JP2020514418A5 - - Google Patents
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- Publication number
- JP2020514418A5 JP2020514418A5 JP2020500006A JP2020500006A JP2020514418A5 JP 2020514418 A5 JP2020514418 A5 JP 2020514418A5 JP 2020500006 A JP2020500006 A JP 2020500006A JP 2020500006 A JP2020500006 A JP 2020500006A JP 2020514418 A5 JP2020514418 A5 JP 2020514418A5
- Authority
- JP
- Japan
- Prior art keywords
- derivatives
- mitribocin
- alkene
- alkenes
- amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001336 alkenes Chemical class 0.000 claims 15
- -1 cyclic alkene Chemical class 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 150000001299 aldehydes Chemical class 0.000 claims 6
- 150000001408 amides Chemical class 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 150000002170 ethers Chemical class 0.000 claims 6
- 150000002390 heteroarenes Chemical class 0.000 claims 6
- 150000002576 ketones Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000002438 mitochondrial effect Effects 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 150000001344 alkene derivatives Chemical class 0.000 claims 3
- 150000001361 allenes Chemical class 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 235000010233 benzoic acid Nutrition 0.000 claims 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims 3
- 150000001559 benzoic acids Chemical class 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 125000002950 monocyclic group Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 3
- 150000002989 phenols Chemical class 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 206010011906 Death Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 102000017033 Porins Human genes 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 235000020827 calorie restriction Nutrition 0.000 claims 1
- 150000001767 cationic compounds Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002583 male contraceptive agent Substances 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000005445 natural material Substances 0.000 claims 1
- 229940055076 parasympathomimetics choline ester Drugs 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 claims 1
- 230000002165 photosensitisation Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003248 quinolines Chemical class 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000001235 sensitizing effect Effects 0.000 claims 1
- 239000000308 sperm immobilizing agent Substances 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022109390A JP7312891B2 (ja) | 2017-03-15 | 2022-07-07 | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471688P | 2017-03-15 | 2017-03-15 | |
| US62/471,688 | 2017-03-15 | ||
| PCT/US2018/022403 WO2018170109A1 (en) | 2017-03-15 | 2018-03-14 | Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022109390A Division JP7312891B2 (ja) | 2017-03-15 | 2022-07-07 | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514418A JP2020514418A (ja) | 2020-05-21 |
| JP2020514418A5 true JP2020514418A5 (https=) | 2021-04-15 |
| JP7104134B2 JP7104134B2 (ja) | 2022-07-20 |
Family
ID=63523316
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500006A Active JP7104134B2 (ja) | 2017-03-15 | 2018-03-14 | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
| JP2022109390A Active JP7312891B2 (ja) | 2017-03-15 | 2022-07-07 | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022109390A Active JP7312891B2 (ja) | 2017-03-15 | 2022-07-07 | ミトリボシン：癌細胞、細菌、及び病原性酵母を標的とした、ミトコンドリアベースの治療薬 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US11311501B2 (https=) |
