JP2020517263A - がんを治療するための組成物及び方法 - Google Patents

がんを治療するための組成物及び方法 Download PDF

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JP2020517263A
JP2020517263A JP2019556956A JP2019556956A JP2020517263A JP 2020517263 A JP2020517263 A JP 2020517263A JP 2019556956 A JP2019556956 A JP 2019556956A JP 2019556956 A JP2019556956 A JP 2019556956A JP 2020517263 A JP2020517263 A JP 2020517263A
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cells
cell
receptor
antigen
car
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JP2020517263A5 (enExample
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ピン ワン
ピン ワン
ナトナリー シリウォン
ナトナリー シリウォン
シ リ
シ リ
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ユニバーシティ オブ サザン カリフォルニア
ユニバーシティ オブ サザン カリフォルニア
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/55—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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JP2019556956A 2017-04-19 2018-04-19 がんを治療するための組成物及び方法 Pending JP2020517263A (ja)

Applications Claiming Priority (3)

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US201762487358P 2017-04-19 2017-04-19
US62/487,358 2017-04-19
PCT/US2018/028427 WO2018195348A1 (en) 2017-04-19 2018-04-19 Compositions and methods for treating cancer

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JP2020517263A true JP2020517263A (ja) 2020-06-18
JP2020517263A5 JP2020517263A5 (enExample) 2020-07-30

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US (1) US20210095029A1 (enExample)
EP (1) EP3612222A4 (enExample)
JP (1) JP2020517263A (enExample)
CN (1) CN110536700A (enExample)
AU (1) AU2018254517A1 (enExample)
WO (1) WO2018195348A1 (enExample)

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KR20210112310A (ko) * 2018-12-06 2021-09-14 광동 티씨알큐어 바이오파마 테크놀로지 씨오., 엘티디. 종양 항원, tgf-베타 및 면역체크포인트를 표적으로 하는 tcr-t 세포 복합 치료법
US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells
WO2020214957A1 (en) 2019-04-19 2020-10-22 Tcrcure Biopharma Corp. Anti-pd-1 antibodies and uses thereof
EP3999550A4 (en) 2019-07-17 2023-09-06 Legend Biotech USA Inc. ANTI-DLL3 CHIMERIC ANTIGEN RECEPTORS AND THEIR USES
WO2021155518A1 (en) * 2020-02-05 2021-08-12 Tcrcure Biopharma Corp Anti-hpv t cell receptors and engineered cells
TW202216768A (zh) 2020-06-22 2022-05-01 美商恩格姆生物製藥公司 Ｌａｉｒ－１結合劑及其使用方法
CN111704675B (zh) * 2020-07-08 2022-05-10 武汉波睿达生物科技有限公司 一种治疗hiv感染的双特异性嵌合抗原受体、基因、构建方法及其应用
CN111826400A (zh) * 2020-07-21 2020-10-27 中科宝承生物医学科技有限公司 一种双特异性抗体nk细胞制备方法及其细胞和应用
CN114437229B (zh) * 2020-11-01 2024-03-12 复旦大学 携带pd-1単链抗体且靶向egfr抗原的car t免疫细胞的制备及其用途
TW202330909A (zh) * 2021-09-09 2023-08-01 大陸商深圳市菲鵬生物治療股份有限公司 轉基因免疫效應細胞、其製備方法、慢病毒、構建體、癌症治療藥物及其應用
CN115025217B (zh) * 2022-05-13 2023-05-05 广东齐美医药生物科技集团有限公司 干细胞裂解物联合活性多糖以及酪氨酸酶抑制剂在制备药物或化妆品中的用途
CN119286780B (zh) * 2024-12-12 2025-03-21 山东省成体细胞产业技术研究院有限公司 一种t细胞的体外培养方法

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US20210095029A1 (en) 2021-04-01
EP3612222A1 (en) 2020-02-26
CN110536700A (zh) 2019-12-03
WO2018195348A9 (en) 2019-10-03
AU2018254517A1 (en) 2019-12-05
WO2018195348A1 (en) 2018-10-25

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