JP2020512978A5 - - Google Patents
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- Publication number
- JP2020512978A5 JP2020512978A5 JP2019553167A JP2019553167A JP2020512978A5 JP 2020512978 A5 JP2020512978 A5 JP 2020512978A5 JP 2019553167 A JP2019553167 A JP 2019553167A JP 2019553167 A JP2019553167 A JP 2019553167A JP 2020512978 A5 JP2020512978 A5 JP 2020512978A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- antibody
- cancer
- αvβ3
- avb3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 156
- 229920001184 polypeptide Polymers 0.000 claims description 134
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 134
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 134
- 201000011510 cancer Diseases 0.000 claims description 96
- 210000004027 cell Anatomy 0.000 claims description 45
- 210000002540 macrophage Anatomy 0.000 claims description 40
- 210000000130 stem cell Anatomy 0.000 claims description 27
- 210000004881 tumor cell Anatomy 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 15
- 239000003112 inhibitor Substances 0.000 claims description 13
- 102000006495 integrins Human genes 0.000 claims description 12
- 108010044426 integrins Proteins 0.000 claims description 12
- 239000003102 growth factor Substances 0.000 claims description 11
- 238000009472 formulation Methods 0.000 claims description 10
- 210000003690 classically activated macrophage Anatomy 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 9
- 230000001939 inductive effect Effects 0.000 claims description 9
- 230000028709 inflammatory response Effects 0.000 claims description 9
- 230000002401 inhibitory effect Effects 0.000 claims description 9
- 238000002560 therapeutic procedure Methods 0.000 claims description 9
- 230000004614 tumor growth Effects 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000000977 initiatory effect Effects 0.000 claims description 5
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 4
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 4
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 4
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims description 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 4
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 4
- 229960001433 erlotinib Drugs 0.000 claims description 3
- 201000009030 Carcinoma Diseases 0.000 claims description 2
- 229940122924 Src inhibitor Drugs 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 230000005889 cellular cytotoxicity Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- 229940020967 gemzar Drugs 0.000 claims description 2
- 238000011577 humanized mouse model Methods 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 229940043355 kinase inhibitor Drugs 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 230000002503 metabolic effect Effects 0.000 claims description 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 15
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 229940028652 abraxane Drugs 0.000 claims 1
- 229940082789 erbitux Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- 230000000394 mitotic effect Effects 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 229940120982 tarceva Drugs 0.000 claims 1
- 210000004981 tumor-associated macrophage Anatomy 0.000 claims 1
- 229940094060 tykerb Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021054730A JP2021095423A (ja) | 2017-03-31 | 2021-03-29 | アルファ−Ｖ ベータ−３（αｖβ３）陽性がん幹細胞（ＣＳＣＳ）を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479768P | 2017-03-31 | 2017-03-31 | |
| US62/479,768 | 2017-03-31 | ||
| PCT/US2018/025470 WO2018183894A1 (en) | 2017-03-31 | 2018-03-30 | Compositions and methods for targeting and killing alpha-v beta-3-positive cancer stem cells (cscs) and treating drug resistant cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021054730A Division JP2021095423A (ja) | 2017-03-31 | 2021-03-29 | アルファ−Ｖ ベータ−３（αｖβ３）陽性がん幹細胞（ＣＳＣＳ）を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020512978A JP2020512978A (ja) | 2020-04-30 |
| JP2020512978A5 true JP2020512978A5 (enExample) | 2021-05-06 |
Family
ID=63676868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553167A Pending JP2020512978A (ja) | 2017-03-31 | 2018-03-30 | アルファ−Ｖ ベータ−３（αｖβ３）陽性がん幹細胞（ＣＳＣＳ）を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
| JP2021054730A Pending JP2021095423A (ja) | 2017-03-31 | 2021-03-29 | アルファ−Ｖ ベータ−３（αｖβ３）陽性がん幹細胞（ＣＳＣＳ）を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021054730A Pending JP2021095423A (ja) | 2017-03-31 | 2021-03-29 | アルファ−Ｖ ベータ−３（αｖβ３）陽性がん幹細胞（ＣＳＣＳ）を処置および殺滅するためならびに薬物耐性がんを処置するための組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20200109205A1 (enExample) |
| EP (2) | EP4353318A3 (enExample) |
| JP (2) | JP2020512978A (enExample) |
| KR (1) | KR102630070B1 (enExample) |
| CN (1) | CN110662559A (enExample) |
| AU (1) | AU2018243670B2 (enExample) |
| BR (1) | BR112019020451A2 (enExample) |
| CA (1) | CA3058458A1 (enExample) |
| EA (1) | EA201992326A1 (enExample) |
| IL (1) | IL269746A (enExample) |
| MX (1) | MX2019011717A (enExample) |
| WO (1) | WO2018183894A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12383634B2 (en) | 2019-07-24 | 2025-08-12 | Korea Basic Science Institute | Single domain antibody targeting αVβ3 integrin |
