species 0.000 claims 2
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 101100386242 Homo sapiens CD55 gene Proteins 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762504120P | 2017-05-10 | 2017-05-10 | |
| US62/504,120 | 2017-05-10 | ||
| PCT/US2018/032018 WO2018209052A1 (en) | 2017-05-10 | 2018-05-10 | Enveloped virus resistant to complement inactivation for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519230A JP2020519230A (ja) | 2020-07-02 |
| JP2020519230A5 true JP2020519230A5 (OSRAM) | 2021-05-20 |
| JP7161940B2 JP7161940B2 (ja) | 2022-10-27 |
Family
ID=64105722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564966A Active JP7161940B2 (ja) | 2017-05-10 | 2018-05-10 | がんの治療のための、補体不活性化に耐性のエンベロープウイルス |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11274141B2 (OSRAM) |
| EP (1) | EP3621635A4 (OSRAM) |
| JP (1) | JP7161940B2 (OSRAM) |
| KR (3) | KR20250118857A (OSRAM) |
| CN (1) | CN109414483B (OSRAM) |
| AU (1) | AU2018265258B2 (OSRAM) |
| BR (1) | BR112018075281A2 (OSRAM) |
| CA (1) | CA3026892A1 (OSRAM) |
| IL (1) | IL263979B2 (OSRAM) |
| MX (1) | MX2018015599A (OSRAM) |
| WO (1) | WO2018209052A1 (OSRAM) |
| ZA (1) | ZA201808040B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CN112759654A (zh) * | 2019-11-06 | 2021-05-07 | 深圳普菲科生命科技有限公司 | 一种病毒囊膜蛋白装配系统及其方法和应用 |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| US20240067936A1 (en) * | 2021-02-26 | 2024-02-29 | Sillajen, Inc. | Oncolytic virus and uses thereof |
| CN113736810B (zh) * | 2021-09-08 | 2024-05-24 | 苏州因特药物研发有限公司 | 构建体、载体、蛋白、细胞、制备方法、产品及应用 |
| KR20240003051A (ko) * | 2022-06-29 | 2024-01-08 | 신라젠(주) | Cd55 및 cd59를 동시 발현하는 항암 바이러스 |
| JP2025531806A (ja) * | 2022-09-07 | 2025-09-25 | シルラジェン，インコーポレイテッド | 抗癌ウイルスの新規用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| ATE411809T1 (de) | 1993-04-30 | 2008-11-15 | Wellstat Biologics Corp | Zusuammensetzungen zur behandlung von krebs mittels viren |
| JPH10313865A (ja) * | 1997-05-15 | 1998-12-02 | Deinabetsuku Kenkyusho:Kk | ヒト補体制御因子が呈示されたベクター |
| WO1999027121A1 (en) | 1997-11-21 | 1999-06-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Development of viruses resistant to inactivation by the human complement system |
| WO1999032648A1 (en) | 1997-12-22 | 1999-07-01 | The University Of Tennessee Research Corporation | Recombinant rhabdovirus containing a heterologous fusion protein |
| EP1071705A2 (en) * | 1998-04-02 | 2001-01-31 | Rigel Pharmaceuticals, Inc. | Peptides causing formation of compact structures |
| CN1477964A (zh) | 1999-04-15 | 2004-02-25 | 应用病毒治疗肿瘤 | |
| DK1569685T3 (da) * | 2002-11-15 | 2012-11-12 | Univ Colorado Regents | Komplementmodulatorer rettet mod komplementreceptor-2 |
| US8828727B2 (en) * | 2004-07-21 | 2014-09-09 | Dana-Farber Cancer Institute | Lentiviral vectors and uses thereof |
| JP5050198B2 (ja) * | 2006-09-05 | 2012-10-17 | 国立大学法人大阪大学 | ヒト補体制御因子発現遺伝子およびその利用 |
| CA2676090A1 (en) * | 2007-02-06 | 2008-10-02 | Genizon Biosciences Inc. | Genemap of the human genes associated with adhd |
| CA2678774A1 (en) * | 2007-03-01 | 2008-09-04 | Advanced Vision Therapies, Inc. | Treatment of diseases characterized by inflammation |
| US8877896B2 (en) | 2008-02-15 | 2014-11-04 | Tufts University | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders |
| US20140206850A1 (en) | 2011-04-29 | 2014-07-24 | Keygene N.V. | Glyphosate resistance enhancement |
| KR101949293B1 (ko) | 2011-05-05 | 2019-02-18 | 웰스태트 이뮤노테라퓨틱스, 엘엘씨 | 보체 인자 ｂ 유사체 및 그의 용도 |
| AU2012318288B2 (en) * | 2011-12-01 | 2015-09-17 | Ap Biosciences, Inc. | Protein inhibitors to complement and VEGF pathways and methods of use thereof |
| PL3888674T3 (pl) * | 2014-04-07 | 2024-09-23 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| MX387517B (es) | 2015-04-06 | 2025-03-18 | Subdomain Llc | Polipeptidos que contienen dominios de union de novo y usos de los mismos. |
| GB201507119D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| EP3307282A4 (en) | 2015-06-12 | 2019-05-01 | Immunomedics, Inc. | DISEASE THERAPY WITH CONSTRUCTS OF CHIMERIC ANTIGEN RECEPTOR (CAR) AND T-CELL (CAR-T) OR NK-CELL (CAR-NK) EXPRESSIVE CAR CONSTRUCTS |
| US20190282640A1 (en) | 2016-05-19 | 2019-09-19 | Turnstone Limited Partnership | Pseudotyped oncolytic rhabdoviruses and their use in combination therapy |
-
2018
- 2018-05-10 IL IL263979A patent/IL263979B2/en unknown
- 2018-05-10 KR KR1020257024807A patent/KR20250118857A/ko active Pending
- 2018-05-10 KR KR1020247013722A patent/KR102839445B1/ko active Active
- 2018-05-10 US US16/303,729 patent/US11274141B2/en active Active
- 2018-05-10 KR KR1020187037869A patent/KR102662049B1/ko active Active
- 2018-05-10 JP JP2018564966A patent/JP7161940B2/ja active Active
- 2018-05-10 BR BR112018075281-9A patent/BR112018075281A2/pt unknown
- 2018-05-10 AU AU2018265258A patent/AU2018265258B2/en active Active
- 2018-05-10 EP EP18798575.9A patent/EP3621635A4/en active Pending
- 2018-05-10 CN CN201880002553.7A patent/CN109414483B/zh active Active
- 2018-05-10 WO PCT/US2018/032018 patent/WO2018209052A1/en not_active Ceased
- 2018-05-10 MX MX2018015599A patent/MX2018015599A/es unknown
- 2018-05-10 CA CA3026892A patent/CA3026892A1/en active Pending
- 2018-11-28 ZA ZA2018/08040A patent/ZA201808040B/en unknown
-
2022
- 2022-02-18 US US17/674,990 patent/US20220169701A1/en not_active Abandoned
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