| EP (1) | EP3596043B1 (https=) |
| JP (2) | JP7104134B2 (https=) |
| KR (1) | KR102623283B1 (https=) |
| CN (1) | CN110621655B (https=) |
| AU (2) | AU2018235937A1 (https=) |
| BR (1) | BR112019019109B1 (https=) |
| CA (1) | CA3056086A1 (https=) |
| CL (1) | CL2019002580A1 (https=) |
| CO (1) | CO2019010027A2 (https=) |
| CR (2) | CR20220381A (https=) |
| CU (3) | CU20190079A7 (https=) |
| DO (3) | DOP2019000230A (https=) |
| EC (1) | ECSP19073204A (https=) |
| IL (2) | IL305316B2 (https=) |
| MX (3) | MX2022000938A (https=) |
| NZ (1) | NZ756854A (https=) |
| PE (1) | PE20191485A1 (https=) |
| PH (1) | PH12019502056B1 (https=) |
| RU (1) | RU2019132396A (https=) |
| SG (1) | SG11201908487YA (https=) |
| WO (1) | WO2018170109A1 (https=) |
| ZA (5) | ZA201905970B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2744989B2 (ja) | 1992-07-24 | 1998-04-28 | 光洋機械工業株式会社 | 小径工作物の外径寸法測定システム |
| US20220339125A1 (en) * | 2017-03-15 | 2022-10-27 | Lunella Biotech, Inc. | Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast |
| WO2019075219A1 (en) | 2017-10-11 | 2019-04-18 | Lunella Biotech, Inc. | ANTIMITOCHONDRIAL INHIBITORS FOR ONCOGENES RAS AND MYC |
| WO2019232161A1 (en) | 2018-06-01 | 2019-12-05 | Lunella Biotech, Inc. | Biomarkers and therapeutics for endocrine therapy resistance |
| KR20210072026A (ko) | 2018-10-02 | 2021-06-16 | 루넬라 바이오테크 인코포레이티드 | 세놀리틱 약물로서 아지트로마이신 및 록시스로마이신 유도체 |
| AU2019403048B2 (en) * | 2018-12-17 | 2025-01-23 | Lunella Biotech, Inc. | Triple combination therapies for targeting mitochondria and killing cancer stem cells |
| AU2019402099B2 (en) * | 2018-12-17 | 2025-01-23 | Lunella Biotech, Inc. | Triple combination therapies for anti-aging |
| WO2020214754A1 (en) * | 2019-04-16 | 2020-10-22 | Lunella Biotech, Inc. | Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments |
| US11672810B2 (en) | 2019-05-24 | 2023-06-13 | Lunella Biotech, Inc. | Therapeutics and methods for predicting and overcoming endocrine resistance in breast cancer |
| WO2021214727A1 (en) | 2020-04-24 | 2021-10-28 | Lunella Biotech, Inc. | Therapeutic methods for preventing tumor metastasis and tumor recurrence |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2062025A (en) * | 1931-12-19 | 1936-11-24 | Harrington Joseph | Method and apparatus for treating moisture-containing substances |
| US2059764A (en) * | 1933-11-03 | 1936-11-03 | Zerillo Frank | Pneumatic tire |
| US2058655A (en) * | 1934-10-12 | 1936-10-27 | Borg Warner | Friction clutch |
| JPS537424B2 (https=) * | 1971-10-08 | 1978-03-17 | ||
| US5756507A (en) | 1995-12-14 | 1998-05-26 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2000001433A (ja) | 1998-06-11 | 2000-01-07 | Pfizer Pharmaceuticals Inc | ５―リポキシゲナ―ゼ阻害剤 |
| GB0323585D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| KR101274524B1 (ko) * | 2004-03-16 | 2013-06-19 | 온코노바 테라퓨틱스, 인코포레이티드 | 증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체 |
| US8778874B2 (en) * | 2004-11-29 | 2014-07-15 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
| US8022042B2 (en) * | 2006-02-16 | 2011-09-20 | Young Hee Ko | Composition and methods for the treatment of cancer |
| US8097626B2 (en) * | 2006-04-21 | 2012-01-17 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| KR20100049500A (ko) | 2007-03-15 | 2010-05-12 | 쉐링 코포레이션 | 글루칸 신타제 억제제로서 유용한 피리다지논 유도체 |
| FR2932483A1 (fr) * | 2008-06-13 | 2009-12-18 | Cytomics Systems | Composes utiles pour le traitement des cancers. |
| US8815844B2 (en) * | 2009-05-20 | 2014-08-26 | Universite De Geneve | Mitochondrial activity inhibitors of cancer-initiating cells and use thereof |
