CA3047177A1 - Method for promoting expression of insulin receptor substrate-2 - Google Patents

Method for promoting expression of insulin receptor substrate-2 Download PDF

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Publication number
CA3047177A1
CA3047177A1 CA3047177A CA3047177A CA3047177A1 CA 3047177 A1 CA3047177 A1 CA 3047177A1 CA 3047177 A CA3047177 A CA 3047177A CA 3047177 A CA3047177 A CA 3047177A CA 3047177 A1 CA3047177 A1 CA 3047177A1
Authority
CA
Canada
Prior art keywords
plasminogen
mice
subject
group administered
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3047177A
Other languages
English (en)
French (fr)
Inventor
Jinan Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talengen International Ltd
Original Assignee
Talengen International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talengen International Ltd filed Critical Talengen International Ltd
Publication of CA3047177A1 publication Critical patent/CA3047177A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3047177A 2016-12-15 2017-06-19 Method for promoting expression of insulin receptor substrate-2 Abandoned CA3047177A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089069 WO2018107708A1 (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法

Publications (1)

Publication Number Publication Date
CA3047177A1 true CA3047177A1 (en) 2018-06-21

Family

ID=62557852

Family Applications (4)

Application Number Title Priority Date Filing Date
CA3047177A Abandoned CA3047177A1 (en) 2016-12-15 2017-06-19 Method for promoting expression of insulin receptor substrate-2
CA3047172A Abandoned CA3047172A1 (en) 2016-12-15 2017-06-19 Novel method for treating diabetes
CA3047173A Abandoned CA3047173A1 (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting insulin secretion for treatment of diabetes
CA3047176A Active CA3047176C (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting secretion of insulin in treatment of diabetes

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA3047172A Abandoned CA3047172A1 (en) 2016-12-15 2017-06-19 Novel method for treating diabetes
CA3047173A Abandoned CA3047173A1 (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting insulin secretion for treatment of diabetes
CA3047176A Active CA3047176C (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting secretion of insulin in treatment of diabetes

Country Status (9)

Country Link
US (4) US11311607B2 (https=)
EP (4) EP3556390B1 (https=)
JP (6) JP7554557B2 (https=)
CN (4) CN110198732A (https=)
CA (4) CA3047177A1 (https=)
DK (1) DK3556383T5 (https=)
ES (1) ES2981141T3 (https=)
TW (7) TW201822803A (https=)
WO (7) WO2018107701A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2982294T3 (es) 2015-12-18 2024-10-15 Talengen Int Ltd Plasminógeno para su uso en el tratamiento o prevención de lesiones nerviosas por diabetes mellitus
DK3391902T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
CN108463240A (zh) 2015-12-18 2018-08-28 泰伦基国际有限公司 一种预防或治疗糖尿病性视网膜病变的方法
DK3395354T3 (da) 2015-12-18 2024-06-03 Talengen Int Ltd Plasminogen til anvendelse i behandling af diabetisk nefropati
CN110198732A (zh) * 2016-12-15 2019-09-03 泰伦基国际有限公司 一种促进胰岛素受体底物-2表达的方法
JP7213552B2 (ja) 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
CA3067890A1 (en) * 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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Also Published As

Publication number Publication date
EP3556390A4 (en) 2020-09-09
JP2022166028A (ja) 2022-11-01
DK3556383T5 (da) 2024-09-02
CA3047176A1 (en) 2018-06-21
JP7554048B2 (ja) 2024-09-19
EP3556392B1 (en) 2024-04-17
EP3556392A1 (en) 2019-10-23
US11311607B2 (en) 2022-04-26
JP7554557B2 (ja) 2024-09-20
EP3556390A1 (en) 2019-10-23
TW201822801A (zh) 2018-07-01
JP7171572B2 (ja) 2022-11-15
TWI738799B (zh) 2021-09-11
JP7175270B2 (ja) 2022-11-18
TWI642442B (zh) 2018-12-01
JP2020502151A (ja) 2020-01-23
TW201822800A (zh) 2018-07-01
EP3556383A1 (en) 2019-10-23
CA3047173A1 (en) 2018-06-21
CN110198732A (zh) 2019-09-03
TWI669130B (zh) 2019-08-21
WO2018107704A1 (zh) 2018-06-21
TW201822803A (zh) 2018-07-01
EP3556392A4 (en) 2020-09-23
WO2018107708A1 (zh) 2018-06-21
JP2020510628A (ja) 2020-04-09
WO2018107705A1 (zh) 2018-06-21
CA3047176C (en) 2021-11-30
WO2018107703A1 (zh) 2018-06-21
JP2022166026A (ja) 2022-11-01
EP3556383A4 (en) 2020-09-09
US20190314463A1 (en) 2019-10-17
ES2981141T3 (es) 2024-10-07
DK3556383T3 (da) 2024-05-13
EP3556384B1 (en) 2024-04-10
US11129880B2 (en) 2021-09-28
WO2018107702A1 (zh) 2018-06-21
EP3556383B1 (en) 2024-04-10
TWI644682B (zh) 2018-12-21
TW201822802A (zh) 2018-07-01
CA3047172A1 (en) 2018-06-21
TWI763680B (zh) 2022-05-11
EP3556390B1 (en) 2024-04-03
US20190307861A1 (en) 2019-10-10
EP3556384A1 (en) 2019-10-23
TWI763681B (zh) 2022-05-11
WO2018107701A1 (zh) 2018-06-21
TW201822808A (zh) 2018-07-01
CN110366426A (zh) 2019-10-22
TW201822804A (zh) 2018-07-01
WO2018107706A1 (zh) 2018-06-21
JP2020502150A (ja) 2020-01-23
US20190314465A1 (en) 2019-10-17
JP2020502140A (ja) 2020-01-23
CN110139667A (zh) 2019-08-16
EP3556384A4 (en) 2020-09-23
US20190314464A1 (en) 2019-10-17
TW201822807A (zh) 2018-07-01
CN110121357A (zh) 2019-08-13

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