JP2020511123A5 - - Google Patents
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- JP2020511123A5 JP2020511123A5 JP2019545292A JP2019545292A JP2020511123A5 JP 2020511123 A5 JP2020511123 A5 JP 2020511123A5 JP 2019545292 A JP2019545292 A JP 2019545292A JP 2019545292 A JP2019545292 A JP 2019545292A JP 2020511123 A5 JP2020511123 A5 JP 2020511123A5
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- 150000001413 amino acids Chemical group 0.000 claims description 78
- 239000008194 pharmaceutical composition Substances 0.000 claims description 42
- 101001043821 Homo sapiens Interleukin-31 Proteins 0.000 claims description 39
- 102100021596 Interleukin-31 Human genes 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 15
- 241000282326 Felis catus Species 0.000 claims description 14
- 241001465754 Metazoa Species 0.000 claims description 13
- 241000283073 Equus caballus Species 0.000 claims description 12
- 241000282465 Canis Species 0.000 claims description 10
- 239000003937 drug carrier Substances 0.000 claims description 10
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 10
- 241000282472 Canis lupus familiaris Species 0.000 claims description 9
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229940068968 polysorbate 80 Drugs 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 229960002885 histidine Drugs 0.000 claims description 7
- 238000012575 bio-layer interferometry Methods 0.000 claims description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 5
- 229960002216 methylparaben Drugs 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 208000003251 Pruritus Diseases 0.000 claims description 4
- 229940024606 amino acid Drugs 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000003119 immunoblot Methods 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 230000009131 signaling function Effects 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- -1 CD11α Proteins 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 229960002668 sodium chloride Drugs 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 206010027654 Allergic conditions Diseases 0.000 claims description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 2
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 2
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 108010041012 Integrin alpha4 Proteins 0.000 claims description 2
- 108010065805 Interleukin-12 Proteins 0.000 claims description 2
- 102000013462 Interleukin-12 Human genes 0.000 claims description 2
- 108090000176 Interleukin-13 Proteins 0.000 claims description 2
- 102000003816 Interleukin-13 Human genes 0.000 claims description 2
- 102100033461 Interleukin-17A Human genes 0.000 claims description 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 2
- 108010065637 Interleukin-23 Proteins 0.000 claims description 2
- 102000013264 Interleukin-23 Human genes 0.000 claims description 2
- 102000004388 Interleukin-4 Human genes 0.000 claims description 2
- 108090000978 Interleukin-4 Proteins 0.000 claims description 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims description 2
- 229940122245 Janus kinase inhibitor Drugs 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 239000012828 PI3K inhibitor Substances 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 102000045345 human IL31 Human genes 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000001361 intraarterial administration Methods 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 238000007919 intrasynovial administration Methods 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims description 2
- 230000026731 phosphorylation Effects 0.000 claims description 2
- 238000006366 phosphorylation reaction Methods 0.000 claims description 2
