JP2020510628A5 - - Google Patents
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- JP2020510628A5 JP2020510628A5 JP2019532019A JP2019532019A JP2020510628A5 JP 2020510628 A5 JP2020510628 A5 JP 2020510628A5 JP 2019532019 A JP2019532019 A JP 2019532019A JP 2019532019 A JP2019532019 A JP 2019532019A JP 2020510628 A5 JP2020510628 A5 JP 2020510628A5
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- JP
- Japan
- Prior art keywords
- plasminogen
- use according
- pharmaceutical composition
- drug
- islet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022119582A JP2022166028A (ja) | 2016-12-15 | 2022-07-27 | インスリン受容体基質－２の発現を促進する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/110171 | 2016-12-15 | ||
| CNPCT/CN2016/110171 | 2016-12-15 | ||
| PCT/CN2017/089069 WO2018107708A1 (zh) | 2016-12-15 | 2017-06-19 | 一种促进胰岛素受体底物-2表达的方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119582A Division JP2022166028A (ja) | 2016-12-15 | 2022-07-27 | インスリン受容体基質－２の発現を促進する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510628A JP2020510628A (ja) | 2020-04-09 |
| JP2020510628A5 true JP2020510628A5 (https=) | 2020-07-30 |
| JP7554557B2 JP7554557B2 (ja) | 2024-09-20 |
Family
ID=62557852
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532017A Active JP7175270B2 (ja) | 2016-12-15 | 2017-06-19 | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
| JP2019532019A Active JP7554557B2 (ja) | 2016-12-15 | 2017-06-19 | インスリン受容体基質－２の発現を促進する方法 |
| JP2019531895A Active JP7171572B2 (ja) | 2016-12-15 | 2017-06-19 | 糖尿病を治療するための新しい方法 |
| JP2019532043A Active JP7554048B2 (ja) | 2016-12-15 | 2017-06-19 | インスリン分泌を促進する方法 |
| JP2022119543A Pending JP2022166026A (ja) | 2016-12-15 | 2022-07-27 | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
| JP2022119582A Pending JP2022166028A (ja) | 2016-12-15 | 2022-07-27 | インスリン受容体基質－２の発現を促進する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532017A Active JP7175270B2 (ja) | 2016-12-15 | 2017-06-19 | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531895A Active JP7171572B2 (ja) | 2016-12-15 | 2017-06-19 | 糖尿病を治療するための新しい方法 |
| JP2019532043A Active JP7554048B2 (ja) | 2016-12-15 | 2017-06-19 | インスリン分泌を促進する方法 |
| JP2022119543A Pending JP2022166026A (ja) | 2016-12-15 | 2022-07-27 | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
| JP2022119582A Pending JP2022166028A (ja) | 2016-12-15 | 2022-07-27 | インスリン受容体基質－２の発現を促進する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US11129880B2 (https=) |
| EP (4) | EP3556384B1 (https=) |
| JP (6) | JP7175270B2 (https=) |
| CN (4) | CN110198732A (https=) |
| CA (4) | CA3047172A1 (https=) |
| DK (1) | DK3556383T5 (https=) |
| ES (1) | ES2981141T3 (https=) |
| TW (7) | TW201822803A (https=) |
| WO (7) | WO2018107705A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017101870A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
| TWI725092B (zh) | 2015-12-18 | 2021-04-21 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療糖尿病腎病或其相關病症之藥劑上的用途 |
| TWI624268B (zh) | 2015-12-18 | 2018-05-21 | Talengen Institute Of Life Sciences Co Ltd | 纖溶酶原在製備藥劑上的用途及包括纖溶酶原之藥劑 |
| WO2017101867A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
| JP7175270B2 (ja) * | 2016-12-15 | 2022-11-18 | タレンゲン インターナショナル リミテッド | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
