|
MX2019011511A
(es)
*
|
2017-03-30 |
2019-11-18 |
Hoffmann La Roche |
Naftiridinas como inhibidores de cinasa 1 progenitora hematopoyetica (hpk1).
|
|
US11312715B2
(en)
*
|
2017-09-28 |
2022-04-26 |
Cstone Pharmaceuticals (Suzhou) Co., Ltd. |
Fused ring derivative as A2A receptor inhibitor
|
|
JP7167146B2
(ja)
|
2017-11-06 |
2022-11-08 |
ブリストル－マイヤーズ スクイブ カンパニー |
Ｈｐｋ１阻害剤として有用なイソフラノン化合物
|
|
TWI707849B
(zh)
|
2018-02-13 |
2020-10-21 |
美商基利科學股份有限公司 |
Pd‐1/pd‐l1抑制劑
|
|
KR20200143376A
(ko)
|
2018-03-13 |
2020-12-23 |
샤이어 휴먼 지네틱 테라피즈 인크. |
혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도
|
|
KR102591947B1
(ko)
|
2018-04-19 |
2023-10-25 |
길리애드 사이언시즈, 인코포레이티드 |
Pd-1/pd-l1 억제제
|
|
EP3820572B1
(en)
|
2018-07-13 |
2023-08-16 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
TW202012405A
(zh)
*
|
2018-07-24 |
2020-04-01 |
瑞士商赫孚孟拉羅股份公司 |
萘啶化合物及其用途
|
|
CN113454070A
(zh)
*
|
2018-09-30 |
2021-09-28 |
豪夫迈·罗氏有限公司 |
噌啉化合物及用于hpk1依赖性疾患诸如癌症的治疗
|
|
TWI721623B
(zh)
|
2018-10-31 |
2021-03-11 |
美商基利科學股份有限公司 |
經取代之6-氮雜苯并咪唑化合物
|
|
TW202136261A
(zh)
|
2018-10-31 |
2021-10-01 |
美商基利科學股份有限公司 |
經取代之6-氮雜苯并咪唑化合物
|
|
EP3894406A1
(en)
|
2018-12-11 |
2021-10-20 |
Bayer Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
CA3129768A1
(en)
|
2019-03-26 |
2020-10-01 |
Laurence Anne Mevellec |
Hpk1 inhibitors
|
|
TW202102500A
(zh)
|
2019-03-26 |
2021-01-16 |
比利時商健生藥品公司 |
二環ｈｐｋ１抑制劑
|
|
US11453681B2
(en)
|
2019-05-23 |
2022-09-27 |
Gilead Sciences, Inc. |
Substituted eneoxindoles and uses thereof
|
|
CR20210687A
(es)
|
2019-06-25 |
2022-03-03 |
Gilead Sciences Inc |
PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO
|
|
TWI848141B
(zh)
|
2019-07-04 |
2024-07-11 |
英屬開曼群島商百濟神州有限公司 |
及其用途
|
|
TW202116753A
(zh)
*
|
2019-07-11 |
2021-05-01 |
大陸商南京征祥醫藥有限公司 |
以噌啉作為hpk1的抑制劑
|
|
TW202116771A
(zh)
|
2019-07-17 |
2021-05-01 |
英屬開曼群島商百濟神州有限公司 |
作為ｈｐｋ１抑制劑之三環化合物及其用途
|
|
CN110483402B
(zh)
*
|
2019-08-12 |
2021-07-23 |
上海毕得医药科技股份有限公司 |
一种3-溴-5-苯基-1h-吡唑的合成方法
|
|
CN114341127B
(zh)
*
|
2019-08-21 |
2024-12-17 |
百济神州有限公司 |
作为hpk1抑制剂的氨基吡嗪化合物及其用途
|
|
CN114945366B
(zh)
*
|
2019-09-13 |
2025-01-07 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
EP4031547B1
(en)
|
2019-09-18 |
2024-07-17 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof
|
|
CN114667289B
(zh)
|
2019-09-18 |
2025-08-26 |
武田药品工业有限公司 |
杂芳基血浆激肽释放酶抑制剂
|
|
CN114555123B
(zh)
|
2019-10-18 |
2024-04-02 |
四十七公司 |
用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
|
|
KR20220091576A
(ko)
|
2019-10-31 |
2022-06-30 |
포티 세븐, 인코포레이티드 |
혈액암의 항-cd47 및 항-cd20 기반 치료
|
|
TWI778443B
(zh)
|
2019-11-12 |
2022-09-21 |
美商基利科學股份有限公司 |
Mcl1抑制劑
|
|
LT4081305T
(lt)
|
2019-12-24 |
2024-11-25 |
Carna Biosciences, Inc. |
Diacilglicerolio kinazę moduliuojantys junginiai
|
|
EP4090663A1
(en)
|
2020-01-15 |
2022-11-23 |
Blueprint Medicines Corporation |
