AU2018254517A1 - Compositions and methods for treating cancer - Google Patents

Info

Publication number

AU2018254517A1

AU2018254517A1 AU2018254517A AU2018254517A AU2018254517A1 AU 2018254517 A1 AU2018254517 A1 AU 2018254517A1 AU 2018254517 A AU2018254517 A AU 2018254517A AU 2018254517 A AU2018254517 A AU 2018254517A AU 2018254517 A1 AU2018254517 A1 AU 2018254517A1

Authority

AU

Australia

Prior art keywords

cells

cell

receptor

antigen

car

Prior art date

2017-04-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 206010028980 Neoplasm Diseases 0.000 title claims abstract description 127
• 238000000034 method Methods 0.000 title claims abstract description 53
• 201000011510 cancer Diseases 0.000 title claims abstract description 39
• 239000000203 mixture Substances 0.000 title abstract description 43
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims abstract description 134
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims abstract description 63
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims abstract description 63
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 31
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 30
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 30
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 308
• 210000004027 cell Anatomy 0.000 claims description 229
• 239000000427 antigen Substances 0.000 claims description 53
• 108091007433 antigens Proteins 0.000 claims description 51
• 102000036639 antigens Human genes 0.000 claims description 51
• 239000013598 vector Substances 0.000 claims description 35
• -1 CD79b Proteins 0.000 claims description 32
• 108090000623 proteins and genes Proteins 0.000 claims description 19
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
• 229920001184 polypeptide Polymers 0.000 claims description 15
• 102000004169 proteins and genes Human genes 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 13
• 230000004913 activation Effects 0.000 claims description 11
• 238000002560 therapeutic procedure Methods 0.000 claims description 11
• 108091008874 T cell receptors Proteins 0.000 claims description 9
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 9
• 108010060374 FSH Receptors Proteins 0.000 claims description 8
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 8
• 108040005514 choriogonadotropin hormone receptor activity proteins Proteins 0.000 claims description 8
• 208000020816 lung neoplasm Diseases 0.000 claims description 8
• 210000004698 lymphocyte Anatomy 0.000 claims description 8
• 201000001441 melanoma Diseases 0.000 claims description 8
• 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims description 7
• 201000005202 lung cancer Diseases 0.000 claims description 7
• 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims description 6
• 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims description 6
• 108060003951 Immunoglobulin Proteins 0.000 claims description 6
• 102000018358 immunoglobulin Human genes 0.000 claims description 6
• 230000011664 signaling Effects 0.000 claims description 6
• 101710188619 C-type lectin domain family 12 member A Proteins 0.000 claims description 5
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 5
• 102000003886 Glycoproteins Human genes 0.000 claims description 5
• 108090000288 Glycoproteins Proteins 0.000 claims description 5
• 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims description 5
• 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims description 5
• 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 5
• 150000001720 carbohydrates Chemical class 0.000 claims description 5
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims description 5
• 108091033319 polynucleotide Proteins 0.000 claims description 5
• 102000040430 polynucleotide Human genes 0.000 claims description 5
• 239000002157 polynucleotide Substances 0.000 claims description 5
• 230000003612 virological effect Effects 0.000 claims description 5
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 4
• 102100024263 CD160 antigen Human genes 0.000 claims description 4
• 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 4
• 229940045513 CTLA4 antagonist Drugs 0.000 claims description 4
• 102100038083 Endosialin Human genes 0.000 claims description 4
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 4
• 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 4
• 101000884275 Homo sapiens Endosialin Proteins 0.000 claims description 4
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 4
• 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims description 4
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 4
• 206010039491 Sarcoma Diseases 0.000 claims description 4
• 102100021393 Transcriptional repressor CTCFL Human genes 0.000 claims description 4
• 108091008039 hormone receptors Proteins 0.000 claims description 4
• 102000005962 receptors Human genes 0.000 claims description 4
• 108020003175 receptors Proteins 0.000 claims description 4
• 101710109924 A-kinase anchor protein 4 Proteins 0.000 claims description 3
• 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims description 3
• 102100026402 Adhesion G protein-coupled receptor E2 Human genes 0.000 claims description 3
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 3
• 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 3
• 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 3
• 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 3
• 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims description 3
• 102100038078 CD276 antigen Human genes 0.000 claims description 3
• 102100029390 CMRF35-like molecule 1 Human genes 0.000 claims description 3
• 102100025805 Cadherin-1 Human genes 0.000 claims description 3
• 102100038449 Claudin-6 Human genes 0.000 claims description 3
• 102100036939 G-protein coupled receptor 20 Human genes 0.000 claims description 3
• 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims description 3
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
• 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 claims description 3
• 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 3
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 3
• 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 3
• 101000990055 Homo sapiens CMRF35-like molecule 1 Proteins 0.000 claims description 3
• 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims description 3
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
• 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims description 3
• 101001065550 Homo sapiens Lymphocyte antigen 6K Proteins 0.000 claims description 3
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 3
• 101000721757 Homo sapiens Olfactory receptor 51E2 Proteins 0.000 claims description 3
• 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 3
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 3
• 101001047681 Homo sapiens Tyrosine-protein kinase Lck Proteins 0.000 claims description 3
• 241001502974 Human gammaherpesvirus 8 Species 0.000 claims description 3
• 108010031794 IGF Type 1 Receptor Proteins 0.000 claims description 3
• 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims description 3
• 102100029616 Immunoglobulin lambda-like polypeptide 1 Human genes 0.000 claims description 3
• 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 claims description 3
• 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 3
• 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 3
• 102100025586 Leukocyte immunoglobulin-like receptor subfamily A member 2 Human genes 0.000 claims description 3
• 102100032129 Lymphocyte antigen 6K Human genes 0.000 claims description 3
• 102100033486 Lymphocyte antigen 75 Human genes 0.000 claims description 3
• 102000003735 Mesothelin Human genes 0.000 claims description 3
• 108090000015 Mesothelin Proteins 0.000 claims description 3
• 101100328463 Mus musculus Cmya5 gene Proteins 0.000 claims description 3
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 3
• 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims description 3
• 102100025128 Olfactory receptor 51E2 Human genes 0.000 claims description 3
• 102100032364 Pannexin-3 Human genes 0.000 claims description 3
• 102100026181 Placenta-specific protein 1 Human genes 0.000 claims description 3
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims description 3
• 101710094000 Programmed cell death 1 ligand 1 Proteins 0.000 claims description 3
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 3
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 3
• 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 3
• 102100037686 Protein SSX2 Human genes 0.000 claims description 3
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims description 3
• 102100035748 Squamous cell carcinoma antigen recognized by T-cells 3 Human genes 0.000 claims description 3
• 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 3
• 102100034196 Thrombopoietin receptor Human genes 0.000 claims description 3
• 102100029337 Thyrotropin receptor Human genes 0.000 claims description 3
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 3
