JP2020509018A - 養子細胞移植療法と併せてインターロイキン−２受容体α，β−選択的作動薬を用いる免疫療法的治療方法 - Google Patents

養子細胞移植療法と併せてインターロイキン−２受容体α，β−選択的作動薬を用いる免疫療法的治療方法 Download PDF

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JP2020509018A
JP2020509018A JP2019547077A JP2019547077A JP2020509018A JP 2020509018 A JP2020509018 A JP 2020509018A JP 2019547077 A JP2019547077 A JP 2019547077A JP 2019547077 A JP2019547077 A JP 2019547077A JP 2020509018 A JP2020509018 A JP 2020509018A
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cells
tumor
acting
long
cancer
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JP2020509018A5 (https=
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デボラ エイチ． チャリッチ，
デボラ エイチ． チャリッチ，
アントニ リバス，
アントニ リバス，
ジュリア パリシ，
ジュリア パリシ，
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
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  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019547077A 2017-03-01 2018-03-01 養子細胞移植療法と併せてインターロイキン−２受容体α，β−選択的作動薬を用いる免疫療法的治療方法 Pending JP2020509018A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762465506P 2017-03-01 2017-03-01
US62/465,506 2017-03-01
US201762480971P 2017-04-03 2017-04-03
US62/480,971 2017-04-03
PCT/US2018/020514 WO2018160877A1 (en) 2017-03-01 2018-03-01 Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy

Publications (2)

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JP2020509018A true JP2020509018A (ja) 2020-03-26
JP2020509018A5 JP2020509018A5 (https=) 2021-04-08

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JP2019547077A Pending JP2020509018A (ja) 2017-03-01 2018-03-01 養子細胞移植療法と併せてインターロイキン−２受容体α，β−選択的作動薬を用いる免疫療法的治療方法

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US (1) US11318164B2 (https=)
EP (1) EP3589303A4 (https=)
JP (1) JP2020509018A (https=)
KR (1) KR20190121773A (https=)
CN (1) CN110366421A (https=)
AU (1) AU2018227810A1 (https=)
CA (1) CA3055040A1 (https=)
IL (1) IL269015A (https=)
MX (1) MX2019010382A (https=)
WO (1) WO2018160877A1 (https=)

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BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
CA3100005A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
AU2019271148B9 (en) 2018-05-14 2025-05-29 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
KR20220023988A (ko) 2019-05-14 2022-03-03 웨어울프 세라퓨틱스, 인크. 분리 모이어티 및 이의 사용 방법
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
BR112022009110A2 (pt) 2019-11-14 2022-07-26 Werewolf Therapeutics Inc Polipeptídeos de citocina ativáveis e métodos de uso destes
CN113121670B (zh) * 2020-01-15 2022-11-22 天津键凯科技有限公司 二取代peg化白细胞介素2及其制备方法、应用
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
WO2022260916A1 (en) * 2021-06-08 2022-12-15 Merck Sharp & Dohme Llc Functional cell-based potency assay for measuring biological activity of interleukin 2 (il-2) analogs
CN116036243B (zh) * 2022-04-20 2026-03-24 北京大学宁波海洋药物研究院 受体偏向的peg化il-2变体组合及其应用

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JP2008544046A (ja) * 2005-06-16 2008-12-04 ネクター セラピューティックス エイエル，コーポレイション 分解性結合を有する複合体と該複合体の調製に有益なポリマー試薬
JP2014506116A (ja) * 2010-11-12 2014-03-13 ウェルズ ファーゴ バンク ナショナル アソシエイション Ｉｌ−２部分とポリマーとのコンジュゲート
WO2015125159A1 (en) * 2014-02-21 2015-08-27 Nektar Therapeutics (India) Pvt. Ltd. Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody
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Also Published As

Publication number Publication date
EP3589303A4 (en) 2020-11-25
MX2019010382A (es) 2019-10-22
WO2018160877A1 (en) 2018-09-07
KR20190121773A (ko) 2019-10-28
EP3589303A1 (en) 2020-01-08
US11318164B2 (en) 2022-05-03
US20200016206A1 (en) 2020-01-16
IL269015A (en) 2019-10-31
AU2018227810A1 (en) 2019-08-29
CN110366421A (zh) 2019-10-22
CA3055040A1 (en) 2018-09-07

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