- 239000003197 protein kinase B inhibitor Substances 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 241000283086 Equidae Species 0.000 claims 2
- 102000043136 MAP kinase family Human genes 0.000 claims 1
- 108091054455 MAP kinase family Proteins 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229940126638 Akt inhibitor Drugs 0.000 description 1
- 229940126560 MAPK inhibitor Drugs 0.000 description 1
- 238000002022 differential scanning fluorescence spectroscopy Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076588A JP7716441B2 (ja) | 2017-02-24 | 2023-05-08 | 獣医用抗ｉｌ－３１抗体 |
| JP2025087766A JP2025138636A (ja) | 2017-02-24 | 2025-05-27 | 獣医用抗ｉｌ－３１抗体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463543P | 2017-02-24 | 2017-02-24 | |
| US62/463,543 | 2017-02-24 | ||
| PCT/US2017/023788 WO2018156180A1 (en) | 2017-02-24 | 2017-03-23 | Anti-il31 antibodies for veterinary use |
| USPCT/US2017/023788 | 2017-03-23 | ||
| PCT/US2018/017623 WO2018156367A1 (en) | 2017-02-24 | 2018-02-09 | Anti-il31 antibodies for veterinary use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076588A Division JP7716441B2 (ja) | 2017-02-24 | 2023-05-08 | 獣医用抗ｉｌ－３１抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511123A JP2020511123A (ja) | 2020-04-16 |
| JP2020511123A5 true JP2020511123A5 (enExample) | 2021-03-18 |
| JP7277370B2 JP7277370B2 (ja) | 2023-05-18 |
Family
ID=63245488
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545292A Active JP7277370B2 (ja) | 2017-02-24 | 2018-02-09 | 獣医用抗ｉｌ－３１抗体 |
| JP2023076588A Active JP7716441B2 (ja) | 2017-02-24 | 2023-05-08 | 獣医用抗ｉｌ－３１抗体 |
| JP2025087766A Pending JP2025138636A (ja) | 2017-02-24 | 2025-05-27 | 獣医用抗ｉｌ－３１抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076588A Active JP7716441B2 (ja) | 2017-02-24 | 2023-05-08 | 獣医用抗ｉｌ－３１抗体 |
| JP2025087766A Pending JP2025138636A (ja) | 2017-02-24 | 2025-05-27 | 獣医用抗ｉｌ－３１抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US10093731B2 (enExample) |
| EP (1) | EP3585429A4 (enExample) |
| JP (3) | JP7277370B2 (enExample) |
| KR (2) | KR20240093562A (enExample) |
| CN (2) | CN117603350A (enExample) |
| AU (2) | AU2018224711B2 (enExample) |
| BR (1) | BR112019017308A2 (enExample) |
| CA (1) | CA3053525A1 (enExample) |
| MA (1) | MA47609A (enExample) |
| MX (1) | MX2024012304A (enExample) |
| WO (1) | WO2018156180A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017189805A1 (en) | 2016-04-27 | 2017-11-02 | Abbvie Inc. | Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies |
| WO2018156180A1 (en) * | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| WO2018162577A1 (en) * | 2017-03-07 | 2018-09-13 | Universität Zürich | Treatment of pruritus in horses |
| JP7497293B2 (ja) | 2018-03-16 | 2024-06-10 | ゾエティス・サービシーズ・エルエルシー | インターロイキン－３１に対するペプチドワクチン |
| CN114555121A (zh) * | 2019-08-29 | 2022-05-27 | 金德雷德生物科学股份有限公司 | 兽用抗il31抗体 |
| CA3161728A1 (en) | 2019-12-20 | 2021-06-24 | Mohamad Morsey | Bispecific caninized antibodies and bispecific binding partners for treating atopic dermatitis |
| MX2022007677A (es) | 2019-12-20 | 2022-07-19 | Intervet Int Bv | Anticuerpos para receptor alfa de interleucina-4 canino. |
| US20230242635A1 (en) * | 2020-04-17 | 2023-08-03 | Zoetis Services Llc | Canine antibody variants |
| JP2023524643A (ja) * | 2020-04-22 | 2023-06-13 | キンドレッド バイオサイエンシズ インコーポレイテッド | 獣医学的使用のための長時間作用性抗ｉｌ３１抗体 |
| AU2021306179A1 (en) | 2020-07-10 | 2023-03-02 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
| WO2022079138A1 (en) | 2020-10-15 | 2022-04-21 | Intervet International B.V. | Caninized rat antibodies to canine interleukin-31 receptor alpha |
| AU2021383841A1 (en) * | 2020-11-23 | 2023-06-22 | Scout Bio, Inc. | Antigen-binding molecules and uses thereof |