Map4k1 inhibitors
|
|
KR20260017503A
(ko)
|
2020-02-14 |
2026-02-05 |
길리애드 사이언시즈, 인코포레이티드 |
Ccr8에 결합하는 항체 및 융합 단백질, 및 이의 용도
|
|
CN113336747A
(zh)
*
|
2020-03-03 |
2021-09-03 |
轶诺(浙江)药业有限公司 |
新型hpk1抑制剂及其制备方法和应用
|
|
JP7564888B2
(ja)
|
2020-05-01 |
2024-10-09 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｃｄ７３阻害性２，４－ジオキソピリミジン化合物
|
|
WO2021249913A1
(en)
|
2020-06-09 |
2021-12-16 |
Bayer Aktiengesellschaft |
2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
|
|
CN111965367A
(zh)
*
|
2020-07-23 |
2020-11-20 |
北京大学第三医院（北京大学第三临床医学院） |
Hip-55在作为gpcr偏向药物靶点中的应用
|
|
IL301244A
(en)
*
|
2020-09-28 |
2023-05-01 |
1St Biotherapeutics Inc |
INDOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING THEM
|
|
WO2022167627A1
(en)
|
2021-02-05 |
2022-08-11 |
Bayer Aktiengesellschaft |
Map4k1 inhibitors
|
|
CN114907374B
(zh)
*
|
2021-02-07 |
2026-03-10 |
苏州信诺维医药科技股份有限公司 |
杂环化合物、其制备方法、药物组合物及应用
|
|
CN114907375B
(zh)
*
|
2021-02-07 |
2026-03-31 |
苏州信诺维医药科技股份有限公司 |
杂环化合物、其制备方法、药物组合物及应用
|
|
CN117120090A
(zh)
|
2021-02-12 |
2023-11-24 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
EP4301756A4
(en)
|
2021-03-05 |
2025-02-26 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
CN115073308A
(zh)
*
|
2021-03-15 |
2022-09-20 |
苏州信礼发医药技术有限公司 |
1-氨甲基-1-环丙醇的合成方法
|
|
US20240226106A1
(en)
*
|
2021-03-17 |
2024-07-11 |
Shire Human Genetic Therapies, Inc. |
Inhibitors of plasma kallikrein
|
|
WO2022213062A1
(en)
|
2021-03-29 |
2022-10-06 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
WO2022214009A1
(zh)
*
|
2021-04-08 |
2022-10-13 |
杭州阿诺生物医药科技有限公司 |
一种高活性的hpk1激酶抑制剂
|
|
TW202302145A
(zh)
|
2021-04-14 |
2023-01-16 |
美商基利科學股份有限公司 |
ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
|
|
WO2022222951A1
(zh)
*
|
2021-04-22 |
2022-10-27 |
浙江海正药业股份有限公司 |
芳香稠合环类衍生物及其制备方法和用途
|
|
TW202313094A
(zh)
|
2021-05-18 |
2023-04-01 |
美商基利科學股份有限公司 |
使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法
|
|
WO2022271659A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
WO2022271677A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
KR20240005901A
(ko)
|
2021-06-23 |
2024-01-12 |
길리애드 사이언시즈, 인코포레이티드 |
디아실글리세롤 키나제 조절 화합물
|
|
CA3222277A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
KR20240083168A
(ko)
*
|
2021-07-14 |
2024-06-11 |
블루프린트 메디신즈 코포레이션 |
Map4k1 저해제로서의 헤테로사이클 화합물
|
|
US20230183216A1
(en)
|
2021-10-28 |
2023-06-15 |
Gilead Sciences, Inc. |
Pyridizin-3(2h)-one derivatives
|
|
EP4422756A1
(en)
|
2021-10-29 |
2024-09-04 |
Gilead Sciences, Inc. |
Cd73 compounds
|
|
US20230203202A1
(en)
|
2021-12-08 |
2023-06-29 |
Dragonfly Therapeutics, Inc. |
Proteins binding nkg2d, cd16 and 5t4
|
|
WO2023107954A1
(en)
|
2021-12-08 |
2023-06-15 |
Dragonfly Therapeutics, Inc. |
Antibodies targeting 5t4 and uses thereof
|
|
CN118488946A
(zh)
|
2021-12-22 |
2024-08-13 |