| US11154595B2 (en) | 2016-12-15 | 2021-10-26 | Talengen International Limited | Method for preventing and treating pulmonary fibrosis |
| CA3067890A1 (en) * | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
| CN111411072B (zh) * | 2020-03-09 | 2022-10-11 | 同济大学 | SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| GB8721951D0 (en) | 1987-09-18 | 1987-10-28 | Thrombosis Research Trust | Organic compounds |
| JP2764264B2 (ja) | 1987-10-01 | 1998-06-11 | 株式会社ミドリ十字 | 線溶活性増強剤 |
| AU4661493A (en) | 1992-07-01 | 1994-01-31 | Beth Israel Hospital Boston | Enhancement of thrombolytic therapy with deglycosylated plasminogen |
| DK125693D0 (https=) | 1993-11-05 | 1993-11-05 | Novo Nordisk As | |
| DE4411143C2 (de) | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
| AU709633B2 (en) | 1995-04-26 | 1999-09-02 | Children's Medical Center Corporation | Angiostatin fragments and aggregate angiostatin and methods of use |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| US5955627A (en) | 1996-12-16 | 1999-09-21 | Kuraray Co., Ltd. | Process for the preparation of cyclopropylacetylene derivatives |
| EP1001985A1 (en) * | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
| JP3561154B2 (ja) | 1997-12-26 | 2004-09-02 | 株式会社東芝 | 放送受信装置および契約管理装置 |
| US6728260B2 (en) | 1998-06-26 | 2004-04-27 | Intel Corporation | Switch and/or router unit |
| ATE349226T1 (de) | 1998-09-29 | 2007-01-15 | Leuven Res & Dev Vzw | Verwendung von verbindungen die alpha2- antiplasmin in vivo reduzieren zur herstellung einer zusammensetzung zur behandlung ischämischer schlaganfälle |
| CA2360690A1 (en) | 1999-01-28 | 2000-08-03 | Michael S. O'reilly | Plasminogen kringle 4 region fragments and methods of use |
| US6733750B1 (en) | 1999-03-09 | 2004-05-11 | Minu, L.L.C. | Process and composition for inducing posterior vitreous detachment |
| US6899877B2 (en) | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| US20030014787P1 (en) | 1999-03-31 | 2003-01-16 | Olesen L. Pernille | Floribunda rose variety 'POULfeld' |
| JP2003524413A (ja) | 1999-10-07 | 2003-08-19 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | プラスミノーゲン様ポリヌクレオチド、ポリペプチド、および抗体 |
| US6964764B2 (en) | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US20020159992A1 (en) | 2000-09-29 | 2002-10-31 | Jack Henkin | Antiangiogenic polypeptides and methods for inhibiting angiogenesis |
| TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US6596785B2 (en) | 2001-07-17 | 2003-07-22 | Foamex L.P. | Ink retaining foam structure |
| US7067492B2 (en) | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
| US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| US7202066B2 (en) | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
| AU2003210137A1 (en) | 2002-02-06 | 2003-09-02 | N-Zyme Biotec Gmbh | Method for producing recombinant proteins in micro-organisms |
| US6787135B2 (en) | 2002-03-13 | 2004-09-07 | William Beaumont Hospital | Modification of vitreal matrix metalloproteinase activity |
| US20070185017A1 (en) | 2002-10-29 | 2007-08-09 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| CN1451746A (zh) | 2003-03-20 | 2003-10-29 | 广州市启源生物科技有限公司 | 人纤溶酶原Kringle 5缺失突变重组多肽 |