| BR112023016043A2 (pt) * | 2021-02-22 | 2023-12-05 | Zoetis Services Llc | Modelo de prurido induzido por il-31 de cavalo |
| AU2022331122A1 (en) | 2021-08-20 | 2024-02-15 | Intervet International B.V. | Homodimer fusion proteins for treating atopic dermatitis |
| EP4448572A1 (en) | 2021-12-16 | 2024-10-23 | Intervet International B.V. | Caninized antibodies to canine interleukin-31 receptor alpha 1 |
| KR20250130357A (ko) | 2022-12-27 | 2025-09-01 | 인베티엑스 인코포레이티드 | 신생아 fc 수용체 (fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법 |
| EP4642795A2 (en) | 2022-12-27 | 2025-11-05 | Invetx, Inc. | Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use |
| WO2024155982A2 (en) | 2023-01-20 | 2024-07-25 | Invetx, Inc. | Bispecific binding agents for use in companion animals |
| WO2024170485A1 (en) | 2023-02-13 | 2024-08-22 | Intervet International B.V. | Canine antibodies to canine il-13 |
| CN120897928A (zh) | 2023-02-13 | 2025-11-04 | 英特维特国际股份有限公司 | 针对犬il-4的犬抗体 |
| CN118359715B (zh) * | 2023-11-27 | 2025-08-19 | 宁波贝安生物科技有限公司 | 抗il-31的抗体及其用途 |
| CN118667001B (zh) * | 2024-07-16 | 2025-05-06 | 华中农业大学 | 一种抗犬il-31的单克隆抗体及其应用 |
| CN120209126B (zh) * | 2025-05-28 | 2025-09-16 | 中国医学科学院医学生物学研究所 | 人偏肺病毒单克隆抗体及其应用 |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JP3919830B2 (ja) | 1992-11-28 | 2007-05-30 | 財団法人化学及血清療法研究所 | 抗ネコヘルペスウイルス−１組換え抗体および該抗体をコードする遺伝子断片 |
| ATE335072T1 (de) | 1993-05-28 | 2006-08-15 | Scripps Research Inst | Methoden für inhibition der cd14-abhängigen zellaktivierung |
| DE69738539T2 (de) | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DK1270595T3 (da) | 2000-03-03 | 2008-11-10 | Kyowa Hakko Kogyo Kk | Anti-CCR4-antistof og dets fragment |
| US20030138417A1 (en) | 2001-11-08 | 2003-07-24 | Kaisheva Elizabet A. | Stable liquid pharmaceutical formulation of IgG antibodies |
| US7261890B2 (en) | 2001-12-21 | 2007-08-28 | Idexx Laboratories, Inc. | Methods for using canine immunoglobulin variable domains and caninized antibodies |
| EP1476541B1 (en) | 2002-01-18 | 2008-07-16 | ZymoGenetics, Inc. | Cytokine (zcytor17 ligand) |
| KR20050083774A (ko) | 2002-10-16 | 2005-08-26 | 유로-셀티크 소시에떼 아노뉨 | 세포-연관된 ｃａ 125/ｏ772ｐ에 결합하는 항체들 및그것의 용도의 방법들 |
| AR049390A1 (es) | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| EP1671642A1 (en) | 2004-12-15 | 2006-06-21 | Universite D'angers | Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof. |
| ES2579758T3 (es) | 2005-01-28 | 2016-08-16 | Zymogenetics, Inc. | Preparaciones homogéneas de IL-31 |
| EP1856150A2 (en) | 2005-02-14 | 2007-11-21 | ZymoGenetics, Inc. | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
| WO2006088855A1 (en) | 2005-02-14 | 2006-08-24 | Zymogenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| WO2006100449A1 (en) | 2005-03-19 | 2006-09-28 | Medical Research Council | Improvements in or relating to treatment and prevention of viral infections |
| WO2006105062A2 (en) | 2005-03-29 | 2006-10-05 | Verenium Corporation | Altered antibody fc regions and uses thereof |
| RU2444528C2 (ru) | 2005-05-06 | 2012-03-10 | Займоджинетикс, Инк. | Моноклональные антитела против il-31 и способы применения |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| JP5065253B2 (ja) | 2005-05-06 | 2012-10-31 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−３１モノクローナル抗体とその使用法 |
| CN1896229A (zh) * | 2005-06-29 | 2007-01-17 | 北京天广实生物技术有限公司 | 一种新型抗cd20嵌合抗体的制备及其用途 |
| EP1940466B1 (en) * | 2005-10-21 | 2012-11-28 | Merck Sharp & Dohme Corp. | Anti-addl monoclonal antibodies and use thereof |
| MX2008008831A (es) | 2006-01-10 | 2009-03-04 | Zymogenetics Inc | Metodos para tratar dolor e inflamacion en tejidos neuronales usando antagonistas il-31. |
| CN101622276B (zh) | 2006-07-18 | 2015-04-22 | 赛诺菲-安万特 | 用于治疗癌症的抗epha2的拮抗抗体 |
| DK2594586T3 (en) | 2006-09-01 | 2014-11-17 | Zymogenetics Inc | Monoclonal il-31 antibodies and methods of use thereof |