• 102100027212 Tumor-associated calcium signal transducer 2 Human genes 0.000 claims description 3
• 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 claims description 3
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 3
• 241000700605 Viruses Species 0.000 claims description 3
• 238000002512 chemotherapy Methods 0.000 claims description 3
• 210000000265 leukocyte Anatomy 0.000 claims description 3
• 230000005855 radiation Effects 0.000 claims description 3
• 238000000176 thermal ionisation mass spectrometry Methods 0.000 claims description 3
• 238000013055 trapped ion mobility spectrometry Methods 0.000 claims description 3
• WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims description 2
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
• 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims description 2
• 102100032187 Androgen receptor Human genes 0.000 claims description 2
• 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims description 2
• 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims description 2
• 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims description 2
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 2
• 108700012439 CA9 Proteins 0.000 claims description 2
• 108010058905 CD44v6 antigen Proteins 0.000 claims description 2
• 102100025221 CD70 antigen Human genes 0.000 claims description 2
• 108060001253 CD99 Proteins 0.000 claims description 2
• 102000024905 CD99 Human genes 0.000 claims description 2
• 102100024151 Cadherin-16 Human genes 0.000 claims description 2
• 102100024152 Cadherin-17 Human genes 0.000 claims description 2
• 102100022529 Cadherin-19 Human genes 0.000 claims description 2
• 102100029756 Cadherin-6 Human genes 0.000 claims description 2
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 2
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 2
• 108010051152 Carboxylesterase Proteins 0.000 claims description 2
• 102000013392 Carboxylesterase Human genes 0.000 claims description 2
• 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims description 2
• 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 claims description 2
• 102000016736 Cyclin Human genes 0.000 claims description 2
• 108050006400 Cyclin Proteins 0.000 claims description 2
• 108010044090 Ephrin-B2 Proteins 0.000 claims description 2
• 102100023721 Ephrin-B2 Human genes 0.000 claims description 2
• 102000010451 Folate receptor alpha Human genes 0.000 claims description 2
• 108050001931 Folate receptor alpha Proteins 0.000 claims description 2
• 102000010449 Folate receptor beta Human genes 0.000 claims description 2
• 108050001930 Folate receptor beta Proteins 0.000 claims description 2
• 102000003817 Fos-related antigen 1 Human genes 0.000 claims description 2
• 108090000123 Fos-related antigen 1 Proteins 0.000 claims description 2
• 102000044445 Galectin-8 Human genes 0.000 claims description 2
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
• 101000718211 Homo sapiens Adhesion G protein-coupled receptor E2 Proteins 0.000 claims description 2
• 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims description 2
• 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims description 2
• 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims description 2
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 2
• 101000984015 Homo sapiens Cadherin-1 Proteins 0.000 claims description 2
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 2
• 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims description 2
• 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 claims description 2
• 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims description 2
• 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims description 2
• 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims description 2
• 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims description 2
• 101001051490 Homo sapiens Neural cell adhesion molecule L1 Proteins 0.000 claims description 2
• 101000601724 Homo sapiens Paired box protein Pax-5 Proteins 0.000 claims description 2
• 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 2
• 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 2
• 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims description 2
• 101000873927 Homo sapiens Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 claims description 2
• 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims description 2
• 101100453332 Human herpesvirus 8 type P (isolate GK18) K8.1 gene Proteins 0.000 claims description 2
• 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 2
• 102100034872 Kallikrein-4 Human genes 0.000 claims description 2
• 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims description 2
• 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims description 2
• 102000000440 Melanoma-associated antigen Human genes 0.000 claims description 2
• 108050008953 Melanoma-associated antigen Proteins 0.000 claims description 2
• 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims description 2
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 2
• 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims description 2
• 206010029260 Neuroblastoma Diseases 0.000 claims description 2
• 102100040891 Paired box protein Pax-3 Human genes 0.000 claims description 2
• 102100037504 Paired box protein Pax-5 Human genes 0.000 claims description 2
• 206010060862 Prostate cancer Diseases 0.000 claims description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
• 239000004365 Protease Substances 0.000 claims description 2
• 102100029198 SLAM family member 7 Human genes 0.000 claims description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
• 102100038081 Signal transducer CD24 Human genes 0.000 claims description 2
• 102100037253 Solute carrier family 45 member 3 Human genes 0.000 claims description 2
• 108010002687 Survivin Proteins 0.000 claims description 2
• 108010017842 Telomerase Proteins 0.000 claims description 2
• 108010000499 Thromboplastin Proteins 0.000 claims description 2
• 102100030859 Tissue factor Human genes 0.000 claims description 2
• 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims description 2
• 102000003425 Tyrosinase Human genes 0.000 claims description 2
• 108060008724 Tyrosinase Proteins 0.000 claims description 2
• 239000002253 acid Substances 0.000 claims description 2
• 108010080146 androgen receptors Proteins 0.000 claims description 2
• 108010055066 asparaginylendopeptidase Proteins 0.000 claims description 2
• 210000000481 breast Anatomy 0.000 claims description 2
• 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 claims description 2
• 230000004927 fusion Effects 0.000 claims description 2
• 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims description 2
• 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims description 2
• PFJKOHUKELZMLE-VEUXDRLPSA-N ganglioside GM3 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 PFJKOHUKELZMLE-VEUXDRLPSA-N 0.000 claims description 2
• 230000000968 intestinal effect Effects 0.000 claims description 2
• 108010024383 kallikrein 4 Proteins 0.000 claims description 2
• 208000032839 leukemia Diseases 0.000 claims description 2
• 108010079891 prostein Proteins 0.000 claims description 2
• 230000005945 translocation Effects 0.000 claims description 2
• 102000001301 EGF receptor Human genes 0.000 claims 4
• 108060006698 EGF receptor Proteins 0.000 claims 4
• 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims 4
• 241000701806 Human papillomavirus Species 0.000 claims 3
• LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 claims 2
• 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 2
• 101710145634 Antigen 1 Proteins 0.000 claims 2
• 102100034159 Beta-3 adrenergic receptor Human genes 0.000 claims 2
• 108010051118 Bone Marrow Stromal Antigen 2 Proteins 0.000 claims 2
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 2
• 108090000229 Claudin-6 Proteins 0.000 claims 2
• 108010001687 Enterotoxin Receptors Proteins 0.000 claims 2
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 2
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 2
• 101710108873 G-protein coupled receptor 20 Proteins 0.000 claims 2
• 102000010956 Glypican Human genes 0.000 claims 2
• 108050001154 Glypican Proteins 0.000 claims 2
• 108050007237 Glypican-3 Proteins 0.000 claims 2
• 102100022662 Guanylyl cyclase C Human genes 0.000 claims 2
• 101000780539 Homo sapiens Beta-3 adrenergic receptor Proteins 0.000 claims 2
• 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 claims 2
• 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
• 101710107067 Immunoglobulin lambda-like polypeptide 1 Proteins 0.000 claims 2
• 101710099452 Inactive tyrosine-protein kinase 7 Proteins 0.000 claims 2
• 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 2
• 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 2
• 101710192606 Latent membrane protein 2 Proteins 0.000 claims 2
• 101710196509 Leukocyte immunoglobulin-like receptor subfamily A member 2 Proteins 0.000 claims 2
• 101710157884 Lymphocyte antigen 75 Proteins 0.000 claims 2
• 102000007298 Mucin-1 Human genes 0.000 claims 2
• 108010008707 Mucin-1 Proteins 0.000 claims 2
