JP2020509018A5 - - Google Patents
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- JP2020509018A5 JP2020509018A5 JP2019547077A JP2019547077A JP2020509018A5 JP 2020509018 A5 JP2020509018 A5 JP 2020509018A5 JP 2019547077 A JP2019547077 A JP 2019547077A JP 2019547077 A JP2019547077 A JP 2019547077A JP 2020509018 A5 JP2020509018 A5 JP 2020509018A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- acting
- long
- combination according
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010028980 Neoplasm Diseases 0.000 claims description 53
- 239000000556 agonist Substances 0.000 claims description 37
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 25
- 108010002350 Interleukin-2 Proteins 0.000 claims description 16
- 102000000588 Interleukin-2 Human genes 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 16
- 239000002202 Polyethylene glycol Substances 0.000 claims description 12
- 229920001223 polyethylene glycol Polymers 0.000 claims description 12
- 125000003827 glycol group Chemical group 0.000 claims description 11
- 230000000717 retained effect Effects 0.000 claims description 6
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 108700025316 aldesleukin Proteins 0.000 claims description 4
- 229960005310 aldesleukin Drugs 0.000 claims description 4
- 230000009286 beneficial effect Effects 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 210000003289 regulatory T cell Anatomy 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 3
- 238000010171 animal model Methods 0.000 claims description 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 239000012636 effector Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762465506P | 2017-03-01 | 2017-03-01 | |
| US62/465,506 | 2017-03-01 | ||
| US201762480971P | 2017-04-03 | 2017-04-03 | |
| US62/480,971 | 2017-04-03 | ||
| PCT/US2018/020514 WO2018160877A1 (en) | 2017-03-01 | 2018-03-01 | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020509018A JP2020509018A (ja) | 2020-03-26 |
| JP2020509018A5 true JP2020509018A5 (https=) | 2021-04-08 |
Family
ID=63371348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547077A Pending JP2020509018A (ja) | 2017-03-01 | 2018-03-01 | 養子細胞移植療法と併せてインターロイキン−２受容体α，β−選択的作動薬を用いる免疫療法的治療方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11318164B2 (https=) |
| EP (1) | EP3589303A4 (https=) |
| JP (1) | JP2020509018A (https=) |
| KR (1) | KR20190121773A (https=) |
| CN (1) | CN110366421A (https=) |
| AU (1) | AU2018227810A1 (https=) |
| CA (1) | CA3055040A1 (https=) |
| IL (1) | IL269015A (https=) |
| MX (1) | MX2019010382A (https=) |
| WO (1) | WO2018160877A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| AU2019271148B9 (en) | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| WO2019222296A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| EP3969035A4 (en) | 2019-05-14 | 2023-06-21 | Werewolf Therapeutics, Inc. | SEPARATION UNITS AND METHODS AND THEIR USE |
| BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
| MX2022005666A (es) | 2019-11-14 | 2022-10-07 | Werewolf Therapeutics Inc | Polipeptidos de citocina activables y metodos de uso de los mismos. |
| CN113121670B (zh) * | 2020-01-15 | 2022-11-22 | 天津键凯科技有限公司 | 二取代peg化白细胞介素2及其制备方法、应用 |
| EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations, Inc. | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
| EP4352087A4 (en) * | 2021-06-08 | 2025-05-14 | Merck Sharp & Dohme LLC | FUNCTIONAL CELL-BASED BIOLOGICAL ACTIVITY ASSAY FOR MEASURING THE BIOLOGICAL ACTIVITY OF INTERLEUKIN 2 (IL-2) ANALOGUES |
| WO2023202035A1 (zh) * | 2022-04-20 | 2023-10-26 | 北京大学宁波海洋药物研究院 | 受体偏向的peg化il-2变体组合及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| HUE025208T2 (en) * | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| WO2012065086A1 (en) * | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| KR102410090B1 (ko) * | 2014-02-21 | 2022-06-16 | 넥타르 테라퓨틱스 (인디아) 프라이빗 리미티드 | 항-ｃｔｌａ－４ 항체 또는 항-ｐｄ－１ 항체와 조합한 ｉｌ－２ｒ베타-선택적 효현제 |
| AU2015231041B2 (en) * | 2014-03-20 | 2020-07-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor-infiltrating lymphocytes for adoptive cell therapy |
| EP3034092A1 (en) | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| MX2019007963A (es) * | 2017-01-06 | 2019-10-21 | Iovance Biotherapeutics Inc | Expansion de linfocitos infiltrantes de tumor (til) con agonistas de la superfamilia de recptor de factor de necrosis tumoral (tnfrsf) y combinaciones terapeuticas de til- y agonistas de tnfrsf. |
-
2018
- 2018-03-01 WO PCT/US2018/020514 patent/WO2018160877A1/en not_active Ceased
- 2018-03-01 KR KR1020197024673A patent/KR20190121773A/ko not_active Ceased
- 2018-03-01 JP JP2019547077A patent/JP2020509018A/ja active Pending
- 2018-03-01 CN CN201880014971.8A patent/CN110366421A/zh active Pending
- 2018-03-01 MX MX2019010382A patent/MX2019010382A/es unknown
- 2018-03-01 EP EP18760525.8A patent/EP3589303A4/en not_active Withdrawn
- 2018-03-01 AU AU2018227810A patent/AU2018227810A1/en not_active Abandoned
- 2018-03-01 US US16/490,443 patent/US11318164B2/en active Active
- 2018-03-01 CA CA3055040A patent/CA3055040A1/en active Pending
-
2019
- 2019-08-29 IL IL26901519A patent/IL269015A/en unknown
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