| MY161894A (en) | 2006-09-08 | 2017-05-15 | Abbvie Bahamas Ltd | Interleukin-13 binding proteins |
| PL2068921T3 (pl) | 2006-10-19 | 2014-12-31 | Csl Ltd | Przeciwciała o dużym powinowactwie będące antagonistami receptora alfa1 interleukiny 13 |
| AU2008204823A1 (en) | 2007-01-10 | 2008-07-17 | Zymogenetics, Inc | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| AU2008333131B2 (en) | 2007-12-07 | 2013-10-24 | Merck Serono S/A | Humanized antibody molecules specific for IL-31 |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| PT2384326E (pt) | 2008-08-20 | 2014-06-09 | Zoetis Llc | Compostos de pirrolo[2,3-d]pirimidina |
| US8337842B2 (en) | 2008-09-04 | 2012-12-25 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| DK2842573T3 (en) | 2008-11-07 | 2017-10-30 | Galaxy Biotech Llc | Monoclonal antibodies to fibroblast growth factor receptor 2 |
| US20110287454A1 (en) | 2008-11-25 | 2011-11-24 | Cornell University | Methods for monoclonal antibody production |
| WO2011065935A1 (en) | 2009-11-24 | 2011-06-03 | Cornell University | Methods for monoclonal antibody production |
| AU2013203075A1 (en) * | 2008-11-28 | 2013-05-02 | Abbott Laboratories | Stable antibody compositions and methods for stabilizing same |
| US20110165063A1 (en) | 2009-01-29 | 2011-07-07 | Abbott Laboratories | Il-1 binding proteins |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| US20120100155A1 (en) | 2009-06-22 | 2012-04-26 | Peptcell Limited | Pharmaceutical agent |
| UY32948A (es) | 2009-10-15 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| SG10201501342UA (en) | 2010-02-24 | 2015-04-29 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| EP2571532B1 (en) | 2010-05-14 | 2017-05-03 | Abbvie Inc. | Il-1 binding proteins |
| TWI560199B (en) | 2010-08-31 | 2016-12-01 | Sanofi Sa | Peptide or peptide complex binding to α2 integrin and methods and uses involving the same |
| US9255925B2 (en) | 2010-10-20 | 2016-02-09 | Medical Diagnostic Laboratories, Llc | ELISA detection of urine DEK to predict and diagnose bladder cancer in humans |
| TR201802772T4 (tr) | 2010-11-17 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül. |
| AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| US20120275996A1 (en) | 2010-12-21 | 2012-11-01 | Abbott Laboratories | IL-1 Binding Proteins |
| LT2703486T (lt) | 2011-04-25 | 2018-05-25 | Daiichi Sankyo Company, Limited | Anti-b7-h3 antikūnas |
| AR086250A1 (es) | 2011-05-05 | 2013-11-27 | Hoffmann La Roche | Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo |
| KR20170070272A (ko) | 2011-05-06 | 2017-06-21 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
| JP2014516960A (ja) | 2011-05-19 | 2014-07-17 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | 抗ヒトｈｅｒ３抗体及びその使用 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| KR20130036993A (ko) | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| CN105452298B (zh) | 2013-03-15 | 2021-08-31 | 拜尔健康护理有限责任公司 | 改善药代动力学的具有跨pH范围差异结合的抗TFPI抗体变体 |
| MX364591B (es) | 2013-03-15 | 2019-05-02 | Regeneron Pharma | Antagonistas de il-33 y usos de estos. |
| EP3639841B1 (en) | 2013-03-27 | 2023-09-06 | Cedars-Sinai Medical Center | Treating fibrosis by inhibiting tl1a |
| WO2014191391A1 (en) | 2013-05-27 | 2014-12-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Targeted modulation of macrophages |
| KR101882366B1 (ko) * | 2013-05-30 | 2018-07-30 | 키닉사 파마슈티컬스, 리미티드 | 온코스타틴 m 수용체 항원 결합 단백질 |
| JP5650871B1 (ja) | 2013-06-28 | 2015-01-07 | 中外製薬株式会社 | そう痒を伴う疾患に罹患した患者のｉｌ−３１アンタゴニストによる治療に対する応答を予測する方法 |
| WO2015002985A2 (en) | 2013-07-01 | 2015-01-08 | University Of Maryland | Fc coupled compositions and methods of their use |
