CL2019002580A1 - Mythriboscines: Mitochondria-based therapeutic compounds that target cancer cells, bacteria, and pathogenic yeast. - Google Patents

Mythriboscines: Mitochondria-based therapeutic compounds that target cancer cells, bacteria, and pathogenic yeast.

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Publication number
CL2019002580A1
CL2019002580A1 CL2019002580A CL2019002580A CL2019002580A1 CL 2019002580 A1 CL2019002580 A1 CL 2019002580A1 CL 2019002580 A CL2019002580 A CL 2019002580A CL 2019002580 A CL2019002580 A CL 2019002580A CL 2019002580 A1 CL2019002580 A1 CL 2019002580A1
Authority
CL
Chile
Prior art keywords
mitochondria
mitochondrial
mythriboscines
bacteria
cancer cells
Prior art date
Application number
CL2019002580A
Other languages
Spanish (es)
Inventor
Michael P Lisanti
Federica Sotgia
Original Assignee
Lunella Biotech Inc
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Filing date
Publication date
Application filed by Lunella Biotech Inc filed Critical Lunella Biotech Inc
Publication of CL2019002580A1 publication Critical patent/CL2019002580A1/en

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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

LA PRESENTE DESCRIPCIÓN SE REFIERE A INHIBIDORES DE LA FUNCIÓN MITOCONDRIAL. SE DAN A CONOCER MÉTODOS DE PROSPECCIÓN DE LOS COMPUESTOS PARA LA INHIBICIÓN MITOCONDRIAL. TAMBIÉN SE DESCRIBEN MÉTODOS PARA USAR INHIBIDORES MITOCONDRIALES LLAMADOS MITORRIBOSCINAS - COMPUESTOS TERAPÉUTICOS BASADOS EN MITOCONDRIAS QUE TIENEN PROPIEDADES ANTI-CANCEROSAS Y ANTIBIÓTICAS - PARA PREVENIR O TRATAR EL CÁNCER, INFECCIONES BACTERIANAS Y LEVADURAS PATÓGENAS, ASÍ COMO TAMBIÉN MÉTODOS PARA USAR INHIBIDORES MITOCONDRIALES PARA PROPORCIONAR BENEFICIOS ANTI-ENVEJECIMIENTO. TAMBIÉN SE DAN A CONOCER COMPUESTOS ESPECÍFICOS DE MITORRIBOSCINA Y GRUPOS DE MITORRIBOSCINAS.THIS DESCRIPTION REFERS TO INHIBITORS OF MITOCHONDRIAL FUNCTION. PROSPECTING METHODS FOR MITOCHONDRIAL INHIBITION COMPOUNDS ARE DISCLOSED. ALSO DESCRIBED METHODS FOR USING INHIBITORS Mitochondrial CALLED MITORRIBOSCINAS - COMPOSITE based therapeutics Mitochondria have anti-cancerous and antibiotic - TO PREVENT OR TREAT CANCER, INFECTIONS BACTERIAL AND YEAST pathogenic WELL AS METHODS FOR USING INHIBITORS Mitochondrial TO PROVIDE BENEFITS ANTI -AGING. SPECIFIC MITORRIBOSCINE COMPOUNDS AND MITORRIBOSCINE GROUPS ARE ALSO LEARNED.

CL2019002580A 2017-03-15 2019-09-10 Mythriboscines: Mitochondria-based therapeutic compounds that target cancer cells, bacteria, and pathogenic yeast. CL2019002580A1 (en)

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US201762471688P 2017-03-15 2017-03-15

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EP (1) EP3596043A1 (en)
JP (2) JP7104134B2 (en)
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AU (2) AU2018235937A1 (en)
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CA (1) CA3056086A1 (en)
CL (1) CL2019002580A1 (en)
CO (1) CO2019010027A2 (en)
CR (2) CR20190458A (en)
CU (3) CU20190079A7 (en)
DO (3) DOP2019000230A (en)
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