CN110366421A - 使用白介素-2受体α,β选择性激动剂与过继性细胞转移疗法的组合的免疫治疗肿瘤治疗方法 - Google Patents

使用白介素-2受体α,β选择性激动剂与过继性细胞转移疗法的组合的免疫治疗肿瘤治疗方法 Download PDF

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CN110366421A
CN110366421A CN201880014971.8A CN201880014971A CN110366421A CN 110366421 A CN110366421 A CN 110366421A CN 201880014971 A CN201880014971 A CN 201880014971A CN 110366421 A CN110366421 A CN 110366421A
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cells
tumor
acting
cancer
long
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D·H·卡瑞士
A·里巴斯
G·帕里斯
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Nikta Therapeutic Co
University of California
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Nikta Therapeutic Co
University of California
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CN201880014971.8A 2017-03-01 2018-03-01 使用白介素-2受体α,β选择性激动剂与过继性细胞转移疗法的组合的免疫治疗肿瘤治疗方法 Pending CN110366421A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762465506P 2017-03-01 2017-03-01
US62/465,506 2017-03-01
US201762480971P 2017-04-03 2017-04-03
US62/480,971 2017-04-03
PCT/US2018/020514 WO2018160877A1 (en) 2017-03-01 2018-03-01 Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy

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CN110366421A true CN110366421A (zh) 2019-10-22

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CN201880014971.8A Pending CN110366421A (zh) 2017-03-01 2018-03-01 使用白介素-2受体α,β选择性激动剂与过继性细胞转移疗法的组合的免疫治疗肿瘤治疗方法

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US (1) US11318164B2 (https=)
EP (1) EP3589303A4 (https=)
JP (1) JP2020509018A (https=)
KR (1) KR20190121773A (https=)
CN (1) CN110366421A (https=)
AU (1) AU2018227810A1 (https=)
CA (1) CA3055040A1 (https=)
IL (1) IL269015A (https=)
MX (1) MX2019010382A (https=)
WO (1) WO2018160877A1 (https=)

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WO2021143573A1 (zh) * 2020-01-15 2021-07-22 天津键凯科技有限公司 二取代peg化白细胞介素2及其制备方法、应用
WO2023202035A1 (zh) * 2022-04-20 2023-10-26 北京大学宁波海洋药物研究院 受体偏向的peg化il-2变体组合及其应用

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BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
CA3100005A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
AU2019271148B9 (en) 2018-05-14 2025-05-29 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
KR20220023988A (ko) 2019-05-14 2022-03-03 웨어울프 세라퓨틱스, 인크. 분리 모이어티 및 이의 사용 방법
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
BR112022009110A2 (pt) 2019-11-14 2022-07-26 Werewolf Therapeutics Inc Polipeptídeos de citocina ativáveis e métodos de uso destes
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
WO2022260916A1 (en) * 2021-06-08 2022-12-15 Merck Sharp & Dohme Llc Functional cell-based potency assay for measuring biological activity of interleukin 2 (il-2) analogs

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WO2015143328A1 (en) * 2014-03-20 2015-09-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tumor-infiltrating lymphocytes for adoptive cell therapy
CN106132438A (zh) * 2014-02-21 2016-11-16 尼克塔治疗印度私人有限公司 与抗CTLA‑4抗体或抗PD‑1抗体组合的IL‑2Rβ选择性激动剂

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CN106132438A (zh) * 2014-02-21 2016-11-16 尼克塔治疗印度私人有限公司 与抗CTLA‑4抗体或抗PD‑1抗体组合的IL‑2Rβ选择性激动剂
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021143573A1 (zh) * 2020-01-15 2021-07-22 天津键凯科技有限公司 二取代peg化白细胞介素2及其制备方法、应用
WO2023202035A1 (zh) * 2022-04-20 2023-10-26 北京大学宁波海洋药物研究院 受体偏向的peg化il-2变体组合及其应用

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EP3589303A4 (en) 2020-11-25
MX2019010382A (es) 2019-10-22
WO2018160877A1 (en) 2018-09-07
KR20190121773A (ko) 2019-10-28
JP2020509018A (ja) 2020-03-26
EP3589303A1 (en) 2020-01-08
US11318164B2 (en) 2022-05-03
US20200016206A1 (en) 2020-01-16
IL269015A (en) 2019-10-31
AU2018227810A1 (en) 2019-08-29
CA3055040A1 (en) 2018-09-07

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