| WO2015042596A1 (en) | 2013-09-23 | 2015-03-26 | Kindred Biosciences, Inc | Treatment of atopic dermatitis in non-human animals |
| EP3066132A2 (en) | 2013-11-07 | 2016-09-14 | Novo Nordisk A/S | Novel methods and antibodies for treating coagulapathy |
| WO2015086830A1 (en) | 2013-12-13 | 2015-06-18 | Delenex Therapeutics Ag | Skin penetrating polypeptides |
| CN103965357B (zh) | 2013-12-31 | 2016-08-17 | 嘉和生物药业有限公司 | 一种抗人rankl抗体 |
| TWI694836B (zh) * | 2014-05-16 | 2020-06-01 | 英商葛蘭素史克智慧財產管理有限公司 | 抗體調配物 |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| CA2975017A1 (en) | 2015-01-29 | 2016-08-04 | Nexvet Australia Pty Ltd | Therapeutic and diagnostic agents |
| CN104710528B (zh) * | 2015-03-13 | 2019-02-15 | 西北农林科技大学 | 一种特异性结合PRRS病毒非结构蛋白Nsp9纳米抗体及其应用 |
| WO2016167263A1 (ja) | 2015-04-14 | 2016-10-20 | 中外製薬株式会社 | Ｉｌ－３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| AU2016251687C1 (en) | 2015-04-22 | 2023-07-27 | CureVac SE | RNA containing composition for treatment of tumor diseases |
| CN116726190A (zh) | 2015-06-20 | 2023-09-12 | 杭州多禧生物科技有限公司 | 澳瑞他汀类似物及其与细胞结合分子的共轭偶联物 |
| WO2017025698A1 (en) | 2015-08-11 | 2017-02-16 | Queen Mary University Of London | Bispecific, cleavable antibodies |
| TW201729810A (zh) | 2015-10-26 | 2017-09-01 | 札爾科製藥公司 | 嘧啶組成物、其超純組成物及鹽類、製造彼之方法、及使用彼於治療組織胺h4受體(h 4 )仲介之疾病與病情之方法 |
| WO2017172990A1 (en) * | 2016-03-29 | 2017-10-05 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| EP3448412A4 (en) | 2016-04-15 | 2020-03-25 | Immunext Inc. | ANTI-HUMAN-VISTA ANTIBODIES AND USE THEREOF |
| KR102295190B1 (ko) | 2016-04-20 | 2021-08-30 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 아마니타 독소의 유도체 및 세포 결합 분자와의 그것의 결합 |
| EP3526246A1 (en) | 2016-10-17 | 2019-08-21 | Vetoquinol SA | Modified antibody constant region |
| KR102345175B1 (ko) | 2016-11-14 | 2021-12-31 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| TWI857389B (zh) | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2018156367A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| MX2019011957A (es) | 2017-04-06 | 2019-11-07 | Hangzhou Dac Biotech Co Ltd | Conjugacion de un farmaco citotoxico con enlace bis. |
| MY200973A (en) | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
| CA3059731A1 (en) | 2017-04-21 | 2018-10-25 | Kindred Biosciences, Inc. | Il4/il13 receptor molecule for veterinary use |
| EP3483180A1 (en) | 2017-11-14 | 2019-05-15 | Affilogic | Multi specific molecules |
| CA3085318A1 (en) | 2017-12-11 | 2019-06-20 | Ubi Ip Holdings | Peptide immunogens of il-31 and formulations thereof for the treatment and/or prevention of atopic dermatitis |
| SG11202004801WA (en) | 2017-12-31 | 2020-06-29 | Hangzhou Dac Biotech Co Ltd | A conjugate of a tubulysin analog with branched linkers |
| KR102828306B1 (ko) | 2018-03-16 | 2025-07-01 | 조에티스 서비시즈 엘엘씨 | 수의학적 용도를 위한 인터류킨-31 단클론성 항체 |
| US20210009678A1 (en) | 2018-03-23 | 2021-01-14 | North Carolina State University | Methods and compositions for allergic disorders |
| IL323061A (en) | 2018-04-11 | 2025-10-01 | Inhibrx Biosciences Inc | Multispecific polypeptide constructs with forced CD3 binding and related methods and uses |
| MX2020014083A (es) | 2018-07-05 | 2021-04-12 | Hangzhou Dac Biotech Co Ltd | Un derivado de dímero de pirrolobenzodiazepina (pbd) reticulado y sus conjugados. |
| US20220049002A1 (en) | 2018-09-14 | 2022-02-17 | Kindred Biosciences, Inc. | Anti-IL4 Receptor Antibodies for Veterinary Use |
| JP2022504745A (ja) | 2018-10-12 | 2022-01-13 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | ２，３－ジアミノスクシニル基を含む共役連結体 |
| BR112021006977A2 (pt) | 2018-10-18 | 2021-07-27 | Kindred Biosciences, Inc. | variantes fc com ligação alterada a receptor fc neonatal (fcrn) para uso veterinário |