| US7075933B2 (en) | 2003-08-01 | 2006-07-11 | Nortel Networks, Ltd. | Method and apparatus for implementing hub-and-spoke topology virtual private networks |
| JP4740531B2 (ja) | 2003-09-30 | 2011-08-03 | 雪印乳業株式会社 | 骨吸収抑制剤 |
| US20050250694A1 (en) | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
| CN1946352A (zh) | 2004-04-09 | 2007-04-11 | 狄科特康坦特公司 | 递送药物至眼以治疗后段疾病的方法和物品 |
| CN102660564B (zh) | 2004-04-22 | 2013-05-08 | 泰勒克里斯生物治疗学公司 | 重组修饰的纤溶酶 |
| MX2007002178A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares. |
| JP2008510814A (ja) | 2004-08-23 | 2008-04-10 | ワイス | Ｐａｉ−１阻害剤としてのピロロ−ナフチル酸 |
| CN101227918A (zh) | 2005-04-29 | 2008-07-23 | 加州大学评议会 | 治疗以炎症反应为特征的病理的肽和肽模拟物 |
| US20060257391A1 (en) | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US8064439B2 (en) | 2005-06-30 | 2011-11-22 | Cisco Technology, Inc. | Method and system for call processing |
| CN101263115A (zh) | 2005-08-17 | 2008-09-10 | 惠氏公司 | 经取代吲哚和其用途 |
| US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| WO2007051314A1 (en) | 2005-11-07 | 2007-05-10 | American Diagnostica Inc. | Curcuminoid compounds for inhibiting plasminogen activator inhibitor-1 |
| CN100529085C (zh) | 2005-12-30 | 2009-08-19 | 上海新生源医药研究有限公司 | 重组人纤溶酶原Kringle 5(hk5)生产方法 |
| CN101002888A (zh) | 2006-01-16 | 2007-07-25 | 陈维森 | 复方糖尿康 |
| US20070196350A1 (en) | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| AU2007290881B2 (en) * | 2006-08-28 | 2013-03-07 | Omnio Healer Ab | Candidates against infection |
| US20100080773A1 (en) | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
| CN101842093B (zh) * | 2007-10-23 | 2012-08-22 | 株式会社医药分子设计研究所 | Pai-1产生抑制剂 |
| PL2220221T3 (pl) * | 2007-11-29 | 2015-07-31 | Grifols Therapeutics Inc | Rekombinacyjnie zmodyfikowana plazmina |
| US20090208448A1 (en) * | 2008-02-15 | 2009-08-20 | Solomon Keith R | Inhibition of angiogenesis |
| JP2009196927A (ja) | 2008-02-21 | 2009-09-03 | Chemo Sero Therapeut Res Inst | 血管障害に起因する網膜障害の進展阻害または治療剤 |
| EP2424561A2 (en) | 2009-04-30 | 2012-03-07 | Catherine Blondel | Methods for treating ocular conditions |
| WO2011004011A1 (en) | 2009-07-10 | 2011-01-13 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| CN102250210B (zh) | 2010-05-21 | 2014-05-28 | 厦门大学 | 人纤溶酶原Kringle 5短肽、其药物组合物、用途和编码该种短肽的多核苷酸 |
| CN102121023B (zh) | 2010-12-22 | 2012-07-04 | 中山大学 | 突变型人纤溶酶原kringle5及其制备方法及应用 |
| JP6085568B2 (ja) | 2011-01-05 | 2017-02-22 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
| US9644196B2 (en) * | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
| DK2914575T3 (da) * | 2012-10-31 | 2021-01-18 | Univ Michigan Regents | Plasminogen-aktivator-1-inhibitorer og fremgangsmåder til anvendelse deraf |
| TN2016000048A1 (en) * | 2013-08-13 | 2017-07-05 | Sanofi Sa | Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof |
| CN111879948A (zh) | 2013-10-17 | 2020-11-03 | 综合医院公司 | 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物 |
| CN104789544B (zh) * | 2014-01-16 | 2019-11-26 | 中国科学院福建物质结构研究所 | 重组pai-1抑制剂、包含其的组合物及其用于治疗和检测用途 |
| PY1577621A (es) | 2014-12-19 | 2017-10-02 | Prometic Biotherapeutics Inc | Composicion farmaceutica que comprende plasminogeno y uso para el mismo |
| TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
| WO2017101870A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
| WO2017101867A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