吉利德科学公司 |
Ikaros锌指家族降解剂及其用途
|
|
EP4452415B1
(en)
|
2021-12-22 |
2026-02-25 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
TW202340168A
(zh)
|
2022-01-28 |
2023-10-16 |
美商基利科學股份有限公司 |
Ｐａｒｐ７抑制劑
|
|
CA3253296A1
(en)
|
2022-03-17 |
2023-09-21 |
Gilead Sciences, Inc. |
Zinc Finger Degradation Agents of the Ikaros Family and Their Uses
|
|
AU2023240346A1
(en)
|
2022-03-24 |
2024-09-19 |
Gilead Sciences, Inc. |
Combination therapy for treating trop-2 expressing cancers
|
|
TWI876305B
(zh)
|
2022-04-05 |
2025-03-11 |
美商基利科學股份有限公司 |
用於治療結腸直腸癌之組合療法
|
|
WO2023193759A1
(en)
*
|
2022-04-07 |
2023-10-12 |
Insilico Medicine Ip Limited |
Hpk1 antagonists and uses thereof
|
|
WO2023205719A1
(en)
|
2022-04-21 |
2023-10-26 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
WO2023244788A1
(en)
*
|
2022-06-17 |
2023-12-21 |
Neuron23, Inc. |
Kinase modulators and methods of use thereof
|
|
US20240116928A1
(en)
|
2022-07-01 |
2024-04-11 |
Gilead Sciences, Inc. |
Cd73 compounds
|
|
WO2024003773A1
(en)
*
|
2022-07-01 |
2024-01-04 |
Pfizer Inc. |
2,7-naphthyridine compounds as mastl inhibitors
|
|
WO2024064668A1
(en)
|
2022-09-21 |
2024-03-28 |
Gilead Sciences, Inc. |
FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
|
|
JP2025531158A
(ja)
*
|
2022-09-21 |
2025-09-19 |
武田薬品工業株式会社 |
シクロプロパンカルボン酸の合成
|
|
EP4574830A4
(en)
*
|
2022-09-23 |
2025-11-26 |
Guangzhou Vinnocent Pharmaceutical Ltd |
PYRIDINE INHIBITOR, RINGED STEROID SYNTHETASE, ITS PREPARATION PROCESS AND ITS USE
|
|
EP4638436A1
(en)
|
2022-12-22 |
2025-10-29 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
CN120882725A
(zh)
|
2023-04-11 |
2025-10-31 |
吉利德科学公司 |
Kras调节化合物
|
|
WO2024220917A1
(en)
|
2023-04-21 |
2024-10-24 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2024243025A1
(en)
*
|
2023-05-19 |
2024-11-28 |
Ikena Oncology, Inc. |
Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions
|
|
US20250042922A1
(en)
|
2023-06-30 |
2025-02-06 |
Gilead Sciences, Inc. |
Kras modulating compounds
|
|
AU2024297978A1
(en)
|
2023-07-26 |
2026-02-05 |
Gilead Sciences, Inc. |
Parp7 inhibitors
|
|
US20250066328A1
(en)
|
2023-07-26 |
2025-02-27 |
Gilead Sciences, Inc. |
Parp7 inhibitors
|
|
AU2024337913A1
(en)
|
2023-09-08 |
2026-03-26 |
Gilead Sciences, Inc. |
Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
|
|
WO2025054347A1
(en)
|
2023-09-08 |
2025-03-13 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
US20250154172A1
(en)
|
2023-11-03 |
2025-05-15 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2025137640A1
(en)
|
2023-12-22 |
2025-06-26 |
Gilead Sciences, Inc. |
Azaspiro wrn inhibitors
|
|
US20250376484A1
(en)
|
2024-05-21 |
2025-12-11 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2026039365A1
(en)
|
2024-08-12 |
2026-02-19 |
Gilead Sciences, Inc. |
Kras modulating compounds
|