| US12428466B2 (en) | 2018-10-25 | 2025-09-30 | Elanco Us Inc. | IL4/IL13 receptor molecule for veterinary use |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| MX2021007680A (es) | 2018-12-27 | 2021-10-13 | Kindred Biosciences Inc | Variantes de igg fc para uso veterinario. |
| MX2021008144A (es) | 2019-01-03 | 2021-10-13 | Invetx Inc | Composiciones para aumentar la media vida de un agente terapeutico en caninos y metodos de uso. |
| KR20210117302A (ko) | 2019-01-31 | 2021-09-28 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 분지형 링커를 갖는 아마니타 독소의 접합체 |
| MX2021011141A (es) | 2019-03-21 | 2022-01-19 | Regeneron Pharma | Combinacion de inhibidores de la via de il-4/il-13 y ablacion de celulas plasmaticas para el tratamiento de alergia. |
| CR20210489A (es) | 2019-03-25 | 2021-12-07 | Alteogen Inc | Composición farmacéutica para inyección subcutánea que comprende una variante de hialuronidasa ph20 y un medicamento |
| JP2022539076A (ja) | 2019-06-24 | 2022-09-07 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 分岐連結体を有する細胞結合分子と細胞毒性剤との共役体 |
| JP2022544442A (ja) | 2019-06-24 | 2022-10-19 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | チューブリシン類縁体と細胞結合分子との共役体の製剤 |
| CN114555121A (zh) | 2019-08-29 | 2022-05-27 | 金德雷德生物科学股份有限公司 | 兽用抗il31抗体 |
| KR20220113673A (ko) | 2019-12-13 | 2022-08-16 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 항-tslp 항체 및 그 용도 |
| CA3161728A1 (en) | 2019-12-20 | 2021-06-24 | Mohamad Morsey | Bispecific caninized antibodies and bispecific binding partners for treating atopic dermatitis |
| US20230348577A1 (en) | 2020-02-19 | 2023-11-02 | Adivo Gmbh | Modified fc regions |
| WO2021188631A1 (en) | 2020-03-18 | 2021-09-23 | Kindred Biosciences, Inc. | Anti-il4 receptor antibodies for veterinary use |
| US20230242635A1 (en) | 2020-04-17 | 2023-08-03 | Zoetis Services Llc | Canine antibody variants |
| CA3173927A1 (en) | 2020-04-22 | 2021-10-28 | Shyr Jiann Li | Il4/il13 receptor molecules for veterinary use |
| JP2023524643A (ja) * | 2020-04-22 | 2023-06-13 | キンドレッド バイオサイエンシズ インコーポレイテッド | 獣医学的使用のための長時間作用性抗ｉｌ３１抗体 |
| BR112022025583A2 (pt) | 2020-06-19 | 2023-01-03 | Hangzhou Dac Biotech Co Ltd | Conjugado de molécula de ligação à superfície celular e análogo de camptotecina, composto conjugável, célula de tumor, composição farmacêutica, agente quimioterapêutico, e, agentes sinergísticos |
| AU2021306179A1 (en) | 2020-07-10 | 2023-03-02 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
| GB202012331D0 (en) | 2020-08-07 | 2020-09-23 | Petmedix Ltd | Therapeutic antibodies |
| JP6799831B1 (ja) | 2020-09-01 | 2020-12-16 | 中外製薬株式会社 | Ｉｌ−３１アンタゴニストを有効成分として含有する、透析そう痒症の予防用及び／又は治療用医薬組成物 |
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2017
- 2017-03-23 WO PCT/US2017/023788 patent/WO2018156180A1/en not_active Ceased
- 2017-03-23 US US15/467,464 patent/US10093731B2/en active Active
- 2017-12-15 US US15/844,142 patent/US10150810B2/en active Active
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- 2018-02-09 AU AU2018224711A patent/AU2018224711B2/en active Active
- 2018-02-09 KR KR1020247015851A patent/KR20240093562A/ko active Pending
- 2018-02-09 JP JP2019545292A patent/JP7277370B2/ja active Active
- 2018-02-09 CA CA3053525A patent/CA3053525A1/en active Pending
- 2018-02-09 CN CN202311589839.9A patent/CN117603350A/zh active Pending
- 2018-02-09 KR KR1020197025631A patent/KR20190127703A/ko not_active Ceased
- 2018-02-09 EP EP18756690.6A patent/EP3585429A4/en active Pending
- 2018-02-09 US US16/488,045 patent/US11673946B2/en active Active
- 2018-02-09 BR BR112019017308A patent/BR112019017308A2/pt unknown
- 2018-02-09 MA MA047609A patent/MA47609A/fr unknown
- 2018-02-09 CN CN201880026436.4A patent/CN110769851B/zh active Active
- 2018-11-09 US US16/186,013 patent/US20190169285A1/en not_active Abandoned
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