• 101710191829 Myeloproliferative leukemia protein Proteins 0.000 claims 2
• 101710165197 Pannexin-3 Proteins 0.000 claims 2
• 108050005093 Placenta-specific protein 1 Proteins 0.000 claims 2
• 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 claims 2
• 101710120463 Prostate stem cell antigen Proteins 0.000 claims 2
• 102100035703 Prostatic acid phosphatase Human genes 0.000 claims 2
• 101710149284 Protein SSX2 Proteins 0.000 claims 2
• 102100038098 Protein-glutamine gamma-glutamyltransferase 5 Human genes 0.000 claims 2
• 102000005622 Receptor for Advanced Glycation End Products Human genes 0.000 claims 2
• 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 claims 2
• 101710148535 Thrombopoietin receptor Proteins 0.000 claims 2
• 108090000253 Thyrotropin Receptors Proteins 0.000 claims 2
• 102000013532 Uroplakin II Human genes 0.000 claims 2
• 108010065940 Uroplakin II Proteins 0.000 claims 2
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 2
• 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
• 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
• 230000004069 differentiation Effects 0.000 claims 2
• 108010051081 dopachrome isomerase Proteins 0.000 claims 2
• 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 claims 2
• 150000002270 gangliosides Chemical class 0.000 claims 2
• 108010043671 prostatic acid phosphatase Proteins 0.000 claims 2
• 108010058721 transglutaminase 5 Proteins 0.000 claims 2
• 102100022907 Acrosin-binding protein Human genes 0.000 claims 1
• 101710107749 Acrosin-binding protein Proteins 0.000 claims 1
• 101710096292 Adhesion G protein-coupled receptor E2 Proteins 0.000 claims 1
• 102100037982 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A Human genes 0.000 claims 1
• 102100022014 Angiopoietin-1 receptor Human genes 0.000 claims 1
• 101710131689 Angiopoietin-1 receptor Proteins 0.000 claims 1
• TZBJAXGYGSIUHQ-XUXIUFHCSA-N Asp-Leu-Leu-Ser Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O TZBJAXGYGSIUHQ-XUXIUFHCSA-N 0.000 claims 1
• 241000271566 Aves Species 0.000 claims 1
• 108091007065 BIRCs Proteins 0.000 claims 1
• 102000018202 CC chemokine receptor 4 Human genes 0.000 claims 1
• 108010014064 CCCTC-Binding Factor Proteins 0.000 claims 1
• 108010017317 CCR4 Receptors Proteins 0.000 claims 1
• 102000000905 Cadherin Human genes 0.000 claims 1
• 108050007957 Cadherin Proteins 0.000 claims 1
• 101710196874 Cadherin-16 Proteins 0.000 claims 1
• 101710196881 Cadherin-17 Proteins 0.000 claims 1
• 101710196922 Cadherin-19 Proteins 0.000 claims 1
• 101100518995 Caenorhabditis elegans pax-3 gene Proteins 0.000 claims 1
• 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 claims 1
• 101710181340 Chaperone protein DnaK2 Proteins 0.000 claims 1
• 102000018832 Cytochromes Human genes 0.000 claims 1
• 108010052832 Cytochromes Proteins 0.000 claims 1
• 102100031334 Elongation factor 2 Human genes 0.000 claims 1
• 102000003951 Erythropoietin Human genes 0.000 claims 1
• 108090000394 Erythropoietin Proteins 0.000 claims 1
• 229930186217 Glycolipid Natural products 0.000 claims 1
• 101710178419 Heat shock protein 70 2 Proteins 0.000 claims 1
• 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 claims 1
• 102100020787 Interleukin-11 receptor subunit alpha Human genes 0.000 claims 1
• 101710101479 Interleukin-11 receptor subunit alpha Proteins 0.000 claims 1
• 108010056045 K cadherin Proteins 0.000 claims 1
• 102000016200 MART-1 Antigen Human genes 0.000 claims 1
• 108010010995 MART-1 Antigen Proteins 0.000 claims 1
• 101100518997 Mus musculus Pax3 gene Proteins 0.000 claims 1
• KUIFHYPNNRVEKZ-VIJRYAKMSA-N O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine Chemical compound OC(=O)[C@@H](N)[C@@H](C)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O KUIFHYPNNRVEKZ-VIJRYAKMSA-N 0.000 claims 1
• 108700020796 Oncogene Proteins 0.000 claims 1
• 101710149060 Paired box protein Pax-3 Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 108010077519 Peptide Elongation Factor 2 Proteins 0.000 claims 1
• 102100037891 Plexin domain-containing protein 1 Human genes 0.000 claims 1
• 108050009432 Plexin domain-containing protein 1 Proteins 0.000 claims 1
• 108010006700 Receptor Tyrosine Kinase-like Orphan Receptors Proteins 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 102100027610 Rho-related GTP-binding protein RhoC Human genes 0.000 claims 1
• 108010062314 Signaling Lymphocytic Activation Molecule Family Proteins 0.000 claims 1
• 102000010841 Signaling Lymphocytic Activation Molecule Family Human genes 0.000 claims 1
• 101710185775 Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 claims 1
• 101710128101 Transcriptional repressor CTCFL Proteins 0.000 claims 1
• 101710186513 Tyrosine-protein kinase receptor Tie-2 Proteins 0.000 claims 1
• 208000008383 Wilms tumor Diseases 0.000 claims 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
• 108010034034 alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase Proteins 0.000 claims 1
• XBSNXOHQOTUENA-KRAHZTDDSA-N alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)C(O)O[C@@H]1CO XBSNXOHQOTUENA-KRAHZTDDSA-N 0.000 claims 1
• CXQCLLQQYTUUKJ-ALWAHNIESA-N beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer(d18:1/18:0) Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@@H](CO)O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 CXQCLLQQYTUUKJ-ALWAHNIESA-N 0.000 claims 1
• 229940105423 erythropoietin Drugs 0.000 claims 1
• 210000002950 fibroblast Anatomy 0.000 claims 1
• 238000010362 genome editing Methods 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 210000002752 melanocyte Anatomy 0.000 claims 1
• 201000008026 nephroblastoma Diseases 0.000 claims 1
• 230000001537 neural effect Effects 0.000 claims 1
• 101710135378 pH 6 antigen Proteins 0.000 claims 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
• 108010073531 rhoC GTP-Binding Protein Proteins 0.000 claims 1
• 239000011701 zinc Substances 0.000 claims 1
• 229910052725 zinc Inorganic materials 0.000 claims 1
• 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 description 76
• 230000014509 gene expression Effects 0.000 description 66
• 238000011282 treatment Methods 0.000 description 47
• 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 43
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 31
• 102100037850 Interferon gamma Human genes 0.000 description 28
• 108010074328 Interferon-gamma Proteins 0.000 description 28
• 108010074708 B7-H1 Antigen Proteins 0.000 description 27
• 102000008096 B7-H1 Antigen Human genes 0.000 description 27
• 201000010099 disease Diseases 0.000 description 26
• 230000000638 stimulation Effects 0.000 description 25
• 241000699670 Mus sp. Species 0.000 description 24
• 239000012634 fragment Substances 0.000 description 23
• 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 20
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 20
• 230000006870 function Effects 0.000 description 20
• 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 description 19
• 230000000694 effects Effects 0.000 description 19
• 210000001519 tissue Anatomy 0.000 description 19
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 18
• 239000012636 effector Substances 0.000 description 18
• 230000003248 secreting effect Effects 0.000 description 18
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 17
• 230000000259 anti-tumor effect Effects 0.000 description 16
• 229940121354 immunomodulator Drugs 0.000 description 15
• 210000000822 natural killer cell Anatomy 0.000 description 15
• 239000012642 immune effector Substances 0.000 description 14
• 238000002347 injection Methods 0.000 description 14
• 239000007924 injection Substances 0.000 description 14
• 239000000463 material Substances 0.000 description 14
• 230000027455 binding Effects 0.000 description 13
• 238000000684 flow cytometry Methods 0.000 description 13
• 230000004083 survival effect Effects 0.000 description 13
• 238000004519 manufacturing process Methods 0.000 description 12
• 230000001177 retroviral effect Effects 0.000 description 12
• 208000024891 symptom Diseases 0.000 description 12
• 230000002401 inhibitory effect Effects 0.000 description 11
• 239000002609 medium Substances 0.000 description 11
• 238000002965 ELISA Methods 0.000 description 10
• 210000004369 blood Anatomy 0.000 description 10
• 239000008280 blood Substances 0.000 description 10
• 238000004113 cell culture Methods 0.000 description 10
• 238000001727 in vivo Methods 0.000 description 10
• 230000001965 increasing effect Effects 0.000 description 10
• 238000001802 infusion Methods 0.000 description 10
• 235000018102 proteins Nutrition 0.000 description 10
• 210000000952 spleen Anatomy 0.000 description 10
• 239000006228 supernatant Substances 0.000 description 10
• 238000010361 transduction Methods 0.000 description 10
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 9
• 206010027476 Metastases Diseases 0.000 description 9
• 241001465754 Metazoa Species 0.000 description 9
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 9
• 230000010261 cell growth Effects 0.000 description 9
• 238000012986 modification Methods 0.000 description 9
• 230000004048 modification Effects 0.000 description 9
• 239000000872 buffer Substances 0.000 description 8
