JP2020511306A - リガンド結合mbp膜、使用及び製造方法 - Google Patents
リガンド結合mbp膜、使用及び製造方法 Download PDFInfo
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- JP2020511306A JP2020511306A JP2019566063A JP2019566063A JP2020511306A JP 2020511306 A JP2020511306 A JP 2020511306A JP 2019566063 A JP2019566063 A JP 2019566063A JP 2019566063 A JP2019566063 A JP 2019566063A JP 2020511306 A JP2020511306 A JP 2020511306A
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- Prior art keywords
- mbp
- affinity
- ligand
- affinity ligand
- analyte
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Classifications
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Abstract
Description
本発明は、リガンド結合マルチブロックポリマー(「MBP」)イソポーラス材料、それらの調製、及び実験室、スケールアップ又は商業環境、例えばこれらに限定されないが、タンパク質の精製と生産プロセスに必要な分離技術、及び特に、カラムベースのアフィニティ分離の代替品として、並びに興味対象の分析物を監視及び検出するためのセンサ、のための、分析、検出及び分離プロトコルにおける使用に関する。
タンパク質精製は、R&Dから大規模製造まで、生体分子分離市場における重要かつ挑戦的な態様である。タンパク質精製プロセス全体の主要なボトルネックは、多数の分離プロトコルに関係していることが広く認識されている。現在のタンパク質精製の1つの態様には、多孔質膜、複数のサイズレジームの相互接続された細孔を持つサポートされた多孔性材料、を使用したアフィニティ分離が含まれる。多くの場合、アフィニティ分離に有用な前記多孔質膜は、反応性基(とりわけ、カルボン酸基が開示されている)を生物学的活性剤、例えば、とりわけプロテインA、に結合することにより形成される。前記膜は高分子材料でできている。反応性基は、直接にはポリマーの一部であり得るか、又は後続の処理により前記反応性基を形成する前駆体を介して形成され得る。
ブロックコポリマー、ターポリマー、テトラポリマー、一括マルチブロックポリマー(MBP)材料/構造は、材料又は構造が階層的に多孔性であるように(複数の長さスケールの細孔を有する)、自己組織化によって形成された材料/構造の少なくとも一部とともに開示される。前記自己組織化ポリマー材料は、マクロ細孔、メソ細孔又はミクロ細孔のうち少なくとも1つを含有し、その少なくともいくつかはイソポーラスである。ミクロ細孔は、0.1〜1nmの直径を有すると定義される。メソ細孔は、1nm〜200nmの直径を持つと定義される。マクロ細孔は、200nmから1000μmの直径を持つと定義される。
それらの全体に組み込まれている参照対象主題
Claims (20)
- 少なくともいくつかがイソポーラスであるマクロ、メソ、又はミクロ細孔のうち少なくとも1つを含有する自己組織化ポリマー材料であって、少なくとも1つのマルチブロックポリマー(MBP)を含み、
前記ポリマーブロックの少なくとも2つが化学的に異なり、前記化学的に異なるブロックの少なくとも1つが共有又は非共有部分結合を包含するように修飾され、且つ、親和性リガンドが前記部分連結に結合している、材料。 - 非対称又は対象のいずれかである、請求項1に記載の材料。
- 単一の一体型のスケーラブルな構造内にマクロポーラスドメイン及びメソポーラス壁構造をさらに含有する、請求項1に記載の材料。
- 連続マクロ多孔質ドメインをさらに含有する、請求項2に記載の材料。
- 当該材料は非対称であり、且つメソ細孔及びマクロ細孔を有する、請求項4に記載の材料。
- 請求項1に記載の材料であって、さらに、
a.複数の親和性リガンド若しくはリンカー、又は
b.複数の官能性を含有する親和性リガンド又はリンカー、又は
c.複数のポリマーブロックに部分的又は完全に配置されている親和性リガンド又はリンカー、
を包含する、材料。 - 請求項1に記載の材料を製造する方法であって、
a.非共有付着、例えば吸着、により親和性リガンドで前記MBPの表面を修飾すること;又は
b.親和性リガンドの後続の付着のための官能性を提供するリンカーで前記MBPを修飾すること;又は
c.前記MPBは、フィルムへの製造前に、前記MBPの前記ブロックを親和性リガンド若しくはリンカーで修飾するリンカー若しくは親和性リガンドを有する階層的多孔性を包含する三次元ブロックターポリマー構造であること;又は
d.リンカー若しくは親和性リガンドで修飾されたMBPの量を、前記MBPの化学量論に対して変化させることであって、利用可能なサイトの10〜100%を修飾するために、時間、温度、及び修飾剤の濃度を変更することを含むこと;又は
e.前記リンカー若しくは親和性リガンドの一体的であるが別個の物理層を提供するため、前記材料の表面に共有若しくは非共有部分によって連結材料をコンフォーマルにコーティングすること;又は
f.前記MBPメソ細孔マクロ構造の前記メソ細孔に加えて、マイクロポーラス材料を前記フィルム内/上に、例えばゼオライト、マイクロポーラス炭素を前記材料内に、組み込むことにより、前記材料にミクロ細孔を設けること;又は
g.