| PE20130774A1 (es) | 2010-07-29 | 2013-06-26 | Rigel Pharmaceuticals Inc | Compuestos heterociclicos activadores de ampk y metodos para emplearlos |
| WO2013006734A1 (en) * | 2011-07-05 | 2013-01-10 | St. Jude Children's Research Hospital | Substituted 4-phenoxyphenol analogs as modulators of proliferating cell nuclear antigen activity |
| CN102886054B (zh) * | 2011-07-19 | 2014-04-02 | 复旦大学 | 一种抑制细菌信号转导系统PhoQ组氨酸激酶活性的制剂 |
| WO2014120995A2 (en) * | 2013-02-01 | 2014-08-07 | Wellstat Therapeutics Corporation | Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
| CA2884607A1 (en) * | 2015-03-11 | 2016-09-11 | Stealth Peptides International, Inc. | Therapeutic compositions including acrylamido compounds or phenyl-substiituted maleimide compounds and uses thereof to treat and prevent mitochondrial diseases and conditions |
-
2018
- 2018-03-14 US US16/493,871 patent/US11311501B2/en active Active
- 2018-03-14 PE PE2019001841A patent/PE20191485A1/es unknown
- 2018-03-14 WO PCT/US2018/022403 patent/WO2018170109A1/en not_active Ceased
- 2018-03-14 EP EP18767458.5A patent/EP3596043B1/en active Active
- 2018-03-14 CR CR20220381A patent/CR20220381A/es unknown
- 2018-03-14 JP JP2020500006A patent/JP7104134B2/ja active Active
- 2018-03-14 BR BR112019019109-7A patent/BR112019019109B1/pt active IP Right Grant
- 2018-03-14 SG SG11201908487Y patent/SG11201908487YA/en unknown
- 2018-03-14 CU CU2019000079A patent/CU20190079A7/es unknown
- 2018-03-14 IL IL305316A patent/IL305316B2/en unknown
- 2018-03-14 MX MX2022000938A patent/MX2022000938A/es unknown
- 2018-03-14 CA CA3056086A patent/CA3056086A1/en active Pending
- 2018-03-14 MX MX2019010759A patent/MX390968B/es unknown
- 2018-03-14 PH PH1/2019/502056A patent/PH12019502056B1/en unknown
- 2018-03-14 NZ NZ756854A patent/NZ756854A/en unknown
- 2018-03-14 CR CR20190458A patent/CR20190458A/es unknown
- 2018-03-14 RU RU2019132396A patent/RU2019132396A/ru unknown
- 2018-03-14 KR KR1020197029542A patent/KR102623283B1/ko active Active
- 2018-03-14 CN CN201880031954.5A patent/CN110621655B/zh active Active
- 2018-03-14 CU CU2019000096A patent/CU20190096A7/es unknown
- 2018-03-14 AU AU2018235937A patent/AU2018235937A1/en not_active Abandoned
- 2018-03-14 IL IL269309A patent/IL269309B2/en unknown
- 2018-03-14 MX MX2022000937A patent/MX2022000937A/es unknown
- 2018-03-14 CU CU2019000097A patent/CU20190097A7/es unknown
- 2018-11-29 US US16/204,173 patent/US10512618B2/en active Active
-
2019
- 2019-09-06 DO DO2019000230A patent/DOP2019000230A/es unknown
- 2019-09-10 ZA ZA2019/05970A patent/ZA201905970B/en unknown
- 2019-09-10 CL CL2019002580A patent/CL2019002580A1/es unknown
- 2019-09-16 CO CONC2019/0010027A patent/CO2019010027A2/es unknown
- 2019-10-10 EC ECSENADI201973204A patent/ECSP19073204A/es unknown
- 2019-10-31 US US16/670,326 patent/US11547679B2/en active Active
- 2019-10-31 US US16/670,443 patent/US11364210B2/en active Active
-
2020
- 2020-02-19 ZA ZA2020/01041A patent/ZA202001041B/en unknown
- 2020-02-19 ZA ZA2020/01040A patent/ZA202001040B/en unknown
-
2021
- 2021-03-05 ZA ZA2021/01517A patent/ZA202101517B/en unknown
-
2022
- 2022-03-29 ZA ZA2022/03603A patent/ZA202203603B/en unknown
- 2022-07-07 JP JP2022109390A patent/JP7312891B2/ja active Active
- 2022-07-13 AU AU2022205218A patent/AU2022205218B2/en active Active
- 2022-08-11 DO DO2022000165A patent/DOP2022000165A/es unknown
- 2022-08-11 DO DO2022000164A patent/DOP2022000164A/es unknown
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