• 230000003915 cell function Effects 0.000 description 8
• 230000003247 decreasing effect Effects 0.000 description 8
• 230000009401 metastasis Effects 0.000 description 8
• 230000035755 proliferation Effects 0.000 description 8
• 230000026683 transduction Effects 0.000 description 8
• 238000012546 transfer Methods 0.000 description 8
• VDABVNMGKGUPEY-UHFFFAOYSA-N 6-carboxyfluorescein succinimidyl ester Chemical compound C=1C(O)=CC=C2C=1OC1=CC(O)=CC=C1C2(C1=C2)OC(=O)C1=CC=C2C(=O)ON1C(=O)CCC1=O VDABVNMGKGUPEY-UHFFFAOYSA-N 0.000 description 7
• 238000003556 assay Methods 0.000 description 7
• 230000008901 benefit Effects 0.000 description 7
• 230000000903 blocking effect Effects 0.000 description 7
• 210000001185 bone marrow Anatomy 0.000 description 7
• 239000003795 chemical substances by application Substances 0.000 description 7
• 239000012228 culture supernatant Substances 0.000 description 7
• 230000002708 enhancing effect Effects 0.000 description 7
• 230000001506 immunosuppresive effect Effects 0.000 description 7
• 239000007788 liquid Substances 0.000 description 7
• 210000000056 organ Anatomy 0.000 description 7
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 7
• 239000000546 pharmaceutical excipient Substances 0.000 description 7
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
• 238000011357 CAR T-cell therapy Methods 0.000 description 6
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 6
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 239000003814 drug Substances 0.000 description 6
• 238000002474 experimental method Methods 0.000 description 6
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 6
• 238000000338 in vitro Methods 0.000 description 6
• 230000003834 intracellular effect Effects 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 230000028327 secretion Effects 0.000 description 6
• 230000004614 tumor growth Effects 0.000 description 6
• 230000003827 upregulation Effects 0.000 description 6
• 238000001262 western blot Methods 0.000 description 6
• 108020004414 DNA Proteins 0.000 description 5
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
• 241000699666 Mus <mouse, genus> Species 0.000 description 5
• 150000001413 amino acids Chemical class 0.000 description 5
• 238000004458 analytical method Methods 0.000 description 5
• 230000005809 anti-tumor immunity Effects 0.000 description 5
• 238000001514 detection method Methods 0.000 description 5
• 208000035475 disorder Diseases 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• 230000008029 eradication Effects 0.000 description 5
• 239000012091 fetal bovine serum Substances 0.000 description 5
• 238000009169 immunotherapy Methods 0.000 description 5
• 108091008042 inhibitory receptors Proteins 0.000 description 5
• 239000003446 ligand Substances 0.000 description 5
• 230000000670 limiting effect Effects 0.000 description 5
• 230000037361 pathway Effects 0.000 description 5
• 239000007787 solid Substances 0.000 description 5
• 239000000243 solution Substances 0.000 description 5
• 235000000346 sugar Nutrition 0.000 description 5
• 150000005846 sugar alcohols Chemical class 0.000 description 5
• 238000012447 xenograft mouse model Methods 0.000 description 5
• 206010006187 Breast cancer Diseases 0.000 description 4
• 208000026310 Breast neoplasm Diseases 0.000 description 4
• 241000283707 Capra Species 0.000 description 4
• 102000018343 Follicle stimulating hormone receptors Human genes 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 208000002250 Hematologic Neoplasms Diseases 0.000 description 4
• 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 4
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 4
• 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 4
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 4
• 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 description 4
• 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 description 4
• 102100022339 Integrin alpha-L Human genes 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 4
• 102100029197 SLAM family member 6 Human genes 0.000 description 4
• 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 description 4
• 229920002472 Starch Polymers 0.000 description 4
• 230000006052 T cell proliferation Effects 0.000 description 4
• 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 description 4
• 235000001014 amino acid Nutrition 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 238000002659 cell therapy Methods 0.000 description 4
• 238000003776 cleavage reaction Methods 0.000 description 4
• 230000001472 cytotoxic effect Effects 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 210000002865 immune cell Anatomy 0.000 description 4
• 230000036039 immunity Effects 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 239000005022 packaging material Substances 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 230000001105 regulatory effect Effects 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 230000004044 response Effects 0.000 description 4
• 230000002441 reversible effect Effects 0.000 description 4
• 230000007017 scission Effects 0.000 description 4
• 238000010186 staining Methods 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
• 238000007920 subcutaneous administration Methods 0.000 description 4
• 239000006188 syrup Substances 0.000 description 4
• 235000020357 syrup Nutrition 0.000 description 4
• 230000009885 systemic effect Effects 0.000 description 4
• 230000008685 targeting Effects 0.000 description 4
• 229940124597 therapeutic agent Drugs 0.000 description 4
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 3
• 239000007995 HEPES buffer Substances 0.000 description 3
• 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 description 3
• 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 3
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 3
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
• 102100025323 Integrin alpha-1 Human genes 0.000 description 3
• 102100032816 Integrin alpha-6 Human genes 0.000 description 3
• 102100025390 Integrin beta-2 Human genes 0.000 description 3
• 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 3
• 208000008839 Kidney Neoplasms Diseases 0.000 description 3
• 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 3
• 206010033128 Ovarian cancer Diseases 0.000 description 3
• 206010061535 Ovarian neoplasm Diseases 0.000 description 3
• 108020004511 Recombinant DNA Proteins 0.000 description 3
• 108010090804 Streptavidin Proteins 0.000 description 3
• 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 3
• 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 3
• 238000010171 animal model Methods 0.000 description 3
• 210000003719 b-lymphocyte Anatomy 0.000 description 3
• 239000011324 bead Substances 0.000 description 3
• 230000009286 beneficial effect Effects 0.000 description 3
• 108091006004 biotinylated proteins Proteins 0.000 description 3
• 210000001072 colon Anatomy 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 238000010276 construction Methods 0.000 description 3
• 230000000139 costimulatory effect Effects 0.000 description 3
• 230000001461 cytolytic effect Effects 0.000 description 3
• 231100000433 cytotoxic Toxicity 0.000 description 3
• 231100000135 cytotoxicity Toxicity 0.000 description 3
• 230000003013 cytotoxicity Effects 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 210000004443 dendritic cell Anatomy 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000003828 downregulation Effects 0.000 description 3
• 238000012377 drug delivery Methods 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 238000011534 incubation Methods 0.000 description 3
• 230000004068 intracellular signaling Effects 0.000 description 3
• 210000002540 macrophage Anatomy 0.000 description 3
• 230000036210 malignancy Effects 0.000 description 3
• 229920000642 polymer Polymers 0.000 description 3
• 230000003389 potentiating effect Effects 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 238000009097 single-agent therapy Methods 0.000 description 3
• 235000002639 sodium chloride Nutrition 0.000 description 3
• 239000008107 starch Substances 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 239000000725 suspension Substances 0.000 description 3
• 230000002459 sustained effect Effects 0.000 description 3
• 230000001225 therapeutic effect Effects 0.000 description 3
• 210000004881 tumor cell Anatomy 0.000 description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 2
• IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
• 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 2
• 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 description 2
• 102100038077 CD226 antigen Human genes 0.000 description 2
• 102100027207 CD27 antigen Human genes 0.000 description 2
• 101150013553 CD40 gene Proteins 0.000 description 2
• 201000009030 Carcinoma Diseases 0.000 description 2
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 208000035473 Communicable disease Diseases 0.000 description 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
• 229930105110 Cyclosporin A Natural products 0.000 description 2
• 108010036949 Cyclosporine Proteins 0.000 description 2
