|
GB9207381D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
|
ES2284247T3
(es)
|
1998-04-03 |
2007-11-01 |
University Of Iowa Research Foundation |
Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
|
|
WO2004030634A2
(en)
|
2002-10-02 |
2004-04-15 |
Alnylam Pharmaceuticals Inc. |
Therapeutic compositions
|
|
EP3450559A1
(en)
|
2003-03-07 |
2019-03-06 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
|
EP1608735A4
(en)
|
2003-04-03 |
2008-11-05 |
Alnylam Pharmaceuticals |
RNAI CONJUGATES
|
|
US8969543B2
(en)
|
2003-04-03 |
2015-03-03 |
Bioneer Corporation |
SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
|
CA2521464C
(en)
|
2003-04-09 |
2013-02-05 |
Alnylam Pharmaceuticals, Inc. |
Irna conjugates
|
|
KR20060015505A
(ko)
|
2003-04-13 |
2006-02-17 |
엔존 파마슈티컬즈, 인코포레이티드 |
올리고뉴클레오타이드 전구약물
|
|
CA2522349A1
(en)
|
2003-04-17 |
2004-11-04 |
Alnylam Pharmaceuticals, Inc. |
Protected monomers
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
US20100170000A9
(en)
|
2004-10-25 |
2010-07-01 |
Devgen Nv |
Rna constructs
|
|
CN101292033B
(zh)
*
|
2005-08-01 |
2013-04-03 |
普渡研究基金会 |
用于活性试剂向细胞的递送的多价rna纳粒
|
|
KR20120115412A
(ko)
|
2006-04-07 |
2012-10-17 |
이데라 파마슈티칼즈, 인코포레이티드 |
Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물
|
|
AU2007345648A1
(en)
|
2007-01-26 |
2008-08-07 |
City Of Hope |
Methods and compositions for the treatment of cancer or other diseases
|
|
US8748405B2
(en)
|
2007-01-26 |
2014-06-10 |
City Of Hope |
Methods and compositions for the treatment of cancer or other diseases
|
|
WO2008109373A1
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting erbb gene expression and uses thereof
|
|
WO2008109105A2
(en)
|
2007-03-06 |
2008-09-12 |
Flagship Ventures |
Methods and compositions for improved therapeutic effects with sirna
|
|
CA2692161C
(en)
|
2007-07-09 |
2015-09-29 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory rna (simra) compounds
|
|
AU2009234266B2
(en)
|
2008-04-11 |
2015-08-06 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2010021720A1
(en)
|
2008-08-19 |
2010-02-25 |
Nektar Therapeutics |
Conjugates of small-interfering nucleic acids
|
|
US8637194B2
(en)
|
2008-09-02 |
2014-01-28 |
Bio-Nano Power, Llc |
Bio-nano power cells and their uses
|
|
RU2015151857A
(ru)
|
2008-12-02 |
2019-01-15 |
Уэйв Лайф Сайенсес Джапан, Инк. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
EP2395085B1
(en)
*
|
2009-02-04 |
2015-06-10 |
Sungkyunkwan University Foundation for Corporate Collaboration |
Small interference rna complex with increased intracellular transmission capacity
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
KR101141544B1
(ko)
|
2009-03-13 |
2012-05-03 |
한국과학기술원 |
에스아이알엔에이 다중 접합체 및 이의 제조방법
|
|
HRP20150566T1
(hr)
|
2009-08-27 |
2015-07-17 |
Idera Pharmaceuticals, Inc. |
Kompozicija za inhibiciju ekspresije gena i njegova upotreba
|
|
KR101678876B1
(ko)
|
2010-01-15 |
2016-11-23 |
한국과학기술원 |
복합 유전자를 표적하는 ｓｉＲＮＡ 다중 접합체 및 이의 제조방법
|
|
ES2562817T3
(es)
|
2010-02-24 |
2016-03-08 |
Arrowhead Research Corporation |
Composiciones para el suministro dirigido de ARNip
|
|
AU2011223820B2
(en)
|
2010-03-01 |
2016-01-14 |
The Children's Hospital Of Philadelphia |
Nucleic acids for targeting multiple regions of the HCV genome
|
|
EP3248982A1
(en)
|
2011-07-19 |
2017-11-29 |
Wave Life Sciences Ltd. |
Thiosulfonate reagents for the synthesis of functionalized nucleic acids
|
|
EP3533873A1
(en)
*
|
2011-09-14 |
2019-09-04 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
KR101340290B1
(ko)
*
|
2011-09-14 |
2013-12-11 |
한국과학기술원 |
유전자 표적용 ｓｉＲＮＡ 하이드로젤 및 그 제조방법
|
|
WO2014043544A1
(en)
|
2012-09-14 |
2014-03-20 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
US9956294B2
(en)
|
2013-01-18 |
2018-05-01 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Targeted sensitization of non-del(5q) malignant cells
|
|
KR101629681B1
(ko)
|
2013-06-24 |
2016-06-14 |
건국대학교 산학협력단 |
다중 리간드가 도입된 에스아이알엔에이 접합체
|
|
GB201311840D0
(en)
*
|
2013-07-02 |
2013-08-14 |
Univ Aberdeen |
Control of varroa mite infestation
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
KR102344559B1
(ko)
|
2013-12-12 |
2021-12-31 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 성분 ｉＲＮＡ 조성물 및 이의 이용 방법
|
|
CA2935426C
(en)
|
2014-01-30 |
2023-07-25 |
F. Hoffmann-La Roche Ag |
Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
|
|
WO2016110691A1
(en)
*
|
2015-01-06 |
2016-07-14 |
The University Court Of The University Of Aberdeen |
Enhanced rnai mediated gene regulation
|
|
IL316159A
(en)
*
|
2015-06-15 |
2024-12-01 |
Mpeg La Llc |
Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
|
|
CN114224907A
(zh)
|
2015-07-02 |
2022-03-25 |
希望之城 |
包括硫代磷酸化寡脱氧核苷酸的化合物和组合物及其使用方法
|
|
US20180312839A1
(en)
|
2015-10-26 |
2018-11-01 |
Translate Bio Ma, Inc. |
Methods and compositions for increasing smn expression
|
|
CN117503923A
(zh)
|
2016-01-05 |
2024-02-06 |
莱斯特大学 |
用于抑制有需要的受试者的纤维化的方法
|
|
WO2018030338A1
(ja)
|
2016-08-08 |
2018-02-15 |
浩文 山本 |
アジュバント組成物
|
|
SG11201906728TA
(en)
|
2017-02-06 |
2019-08-27 |
Mpeg La Llc |
Multimeric oligonucleotides having decreased kidney clearance
|
|
WO2018223073A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
CN111741967A
(zh)
|
2017-11-30 |
2020-10-02 |
深圳市真迈生物科技有限公司 |
核苷类似物、制备方法及应用
|
|
JP2022523226A
(ja)
|
2019-03-04 |
2022-04-21 |
エムペグ エルエイ リミテッド ライアビリティ カンパニー |
増強された生理活性を有する多量体オリゴヌクレオチド
|
|
CA3144467A1
(en)
|
2019-07-30 |
2021-02-04 |
Jonathan Miles Brown |
Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity
|
|
CA3178559A1
(en)
|
2020-05-19 |
2021-11-25 |
Jonathan Miles Brown |
Orthogonally linked multimeric oligonucleotides
|