JP2020508078A5 - - Google Patents
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- JP2020508078A5 JP2020508078A5 JP2019565074A JP2019565074A JP2020508078A5 JP 2020508078 A5 JP2020508078 A5 JP 2020508078A5 JP 2019565074 A JP2019565074 A JP 2019565074A JP 2019565074 A JP2019565074 A JP 2019565074A JP 2020508078 A5 JP2020508078 A5 JP 2020508078A5
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- ldrna
- target mrna
- nucleotides
- mrna
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- 108020004999 messenger RNA Proteins 0.000 claims description 32
- 230000000295 complement effect Effects 0.000 claims description 13
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- 239000000203 mixture Substances 0.000 claims description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 6
- 230000019491 signal transduction Effects 0.000 claims description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 4
- 230000000692 anti-sense effect Effects 0.000 claims description 3
- 230000006870 function Effects 0.000 claims description 3
- 230000014509 gene expression Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 102000034285 signal transducing proteins Human genes 0.000 claims description 3
- 108091006024 signal transducing proteins Proteins 0.000 claims description 3
- 108020004394 Complementary RNA Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
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- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 claims description 2
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- 108090000623 proteins and genes Proteins 0.000 claims description 2
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- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 claims 1
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- ZGDVRBVTNMQMEX-LDHZKLTISA-N (8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylhept-6-en-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCCC(C)=C)C)[C@@]1(C)CC2 ZGDVRBVTNMQMEX-LDHZKLTISA-N 0.000 description 2
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- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
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- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- UVBYMVOUBXYSFV-XUTVFYLZSA-N 1-methylpseudouridine Chemical compound O=C1NC(=O)N(C)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UVBYMVOUBXYSFV-XUTVFYLZSA-N 0.000 description 1
- OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 description 1
- ZAYHVCMSTBRABG-UHFFFAOYSA-N 5-Methylcytidine Natural products O=C1N=C(N)C(C)=CN1C1C(O)C(O)C(CO)O1 ZAYHVCMSTBRABG-UHFFFAOYSA-N 0.000 description 1
- ZAYHVCMSTBRABG-JXOAFFINSA-N 5-methylcytidine Chemical compound O=C1N=C(N)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZAYHVCMSTBRABG-JXOAFFINSA-N 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
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- PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 102000002689 Toll-like receptor Human genes 0.000 description 1
- 108020000411 Toll-like receptor Proteins 0.000 description 1
- WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
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- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
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- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457282P | 2017-02-10 | 2017-02-10 | |
| US62/457,282 | 2017-02-10 | ||
| PCT/IB2018/000330 WO2018146557A2 (en) | 2017-02-10 | 2018-02-12 | Long double-stranded rna for rna interference |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508078A JP2020508078A (ja) | 2020-03-19 |
| JP2020508078A5 true JP2020508078A5 (enExample) | 2021-03-25 |
| JP7424728B2 JP7424728B2 (ja) | 2024-01-30 |
Family
ID=63107285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565074A Active JP7424728B2 (ja) | 2017-02-10 | 2018-02-12 | Ｒｎａ干渉のための長鎖の二本鎖ｒｎａ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11591600B2 (enExample) |
| EP (1) | EP3580339A4 (enExample) |
| JP (1) | JP7424728B2 (enExample) |
| KR (1) | KR20190108167A (enExample) |
| CN (1) | CN110770343A (enExample) |
| WO (1) | WO2018146557A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2818662C (en) | 2010-10-22 | 2021-07-06 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid molecule inducing rna interference, and uses thereof |
| EP3514236A1 (en) | 2012-05-22 | 2019-07-24 | Olix Pharmaceuticals, Inc. | Rna-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| EP3377630A4 (en) | 2015-11-16 | 2020-01-01 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| CN108779463B (zh) | 2016-02-02 | 2022-05-24 | 奥利克斯医药有限公司 | 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 |
| WO2017134526A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb |
| WO2017178883A2 (en) | 2016-04-11 | 2017-10-19 | Olix Pharmaceuticals, Inc. | Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
| WO2023043239A1 (ko) * | 2021-09-15 | 2023-03-23 | 올릭스 주식회사 | 선천성 면역 반응 유도 효과를 갖는 이중가닥 rna 및 이의 용도 |
| WO2024186166A1 (ko) * | 2023-03-08 | 2024-09-12 | 올릭스 주식회사 | 선천성 면역 반응 유도 효과를 갖는 이중가닥 rna 및 이의 용도 |
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-
2018
- 2018-02-12 US US16/484,643 patent/US11591600B2/en active Active
- 2018-02-12 JP JP2019565074A patent/JP7424728B2/ja active Active
- 2018-02-12 KR KR1020197025890A patent/KR20190108167A/ko not_active Ceased
- 2018-02-12 WO PCT/IB2018/000330 patent/WO2018146557A2/en not_active Ceased
- 2018-02-12 EP EP18750685.2A patent/EP3580339A4/en active Pending
- 2018-02-12 CN CN201880024222.3A patent/CN110770343A/zh active Pending
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