• 102000004127 Cytokines Human genes 0.000 description 2
• 108090000695 Cytokines Proteins 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
• 229920001503 Glucan Polymers 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
• 101000884298 Homo sapiens CD226 antigen Proteins 0.000 description 2
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 2
• 101000884279 Homo sapiens CD276 antigen Proteins 0.000 description 2
• 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 description 2
• 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 2
• 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 description 2
• 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 description 2
• 101000633782 Homo sapiens SLAM family member 8 Proteins 0.000 description 2
• 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 description 2
• 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 2
• 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 description 2
• 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 description 2
• 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 2
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 2
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
• 102100022297 Integrin alpha-X Human genes 0.000 description 2
• 102100025304 Integrin beta-1 Human genes 0.000 description 2
• 108010002350 Interleukin-2 Proteins 0.000 description 2
• 102000000588 Interleukin-2 Human genes 0.000 description 2
• 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
• 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 description 2
• 102000015636 Oligopeptides Human genes 0.000 description 2
• 108010038807 Oligopeptides Proteins 0.000 description 2
• 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 description 2
• 229930182555 Penicillin Natural products 0.000 description 2
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 description 2
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 description 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 208000015634 Rectal Neoplasms Diseases 0.000 description 2
• 102100029214 SLAM family member 8 Human genes 0.000 description 2
• 102100027744 Semaphorin-4D Human genes 0.000 description 2
• 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 230000006044 T cell activation Effects 0.000 description 2
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 2
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
• 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 2
• 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
• 208000002495 Uterine Neoplasms Diseases 0.000 description 2
• 208000009956 adenocarcinoma Diseases 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 230000006023 anti-tumor response Effects 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 230000003190 augmentative effect Effects 0.000 description 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 239000006143 cell culture medium Substances 0.000 description 2
• 230000006037 cell lysis Effects 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 239000006285 cell suspension Substances 0.000 description 2
• 238000012512 characterization method Methods 0.000 description 2
• 229960001265 ciclosporin Drugs 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 238000002648 combination therapy Methods 0.000 description 2
• 238000011284 combination treatment Methods 0.000 description 2
• 230000000875 corresponding effect Effects 0.000 description 2
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 2
• 229930182912 cyclosporin Natural products 0.000 description 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 229960004679 doxorubicin Drugs 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 239000013604 expression vector Substances 0.000 description 2
• 229960000390 fludarabine Drugs 0.000 description 2
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 239000007903 gelatin capsule Substances 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• 235000011187 glycerol Nutrition 0.000 description 2
• KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
• 239000001963 growth medium Substances 0.000 description 2
• 208000014829 head and neck neoplasm Diseases 0.000 description 2
• 102000048362 human PDCD1 Human genes 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 238000010212 intracellular staining Methods 0.000 description 2
• 238000010253 intravenous injection Methods 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 230000003902 lesion Effects 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 239000012669 liquid formulation Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 239000003550 marker Substances 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 230000001404 mediated effect Effects 0.000 description 2
• 210000003071 memory t lymphocyte Anatomy 0.000 description 2
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
• 230000001394 metastastic effect Effects 0.000 description 2
• 208000037819 metastatic cancer Diseases 0.000 description 2
• 208000011575 metastatic malignant neoplasm Diseases 0.000 description 2
• 206010061289 metastatic neoplasm Diseases 0.000 description 2
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 2
• 238000003801 milling Methods 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 238000001543 one-way ANOVA Methods 0.000 description 2
• 210000003463 organelle Anatomy 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 229940049954 penicillin Drugs 0.000 description 2
• 230000004962 physiological condition Effects 0.000 description 2
• 229920001223 polyethylene glycol Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 238000009258 post-therapy Methods 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 239000013608 rAAV vector Substances 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 206010038038 rectal cancer Diseases 0.000 description 2
• 201000001275 rectum cancer Diseases 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 210000003289 regulatory T cell Anatomy 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• 210000000813 small intestine Anatomy 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 125000006850 spacer group Chemical group 0.000 description 2
• 230000002269 spontaneous effect Effects 0.000 description 2
• 238000007619 statistical method Methods 0.000 description 2
• 229960005322 streptomycin Drugs 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 231100000057 systemic toxicity Toxicity 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
• 206010046766 uterine cancer Diseases 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 1
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
• LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
• YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 description 1
• 108700012813 7-aminoactinomycin D Proteins 0.000 description 1
• 102100040079 A-kinase anchor protein 4 Human genes 0.000 description 1
• 102000017918 ADRB3 Human genes 0.000 description 1
• 108060003355 ADRB3 Proteins 0.000 description 1
• PITHJRRCEANNKJ-UHFFFAOYSA-N Aclacinomycin A Natural products C12=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C=C2C(C(=O)OC)C(CC)(O)CC1OC(OC1C)CC(N(C)C)C1OC(OC1C)CC(O)C1OC1CCC(=O)C(C)O1 PITHJRRCEANNKJ-UHFFFAOYSA-N 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
• 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 108010031480 Artificial Receptors Proteins 0.000 description 1
• CPMKYMGGYUFOHS-FSPLSTOPSA-N Asp-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(O)=O CPMKYMGGYUFOHS-FSPLSTOPSA-N 0.000 description 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
• 102100027522 Baculoviral IAP repeat-containing protein 7 Human genes 0.000 description 1
• 206010005949 Bone cancer Diseases 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 206010006143 Brain stem glioma Diseases 0.000 description 1
• 102100026008 Breakpoint cluster region protein Human genes 0.000 description 1
• 102100023458 C-type lectin-like domain family 1 Human genes 0.000 description 1
• 108010056102 CD100 antigen Proteins 0.000 description 1
• 108010017009 CD11b Antigen Proteins 0.000 description 1
• 108010005327 CD19-specific chimeric antigen receptor Proteins 0.000 description 1
• 102100027217 CD82 antigen Human genes 0.000 description 1
• 101710139831 CD82 antigen Proteins 0.000 description 1
• 102100037904 CD9 antigen Human genes 0.000 description 1
• 101100067721 Caenorhabditis elegans gly-3 gene Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 239000004215 Carbon black (E152) Substances 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 108091007854 Cdh1/Fizzy-related Proteins 0.000 description 1
• 206010007953 Central nervous system lymphoma Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 101710178046 Chorismate synthase 1 Proteins 0.000 description 1
• 208000017667 Chronic Disease Diseases 0.000 description 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• 101710152695 Cysteine synthase 1 Proteins 0.000 description 1
• 102100027417 Cytochrome P450 1B1 Human genes 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 101100481408 Danio rerio tie2 gene Proteins 0.000 description 1