i.二次元に、若しくは
ii.三次元に、若しくは
iii.リソグラフィによるパターンに、若しくは
iv.修飾された材料の一部分もしくは部分を未修飾のフィルム若しくは別の基板に取り付けることにより、
配置するため、親和性リガンド若しくはリンカーで修飾された材料のジオメトリ及び面積を制御すること;
を含む方法。 - 請求項1に記載の材料を含有する物品であって、機械的安定性を提供するために支持材料上に前記材料を固定化することを含む、物品。
- 請求項1に記載の材料を含有する物品であって、前記材料をテキスタイルと一体化することを含む、物品。
- 請求項1に記載の材料を含むセンサ。
- 興味対象の分析物を分離する及び/又は検出するプロセスであって、興味対象の前記分析物を含有する媒体を請求項1に記載の材料と接触させる、プロセス。
- 興味対象の前記分析物がタンパク質である、請求項11に記載のプロセス。
- 分離は、前記分析物が標的種であり、且つ、それを単離するために前記親和性リガンドに結合される、結合及び溶出操作を伴い、ここで、前記標的種は、前記標的種を記録するために前記材料から結合解除することができる、請求項11に記載のプロセス。
- 対象の分析物又は種を検出する方法であって、
請求項1に記載の材料を包含するセンサに接触すること、及び興味対象の前記分析物又は種と前記材料リガンドとの間の相互作用の結果としての光学的/電気的変化を測定すること、を含む方法。 - 単一の一体型のスケーラブルな構造内にマクロポーラスドメイン及びメソポーラス壁構造をさらに含有する、請求項1に記載の材料。
- 前記マクロポーラス構造的フィーチャは、改善された対流溶液の流れ、迅速な処理を提供し、且つ、前記メソポーラス壁は、高密度の表面官能化のために高い表面積を作り出す、請求項1に記載の材料。
- 前記分析物が核酸を含み、且つ分離される、請求項11に記載のプロセス。
- 請求項1に記載の材料を利用するデバイスであって、前記材料は、クロスフローカセット若しくはモジュール、又はらせん状に巻かれたモジュールの、平らなシートとして、プリーツ状のパックへと形成される、デバイス。
- 結合と溶出により分子を分離する請求項18に記載のデバイスを利用するプロセス。
- 濾過による分子又は懸濁粒子の分離のために請求項18に記載のデバイスを利用するプロセス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762462161P | 2017-02-22 | 2017-02-22 | |
US62/462,161 | 2017-02-22 | ||
PCT/US2018/019173 WO2018156731A1 (en) | 2017-02-22 | 2018-02-22 | Ligand bound mbp membranes, uses and method of manufacturing |
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JP2020511306A true JP2020511306A (ja) | 2020-04-16 |
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CN110785219A (zh) | 2020-02-11 |
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