| CA3008185C (en) | 2015-12-18 | 2024-01-16 | Talengen International Limited | Method for prevention or treatment of acute and chronic thrombosis |
| TWI725092B (zh) | 2015-12-18 | 2021-04-21 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療糖尿病腎病或其相關病症之藥劑上的用途 |
| JP7175270B2 (ja) | 2016-12-15 | 2022-11-18 | タレンゲン インターナショナル リミテッド | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
| WO2018107688A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗脂肪肝的方法 |
| EP3725326B1 (en) | 2017-12-15 | 2026-04-22 | Talengen International Limited | Plasminogen for treating osteoarthritis |
-
2017
- 2017-06-19 JP JP2019532017A patent/JP7175270B2/ja active Active
- 2017-06-19 WO PCT/CN2017/089065 patent/WO2018107705A1/zh not_active Ceased
- 2017-06-19 CA CA3047172A patent/CA3047172A1/en not_active Abandoned
- 2017-06-19 CN CN201780078168.6A patent/CN110198732A/zh active Pending
- 2017-06-19 CN CN201780078122.4A patent/CN110366426A/zh active Pending
- 2017-06-19 TW TW106120484A patent/TW201822803A/zh unknown
- 2017-06-19 JP JP2019532019A patent/JP7554557B2/ja active Active
- 2017-06-19 WO PCT/CN2017/089069 patent/WO2018107708A1/zh not_active Ceased
- 2017-06-19 US US16/470,120 patent/US11129880B2/en active Active
- 2017-06-19 CA CA3047176A patent/CA3047176C/en active Active
- 2017-06-19 US US16/470,117 patent/US20190314464A1/en not_active Abandoned
- 2017-06-19 TW TW106120493A patent/TWI763681B/zh active
- 2017-06-19 CA CA3047173A patent/CA3047173A1/en not_active Abandoned
- 2017-06-19 EP EP17880563.6A patent/EP3556384B1/en active Active
- 2017-06-19 TW TW106120480A patent/TWI738799B/zh active
- 2017-06-19 JP JP2019531895A patent/JP7171572B2/ja active Active
- 2017-06-19 EP EP17882072.6A patent/EP3556392B1/en active Active
- 2017-06-19 EP EP17881683.1A patent/EP3556390B1/en active Active
- 2017-06-19 DK DK17880561.0T patent/DK3556383T5/da active
- 2017-06-19 ES ES17880561T patent/ES2981141T3/es active Active
- 2017-06-19 CN CN201780078124.3A patent/CN110139667A/zh active Pending
- 2017-06-19 CN CN201780078131.3A patent/CN110121357A/zh active Pending
- 2017-06-19 WO PCT/CN2017/089062 patent/WO2018107702A1/zh not_active Ceased
- 2017-06-19 WO PCT/CN2017/089064 patent/WO2018107704A1/zh not_active Ceased
- 2017-06-19 WO PCT/CN2017/089066 patent/WO2018107706A1/zh not_active Ceased
- 2017-06-19 TW TW106120494A patent/TWI669130B/zh active
- 2017-06-19 EP EP17880561.0A patent/EP3556383B1/en active Active
- 2017-06-19 WO PCT/CN2017/089063 patent/WO2018107703A1/zh not_active Ceased
- 2017-06-19 TW TW106120482A patent/TWI644682B/zh active
- 2017-06-19 TW TW106120485A patent/TWI642442B/zh active
- 2017-06-19 US US16/469,845 patent/US20190307861A1/en not_active Abandoned
- 2017-06-19 US US16/469,817 patent/US11311607B2/en active Active
- 2017-06-19 TW TW106120481A patent/TWI763680B/zh active
- 2017-06-19 CA CA3047177A patent/CA3047177A1/en not_active Abandoned
- 2017-06-19 WO PCT/CN2017/089061 patent/WO2018107701A1/zh not_active Ceased
- 2017-06-19 JP JP2019532043A patent/JP7554048B2/ja active Active
-
2022
- 2022-07-27 JP JP2022119543A patent/JP2022166026A/ja active Pending
- 2022-07-27 JP JP2022119582A patent/JP2022166028A/ja active Pending
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