• 102100036466 Delta-like protein 3 Human genes 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• 239000004375 Dextrin Substances 0.000 description 1
• 229920001353 Dextrin Polymers 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 101100044298 Drosophila melanogaster fand gene Proteins 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 238000008157 ELISA kit Methods 0.000 description 1
• 102000012804 EPCAM Human genes 0.000 description 1
• 101150084967 EPCAM gene Proteins 0.000 description 1
• 101150029707 ERBB2 gene Proteins 0.000 description 1
• 108010055196 EphA2 Receptor Proteins 0.000 description 1
• 102100030340 Ephrin type-A receptor 2 Human genes 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 102100029951 Estrogen receptor beta Human genes 0.000 description 1
• 101150064015 FAS gene Proteins 0.000 description 1
• 239000001116 FEMA 4028 Substances 0.000 description 1
• 101150032879 Fcrl5 gene Proteins 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 101710088083 Glomulin Proteins 0.000 description 1
• 102100032530 Glypican-3 Human genes 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical group C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 102000025850 HLA-A2 Antigen Human genes 0.000 description 1
• 108010074032 HLA-A2 Antigen Proteins 0.000 description 1
• 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 description 1
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
• 102100028721 Hermansky-Pudlak syndrome 5 protein Human genes 0.000 description 1
• SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
• 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 241001272567 Hominoidea Species 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000936083 Homo sapiens Baculoviral IAP repeat-containing protein 7 Proteins 0.000 description 1
• 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 description 1
• 101000912622 Homo sapiens C-type lectin domain family 12 member A Proteins 0.000 description 1
• 101000906643 Homo sapiens C-type lectin-like domain family 1 Proteins 0.000 description 1
• 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 1
• 101000762246 Homo sapiens Cadherin-16 Proteins 0.000 description 1
• 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 description 1
• 101000899410 Homo sapiens Cadherin-19 Proteins 0.000 description 1
• 101000794604 Homo sapiens Cadherin-6 Proteins 0.000 description 1
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 1
• 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 description 1
• 101000882898 Homo sapiens Claudin-6 Proteins 0.000 description 1
• 101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 description 1
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 description 1
• 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 description 1
• 101000954709 Homo sapiens Doublecortin domain-containing protein 2 Proteins 0.000 description 1
• 101001010910 Homo sapiens Estrogen receptor beta Proteins 0.000 description 1
• 101001071355 Homo sapiens G-protein coupled receptor 20 Proteins 0.000 description 1
• 101001014668 Homo sapiens Glypican-3 Proteins 0.000 description 1
• 101000985516 Homo sapiens Hermansky-Pudlak syndrome 5 protein Proteins 0.000 description 1
• 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 1
• 101000840267 Homo sapiens Immunoglobulin lambda-like polypeptide 1 Proteins 0.000 description 1
• 101000606465 Homo sapiens Inactive tyrosine-protein kinase 7 Proteins 0.000 description 1
• 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 1
• 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 1
• 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 description 1
• 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 description 1
• 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 description 1
• 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 description 1
• 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 description 1
• 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
• 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 description 1
• 101000614481 Homo sapiens Kidney-associated antigen 1 Proteins 0.000 description 1
• 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 1
• 101000984197 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily A member 2 Proteins 0.000 description 1
• 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
• 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
• 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 description 1
• 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 description 1
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 1
• 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 description 1
• 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 1
• 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 description 1
• 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 1
• 101000613490 Homo sapiens Paired box protein Pax-3 Proteins 0.000 description 1
• 101000589399 Homo sapiens Pannexin-3 Proteins 0.000 description 1
• 101000691463 Homo sapiens Placenta-specific protein 1 Proteins 0.000 description 1
• 101001064779 Homo sapiens Plexin domain-containing protein 2 Proteins 0.000 description 1
• 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 description 1
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 description 1
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 1
• 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 description 1
• 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 description 1
• 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
• 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 description 1
• 101000665137 Homo sapiens Scm-like with four MBT domains protein 1 Proteins 0.000 description 1
• 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 description 1
• 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 description 1
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
• 101000714168 Homo sapiens Testisin Proteins 0.000 description 1
• 101000799466 Homo sapiens Thrombopoietin receptor Proteins 0.000 description 1
• 101000772267 Homo sapiens Thyrotropin receptor Proteins 0.000 description 1
• 101000894428 Homo sapiens Transcriptional repressor CTCFL Proteins 0.000 description 1
• 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 description 1
• 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 description 1
• 101000808105 Homo sapiens Uroplakin-2 Proteins 0.000 description 1
• 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
• 241000714192 Human spumaretrovirus Species 0.000 description 1
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 206010062016 Immunosuppression Diseases 0.000 description 1
• 102100034343 Integrase Human genes 0.000 description 1
• 108010061833 Integrases Proteins 0.000 description 1
• 102100032818 Integrin alpha-4 Human genes 0.000 description 1
• 102100039904 Integrin alpha-D Human genes 0.000 description 1
• 102100022341 Integrin alpha-E Human genes 0.000 description 1
• 102100022338 Integrin alpha-M Human genes 0.000 description 1
• 108010041100 Integrin alpha6 Proteins 0.000 description 1
• 108010030465 Integrin alpha6beta1 Proteins 0.000 description 1
• 102100033016 Integrin beta-7 Human genes 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
• 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• 101710093778 L-dopachrome tautomerase Proteins 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
• 240000007472 Leucaena leucocephala Species 0.000 description 1
• 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 1
• 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
• 101710092458 Lymphocyte activation gene 3 protein Proteins 0.000 description 1
• 206010052178 Lymphocytic lymphoma Diseases 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 description 1
• 108700012912 MYCN Proteins 0.000 description 1
• 101150022024 MYCN gene Proteins 0.000 description 1
• 206010025671 Malignant melanoma stage IV Diseases 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 102100034256 Mucin-1 Human genes 0.000 description 1
• 102000007295 Mucin-3 Human genes 0.000 description 1
• 108010008701 Mucin-3 Proteins 0.000 description 1
• 108010063954 Mucins Proteins 0.000 description 1
• 102000015728 Mucins Human genes 0.000 description 1
• 101100481410 Mus musculus Tek gene Proteins 0.000 description 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• RHRMCQAKLLGSMI-UHFFFAOYSA-N N-(2-oxo-1-propyl-3,4-dihydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide Chemical compound C1(=C(C(=C(C(=C1F)CS(=O)(=O)NC1=CC=C2N(CCC)C(=O)CCC2=C1)F)F)C)F RHRMCQAKLLGSMI-UHFFFAOYSA-N 0.000 description 1
• 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
• 102100030124 N-myc proto-oncogene protein Human genes 0.000 description 1
• 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 1
• 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 description 1
• 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 description 1
• 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 description 1
• 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 description 1
• 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 description 1
