CL2019002580A1 - Mitorriboscinas: compuestos terapéuticos basados en mitocondrias que fijan como objetivo células cancerosas, bacterias y levaduras patógenas. - Google Patents
Mitorriboscinas: compuestos terapéuticos basados en mitocondrias que fijan como objetivo células cancerosas, bacterias y levaduras patógenas.Info
- Publication number
- CL2019002580A1 CL2019002580A1 CL2019002580A CL2019002580A CL2019002580A1 CL 2019002580 A1 CL2019002580 A1 CL 2019002580A1 CL 2019002580 A CL2019002580 A CL 2019002580A CL 2019002580 A CL2019002580 A CL 2019002580A CL 2019002580 A1 CL2019002580 A1 CL 2019002580A1
- Authority
- CL
- Chile
- Prior art keywords
- mitochondria
- mitochondrial
- mythriboscines
- bacteria
- cancer cells
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 210000003470 mitochondria Anatomy 0.000 title abstract 2
- 230000001717 pathogenic effect Effects 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 3
- 230000002438 mitochondrial effect Effects 0.000 abstract 3
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000004898 mitochondrial function Effects 0.000 abstract 1
Classifications
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
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- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Abstract
LA PRESENTE DESCRIPCIÓN SE REFIERE A INHIBIDORES DE LA FUNCIÓN MITOCONDRIAL. SE DAN A CONOCER MÉTODOS DE PROSPECCIÓN DE LOS COMPUESTOS PARA LA INHIBICIÓN MITOCONDRIAL. TAMBIÉN SE DESCRIBEN MÉTODOS PARA USAR INHIBIDORES MITOCONDRIALES LLAMADOS MITORRIBOSCINAS - COMPUESTOS TERAPÉUTICOS BASADOS EN MITOCONDRIAS QUE TIENEN PROPIEDADES ANTI-CANCEROSAS Y ANTIBIÓTICAS - PARA PREVENIR O TRATAR EL CÁNCER, INFECCIONES BACTERIANAS Y LEVADURAS PATÓGENAS, ASÍ COMO TAMBIÉN MÉTODOS PARA USAR INHIBIDORES MITOCONDRIALES PARA PROPORCIONAR BENEFICIOS ANTI-ENVEJECIMIENTO. TAMBIÉN SE DAN A CONOCER COMPUESTOS ESPECÍFICOS DE MITORRIBOSCINA Y GRUPOS DE MITORRIBOSCINAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201762471688P | 2017-03-15 | 2017-03-15 |
Publications (1)
Publication Number | Publication Date |
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CL2019002580A1 true CL2019002580A1 (es) | 2020-02-14 |
Family
ID=63523316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2019002580A CL2019002580A1 (es) | 2017-03-15 | 2019-09-10 | Mitorriboscinas: compuestos terapéuticos basados en mitocondrias que fijan como objetivo células cancerosas, bacterias y levaduras patógenas. |
Country Status (23)
Country | Link |
---|---|
US (4) | US11311501B2 (es) |
EP (1) | EP3596043A1 (es) |
JP (2) | JP7104134B2 (es) |
KR (1) | KR102623283B1 (es) |
CN (1) | CN110621655B (es) |
AU (2) | AU2018235937A1 (es) |
BR (1) | BR112019019109B1 (es) |
CA (1) | CA3056086A1 (es) |
CL (1) | CL2019002580A1 (es) |
CO (1) | CO2019010027A2 (es) |
CR (2) | CR20220381A (es) |
CU (3) | CU20190096A7 (es) |
DO (3) | DOP2019000230A (es) |
EC (1) | ECSP19073204A (es) |
IL (2) | IL269309B2 (es) |
MX (3) | MX2022000938A (es) |
NZ (1) | NZ756854A (es) |
PE (1) | PE20191485A1 (es) |
PH (1) | PH12019502056A1 (es) |
RU (1) | RU2019132396A (es) |
SG (1) | SG11201908487YA (es) |
WO (1) | WO2018170109A1 (es) |
ZA (5) | ZA201905970B (es) |
Families Citing this family (6)
