CA3055040A1 - Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy - Google Patents
Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (5)
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| US201762465506P | 2017-03-01 | 2017-03-01 | |
| US62/465,506 | 2017-03-01 | ||
| US201762480971P | 2017-04-03 | 2017-04-03 | |
| US62/480,971 | 2017-04-03 | ||
| PCT/US2018/020514 WO2018160877A1 (en) | 2017-03-01 | 2018-03-01 | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
Publications (1)
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| CA3055040A1 true CA3055040A1 (en) | 2018-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA3055040A Pending CA3055040A1 (en) | 2017-03-01 | 2018-03-01 | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
Country Status (10)
| Country | Link |
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| US (1) | US11318164B2 (https=) |
| EP (1) | EP3589303A4 (https=) |
| JP (1) | JP2020509018A (https=) |
| KR (1) | KR20190121773A (https=) |
| CN (1) | CN110366421A (https=) |
| AU (1) | AU2018227810A1 (https=) |
| CA (1) | CA3055040A1 (https=) |
| IL (1) | IL269015A (https=) |
| MX (1) | MX2019010382A (https=) |
| WO (1) | WO2018160877A1 (https=) |
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| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CA3100005A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| AU2019271148B9 (en) | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| CN113121670B (zh) * | 2020-01-15 | 2022-11-22 | 天津键凯科技有限公司 | 二取代peg化白细胞介素2及其制备方法、应用 |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| WO2022260916A1 (en) * | 2021-06-08 | 2022-12-15 | Merck Sharp & Dohme Llc | Functional cell-based potency assay for measuring biological activity of interleukin 2 (il-2) analogs |
| CN116036243B (zh) * | 2022-04-20 | 2026-03-24 | 北京大学宁波海洋药物研究院 | 受体偏向的peg化il-2变体组合及其应用 |
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| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| BRPI0611872B8 (pt) * | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| MX385194B (es) * | 2014-02-21 | 2025-03-14 | Nektar Therapeutics India Pvt Ltd | Agonistas il-2rbeta-selectivos en combinación con un anticuerpo anti-ctla-4 o un anticuerpo anti-pd-1. |
| JP2017511375A (ja) * | 2014-03-20 | 2017-04-20 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 養子細胞療法のための腫瘍浸潤リンパ球 |
| EP3034092A1 (en) * | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| BR112019013940A2 (pt) * | 2017-01-06 | 2020-02-11 | Iovance Biotherapeutics, Inc. | Método de tratar um câncer com uma população de linfócitos infiltrantes de tumor, processo para preparação de uma população de linfócitos infiltrantes de tumor, população de linfócitos infiltrantes de tumor, e, composição farmacêutica. |
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2018
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2019
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| EP3589303A4 (en) | 2020-11-25 |
| MX2019010382A (es) | 2019-10-22 |
| WO2018160877A1 (en) | 2018-09-07 |
| KR20190121773A (ko) | 2019-10-28 |
| JP2020509018A (ja) | 2020-03-26 |
| EP3589303A1 (en) | 2020-01-08 |
| US11318164B2 (en) | 2022-05-03 |
| US20200016206A1 (en) | 2020-01-16 |
| IL269015A (en) | 2019-10-31 |
| AU2018227810A1 (en) | 2019-08-29 |
| CN110366421A (zh) | 2019-10-22 |
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