• 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 240000007019 Oxalis corniculata Species 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 241000282579 Pan Species 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 208000000821 Parathyroid Neoplasms Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 208000002471 Penile Neoplasms Diseases 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 201000005746 Pituitary adenoma Diseases 0.000 description 1
• 206010061538 Pituitary tumour benign Diseases 0.000 description 1
• 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 description 1
• 102100031889 Plexin domain-containing protein 2 Human genes 0.000 description 1
• 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 206010035742 Pneumonitis Diseases 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
• 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 1
• 229940079156 Proteasome inhibitor Drugs 0.000 description 1
• 102100035764 Proteasome subunit beta type-9 Human genes 0.000 description 1
• 102000006010 Protein Disulfide-Isomerase Human genes 0.000 description 1
• 102100032831 Protein ITPRID2 Human genes 0.000 description 1
• 239000004373 Pullulan Substances 0.000 description 1
• 229920001218 Pullulan Polymers 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 208000006265 Renal cell carcinoma Diseases 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 102100029216 SLAM family member 5 Human genes 0.000 description 1
• 102100038689 Scm-like with four MBT domains protein 1 Human genes 0.000 description 1
• 101710173694 Short transient receptor potential channel 2 Proteins 0.000 description 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• 108091027967 Small hairpin RNA Proteins 0.000 description 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 208000005718 Stomach Neoplasms Diseases 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 1
• 206010042971 T-cell lymphoma Diseases 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 description 1
• 102100035268 T-cell surface protein tactile Human genes 0.000 description 1
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
• 101150057140 TACSTD1 gene Proteins 0.000 description 1
• 108010032166 TARP Proteins 0.000 description 1
• 101150117918 Tacstd2 gene Proteins 0.000 description 1
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
• 241000249107 Teschovirus A Species 0.000 description 1
• 208000024313 Testicular Neoplasms Diseases 0.000 description 1
• 206010057644 Testis cancer Diseases 0.000 description 1
• 102100036494 Testisin Human genes 0.000 description 1
• 241001420369 Thosea Species 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 1
• 101710187882 Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 1
• 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 1
• 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 1
• 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 description 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
• 108091005906 Type I transmembrane proteins Proteins 0.000 description 1
• 208000025865 Ulcer Diseases 0.000 description 1
• 208000023915 Ureteral Neoplasms Diseases 0.000 description 1
• 206010046458 Urethral neoplasms Diseases 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 102100038851 Uroplakin-2 Human genes 0.000 description 1
• 201000003761 Vaginal carcinoma Diseases 0.000 description 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
• 229940122803 Vinca alkaloid Drugs 0.000 description 1
• 108700020467 WT1 Proteins 0.000 description 1
• 101150084041 WT1 gene Proteins 0.000 description 1
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
• 102000007624 ZAP-70 Protein-Tyrosine Kinase Human genes 0.000 description 1
• 108010046882 ZAP-70 Protein-Tyrosine Kinase Proteins 0.000 description 1
• 229960004308 acetylcysteine Drugs 0.000 description 1
• USZYSDMBJDPRIF-SVEJIMAYSA-N aclacinomycin A Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@H]1C)O[C@H]1[C@H](C[C@@H](O[C@H]1C)O[C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)N(C)C)[C@H]1CCC(=O)[C@H](C)O1 USZYSDMBJDPRIF-SVEJIMAYSA-N 0.000 description 1
• 229960004176 aclarubicin Drugs 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 230000006786 activation induced cell death Effects 0.000 description 1
• 230000003044 adaptive effect Effects 0.000 description 1
• 239000002487 adenosine deaminase inhibitor Substances 0.000 description 1
• 208000024447 adrenal gland neoplasm Diseases 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 235000010419 agar Nutrition 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
• 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
• 230000003042 antagnostic effect Effects 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 238000009175 antibody therapy Methods 0.000 description 1
• 210000000612 antigen-presenting cell Anatomy 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 238000011398 antitumor immunotherapy Methods 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 229960003121 arginine Drugs 0.000 description 1
• 239000010425 asbestos Substances 0.000 description 1
• FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 description 1
• 239000012131 assay buffer Substances 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 229960002170 azathioprine Drugs 0.000 description 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 229960004853 betadex Drugs 0.000 description 1
• 229960003237 betaine Drugs 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• 239000000090 biomarker Substances 0.000 description 1
• 201000000053 blastoma Diseases 0.000 description 1
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
• 229960001467 bortezomib Drugs 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 201000008275 breast carcinoma Diseases 0.000 description 1
• KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 description 1
• JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 description 1
• 229960000455 brentuximab vedotin Drugs 0.000 description 1
• 239000004067 bulking agent Substances 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
• PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 description 1
• 229940112129 campath Drugs 0.000 description 1
• 230000009702 cancer cell proliferation Effects 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• JGPOSNWWINVNFV-UHFFFAOYSA-N carboxyfluorescein diacetate succinimidyl ester Chemical compound C=1C(OC(=O)C)=CC=C2C=1OC1=CC(OC(C)=O)=CC=C1C2(C1=C2)OC(=O)C1=CC=C2C(=O)ON1C(=O)CCC1=O JGPOSNWWINVNFV-UHFFFAOYSA-N 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 229960004203 carnitine Drugs 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 239000012592 cell culture supplement Substances 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000007910 cell fusion Effects 0.000 description 1
• 230000009087 cell motility Effects 0.000 description 1
• 238000001516 cell proliferation assay Methods 0.000 description 1
• 230000007969 cellular immunity Effects 0.000 description 1
• 230000008614 cellular interaction Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 208000025997 central nervous system neoplasm Diseases 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 239000012707 chemical precursor Substances 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 208000024207 chronic leukemia Diseases 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 239000013599 cloning vector Substances 0.000 description 1
• 230000004186 co-expression Effects 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 206010009887 colitis Diseases 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 230000009137 competitive binding Effects 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 230000001143 conditioned effect Effects 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 238000012937 correction Methods 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 238000002784 cytotoxicity assay Methods 0.000 description 1
• 231100000263 cytotoxicity test Toxicity 0.000 description 1
• 230000006735 deficit Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 229940127276 delta-like ligand 3 Drugs 0.000 description 1
• 230000000994 depressogenic effect Effects 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• 235000019425 dextrin Nutrition 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 229940057307 dihydrate calcium sulfate Drugs 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 239000008298 dragée Substances 0.000 description 1
• 230000009977 dual effect Effects 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 201000008184 embryoma Diseases 0.000 description 1
• 210000001671 embryonic stem cell Anatomy 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 210000000750 endocrine system Anatomy 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 235000019441 ethanol Nutrition 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000011124 ex vivo culture Methods 0.000 description 1
• 238000013401 experimental design Methods 0.000 description 1
• 201000001343 fallopian tube carcinoma Diseases 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 210000003754 fetus Anatomy 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 239000011888 foil Substances 0.000 description 1