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WO2019075226A1 (en) | 2017-10-11 | 2019-04-18 | Lunella Biotech, Inc. | ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC |
PE20211006A1 (es) | 2018-10-02 | 2021-06-01 | Lunella Biotech Inc | Derivados de azitromicina y roxitromicina como farmacos senoliticos |
CN113573715A (zh) * | 2018-12-17 | 2021-10-29 | 卢内拉生物技术有限公司 | 用于靶向线粒体和杀死癌症干细胞的三联疗法 |
AU2019402099A1 (en) * | 2018-12-17 | 2021-07-08 | Lunella Biotech, Inc. | Triple combination therapies for anti-aging |
US20220211728A1 (en) * | 2019-04-16 | 2022-07-07 | Lunella Biotech, Inc. | Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments |
US11672810B2 (en) | 2019-05-24 | 2023-06-13 | Lunella Biotech, Inc. | Therapeutics and methods for predicting and overcoming endocrine resistance in breast cancer |
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---|---|---|---|---|
US2062025A (en) * | 1931-12-19 | 1936-11-24 | Harrington Joseph | Method and apparatus for treating moisture-containing substances |
US2059764A (en) * | 1933-11-03 | 1936-11-03 | Zerillo Frank | Pneumatic tire |
US2058655A (en) * | 1934-10-12 | 1936-10-27 | Borg Warner | Friction clutch |
JPS537424B2 (es) | 1971-10-08 | 1978-03-17 | ||
US5756507A (en) | 1995-12-14 | 1998-05-26 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2000001433A (ja) | 1998-06-11 | 2000-01-07 | Pfizer Pharmaceuticals Inc | 5―リポキシゲナ―ゼ阻害剤 |
GB0323585D0 (en) * | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
EA012980B1 (ru) | 2004-03-16 | 2010-02-26 | Темпл Юниверсити Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Замещённые фенокси- и фенилтиопроизводные для лечения пролиферативных нарушений |
WO2006057303A1 (ja) * | 2004-11-29 | 2006-06-01 | National University Corporation Nagoya University | グリコペプチド抗生物質モノマー誘導体 |
CN101495113A (zh) * | 2006-04-21 | 2009-07-29 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
MX2009009948A (es) * | 2007-03-15 | 2009-09-24 | Schering Corp | Derivados de piridazinona utiles como inhibidores de glucano sintasa. |
FR2932483A1 (fr) | 2008-06-13 | 2009-12-18 | Cytomics Systems | Composes utiles pour le traitement des cancers. |
DK2391363T3 (en) * | 2009-01-29 | 2017-01-16 | Young Hee Ko | COMPOSITIONS AND PROCEDURES FOR TREATING CANCER |
AU2010250814B2 (en) * | 2009-05-20 | 2015-03-05 | Hopitaux Universitaires De Geneve | Mitochondrial activity inhibitors of cancer-initiating cells and use thereof |
HUE052110T2 (hu) | 2010-07-29 | 2021-04-28 | Rigel Pharmaceuticals Inc | AMPK-t aktiváló heterociklusos vegyületek és alkalmazásuk |
WO2013006734A1 (en) | 2011-07-05 | 2013-01-10 | St. Jude Children's Research Hospital | Substituted 4-phenoxyphenol analogs as modulators of proliferating cell nuclear antigen activity |
CN102886054B (zh) * | 2011-07-19 | 2014-04-02 | 复旦大学 | 一种抑制细菌信号转导系统PhoQ组氨酸激酶活性的制剂 |
CA3217159A1 (en) * | 2013-02-01 | 2014-08-07 | Wellstat Therapeutics Corporation | Substituted quinazolin-4-amine compounds and pharmaceutical compositions thereof having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
CA2884607A1 (en) * | 2015-03-11 | 2016-09-11 | Stealth Peptides International, Inc. | Therapeutic compositions including acrylamido compounds or phenyl-substiituted maleimide compounds and uses thereof to treat and prevent mitochondrial diseases and conditions |
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