|
GB9207381D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
|
JP2002510644A
(ja)
|
1998-04-03 |
2002-04-09 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
免疫治療用オリゴヌクレオチドおよびサイトカインを用いる免疫系刺激のための方法および産物
|
|
WO2004030634A2
(en)
|
2002-10-02 |
2004-04-15 |
Alnylam Pharmaceuticals Inc. |
Therapeutic compositions
|
|
AU2004220556B2
(en)
|
2003-03-07 |
2009-05-07 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
|
EP1608735A4
(en)
|
2003-04-03 |
2008-11-05 |
Alnylam Pharmaceuticals |
RNAI CONJUGATES
|
|
US8969543B2
(en)
|
2003-04-03 |
2015-03-03 |
Bioneer Corporation |
SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
|
CA2521464C
(en)
|
2003-04-09 |
2013-02-05 |
Alnylam Pharmaceuticals, Inc. |
Irna conjugates
|
|
CN101273051B
(zh)
|
2003-04-13 |
2012-04-18 |
安龙制药公司 |
聚合寡核苷酸前体药物
|
|
CA2522349A1
(en)
|
2003-04-17 |
2004-11-04 |
Alnylam Pharmaceuticals, Inc. |
Protected monomers
|
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
|
EP2669377A3
(en)
|
2003-04-17 |
2015-10-14 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
WO2006046148A2
(en)
|
2004-10-25 |
2006-05-04 |
Devgen Nv |
Rna constructs
|
|
EP1917357A2
(en)
*
|
2005-08-01 |
2008-05-07 |
Purdue Research Foundation |
Multivalent rna nanoparticles for delivery of active agents to a cell
|
|
KR101221589B1
(ko)
|
2006-04-07 |
2013-01-15 |
이데라 파마슈티칼즈, 인코포레이티드 |
Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물
|
|
EP2125855A4
(en)
|
2007-01-26 |
2013-03-27 |
Hope City |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND OTHER DISEASES
|
|
US8748405B2
(en)
|
2007-01-26 |
2014-06-10 |
City Of Hope |
Methods and compositions for the treatment of cancer or other diseases
|
|
WO2008109373A1
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting erbb gene expression and uses thereof
|
|
WO2008109105A2
(en)
|
2007-03-06 |
2008-09-12 |
Flagship Ventures |
Methods and compositions for improved therapeutic effects with sirna
|
|
JP5737937B2
(ja)
|
2007-07-09 |
2015-06-17 |
イデラ ファーマシューティカルズ インコーポレイテッドIdera Pharmaceuticals, Inc. |
安定化免疫調節rna(simra)化合物
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
EP2323695B1
(en)
|
2008-08-19 |
2018-12-05 |
Nektar Therapeutics |
Complexes of small-interfering nucleic acids
|
|
US8637194B2
(en)
|
2008-09-02 |
2014-01-28 |
Bio-Nano Power, Llc |
Bio-nano power cells and their uses
|
|
US9394333B2
(en)
|
2008-12-02 |
2016-07-19 |
Wave Life Sciences Japan |
Method for the synthesis of phosphorus atom modified nucleic acids
|
|
WO2010090452A2
(ko)
*
|
2009-02-04 |
2010-08-12 |
성균관대학교산학협력단 |
세포 내 전달능이 증가된 작은 간섭 rna 복합체
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
KR101141544B1
(ko)
|
2009-03-13 |
2012-05-03 |
한국과학기술원 |
에스아이알엔에이 다중 접합체 및 이의 제조방법
|
|
HRP20150566T1
(hr)
|
2009-08-27 |
2015-07-17 |
Idera Pharmaceuticals, Inc. |
Kompozicija za inhibiciju ekspresije gena i njegova upotreba
|
|
KR101678876B1
(ko)
|
2010-01-15 |
2016-11-23 |
한국과학기술원 |
복합 유전자를 표적하는 siRNA 다중 접합체 및 이의 제조방법
|
|
SG183374A1
(en)
|
2010-02-24 |
2012-09-27 |
Arrowhead Res Corp |
Compositions for targeted delivery of sirna
|
|
AU2011223820B2
(en)
*
|
2010-03-01 |
2016-01-14 |
The Children's Hospital Of Philadelphia |
Nucleic acids for targeting multiple regions of the HCV genome
|
|
US9605019B2
(en)
|
2011-07-19 |
2017-03-28 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
KR101340290B1
(ko)
|
2011-09-14 |
2013-12-11 |
한국과학기술원 |
유전자 표적용 siRNA 하이드로젤 및 그 제조방법
|
|
US9580708B2
(en)
|
2011-09-14 |
2017-02-28 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotides compounds
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
WO2014113802A1
(en)
|
2013-01-18 |
2014-07-24 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
TARGETED SENSITIZATION OF NON-DEL(5q) MALIGNANT CELLS
|
|
KR101629681B1
(ko)
|
2013-06-24 |
2016-06-14 |
건국대학교 산학협력단 |
다중 리간드가 도입된 에스아이알엔에이 접합체
|
|
GB201311840D0
(en)
*
|
2013-07-02 |
2013-08-14 |
Univ Aberdeen |
Control of varroa mite infestation
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
IL314045A
(en)
|
2013-12-12 |
2024-09-01 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
|
KR102287532B1
(ko)
|
2014-01-30 |
2021-08-11 |
에프. 호프만-라 로슈 아게 |
생분해성 컨쥬게이트를 갖는 폴리 올리고머 화합물
|
|
WO2016110691A1
(en)
*
|
2015-01-06 |
2016-07-14 |
The University Court Of The University Of Aberdeen |
Enhanced rnai mediated gene regulation
|
|
IL316159A
(en)
*
|
2015-06-15 |
2024-12-01 |
Mpeg La Llc |
Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
|
|
JP7073109B2
(ja)
|
2015-07-02 |
2022-05-23 |
シティ・オブ・ホープ |
ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法
|
|
EP3368671A1
(en)
|
2015-10-26 |
2018-09-05 |
Translate Bio Ma, Inc. |
Methods and compositions for increasing smn expression
|
|
CA3010593C
(en)
|
2016-01-05 |
2024-02-13 |
University Of Leicester |
Methods for inhibiting fibrosis in a subject in need thereof
|
|
JP7016317B2
(ja)
|
2016-08-08 |
2022-02-21 |
浩文 山本 |
アジュバント組成物
|
|
MX2019009347A
(es)
|
2017-02-06 |
2019-10-07 |
Mpeg La Llc |
Oligonucleotidos multimericos con menor eliminacion en el riñon.
|
|
CN120330183A
(zh)
|
2017-06-02 |
2025-07-18 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
WO2019105421A1
(zh)
|
2017-11-30 |
2019-06-06 |
深圳市瀚海基因生物科技有限公司 |
核苷类似物、制备方法及应用
|
|
WO2020180897A1
(en)
|
2019-03-04 |
2020-09-10 |
Mpeg La, L.L.C. |
Multimeric oligonucleotides with enhanced bioactivity
|
|
AU2020319911A1
(en)
|
2019-07-30 |
2022-02-24 |
Mpeg La, L.L.C. |
Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity
|
|
IL298095A
(en)
|
2020-05-19 |
2023-01-01 |
Mpeg La L L C |
Orthogonally linked multimeric oligonucleotides
|