• 239000004052 folic acid antagonist Substances 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 108010027225 gag-pol Fusion Proteins Proteins 0.000 description 1
• FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
• 206010017758 gastric cancer Diseases 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 239000003349 gelling agent Substances 0.000 description 1
• 229960000578 gemtuzumab Drugs 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 description 1
• 229940103893 gliotoxin Drugs 0.000 description 1
• 229930190252 gliotoxin Natural products 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• 229960005150 glycerol Drugs 0.000 description 1
• 229940074045 glyceryl distearate Drugs 0.000 description 1
• 229940075507 glyceryl monostearate Drugs 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 239000003979 granulating agent Substances 0.000 description 1
• 238000005469 granulation Methods 0.000 description 1
• 230000003179 granulation Effects 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 230000009036 growth inhibition Effects 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 208000014951 hematologic disease Diseases 0.000 description 1
• 230000009033 hematopoietic malignancy Effects 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 210000003630 histaminocyte Anatomy 0.000 description 1
• 230000003118 histopathologic effect Effects 0.000 description 1
• 102000048776 human CD274 Human genes 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 230000004727 humoral immunity Effects 0.000 description 1
• 229930195733 hydrocarbon Natural products 0.000 description 1
• 150000002430 hydrocarbons Chemical class 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• 229960001101 ifosfamide Drugs 0.000 description 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
• 230000037451 immune surveillance Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 229940124622 immune-modulator drug Drugs 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 239000002955 immunomodulating agent Substances 0.000 description 1
• 230000002584 immunomodulator Effects 0.000 description 1
• 238000012744 immunostaining Methods 0.000 description 1
• 239000003018 immunosuppressive agent Substances 0.000 description 1
• 229940125721 immunosuppressive agent Drugs 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 230000036512 infertility Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 208000027866 inflammatory disease Diseases 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 230000015788 innate immune response Effects 0.000 description 1
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
• 229960000367 inositol Drugs 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 230000002601 intratumoral effect Effects 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 239000013038 irreversible inhibitor Substances 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 229960004942 lenalidomide Drugs 0.000 description 1
• GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• 238000001325 log-rank test Methods 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 201000005296 lung carcinoma Diseases 0.000 description 1
• 239000008176 lyophilized powder Substances 0.000 description 1
• 108010026228 mRNA guanylyltransferase Proteins 0.000 description 1
• 229940124302 mTOR inhibitor Drugs 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 208000026037 malignant tumor of neck Diseases 0.000 description 1
• 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 229960001855 mannitol Drugs 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• 238000012737 microarray-based gene expression Methods 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 238000011242 molecular targeted therapy Methods 0.000 description 1
• 238000009126 molecular therapy Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 238000010172 mouse model Methods 0.000 description 1
• 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
• 229940014456 mycophenolate Drugs 0.000 description 1
• 229960000951 mycophenolic acid Drugs 0.000 description 1
• 239000002077 nanosphere Substances 0.000 description 1
• 210000005170 neoplastic cell Anatomy 0.000 description 1
• 210000000440 neutrophil Anatomy 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 229960002450 ofatumumab Drugs 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 235000008390 olive oil Nutrition 0.000 description 1
• 239000004006 olive oil Substances 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 210000004789 organ system Anatomy 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 238000002638 palliative care Methods 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 229940055729 papain Drugs 0.000 description 1
• 235000019834 papain Nutrition 0.000 description 1
• 239000000123 paper Substances 0.000 description 1
• 210000002990 parathyroid gland Anatomy 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 239000001814 pectin Substances 0.000 description 1
• 235000010987 pectin Nutrition 0.000 description 1
• 229920001277 pectin Polymers 0.000 description 1
• 229940023041 peptide vaccine Drugs 0.000 description 1
• 239000002304 perfume Substances 0.000 description 1
• 230000008823 permeabilization Effects 0.000 description 1
• 210000001539 phagocyte Anatomy 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000008196 pharmacological composition Substances 0.000 description 1
• 210000003800 pharynx Anatomy 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 208000021310 pituitary gland adenoma Diseases 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 210000001778 pluripotent stem cell Anatomy 0.000 description 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
• 239000004848 polyfunctional curative Substances 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 238000010837 poor prognosis Methods 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 208000016800 primary central nervous system lymphoma Diseases 0.000 description 1
• 208000037821 progressive disease Diseases 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000002062 proliferating effect Effects 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 239000003207 proteasome inhibitor Substances 0.000 description 1
• 108020003519 protein disulfide isomerase Proteins 0.000 description 1
• 108020001580 protein domains Proteins 0.000 description 1
• 235000019423 pullulan Nutrition 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 238000003753 real-time PCR Methods 0.000 description 1
• 230000024833 regulation of cytokine production Effects 0.000 description 1
• 201000007444 renal pelvis carcinoma Diseases 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 108010056030 retronectin Proteins 0.000 description 1
• 229910052895 riebeckite Inorganic materials 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 229960002930 sirolimus Drugs 0.000 description 1
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 239000004055 small Interfering RNA Substances 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 229960002920 sorbitol Drugs 0.000 description 1
• 235000010356 sorbitol Nutrition 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 208000017572 squamous cell neoplasm Diseases 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 238000002719 stereotactic radiosurgery Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 201000011549 stomach cancer Diseases 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 239000007940 sugar coated tablet Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000011477 surgical intervention Methods 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 238000009121 systemic therapy Methods 0.000 description 1
• 101150047061 tag-72 gene Proteins 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 229960004964 temozolomide Drugs 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• WGTODYJZXSJIAG-UHFFFAOYSA-N tetramethylrhodamine chloride Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C(O)=O WGTODYJZXSJIAG-UHFFFAOYSA-N 0.000 description 1
• 229960003433 thalidomide Drugs 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 229960005267 tositumomab Drugs 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 238000003146 transient transfection Methods 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• 230000005747 tumor angiogenesis Effects 0.000 description 1
• 230000036269 ulceration Effects 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 229960003048 vinblastine Drugs 0.000 description 1
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• 229960004355 vindesine Drugs 0.000 description 1
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
• 229960002066 vinorelbine Drugs 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 208000013013 vulvar carcinoma Diseases 0.000 description 1
• 239000011534 wash buffer Substances 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 235000010447 xylitol Nutrition 0.000 description 1
• 239000000811 xylitol Substances 0.000 description 1
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
• 229960002675 xylitol Drugs 0.000 description 1