JP2020517293A5 - - Google Patents
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- JP2020517293A5 JP2020517293A5 JP2019558599A JP2019558599A JP2020517293A5 JP 2020517293 A5 JP2020517293 A5 JP 2020517293A5 JP 2019558599 A JP2019558599 A JP 2019558599A JP 2019558599 A JP2019558599 A JP 2019558599A JP 2020517293 A5 JP2020517293 A5 JP 2020517293A5
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- Prior art keywords
- seq
- polypeptide
- amino acid
- yeast cell
- sequence identity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 40
- 102000004196 processed proteins & peptides Human genes 0.000 claims 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims 40
- 210000005253 yeast cell Anatomy 0.000 claims 39
- 150000001413 amino acids Chemical group 0.000 claims 34
- 229930003827 cannabinoid Natural products 0.000 claims 30
- 239000003557 cannabinoid Substances 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 102000039446 nucleic acids Human genes 0.000 claims 26
- 108020004707 nucleic acids Proteins 0.000 claims 26
- 239000002253 acid Substances 0.000 claims 17
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 claims 16
- 229940065144 cannabinoids Drugs 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 230000009261 transgenic effect Effects 0.000 claims 9
- GVVPGTZRZFNKDS-YFHOEESVSA-N Geranyl diphosphate Natural products CC(C)=CCC\C(C)=C/COP(O)(=O)OP(O)(O)=O GVVPGTZRZFNKDS-YFHOEESVSA-N 0.000 claims 8
- GVVPGTZRZFNKDS-JXMROGBWSA-N geranyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O GVVPGTZRZFNKDS-JXMROGBWSA-N 0.000 claims 8
- 102000013404 Geranyltranstransferase Human genes 0.000 claims 6
- 108010026318 Geranyltranstransferase Proteins 0.000 claims 6
- 101001120927 Cannabis sativa 3,5,7-trioxododecanoyl-CoA synthase Proteins 0.000 claims 5
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims 5
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims 5
- 101710095468 Cyclase Proteins 0.000 claims 3
- 102100039164 Acetyl-CoA carboxylase 1 Human genes 0.000 claims 2
- 108010018763 Biotin carboxylase Proteins 0.000 claims 2
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 claims 2
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 claims 2
- 102000005454 Dimethylallyltranstransferase Human genes 0.000 claims 2
- 108010006731 Dimethylallyltranstransferase Proteins 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 108010000775 Hydroxymethylglutaryl-CoA synthase Proteins 0.000 claims 2
- 102100028889 Hydroxymethylglutaryl-CoA synthase, mitochondrial Human genes 0.000 claims 2
- 108700040132 Mevalonate kinases Proteins 0.000 claims 2
- 102100024279 Phosphomevalonate kinase Human genes 0.000 claims 2
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 2
- 229960003453 cannabinol Drugs 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 102000002678 mevalonate kinase Human genes 0.000 claims 2
- 108091000116 phosphomevalonate kinase Proteins 0.000 claims 2
- 101710186512 3-ketoacyl-CoA thiolase Proteins 0.000 claims 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 1
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 claims 1
- 101710084186 Acetyl-coenzyme A synthetase Proteins 0.000 claims 1
- 102100035709 Acetyl-coenzyme A synthetase, cytoplasmic Human genes 0.000 claims 1
- 101710194784 Acetyl-coenzyme A synthetase, cytoplasmic Proteins 0.000 claims 1
- 101001058938 Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) Glutaconyl-CoA decarboxylase subunit beta Proteins 0.000 claims 1
- 235000005273 Canna coccinea Nutrition 0.000 claims 1
- 240000008555 Canna flaccida Species 0.000 claims 1
- WVOLTBSCXRRQFR-SJORKVTESA-N Cannabidiolic acid Natural products OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@@H]1[C@@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-SJORKVTESA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000004031 Carboxy-Lyases Human genes 0.000 claims 1
- 102000005870 Coenzyme A Ligases Human genes 0.000 claims 1
- 101150051269 ERG10 gene Proteins 0.000 claims 1
- 101150071502 ERG12 gene Proteins 0.000 claims 1
- 101150014913 ERG13 gene Proteins 0.000 claims 1
- 101150045041 ERG8 gene Proteins 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N Isopentenyl diphosphate Natural products CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 claims 1
- 101100445407 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) erg10B gene Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 108010030975 Polyketide Synthases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 claims 1
- -1 cannavidiols Natural products 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491114P | 2017-04-27 | 2017-04-27 | |
| US62/491,114 | 2017-04-27 | ||
| US201762569532P | 2017-10-07 | 2017-10-07 | |
| US62/569,532 | 2017-10-07 | ||
| PCT/US2018/029668 WO2018200888A1 (en) | 2017-04-27 | 2018-04-27 | Microorganisms and methods for producing cannabinoids and cannabinoid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517293A JP2020517293A (ja) | 2020-06-18 |
| JP2020517293A5 true JP2020517293A5 (enExample) | 2021-06-10 |
| JP7198555B2 JP7198555B2 (ja) | 2023-01-04 |
Family
ID=62455816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558599A Active JP7198555B2 (ja) | 2017-04-27 | 2018-04-27 | カンナビノイドおよびカンナビノイド誘導体を産生するための微生物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10563211B2 (enExample) |
| EP (2) | EP3998336B1 (enExample) |
| JP (1) | JP7198555B2 (enExample) |
| CN (1) | CN110914416B (enExample) |
| AU (1) | AU2018256863B2 (enExample) |
| BR (1) | BR112019022500A2 (enExample) |
| ES (1) | ES2898272T3 (enExample) |
| IL (1) | IL270202B2 (enExample) |
| SG (1) | SG11201910019PA (enExample) |
| WO (1) | WO2018200888A1 (enExample) |
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