| WO2021026024A1 (en) * | 2019-08-02 | 2021-02-11 | The Regents Of The University Of California | Compositions and methods for targeting and killing alpha-v beta-3 -positive cancer stem cells (cscs) and treating drug resistant and metastatic cancers |
| MX2022013207A (es) * | 2020-04-23 | 2023-01-24 | Alpha Beta Holdings Llc | Metodos y composiciones para el tratamiento de cancer. |
| CN112626118B (zh) * | 2020-11-12 | 2023-06-23 | 清华-伯克利深圳学院筹备办公室 | 细胞株及其应用 |
| CN118284622A (zh) * | 2021-09-30 | 2024-07-02 | 阿尔法贝塔控股有限责任公司 | 治疗癌症的组合物和方法 |
| CN115960160B (zh) * | 2021-10-12 | 2024-07-16 | 南京大学 | 活细胞膜整合素αvβ3聚糖的原位糖链延长方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US6007839A (en) | 1996-02-16 | 1999-12-28 | The Liposome Company, Inc. | Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes |
| RU2194528C2 (ru) * | 1996-05-31 | 2002-12-20 | Дзе Скриппс Рисерч Инститьют | Способы и композиции, используемые для ингибирования ангиогенеза |
| US6590079B2 (en) | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
| US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
| CN1261791A (zh) | 1997-07-02 | 2000-08-02 | Sdg有限公司 | 诊断或治疗用途的靶向脂质体构建物 |
| KR100704140B1 (ko) | 1999-02-12 | 2007-04-09 | 더 스크립스 리서치 인스티튜트 | 혈관형성 억제제 및 항-종양 면역요법제를 포함하는, 종양 및 전이를 치료하기 위한 약제학적 조성물 및 이를 포함하는 키트 |
| CN1561968A (zh) | 1999-04-23 | 2005-01-12 | 三菱化学株式会社 | 与抗体和聚亚烷基二醇结合的脂质体 |
| US7671010B2 (en) | 2002-08-30 | 2010-03-02 | The Board Of Regents Of The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| US7858117B2 (en) | 2002-02-21 | 2010-12-28 | Novosom Ag | Amphoteric liposomes and their use |
| US20040001835A1 (en) * | 2002-03-04 | 2004-01-01 | Medimmune, Inc. | Prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
| EP1547581A1 (en) | 2003-12-23 | 2005-06-29 | Vectron Therapeutics AG | Liposomal vaccine for the treatment of human hematological malignancies |
| CN1917859A (zh) | 2003-12-24 | 2007-02-21 | 日本株式会社Ltt生物医药 | 载药纳米微粒及其制备方法以及含有该纳米微粒的非肠道给药用制剂 |
| WO2005084710A2 (en) | 2004-03-02 | 2005-09-15 | Massachusetts Institute Of Technology | Nanocell drug delivery system |
| WO2006014035A1 (en) | 2004-08-06 | 2006-02-09 | Biospectrum, Inc. | Multiple layered liposome and preparation method thereof |
| US20060040325A1 (en) * | 2004-08-16 | 2006-02-23 | Medimmune, Inc. | Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity |
| SG163548A1 (en) * | 2005-06-30 | 2010-08-30 | Centocor Inc | Methods and compositions with enhanced therapeutic activity |
| WO2007012191A1 (en) | 2005-07-27 | 2007-02-01 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
| US20080088046A1 (en) | 2006-10-13 | 2008-04-17 | Steffen Panzner | Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome |
| EP1959958A4 (en) * | 2005-11-14 | 2010-07-14 | Univ Southern California | INTEGRIN-BINDING SMALL MOLECULES |
| US20080089928A1 (en) | 2006-06-13 | 2008-04-17 | Stavroula Sofou | Liposome drug carriers with ph-sensitivity |
| US20110319335A1 (en) * | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
| US20140154264A1 (en) * | 2011-06-02 | 2014-06-05 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to cell growth inhibition |
| WO2013152313A1 (en) * | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition |
| AU2014331118B2 (en) * | 2013-10-01 | 2019-07-25 | Medimmune Limited | Methods of treating and diagnosing alpha-V-beta-6 overexpressing cancer |
| US20160280787A1 (en) * | 2013-11-11 | 2016-09-29 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified antibody variable region |
| US11052089B2 (en) * | 2014-12-18 | 2021-07-06 | The Regents Of The University Of California | Methods for inhibiting alpha-v beta-3 expression on cancer stem cells and inhibiting progression to a cancer stem cell phenotype |
| WO2021026024A1 (en) * | 2019-08-02 | 2021-02-11 | The Regents Of The University Of California | Compositions and methods for targeting and killing alpha-v beta-3 -positive cancer stem cells (cscs) and treating drug resistant and metastatic cancers |
-
2018
- 2018-03-30 KR KR1020197031332A patent/KR102630070B1/ko active Active
- 2018-03-30 US US16/499,623 patent/US20200109205A1/en not_active Abandoned
- 2018-03-30 EP EP23203602.0A patent/EP4353318A3/en active Pending
- 2018-03-30 EA EA201992326A patent/EA201992326A1/ru unknown
- 2018-03-30 BR BR112019020451A patent/BR112019020451A2/pt unknown
- 2018-03-30 AU AU2018243670A patent/AU2018243670B2/en active Active
- 2018-03-30 JP JP2019553167A patent/JP2020512978A/ja active Pending
- 2018-03-30 CN CN201880033739.9A patent/CN110662559A/zh active Pending
- 2018-03-30 WO PCT/US2018/025470 patent/WO2018183894A1/en not_active Ceased
- 2018-03-30 CA CA3058458A patent/CA3058458A1/en active Pending
- 2018-03-30 MX MX2019011717A patent/MX2019011717A/es unknown
- 2018-03-30 EP EP18774300.0A patent/EP3600422B1/en active Active
-
2019
- 2019-10-02 IL IL26974619A patent/IL269746A/en unknown
-
2021
- 2021-03-29 JP JP2021054730A patent/JP2021095423A/ja active Pending
-
2023
- 2023-10-04 US US18/480,778 patent/US20240067733A1/en active Pending
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